Multi-target agents
Target Pair | Drug Name | |
---|---|---|
TRIP5 --- mRNA of KIF11 | (4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
MMP9 --- MMP3 | 3-(Formyl-hydroxy-amino)-2-isobutyl-hexanoic acid [4-{[amino-(pyridine-2-sulfonylimino)-methyl]-amino}-1-(thiazol-2-ylcarbamoyl)-butyl]-amide | Drug Info |
TRIP5 --- mRNA of KIF11 | N-[4-(2,2-dimethyl-1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-cyclohexylmethyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
mTOR --- AKT | N-(2-Chloro-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
TRIP5 --- mRNA of KIF11 | (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide | Drug Info |
mTOR --- AKT | N-(6-(2-(4-Methoxyphenylsulfonamido)pyridin-4-yl)benzo-[d]thiazol-2-yl)acetamide | Drug Info |
TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)-4-biphenylol | Drug Info |
Ftase --- FPTase | {2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid benzyl ester | Drug Info |
mTOR --- PI3K gamma | (S)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-morpholino-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-methyl-2-(1-oxy-pyridin-4-yl)-propan-1-one | Drug Info |
mTOR --- PI3K gamma | Isopropyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
TRIP5 --- mRNA of KIF11 | 4-Thiophene-6-methyl-N-(4-trifluoromethylphenyl)-4,7-dihydro-2H-pyrazole[3,4-b]pyridine-5-carboxamide | Drug Info |
Ftase --- FPTase | (S)-2-(5-((R)-2-amino-3-mercaptopropylamino)biphenyl-2-ylcarboxamido)-4-(methylthio)butanoic acid | Drug Info |
mTOR --- PI3K gamma | 4,6-dihydroxy-2-((1-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-5-methoxy-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
TRIP5 --- mRNA of KIF11 | CHEMBL1829257 | Drug Info |
Ftase --- FPTase | (+)1-[4-(10-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
mTOR --- PI3K gamma | (S)-4-(3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)ureido)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide | Drug Info |
TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-4-methyl-N-(1-(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)benzamide | Drug Info |
Ftase --- FPTase | 15,20-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[19.6.2.13,7.09,13.025,29]triaconta-1(28),3,5,7(30),10,12,21(29),22,24,26-decaen-4-yl cyanide | Drug Info |
NET --- SERT | SID49665789 | Drug Info |
Lck --- VEGFR | 6-o-tolylquinazolin-2-amine | Drug Info |
Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-4-yl)-amide | Drug Info |
NET --- SERT | (2R,3S)-3-(2-Hydroxy-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
Src --- VEGFR | CHEMBL371688 | Drug Info |
Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[3-(3H-imidazol-4-yl)-propyl]-amide} | Drug Info |
NET --- SERT | Benzhydryl-{2-[1-(4-fluoro-benzyl)-piperidin-4-yl]-ethyl}-amine | Drug Info |
VEGFR1 --- FGFR1 | 3-(1H-benzo[d]imidazol-2-yl)-4-hydroxy-1,7-naphthyridin-2(1H)-one | Drug Info |
Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-4-yl-piperidine-1-carboxamidine | Drug Info |
NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinomethyl)phenyl)nicotinonitrile | Drug Info |
VEGFR2 --- CABL | (E)-3-(5-((Z)-4-Methyl-3-oxo-3,4-dihydrobenzo[b][1,4]oxazin-2-ylidenemethyl)thiophen-2-yl)-N-(pyridin-3-ylmethyl)acrylamide | Drug Info |
Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((E)-2-pyridin-2-yl-vinyl)-benzonitrile | Drug Info |
NPKCdelta --- NPKCtheta | (E)-5-(3-((2-methoxyethylamino)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-5-chloro-N-(4-(2-(4-methylpiperazin-1-yl)ethyl)phenyl)pyrimidin-2-amine | Drug Info |
Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-sulfamoyl-butyric acid | Drug Info |
NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(2-(pyrrolidin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
VEGFR2 --- CDK1 | 4-(4-(2-aminopropan-2-yl)phenyl)-2-(4-(2-(2-ethyl-1H-imidazol-1-yl)ethyl)phenylamino)pyrimidine-5-carbonitrile | Drug Info |
Ftase --- FPTase | 6-[(4-Cyano-3-iodo-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
NPKCdelta --- NPKCtheta | 2-(3-((dimethylamino)methyl)-2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
VEGFR2 --- Ckit | OSI-930 | Drug Info |
FTase --- GTase | N-(5'-cyano-2'-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-yl)acetamide | Drug Info |
CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N-methyl-benzamide | Drug Info |
NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Dimethylamino)piperidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-isopropyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-5-oxo-1-phenylpyrrolidine-3-carboxamide | Drug Info |
H3 --- SERT | 2-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)phenol | Drug Info |
EGFR3 --- HER2 | 3-(3-cyano-6,7-dimethoxyquinolin-4-ylamino)benzamide | Drug Info |
PI3K gamma --- PI3K delta | Acetic acid (3aS,5R,5bR,6S,11bR)-5-acetoxy-6-methoxymethyl-3a,5b-dimethyl-8,11-dioxo-3a,4,5,5b,11,11b-hexahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-3-yl ester | Drug Info |
VEGFR2 --- Cmet | N,N-diethyl-7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamide | Drug Info |
Pagination
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