Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- VEGFR1 | 2-{4-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethanol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-phenoxyphenyl)-1-(2-(pyridin-4-yl)ethyl)-1H-pyrazole-5-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 5-(4-(3-(4-phenoxy-2-propylphenoxy)propoxy)-3-propylphenyl)thiazolidine-2,4-dione | Drug Info |
| HDAC1 --- HDAC2 | N-(2-aminophenyl)-3-(4-(2-oxo-1-(2-(tetrahydro-2H-pyran-4-yl)ethylamino)-2-(4-(trifluoromethyl)phenylamino)ethyl)phenyl)acrylamide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-{4-[4-(4-nitro-phenyl)-piperazin-1-yl]-phenyl}-methanone | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Chloro-N-(4-chloro-2-methyl-benzoyl)-benzenesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(4-((4-chloro-2-methylphenoxy)methyl)-2-(pent-2-ynyloxy)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-(2-biphenyl-4-yl-oxazol-5-yl)-heptanoic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 6-Hydroxy-2-(4-hydroxy-phenyl)-3-methyl-inden-1-one | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)isothiazole-3-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-Ethoxy-3-{4-[(Z)-3-(4-furan-2-yl-phenyl)-3-phenyl-allyloxy]-phenyl}-propionic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-2-yl)phenyl)-4-(propionamidomethyl)benzamide | Drug Info |
| Erbeta --- ER | 3-(5-hydroxynaphthalen-2-yl)benzo[d]isoxazol-6-ol | Drug Info |
| VEGFR2 --- VEGFR1 | [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(4-(4-(1,3-dioxoisoindolin-2-yl)-2-ethoxyphenethyl)benzyl)butanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(Benzo[d][1,3]dioxol-5-yl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-cyclopentyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-4-methoxy-benzenesulfonamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-{[4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenyl]oxy}propanoic acid | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) | Drug Info |
| Erbeta --- ER | 3-Bromo-5-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(benzo[d][1,3]dioxol-5-yl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(((4-hydroxybenzo[d]oxazol-2-yl)(3-phenoxypropyl)amino)methyl)phenoxy)butanoic acid | Drug Info |
| HER2 --- CD221 | 2,6-difluoro-N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | Drug Info |
| Erbeta --- ER | 4-(3-Phenyl-1H-indol-2-yl)phenol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-4-(2-(pyridin-4-yl)ethyl)thiazole-5-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (R)-2-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| IKKbeta --- JAK2 | (4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(pyrrolidin-1-yl)methanone | Drug Info |
| Erbeta --- ER | 4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazine-1-carboxylic acid (4-chloro-phenyl)-amide | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-(chlorodifluoromethoxy)phenyl)-5-(2-(2-(pyridin-4-yl)ethyl)pyridin-3-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(1-(4-tert-butylbenzyl)-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)-2-methylpropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-6-ethoxy-5-ethynylpicolinamide | Drug Info |
| Erbeta --- ER | (3S,10S,13S,17S)-10-(hydroxymethyl)-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,4-dichlorophenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-methoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenylmethyl}hexanoic aci | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-methylphenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | rac-9a-butyl-6-cyclopropyl-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 3-methyl-1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-4,6-difluorobiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-(thiophen-3-yl)picolinamide | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 5-methyl-2-(3-(7-methyl-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-(trifluoromethyl)quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 10-bromo-3-hydroxy-4,8-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((R)-3-(4-chloro-2-(pyridin-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 6-hydroxy-3-{4-[2-(1-piperidinyl) ethoxy]phenoxy}-2-(4-aminophenyl)benzo[b] thiophene | Drug Info |
| PPAR gamma --- PPAR delta | 2-(7-(4-(benzyloxy)benzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-2-methyl-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
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