Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| mTOR --- PI3K gamma | 4-({[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(3-methoxyphenyl)urea | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(2-pyridin-4-yl-ethyl)-piperidine-1-carboxamidine | Drug Info |
| mTOR --- PI3K gamma | 1-(2,3'-bipyridin-5-yl)-3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(methylthio)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | (R)-2-({4-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-biphenyl-2-carbonyl}-amino)-3-methylsulfanyl-propionic acid methyl ester | Drug Info |
| NET --- SERT | 1-[3-(5-Iodo-6-methoxy-naphthalen-2-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one | Drug Info |
| VEGFR2 --- Cmet | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Drug Info |
| Ftase --- FPTase | 1-{4-[4-((R)-8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-piperidin-1-yl}-ethanone | Drug Info |
| NET --- SERT | (S)-4-(2-Benzhydryloxy-ethyl)-1-(4-fluoro-benzyl)-piperidin-3-one | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-trifluoromethoxy-biphenyl-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N,N-dimethylacrylamide | Drug Info |
| VEGFR2 --- CSrc | 3-(4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-1-cyclohexyl-1-methylurea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpiperazin-1-yl)methyl)benzo[b]thiophen-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-tert-butylphenyl)-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- CSrc | 3-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-1-cyclohexyl-1-methylurea | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid phenyl ester | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinomethyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-fluorobenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(4-methyl-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(2-(5-(morpholinomethyl)pyridin-2-yl)vinyl)nicotinonitrile | Drug Info |
| VEGFR2 --- FGFR1 | 1-{2-Chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-{4-[(1-methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)phenyl}urea | Drug Info |
| GSK --- TGFR | 3-Imidazo[1,2-a]pyridin-3-yl-4-[9-methyl-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl]-pyrrole-2,5-dione | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-([1,4]Diazepane-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(pyrrolidin-1-ylsulfonyl)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- MCSF | N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzamide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenyl-3-(4-(3-(piperidin-1-yl)propoxy)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | SID144211613 | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957845 | Drug Info |
| VEGFR2 --- TEK | methyl 5-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-1H-benzo[d]imidazol-2-ylcarbamate | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-phenoxy-3-(3-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(4-morpholinyl)-2-butynamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(morpholin-4-yl)-6,7-dihydro-4H-spiro[1,3-benzothiazole-5,1'-cyclohexane]-7-one | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-3,4-diazaindole-2-yl)carbamate | Drug Info |
| H3 --- SERT | (5-(4-(4-isopropyl-1,4-diazepan-1-yl)but-1-ynyl)-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(phenylethynyl)pyrimidin-4-amine | Drug Info |
| PI3K gamma --- PI3K delta | 3-(6-(1H-indazol-5-ylamino)-2-morpholinopyrimidin-4-yl)phenol | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| H3 --- SERT | 3-(3-chlorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-(4-(benzyloxy)phenyl)acrylate | Drug Info |
| PI3K gamma --- PI3K delta | N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)-4-fluorobenzenesulfonamide | Drug Info |
| VEGFR2 --- TEK | N-(3-(4-amino-5-(biphenyl-4-yl)furo[2,3-d]pyrimidin-6-yl)phenyl)methanesulfonamide | Drug Info |
| HD6 --- HDAC4 | 2,2,2-trifluoro-1-(5-(5-phenylthiazol-2-yl)thiophen-2-yl)ethanone | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-3-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PKCA --- NPKC delta | (R)-2-{2,6-Dihydroxy-4-[3-(4-hydroxy-benzoylamino)-azepan-4-ylcarbamoyl]-benzoyl}-3-hydroxy-benzoic acid | Drug Info |
| VEGFR2 --- TEK | 3-{19-methyl-14-oxo-3-propyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-7-yl}-1-[4-(methylsulfanyl)phenyl]urea | Drug Info |
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