Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(N-methylisobutyramido)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 1-(4-bromophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-{5-[5-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)pentyloxy]-1H-indol-1-yl}ethanoic acid | Drug Info |
| JNK1 --- JNK3 | 3-Morpholino-5-(2-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)-phenylamino)pyrimidin-4-yl)benzonitrile | Drug Info |
| Erbeta --- ER | 1-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-pentan-3-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(4-hydroxybut-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | methyl 4-ethyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-4-carbonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylselanyl)phenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine | Drug Info |
| Erbeta --- ER | 2-(4-Methoxycarbonyl-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid methyl ester | Drug Info |
| PPAR gamma --- PPAR delta | {3-[1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-ylmethyl]-phenoxy}-acetic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-(methylsulfonyl)benzyl)-4-amino-5-cyano-6-isopropoxypicolinamide | Drug Info |
| Erbeta --- ER | [4,6-Dihydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,5-bis(benzoyloxy)cinnamyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | 3-(3-Bromo-4-hydroxy-phenyl)-2-ethyl-5-methyl-2H-benzo[1,4]oxazin-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(6-methoxy-1H-indol-1-ylsulfonyl)benzamido)-5-methylbenzoic acid | Drug Info |
| JNK1 --- JNK3 | N-(2-(1H-1,2,4-triazol-3-yl)phenyl)-5-chloro-2-(4-methoxyphenoxy)pyridin-4-amine | Drug Info |
| Erbeta --- ER | 3-(4-(3-cyclopropyl-6-hydroxy-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| JNK1 --- JNK3 | 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(3-morpholin-4-yl-propyl)-benzamide | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-2-propylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| JNK1 --- JNK3 | 4-amino-N-benzyl-5-cyano-6-ethoxypicolinamide | Drug Info |
| Erbeta --- ER | 7-ethynyl-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol | Drug Info |
| JNK1 --- JNK3 | cis-4-(9-((S)-tetrahydrofuran-3-yl)-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylamino)cyclohexanol | Drug Info |
| Erbeta --- ER | 2-Fluoro-4-((1R,2R,5R)-5-hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| COX --- MEK | K00023 | Drug Info |
| Erbeta --- ER | 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-N-methyl-benzamide; TFA | Drug Info |
| MEP --- Cathepsin B | 1-(4-Methoxyphenyl)-6,7-methylenedioxy-2-(4-methylthiophenyl-ureido)-2H-isoquinolin-3-one | Drug Info |
| Erbeta --- ER | 2-(3-Hydroxy-phenyl)-1-[4-(4-isobutyl-piperazin-1-yl)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MEP --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(morpholinomethyl)thiazol-4-yl)benzamide | Drug Info |
| Erbeta --- ER | (S)-5-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol | Drug Info |
| MEP --- Cathepsin B | [(S)-1-(2,5-Dioxo-1-phenethyl-piperidin-4-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Erbeta --- ER | 2-(trifluoroacetyl)-tetrahydro-6-isoquinolinol | Drug Info |
| MEP --- Cathepsin B | 9-(3-hydroxypropyl)-6-(3-(thiophen-2-yl)benzylamino)-9H-purine-2-carbonitrile | Drug Info |
| Erbeta --- ER | 10-[4-(2-Piperidin-1-yl-ethoxy)-benzyl]-10H-benzo[4,5]thieno[3,2-b]indol-7-ol | Drug Info |
| Met --- VEGFR | 7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamide | Drug Info |
| Erbeta --- ER | (2S,3S)-5-Fluoro-7-hydroxy-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-4-one | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| Met --- VEGFR | N1-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-propoxy-benzyl}-butyric acid | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-1-yl)propyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Erbeta --- ER | 4,9-dichloro-3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| PR --- mRNA of AR | 5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| MMP1 --- MMP3 | [(S)-3-((R)-2-Hydroxycarbamoylmethyl-decanoylamino)-2-oxo-azepan-1-yl]-acetic acid methyl ester | Drug Info |
| Erbeta --- ER | 3-epicycloeucalenol | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| MMP1 --- MMP3 | (R)-N*4*-Hydroxy-2-isobutyl-N*1*-[(S)-2-oxo-1-(3-phenoxy-propyl)-azepan-3-yl]-succinamide | Drug Info |
| Erbeta --- ER | 2-(6-hydroxynaphthalen-2-yl)benzo[d]oxazol-6-ol | Drug Info |
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