Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| JAK2 --- STK1 | SID103904526 | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-o-tolyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethoxyphenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 5-chloro-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | 4,4'-(but-3-yne-1,2-diyl)diphenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-ethoxy-3-[(4-trifluoromethylbenzoylamino)-methyl]phenylmethyl}butyric acid | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (3aR,4S,9bS)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-Isopropoxy-3-{4-[5-(4-isopropyl-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| PPAR gamma --- PPAR delta | 2-{4-[2-(5,6,7,8-Tetrahydro-naphthalen-2-yloxy)-ethoxy]-benzyl}-malonic acid monomethyl ester | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-allylpiperazin-1-yl)-3-chlorophenyl)-6-methylpicolinamide | Drug Info |
| Erbeta --- ER | 3-(3-chloro-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-2-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)butanoic acid | Drug Info |
| PR --- mRNA of AR | (Z)-5-(2'-(3'-(E-methylbutenyl)thienylmethylidene))-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]-quinoline | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-{4-[(S)-2-((S)-3-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-chroman-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(2-methyl-4'-(trifluoromethoxy)biphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| PR --- mRNA of AR | 5-(3,5-Dichloro-phenyl)-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| JNK1 --- JNK3 | N-(2-(4-acetylpiperazin-1-yl)-3-chlorophenyl)-5-bromofuran-2-carboxamide | Drug Info |
| Erbeta --- ER | (2R,3S)-7-Chloro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| PR --- mRNA of AR | (Z)-5-(2'-(3'-methoxymethylthienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinoline | Drug Info |
| JNK1 --- JNK3 | 9-ethyl-N8-(2-fluorophenyl)-N2-(4-methoxyphenyl)-9H-purine-2,8-diamine | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-6-(ethoxymethyl)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| PR --- mRNA of AR | 1-cyclopropylmethyl-1,2,3,6-tetrahydro-9-(trifluoromethyl)-7H-[1,4]oxazino[3,2-g]quinolin-7-one | Drug Info |
| JNK1 --- JNK3 | N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide | Drug Info |
| Erbeta --- ER | 3-(4-(3-(methoxymethyl)-2-phenylnaphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| PR --- mRNA of AR | 2-Methyl-1-nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-enylmethyl)-benzene | Drug Info |
| JNK1 --- JNK3 | 2-(2-(4-fluorophenoxy)-5-(trifluoromethyl)pyridin-4-ylamino)benzamide | Drug Info |
| JNK1 --- JNK3 | 4-(3-fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | Drug Info |
| Erbeta --- ER | 10-ethyl-3-hydroxy-8-methoxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-bromophenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| MEP --- Cathepsin B | Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone | Drug Info |
| Erbeta --- ER | CHEMBL242818 | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-(4-methoxyphenyl)propan-1-one | Drug Info |
| MEP --- Cathepsin B | 6-(3-(furan-2-yl)benzylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| Erbeta --- ER | (E)-2-chloro-3,4'-dihydroxybiphenyl-4-carbaldehyde oxime | Drug Info |
| Renin --- Cathepsin D | (S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methyl)-2-{(S)-2-hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-4-methyl-2,15-dioxo-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-3-methyl-butyramide | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-naphthalen-1-yl-ureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| Erbeta --- ER | 1-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-1-methyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Renin --- Cathepsin D | (S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-methyl-amino)-4-(4-methoxy-phenyl)-2,15-dioxo-11-oxa-3,14-diaza-tricyclo[14.3.1.1*5,9*]henicosa-1(20),5,7,9(21),16,18-hexaen-13-yl]-ethyl}-N-isobutyl-3-methyl-butyramideyramide | Drug Info |
| MEP --- Cathepsin B | {(S)-1-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | 11-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-undecanoic acid butyl-methyl-amide | Drug Info |
| S5AR --- SRD5A2 | 17-Aziridin-2-ylmethyl-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one | Drug Info |
| MEP --- Cathepsin B | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-[(3-dimethylcarbamoylallylcarbamoyl)-methyl]-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[(1R,5S)-2-(2-Aza-bicyclo[3.1.0]hex-2-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-4-Bromo-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid tert-butylamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(thiophen-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Erbeta --- ER | (1S,12R,15S)-15-ethyl-5-hydroxy-10-methyltetracyclo[10.3.1.0^{1,9}.0^{3,8}]hexadeca-3,5,7,9-tetraen-11-one | Drug Info |
| S5AR --- SRD5A2 | (7aS,8R)-7a-Methyl-2-oxo-2,3,4,7,7a,8,9,10,10a,10b,11,12-dodecahydro-indeno[4,5-c]quinolizine-8-carboxylic acid tert-butylamide | Drug Info |
| Met --- VEGFR | 7-(6,7-dimethoxyquinolin-4-yloxy)-N-isopropyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
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