Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | 6-mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-[((S)-2-{(S)-2-[2-(3H-imidazol-4-yl)-ethylamino]-3,3-dimethyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | Biphenyl-4-sulfonic acid 2,4-dichloro-benzoylamide | Drug Info |
| MMP2 --- MMP9 | SID56314762 | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-2-carboxylic acid | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-2-fluoro-phenyl)-[6-methoxy-7-(thiophen-3-ylmethoxy)-quinazolin-4-yl]-amine | Drug Info |
| MMP2 --- MMP9 | (R)-2-(Biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[5-((R)-2-Amino-3-mercapto-propionylamino)-2-(4-fluoro-benzyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | (4-Chloro-phenyl)-methyl-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine | Drug Info |
| MMP3 --- MMP8 | [3-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid ethyl ester | Drug Info |
| Ftase --- FPTase | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-amino]-acetic acid ethyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-Bromo-2-methyl-benzoyl)-4-chloro-benzenesulfonamide | Drug Info |
| MMP3 --- MMP8 | [7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (3-methyl-isoxazol-5-yl)-amide | Drug Info |
| VEGFR2 --- VEGFR1 | (2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indazol-3-yl)methanone | Drug Info |
| MMP3 --- MMP8 | [6-tert-Butoxycarbonylamino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-2-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetylamino]-3-methyl-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-morpholinophenyl)benzamide | Drug Info |
| MMP9 --- MMP3 | 3-(Formyl-hydroxy-amino)-2-isobutyl-hexanoic acid [4-{[amino-(pyridine-2-sulfonylimino)-methyl]-amino}-1-(thiazol-2-ylcarbamoyl)-butyl]-amide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-cyclohexylmethyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Acetyl-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| mTOR --- AKT | N-(2-Chloro-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-phenyl-piperidine-1-carboxamidine | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-5-(3-(2-(pyridin-4-yl)ethyl)pyridin-4-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-methyl-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid (3,4-dichloro-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amide | Drug Info |
| mTOR --- PI3K gamma | (S)-N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-morpholino-6-((tetrahydrofuran-3-yl)oxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| Ftase --- FPTase | 4-((2R,3R)-6-Chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-5-methyl-3-phenyl-isoxazole | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-(dimethylamino)ethoxy)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen-2-ylmethyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-phenylurea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-2-phenylethan-1-one | Drug Info |
| NET --- SERT | 8-Dimethylcarbamoylmethyl-3-(4-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| NET --- SERT | SID533835 | Drug Info |
| Ftase --- FPTase | [Hydroxy-(5,9,13-trimethyl-tetradeca-4,8,12-trienyl)-phosphinoylmethyl]-phosphonate | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(6-((4-hydroxypiperidin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-methyl-piperidin-3-yl ester | Drug Info |
| NPKCdelta --- NPKCtheta | CHEMBL2140607 | Drug Info |
| Ftase --- FPTase | N-(4-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzyl)methanesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 5-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carboxylic acid isopropylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(3-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| Ftase --- FPTase | 23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| CAII --- CAI | (2-{[(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-5-ylamino)-2-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| H3 --- SERT | N-methyl(2-(4-(methylthio)phenoxy)-5-(4-thiomorpholinobutyl)phenyl)methanamine | Drug Info |
| EGFR3 --- HER2 | 4-(3,5-dichloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
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