Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 2-(4-Hydroxy-3-methyl-phenyl)-benzo[b]thiophen-6-ol | Drug Info |
| MEP --- Cathepsin B | [1-(3-tert-Butylsulfanyl-2-oxo-1-phenethyl-propylcarbamoyl)-3-methyl-butyl]-carbamic acid pyridin-3-ylmethyl ester | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naphthyridin-2(1H)-one | Drug Info |
| Erbeta --- ER | 3-Chloro-4-{(4S,5R)-5-[2-chloro-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-4,5-dihydro-1H-imidazol-4-yl}-phenol | Drug Info |
| MEP --- Cathepsin B | 2-(4-Acetylphenylureido)-1-(4-methoxyphenyl)-6,7-methylenedioxy-2H-isoquinolin-3-one | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Erbeta --- ER | 4-{2-[4-(4-Phenyl-2,3-dihydro-benzo[b]oxepin-5-yl)-phenoxy]-ethyl}-morpholine | Drug Info |
| MEP --- Cathepsin B | 4'-(4-Fluoro-piperidin-4-yl)-biphenyl-4-carboxylic acid [1-(cyanomethyl-carbamoyl)-cyclohexyl]-amide | Drug Info |
| VEGFR2 --- CD135 | 1-(4-(3-aminobenzo[d]isoxazol-4-yl)phenyl)-3-(2-(trifluoromethyl)phenyl)urea | Drug Info |
| Erbeta --- ER | 3-Ethyl-6-hydroxy-2-(4-hydroxy-phenyl)-1H-indene-1-carboxylic acid [4-(2-piperidin-1-yl-ethoxy)-phenyl]-amide | Drug Info |
| Met --- VEGFR | 7-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-phenyl-pyrrolo[2,1,5-cd]indolizin-6-ol | Drug Info |
| Met --- VEGFR | N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(1H-indol-2-yl)pyrimidine-5-carbonitrile | Drug Info |
| Erbeta --- ER | 1-[1-(4-Bromo-phenyl)-6-hydroxy-3,4-dihydro-1H-isoquinolin-2-yl]-2,2,2-trifluoro-ethanone | Drug Info |
| Met --- VEGFR | N1-cyclohexyl-N3-(4-(2-(1-ethyl-1H-imidazole-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)malonamide | Drug Info |
| VEGFR2 --- Ckit | 1-(4-(3-amino-7-methyl-1H-indazol-4-yl)phenyl)-3-m-tolylurea | Drug Info |
| Erbeta --- ER | 7-hydroxy-9a-methyl-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydropyrido[3'4':3,4]pyrazolo[1,5-a]pyridine-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(morpholine-4-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-5-Fluoro-3-(4-hydroxy-phenyl)-4-methyl-2-{4-[2-((R)-3-methyl-pyrrolidin-1-yl)-ethoxy]-phenyl}-chroman-6-ol | Drug Info |
| MMP1 --- MMP3 | (R)-6-[(1-Acetyl-pyrrolidine-2-carbonyl)-amino]-2-[(S)-1-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-hexanoic acid | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carbothioamide | Drug Info |
| Erbeta --- ER | (2R,3S)-5-Ethyl-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-7-ol | Drug Info |
| MMP1 --- MMP3 | 1-{(S)-1-Benzyl-2-[4-(4-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)benzamide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| MMP1 --- MMP9 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-mercapto-ethyl]-6-hydroxy-nicotinamide | Drug Info |
| VEGFR2 --- CSrc | CHEMBL262721 | Drug Info |
| Erbeta --- ER | geldanamycin-estradiol hybrid | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-2-(4-methoxyphenyl)acetamide | Drug Info |
| VEGFR2 --- CSrc | N-(5-chloro-2-methoxypyridin-4-yl)-7-(3-morpholinopropoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine | Drug Info |
| Erbeta --- ER | 4-{2-[4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-(4-pyridin-3-ylmethyl-piperazin-1-yl)-[1,3,5]triazin-2-ylamino]-ethyl}-phenol | Drug Info |
| MMP13 --- MMP1 | 3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-8-oxa-bicyclo[3.2.1]octane-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- CSrc | 3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-N-(3-methoxyphenyl)-4-methylbenzamide | Drug Info |
| Erbeta --- ER | (S)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol | Drug Info |
| MMP13 --- MMP1 | 1-(4-Methoxy-benzenesulfonylamino)-cyclopentanecarboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[2-fluoro-1-(fluoromethyl)ethoxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-phenyl-pyrrolo[2,1,5-cd]indolizin-5-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-6-(2-(diethylamino)ethyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(4-phenoxy-butylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| Erbeta --- ER | 5'-(2-hexahydro-1-pyridinylethoxy)-2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol | Drug Info |
| MMP13 --- MMP1 | 2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3,5-dimethyl-benzamide | Drug Info |
| VEGFR2 --- TEK | GW673715X | Drug Info |
| Erbeta --- ER | (2R,3aS,4R,9bR)-4-(4-hydroxyphenyl)-2-(trifluoromethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| MMP13 --- MMP1 | N-hydroxy-2-(4-methoxyphenylsulfonyl)-3-methylbutanamide | Drug Info |
| VEGFR2 --- TEK | 3-butyl-7-[(1E)-1-(methoxyimino)ethyl]-19-methyl-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Erbeta --- ER | (2R,3S)-3-(2-Hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(2H-pyrazol-3-yl)-phenoxy]-phenoxy}-piperidine-2,4,6-trione | Drug Info |
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