Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | 2-(4'-Hydroxyphenyl)-3-methyl-6-(piperidin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-4-yl)-amide | Drug Info |
| NET --- SERT | (2R,3S)-3-(2-Hydroxy-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-hydroxypropyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[3-(3H-imidazol-4-yl)-propyl]-amide} | Drug Info |
| NET --- SERT | Benzhydryl-{2-[1-(4-fluoro-benzyl)-piperidin-4-yl]-ethyl}-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4-Methoxybenzyl)-4-furan-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-4-yl-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinomethyl)phenyl)nicotinonitrile | Drug Info |
| DHFR --- VEGFR | 5-[(R/S)-2-(20-Methoxyphenyl)pentyl]furo[2,3-d]pyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-((E)-2-pyridin-2-yl-vinyl)-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(3-((2-methoxyethylamino)methyl)styryl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-5-(cyclohexyloxy)-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-sulfamoyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(2-(pyrrolidin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR1 --- FGFR1 | 4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1,6-naphthyridin-2(1H)-one | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-3-iodo-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3,5-dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(3-((dimethylamino)methyl)-2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-hydroxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| FTase --- GTase | N-(5'-cyano-2'-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-yl)acetamide | Drug Info |
| CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N-methyl-benzamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-{(1E)-4-[4-(Dimethylamino)piperidin-1-yl]but-1-en-1-yl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile | Drug Info |
| VEGFR2 --- CDK1 | 4-(3-(4-(isopropoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline | Drug Info |
| H3 --- SERT | 2-(4-(3-(4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)propyl)piperazin-1-yl)phenol | Drug Info |
| EGFR3 --- HER2 | 3-(3-cyano-6,7-dimethoxyquinolin-4-ylamino)benzamide | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (3aS,5R,5bR,6S,11bR)-5-acetoxy-6-methoxymethyl-3a,5b-dimethyl-8,11-dioxo-3a,4,5,5b,11,11b-hexahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-3-yl ester | Drug Info |
| VEGFR2 --- CDK1 | 2-(2-methyl-1H-indol-5-ylamino)-4-phenylpyrimidine-5-carbonitrile | Drug Info |
| H3 --- SERT | (2-(3-chlorophenoxy)-5-(4-morpholinobut-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {3-cyano-4-[3,5-dichloro-4-(3-fluoro-benzyloxy)-phenylamino]-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| PI3K gamma --- PI3K delta | TG100-115 | Drug Info |
| VEGFR2 --- CDK4 | GW683768X | Drug Info |
| H3 --- SERT | (S)-2-methyl-4-(4-(methylthio)phenyl)-7-(3-morpholinopropoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-morpholinoethyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-2-methyl-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(1-(2-(dimethylamino)ethyl)-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| H3 --- SERT | 7-(3-(4,4-difluoropiperidin-1-yl)propoxy)-4-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | (E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- Cmet | 4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide | Drug Info |
| HD6 --- HDAC4 | ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate | Drug Info |
| EGFR3 --- HER2 | 4-Thiomorpholin-4-yl-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-[2-hydroxy-6-(1H-tetrazol-5-yl)-benzoyl]-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- Cmet | 2-(4-(7-(2-fluoro-4-(3-oxo-3-(phenylamino)propanamido)phenoxy)thieno[3,2-b]pyridine-2-carbonyl)-1H-imidazol-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | ethyl 2-(5-(2-(4-methoxyphenylamino)-2-oxoethyl)thiophen-2-yl)-2-oxoethyl trithiocarbonoate | Drug Info |
| EGFR3 --- HER2 | DDD01067522 | Drug Info |
| PKCA --- NPKC delta | (E)-{2-(hydroxymethyl)-4-[4-methyl-3-(methylethyl)pentylidene]-5-oxo-2,3-dihydrofur-2-yl}methyl 4-hydroxybenzoate | Drug Info |
| VEGFR2 --- CSrc | CHEMBL425209 | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(2-(4-(2-(dimethylamino)ethoxy)phenyl)thiazol-4-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | (4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-fluoren-4-yl)-amine | Drug Info |
| PKCA --- NPKC delta | dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info |
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