Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (3S,4R)-3-Phenyl-4-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-isochroman-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (1'S*,5'R*)-6-[5-Heptyl-2-(oct-1-yn-1-yl)-4-oxo-cyclopent-2-enyloxy]hexanoic Acid | Drug Info |
| JNK1 --- JNK3 | N-(2-methoxyphenyl)-3-phenyl-1H-indazol-6-amine | Drug Info |
| Erbeta --- ER | 2-(4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-N,N-dimethyl-acetamide | Drug Info |
| JNK1 --- JNK3 | 4-(8-chloronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| Erbeta --- ER | 3-(2-(4-hydroxyphenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)benzoyl)benzo[b]thiophen-6-yl)acrylic acid | Drug Info |
| JNK1 --- JNK3 | methyl 2-(2-(1H-indol-7-yl)acetamido)-4-methylthiophene-3-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | 2-(6-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(7-Aza-bicyclo[2.2.1]hept-7-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK1 --- JNK3 | 5-bromo-N-(3-chloro-2-(4-(pyridin-2-yl)piperazin-1-yl)phenyl)furan-2-carboxamide | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-2-fluoro-4-propoxy-benzyl}-butyric acid | Drug Info |
| Erbeta --- ER | 4-(3-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl)phenol | Drug Info |
| JNK3 --- MAPK | (6-Naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-((S)-3-phenyl-2-pyrrolidin-1-yl-propyl)-amine | Drug Info |
| PR --- mRNA of AR | 5-Methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| Erbeta --- ER | methyl 2-(5-(3-chloro-4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-yl)propanoate | Drug Info |
| MEP --- Cathepsin B | 6-(biphenyl-3-ylmethylamino)-9-(3-hydroxypropyl)-9H-purine-2-carbonitrile | Drug Info |
| PR --- mRNA of AR | 15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | Drug Info |
| Erbeta --- ER | 2-Bromo-N-[4-((11S,13S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-butyl]-acetamide | Drug Info |
| MEP --- Cathepsin B | (S)-2-(3-Isopropyl-ureido)-3-methyl-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-cyclohexyl-1-p-tolylpropan-1-one | Drug Info |
| Erbeta --- ER | [2-(4-Chloro-phenyl)-6-hydroxy-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone; hydrochloride | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-1-((S)-4-(isopropylthio)-3-oxo-1-phenylbutan-2-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| PR --- mRNA of AR | 1-Ethyl-6,8,8-trimethyl-4-trifluoromethyl-8,9-dihydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| Erbeta --- ER | SID56320525 | Drug Info |
| MEP --- Cathepsin B | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-[(3-dimethylcarbamoyl-(1S)-1-phenethyl-allylcarbamoyl)-methyl]-(3R)-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-ylmethyl ester | Drug Info |
| PR --- mRNA of AR | N-(3-(4-cyanophenyl)-1-ethyl-1H-indol-6-yl)methanesulfonamide | Drug Info |
| Erbeta --- ER | (R)-2-(1-(4-(4-(piperidin-1-yl)butoxy)benzyl)-2-phenyl-1H-indol-3-yl)-N-(4-(4-hydroxyphenyl)butan-2-yl)acetamide | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(4-methylpiperazine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| PR --- mRNA of AR | 9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 2-(3-Dimethylamino-phenyl)-1-methyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| Met --- VEGFR | (S)-N-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| PR --- mRNA of AR | (+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinolin-3-ol | Drug Info |
| Erbeta --- ER | [4-(2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)phenoxy]acetic AcidMethyl Ester | Drug Info |
| Met --- VEGFR | N-(3-Fluoro-4-((7-methoxyquinolin-4-yl)oxy)phenyl)-1-isobutyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(5-methoxymethyl-1-methyl-2-oxo-pyrrolidin-3-yl)-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| Erbeta --- ER | (R)-2-(naphthalen-2-ylsulfonyl)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | Drug Info |
| MMP1 --- MMP14 | (1S,2R,3R)-1-(6-Chlorothieno[3',2':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | Drug Info |
| Renin --- Cathepsin D | (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imidazol-4-yl)-2-[2-(naphthalen-1-yloxy)-acetylamino]-propionylamino}-2-isopropyl-hexanoic acid {(S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide | Drug Info |
| Erbeta --- ER | SID862559 | Drug Info |
| MMP1 --- MMP3 | 1N-(3-methoxyphenyl)-2-[1-[1-amino-(1R)-ethylcarboxamido]-3-phenyl-(1S)-propylcarboxamido]-4-methyl-(2S)-pentanamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,6-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-[6-methyl(3-pentylsulfanylpropyl)aminohexyl]-(E)-1-butenyl]phenol | Drug Info |
| MMP1 --- MMP3 | (R)-2-[(S)-1-((S)-3-Methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-4-phenylacetylamino-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid [1-(4-tert-butyl-phenyl)-cycloheptyl]-amide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinolin-6-ol | Drug Info |
| MMP1 --- MMP9 | (R)-4-(5,7-Dioxo-5,7-dihydro-[1,3]dioxolo[4,5-f]isoindol-6-yl)-2-[(S)-3-methyl-1-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-butylamino]-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-N-phenyl-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 5,7-dihydroxy-3-(3-fluoro-4-hydroxyphenyl)-4(3H)-quinazolinethione | Drug Info |
| MMP1 --- MMP9 | 12-Isobutyl-13-oxo-1,7diaza-cyclotridecane-2,11-dicarboxylic acid 11-hydroxyamide 2-methylamide | Drug Info |
| S5AR --- SRD5A2 | 4-{3-[2,2-Bis-(4-chloro-phenyl)-benzo[1,3]dioxole-5-carbonyl]-2-methyl-indol-1-yl}-butyric acid | Drug Info |
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