Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP14 | 1-(benzylsulfonyl)-3-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-N-hydroxypiperidine-3-carboxamide | Drug Info |
| Ftase --- FPTase | 4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-biphenyl-3-carboxylic acid 13 (FTI-288) | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid (3-benzoyl-phenyl)-amide | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[1,1';4',1'']terphenyl-4-yl-hexanoic acid | Drug Info |
| Ftase --- FPTase | 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid | Drug Info |
| S5AR --- SRD5A2 | (3R,8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| MMP2 --- MMP3 | 2-[4-(3'-ethoxy-2-methyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxo-ethyl)-piperidin-4-yl]-ethanone | Drug Info |
| ABL --- Src | 4-(4-Chloro-5-methoxy-2-methyl-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-oxo-1-(phenethylamino)propan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| Ftase --- FPTase | [2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylcarbamoyl)-ethyl]-phosphonic acid | Drug Info |
| ABL --- Src | 4-(2-Chloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3-cyclohexyl-1-(3-methoxy-3-oxopropylamino)-1-oxopropan-2-yl)carbamoyl)-6-p-tolylhexanoic acid | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(4-trifluoromethoxy-phenyl)-piperidine-1-carboxamidine | Drug Info |
| PDGFR --- Src | 8-Methyl-2-phenylamino-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| MMP2 --- MMP9 | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-phenyl-pentanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID50085782 | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4'-isopropyl-biphenyl-4-sulfonyl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-thiophen-3-ylmethyl-benzenesulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{4-[5-(4-methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyramide | Drug Info |
| Ftase --- FPTase | 4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(benzo[b]thiophen-3-ylmethyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3-(N-(5-methylisoxazol-3-yl)sulfamoyl)benzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| MMP2 --- MMP9 | 11-(2',6'-Difluoro-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide] | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-((8-(dimethylamino)napththalen-4-yl)sulfonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| MMP2 --- MMP9 | (R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulfonylamino]-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
| MMP2 --- MMP9 | N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionamide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-ethoxy-benzyl ester | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-methyl-4-phenyl-1,2,3,4,8,9-hexahydrofuro[2,3-h]isoquinoline | Drug Info |
| MMP2 --- MMP9 | (S)-2-Amino-N-hydroxy-2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-nitro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-2-hydroxyethanone | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid methyl ester | Drug Info |
| Ftase --- FPTase | 6-[(3-chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-(methylthio)phenyl)diphenylmethylthio)propanoic acid | Drug Info |
| MMP2 --- MMP9 | (-)-(R)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-(pyridin-2-yloxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-5,6,7,8-tetrahydro-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Dimethylamino-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
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