Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CCKBR --- CCKAR | 3-{6-[(6-Acetoxy-naphthalene-2-carbonyl)-amino]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid; hydrate | Drug Info |
| CD135 --- Ckit | 4-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)-N-(2-morpholinoethyl)benzamide | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-acetyl-6-methoxy-1,2,3,4-tetrahydroquinolin-7-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- CDK2 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid dimethylamide | Drug Info |
| CDK1 --- CDK2 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-(4-methanesulfonyl-phenyl)-amine | Drug Info |
| CDK1 --- CDK2 | GW589933X | Drug Info |
| CDK1 --- GSK3 | 9-Bromo-12-methyl-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK1 --- GSK3 | 6-(4-Chloro-phenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine | Drug Info |
| CDK1 --- GSK3 | (E)-3-(6-Oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-benzo[2,3]azepino[4,5-b]indol-2-yl)-acrylonitrile | Drug Info |
| CDK1 --- VEGFR | 5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}-N-[2-(dimethylamino)ethyl]pyridine-3-carboxamide | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(isoquinolin-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | N-Benzyl-1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-fluorobenzamide | Drug Info |
| CDK2 --- CDK1 | GW276655X | Drug Info |
| CDK2 --- CDK1 | 2-(3,4-dihydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(4-isopropoxy-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-cyclohexylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | 4-(2,6-Difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid (trans-4-hydroxycyclohexyl)-amide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-cycloheptylpyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK4 | 1-(4-{5-Bromo-4-[phenyl-(4,4,4-trifluoro-butyl)-amino]-pyrimidin-2-ylamino}-phenoxy)-3-dimethylamino-propan-2-ol | Drug Info |
| CDK2 --- CDK4 | 4-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-3,5-dimethyl-1H-pyrrole-2-carbonitrile | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| CDK2 --- CDK4 | N-[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(4-Oxo-3-propyl-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-iodo-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 4-(4-tert-Butylamino-2-trifluoromethyl-quinazolin-6-yl)-phenol | Drug Info |
| CDK2 --- Cyclin E | (9-Isopropyl-2-pyrrolidin-1-yl-9H-purin-6-yl)-(4-methoxy-benzyl)-amine | Drug Info |
| CDK2 --- Cyclin E | 3-Ethyl-4-methoxy-6-methyl-1-(2,4,6-trichloro-phenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine | Drug Info |
| CDK2 --- Cyclin E | 1-{6-[(Biphenyl-4-ylmethyl)-amino]-9-isopropyl-9H-purin-2-ylamino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | {6-[(Biphenyl-4-ylmethyl)-amino]-2-[bis-(2-hydroxy-ethyl)-amino]-purin-9-yl}-acetic acid tert-butyl ester | Drug Info |
| CDK2 --- GSK3 | 4-(5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)benzenesulfonamide | Drug Info |
| CAII --- CAI | 3-Bromo-4-[(7-chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(Azepane-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | {(2-Hydroxy-phenyl)-[2-((2-hydroxy-phenyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-acetic acid | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(4,5-dihydro-1H-imidazol-2-yl)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 3-(4-(4-bromophenylsulfonyl)phenyl)-4-propyl-1H-1,2,4-triazole-5(4H)-thione | Drug Info |
| COX2 --- 5LOX | 3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-1-(3,4-dimethylphenyl)-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 4-[2-(Heptadecafluorooctane-1-sulfonylamino)-ethyl]-benzenesulfonamide | Drug Info |
| COX2 --- 5LOX | 3-(4-Ethylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | 2-Amino-N-[4-(4-sulfamoyl-phenylsulfamoyl)-phenyl]-acetamide | Drug Info |
| COX2 --- 5LOX | ML-3000 | Drug Info |
| CAII --- CAI | 1,1,2,2,3,3,4,4,4-Nonafluoro-butane-1-sulfonic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| CSrc --- CABL | 7-(2,4-Dichloro-5-methoxy-phenylamino)-2-{4-[2-(4-methyl-piperazin-1-yl)-ethyl]-phenyl}-thieno[3,2-b]pyridine-6-carbonitrile | Drug Info |
| CAII --- CAI | Trifluoro-methanesulfonic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| CSrc --- CABL | 6-Methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-4-(3,4,5-trimethoxy-phenylamino)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 2-(pyridin-4-yl)-N-(4-sulfamoylphenyl)acetamide | Drug Info |
| CSrc --- CABL | N-(4-(dimethylphosphoryl)phenyl)-9-(2-(5-methyl-1H-indazol-4-yl)vinyl)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | {{2-[Carboxymethyl-(2-{carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethyl)-amino]-ethyl}-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 4-((6-bromobenzo[d][1,3]dioxol-5-yl)methylene)-1-(4-iodophenyl)pyrazolidine-3,5-dione | Drug Info |
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