Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CALM2 --- Cathepsin B | Benzenesulfonic acid (3S,5R)-1-benzenesulfonyl-5-((S)-1-benzyl-2-oxo-ethylcarbamoyl)-pyrrolidin-3-yl ester | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-ethanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | (3-Methyl-1-{1-[3-(3,4,4a,8a-tetrahydro-1H-isoquinolin-2-yl)-propylaminooxalyl]-propylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | Benzofuran-2-carboxylic acid {3-methyl-1-[2-oxo-3-(pyridine-2-sulfonylamino)-propylcarbamoyl]-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[3-(2-imidazol-1-yl-ethoxy)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | SID85147302 | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(4-phenylpiperidin-1-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | (S)-2-((S)-1-(4-benzoylphenyl)-2,2,2-trifluoroethylamino)-N-(cyanomethyl)-4-methylpentanamide | Drug Info |
| Cathepsin K --- MEP | (S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | (S)-N-(1-(2-(4-chlorophenylamino)ethylamino)-4-methyl-1-oxopentan-2-yl)-3-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2-(1-methyl-cyclopentyl)-ethyl]-4-methanesulfonylamino-3-methyl-benzamide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(toluene-2-sulfonylamino)-benzamide | Drug Info |
| CCKBR --- CCKAR | 3-(2-{[2-(3-tert-Butoxycarbonylamino-propionylamino)-3-(1H-indol-3-yl)-propionyl]-methyl-amino}-hexanoylamino)-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | [1-[2-(2,4-Dichloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | 1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-chloro-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | Morpholine-4-carboxylic acid (R)-3-(4-benzoyl-piperidin-1-yl)-3-oxo-2-(3-m-tolyl-ureido)-propyl ester | Drug Info |
| CCKBR --- CCKAR | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2-[3-(1H-indol-3-yl)-2-(2-{2-[3-(4-sulfonyl-oxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-propionylamino]-hexanoylamino}-succinamic acid | Drug Info |
| CCKBR --- CCKAR | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{[(5R,8R)-8-(1H-indol-3-ylmethyl)-8-methyl-7,10-dioxo-1,2-dithia-6,9-diaza-cyclotetradecane-5-carbonyl]-amino}-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 4-(4-Benzoyl-piperidin-1-yl)-4-(R)-oxo-3-(3-m-tolyl-ureido)-butyric acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | (S)-3-Bromo-N-[5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide | Drug Info |
| CCKBR --- CCKAR | N-{1-[1-[({2-[2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-methyl)-carbamoyl]-2-(1H-indol-3-yl)-ethylcarbamoyl]-pentyl}-3-(2-carbamoyl-3-phenyl-propionylamino)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | CHEMBL375360 | Drug Info |
| CD135 --- Ckit | 1-(3-(4-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)phenyl)pyrrolidin-1-yl)ethanone | Drug Info |
| CD221 --- JNK1 | 2-(2-(5-(3-(dimethylamino)propoxy)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- CDK2 | 2-oxo-3-[1-(4-sulfamoyl-phenylamino)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester | Drug Info |
| CDK1 --- CDK2 | 8-[1-(4-methanesulfonylmethyl-phenylamino)-meth-(Z)-ylidene]-6,8-dihydro-thiazolo[5,4-e]indol-7-one | Drug Info |
| CDK1 --- CDK4 | 2-(4-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-chromen-4-one | Drug Info |
| CDK1 --- GSK3 | SID527399 | Drug Info |
| CDK1 --- GSK3 | SID527125 | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indazol-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)-3-(4-chlorophenyl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(3-Fluoro-2-methylphenylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CDK1 | N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)-3-(4-methylpiperazin-1-yl)propanamide | Drug Info |
| CDK2 --- CDK1 | N-[2-(3H-Imidazol-4-yl)-ethyl]-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | [3-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-phenyl]-methanol | Drug Info |
| CDK2 --- CDK1 | 6-(Cyclohex-3-enylmethoxy)-5-nitroso-pyrimidine-2,4-diamine | Drug Info |
| CDK2 --- CDK1 | 4-[5-(3-Benzenesulfonylamino-phenyl)-2H-pyrazol-3-ylamino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | SID103904953 | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-sulfonic acid | Drug Info |
| CDK2 --- CDK4 | Benzo[1,3]dioxol-5-yl-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | N-(3-((diethylamino)methyl)phenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL421583 | Drug Info |
| CDK2 --- CDK4 | 6-tert-Butyl-4-{[(4-hydroxy-5-phenyl-pyridin-2-ylmethyl)-amino]-methylene}-4H-isoquinoline-1,3-dione | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-nitro-3-(trifluoromethyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-N6-((2'-chlorobiphenyl-4-yl)methyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(thiophen-2-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-pyridin-3-yl-methanone | Drug Info |
| CDK2 --- Cyclin E | 3-{4-[4-(4-chloro-benzoylamino)-5-hydrazinocarbonylmethylsulfanyl-4H-[1,2,4]triazol-3-ylmethyl]-thiazol-2-ylamino}-propionic acid | Drug Info |
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