Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid cis-4-amino-4-methylcyclohexyl ester | Drug Info |
| CAII --- CAI | Sulfamic acid propyl ester | Drug Info |
| EGFR3 --- HER2 | 2-(4-Hydroxy-3-methoxy-5-phenylsulfanylmethyl-benzylidene)-malononitrile | Drug Info |
| CAII --- CAI | [(S)-4-Methyl-2-(4-sulfamoyl-benzoylamino)-pentanoylamino]-acetic acid | Drug Info |
| EGFR3 --- HER2 | 4-(3-bromo-2-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 4-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-dimethylamino-1-methyl-ethyl ester | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| CAII --- CAI | 4-(2-(3-nitrobenzylideneamino)ethyl)benzenesulfonamide | Drug Info |
| CAII --- CAI | {(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| CAII --- CAI | 4-((2,4-Diaminopteridin-6-yl)methylamino)benzenesulfonic acid | Drug Info |
| CAII --- CAI | N-(2-chloro-4-sulfamoylphenyl)-2-phenylacetamide | Drug Info |
| CAII --- CAI | 2-[(1E)-{[2-(4-sulfamoylphenyl)ethyl]imino}methyl]phenyl N-[(4-chlorobenzene)sulfonyl]carbamate | Drug Info |
| CAII --- CAI | (S)-3-Methyl-2-[3-(4-sulfamoyl-phenyl)-thioureido]-butyric acid | Drug Info |
| CAII --- CAI | 4-Chloro-N-(5-mercapto-[1,3,4]thiadiazol-2-yl)-3-sulfamoyl-benzamide | Drug Info |
| CAII --- CAIX | 4-Amino-3-bromo-5-iodo-benzenesulfonamide | Drug Info |
| CAII --- CAXII | Resorcinol | Drug Info |
| CAIX --- CAXII | SID29218043 | Drug Info |
| CALM2 --- Cathepsin B | (S)-3-(4-chlorophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)thiazolidine-4-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | {3-Methyl-1-[1-(3-morpholin-4-yl-propylaminooxalyl)-butylcarbamoyl]-butyl}-carbamic acid benzyl ester | Drug Info |
| CALM2 --- Cathepsin B | 5-Amino-N-cyclopropyl-3-(4-isopropylphenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxamide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 2-(cyclohexylmethyl)-N-(4-(methylsulfonyl)-1-(4-(trifluoromethoxy)phenylamino)butan-2-yl)-4-morpholino-4-oxobutanamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-cyclohexylamino-pyrimidine-5-carboxylic acid [2-(4-pyrrolin-1-ylphenyl)-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | 1H-Indole-2-carboxylic acid {(S)-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | (S)-4-morpholino-4-oxo-2-phenyl-N-((S)-4-phenyl-1-(4-(trifluoromethoxy)phenylamino)butan-2-yl)butanamide | Drug Info |
| Cathepsin K --- MEP | (R)-4-methyl-2-[3'-(2-piperazin-1-ylmethyl-thiazol-4-yl)-biphenyl-3-yl]-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | N-{4-[5-(2-Thienyl)-1,2,4-oxadiazol-3-yl]phenylcarbamoyl}-leucyl-glycine-nitrile | Drug Info |
| Cathepsin K --- MEP | N-((S)-1-((2R,3R)-3-(benzyloxy)-1-(5-fluoroindolin-1-yl)butan-2-ylamino)-4-cyclohexyl-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| CCKBR --- CCKAR | 4-[3-(4-Chloro-phenyl)-ureido]-4-dipentylcarbamoyl-butyric acid: (0.85 methanol) | Drug Info |
| CCKBR --- CCKAR | 3-{[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-phenethyl-amino}-propionic acid | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-((3R,5R)-5-cyclohexyl-8-methyl-2-oxo-3-{3-[3-(1H-tetrazol-5-yl)-phenyl]-ureido}-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide | Drug Info |
| CCKBR --- CCKAR | SID499039 | Drug Info |
| CCKBR --- CCKAR | [1-[2-(3,4-Dichloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | N-tert-butyloxycarbonyl(O-sulfate)-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanine amide | Drug Info |
| CCKBR --- CCKAR | (R)-2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-bromo-N-(2-phenylpropyl)benzamide | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-N-methyl-acetamide | Drug Info |
| CCKBR --- CCKAR | {[2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-[2-(2,4-dichloro-phenyl)-ethyl]-amino}-acetic acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(3-chloro-phenyl)-ureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 1-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea | Drug Info |
| CD135 --- Ckit | (3-(5-amino-1-(pyridin-2-yl)-1H-1,2,4-triazol-3-ylamino)phenyl)(morpholino)methanone | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(1-(3-(4-isopropylpiperazin-1-yl)propanoyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- CDK2 | GW416981X | Drug Info |
| CDK1 --- CDK2 | 4-(6-(cyclohexylmethoxy)-9H-purin-2-ylamino)phenol | Drug Info |
| CDK1 --- GSK3 | 5'-ethylindirubin | Drug Info |
| CDK1 --- GSK3 | SID514878 | Drug Info |
| CDK1 --- GSK3 | SID514879 | Drug Info |
| CDK1 --- VEGFR | 4-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]butanoic acid | Drug Info |
| CDK2 --- AKT | (S)-5-(5-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)-1,3,4-thiadiazol-2-yl)indolin-2-one | Drug Info |
| CDK2 --- AuroraA | 3-(benzo[d][1,3]dioxole-6-carboxamido)-N-isopropylpyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(2-Hydroxyethyl)-1-methyl-8-(phenylamino)-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
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