Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4,5-dichlorobenzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | (S)-3-{(S)-2-[(R)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-phenethyl-succinamic acid | Drug Info |
| CD135 --- Ckit | (3S,5R,E)-5-bromo-16-hydroxy-14-methoxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(3-(dimethylamino)propanoyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- CDK2 | GW305178X | Drug Info |
| CDK1 --- CDK2 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-(4-methoxy-phenyl)-amine | Drug Info |
| CDK1 --- GSK3 | 8-Cyano-6,11-dihydro-thieno[3',2':2,3]azepino[4,5-b]indol-5(4H)-one | Drug Info |
| CDK1 --- GSK3 | SID529042 | Drug Info |
| CDK1 --- GSK3 | 4-(7-Methyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-4-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 8-(Phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-2-phenylacetamide | Drug Info |
| CDK2 --- CDK1 | 4-(4-amino-6-(cyclohexylmethoxy)-5-nitrosopyrimidin-2-ylamino)benzamide | Drug Info |
| CDK2 --- CDK1 | 2-(3-bromo-4-hydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-(2-(pyridin-4-yl)ethoxy)indolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-Methyl-C-{4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-phenyl}-methanesulfonamide | Drug Info |
| CDK2 --- CDK1 | 2-(2-aminopyrimidin-4-yl)-4-(1,1-dioxidothiomorpholin-4-yl)phenol | Drug Info |
| CDK2 --- CDK1 | N5-(4-aminocyclohexyl)-N7-(4-(phenylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diamine | Drug Info |
| CDK2 --- CDK4 | CHEMBL101311 | Drug Info |
| CDK2 --- CDK4 | ((2-chloro-5-methylphenyl)(6-(4-(3-(dimethylamino)-2-hydroxypropoxy)phenylamino)pyrimidin-4-yl)amino)acetonitrile | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | CHEMBL100979 | Drug Info |
| CDK2 --- CSrc | N-(3,5-dimethylphenyl)-4-(5-methylthiazol-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | 4-((2-nitrophenyl)diazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
| CDK2 --- Cyclin E | 1-[(3-Cyclohexyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-ylcarbamoyl)-methyl]-piperidine-4-carboxylic acid amide | Drug Info |
| CDK2 --- Cyclin E | 6-(2-Methylamino-ethyl)-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(3-Cyclopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 3-Methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | N*2*-[2-(1H-Indol-3-yl)-ethyl]-9-isopropyl-N*6*-(4-methoxy-benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 4-{2-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-ethyl}-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(4-Ethyl-piperazine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 6-(2-Sulfamoyl-benzothiazol-6-yloxycarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| CAII --- CAI | N-(4-sulfamoylbenzyl)-2-(thiophen-2-yl)acetamide | Drug Info |
| Ckit --- BRaf | 2-((2-carbamothioylpyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| CAII --- CAI | Ethyl1-(3-((2-hydroxynaphthalen-1-yl)diazenyl)phenyl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| COX2 --- 5LOX | N-{3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-1-methyl-prop-2-ynyl}-N-hydroxy-acetamide | Drug Info |
| CAII --- CAI | 3-[2-(N-Methyl-guanidino)-acetylamino]-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| COX2 --- 5LOX | 3-(4-Trifluoromethylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-benzoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| COX2 --- HRH1 | Sodium; 11-[2-(4-benzyl-piperidin-1-yl)-ethylsulfanyl]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylate | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CSrc --- CABL | 6-Methoxy-4-(5-methoxy-2,4-dimethyl-phenylamino)-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | (S)-2-[3-(4-Sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
| CSrc --- CABL | 4-(1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine | Drug Info |
| CAII --- CAI | 2-Methylamino-N-[4-(3-sulfamoyl-phenylsulfamoyl)-phenyl]-acetamide | Drug Info |
| CSrc --- CABL | N-butyl-1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-amide | Drug Info |
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