Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CCKBR --- CCKAR | 4-tert-Butyl-N-[5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide | Drug Info |
| CCKBR --- CCKAR | (R)-1H-Indole-2-carboxylic acid [1-dipentylcarbamoyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-{6-[3-(2-Bromo-phenyl)-ureido]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-[(S)-3-(1H-indol-3-yl)-2-methylamino-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | CCK7 analogue | Drug Info |
| CCKBR --- CCKAR | {(3R,5R)-3-[3-(3-Chloro-phenyl)-ureido]-8-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetic acid tert-butyl ester | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5R)-7-chloro-3-[3-(3-chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(2-aminoethyl)-N-(4-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)phenyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | GW290597X | Drug Info |
| CDK1 --- CDK4 | 2-(2,4-Dichloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-chromen-4-one | Drug Info |
| CDK1 --- GSK3 | 9-Trifluoromethyl-5,12-dihydro-7H-4,5,12-triaza-dibenzo[a,e]azulen-6-one | Drug Info |
| CDK1 --- GSK3 | 3-(3-hydroxy-4-methoxyphenyl)-8H-thieno[2,3-b]pyrrolizin-8-one | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (R)-4-(3-(isoquinolin-6-yl)-1,2,4-oxadiazol-5-yl)-1-(4-(trifluoromethyl)phenyl)butan-2-amine | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(4-Chloro-2-methylphenylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-4-{2-(2,3-Dimethylphenylamino)-5-methylpyrimidin-4-yl}-N-{1-(3-chlorophenyl)-2-hydroxyethyl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CDK1 | 1-[4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-phenyl]-ethanone | Drug Info |
| CDK2 --- CDK1 | DNDI1417312 | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[1-(4-sulfamoyl-phenylamino)-meth-(Z)-ylidene]-2,3-dihydro-1H-indole-5-carboxylic acid | Drug Info |
| CDK2 --- CDK1 | 2-amino-N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)acetamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-(1H-pyrazol-3-yl)indolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-[5-(4-Amino-phenyl)-2H-pyrazol-3-ylamino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-((4-(hydroxymethyl)-2-oxoindolin-3-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 1-(dimethylamino)-3-(4-(4-(6-morpholinopyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)phenoxy)propan-2-ol | Drug Info |
| CDK2 --- CDK4 | CHEMBL101119 | Drug Info |
| CDK2 --- CDK4 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CSrc | (2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thiazol-4-yl)methanol | Drug Info |
| CDK2 --- Cyclin E | [6-(3-Amino-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-tert-butyl-amine | Drug Info |
| CDK2 --- Cyclin E | 2-[2-[Bis-(2-hydroxy-ethyl)-amino]-6-(4-methoxy-benzylamino)-purin-9-yl]-ethanol | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(4-Bromo-phenylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-9-isopropyl-N6-((3'-methylbiphenyl-4-yl)methyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(3-methoxy-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | (E)-N'-benzylidene-2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | Drug Info |
| CDK2 --- Cyclin E | 3-Methylsulfanyl-6-methylsulfanylmethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- GSK3 | N-(6-(3-bromo-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 4-[N-(2,3,4,5,6-Pentafluoro-benzenesulfonyl)]-Hydrazino-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | N-[3-(2-furyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide | Drug Info |
| CAII --- CAI | 4-phenylacetamido-benzenesulfonamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-methoxyethyl)picolinamide | Drug Info |
| CAII --- CAI | 6-(4-Sulfamoyl-benzylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| COX2 --- 5LOX | 4-[2-(3H-1lambda*4*-Benzo[b]thiophen-3-yl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- 5LOX | 2-Fluoro-6-methyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 4-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-methoxy-ethyl ester | Drug Info |
| COX2 --- 5LOX | 3-(4-tert-Butylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | 4-(3,4,5-Trihydroxy-tetrahydro-pyran-2-ylamino)-benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | N-(2-Fluorobenzyl)(4-sulphonamide phenyl)ethanamine | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
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