Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-4-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 8-(Phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-2-phenylacetamide | Drug Info |
| CDK2 --- CDK1 | 4-(4-amino-6-(cyclohexylmethoxy)-5-nitrosopyrimidin-2-ylamino)benzamide | Drug Info |
| CDK2 --- CDK1 | 2-(3-bromo-4-hydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-(2-(pyridin-4-yl)ethoxy)indolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-Methyl-C-{4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-phenyl}-methanesulfonamide | Drug Info |
| CDK2 --- CDK1 | 2-(2-aminopyrimidin-4-yl)-4-(1,1-dioxidothiomorpholin-4-yl)phenol | Drug Info |
| CDK2 --- CDK1 | N5-(4-aminocyclohexyl)-N7-(4-(phenylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diamine | Drug Info |
| CDK2 --- CDK4 | CHEMBL101311 | Drug Info |
| CDK2 --- CDK4 | ((2-chloro-5-methylphenyl)(6-(4-(3-(dimethylamino)-2-hydroxypropoxy)phenylamino)pyrimidin-4-yl)amino)acetonitrile | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | CHEMBL100979 | Drug Info |
| CDK2 --- CSrc | N-(3,5-dimethylphenyl)-4-(5-methylthiazol-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | 4-((2-nitrophenyl)diazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
| CDK2 --- Cyclin E | 1-[(3-Cyclohexyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-ylcarbamoyl)-methyl]-piperidine-4-carboxylic acid amide | Drug Info |
| CDK2 --- Cyclin E | 6-(2-Methylamino-ethyl)-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; hydrochloride | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(3-Cyclopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
| CDK2 --- Cyclin E | 3-Methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | N*2*-[2-(1H-Indol-3-yl)-ethyl]-9-isopropyl-N*6*-(4-methoxy-benzyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 4-{2-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-ethyl}-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | 1-{3-[5-(4-Ethyl-piperazine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
| CAII --- CAI | 6-(2-Sulfamoyl-benzothiazol-6-yloxycarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| Ckit --- BRaf | 2-((2-cyanopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | 1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole | Drug Info |
| CAII --- CAI | 4-Benzoyl-1-(3-cyanophenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
| COX2 --- 5LOX | 4-[2-(2,6-Difluoro-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid (2-methylamino-acetyl)-amide | Drug Info |
| COX2 --- 5LOX | 2,6-Dimethyl-4-(2-naphthalen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2,3-dichloro-4,6-disulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | 2-iodo-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzamide | Drug Info |
| CAII --- CAI | 5-Phenylmethanesulfonylamino-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CSrc --- CABL | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-2-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 2,4,6-trimethyl-1-(5-sulfamoyl-3-m-tolyl-1H-indole-2-carboxamido)pyridinium perchlorate | Drug Info |
| CSrc --- CABL | 1-(2-bromo-2-phenylethyl)-6-(methylthio)-4-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine | Drug Info |
| CAII --- CAI | 4-tert-butyl-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide | Drug Info |
| CSrc --- CABL | N-benzyl-1-(2-chloro-2-phenylethyl)-6-(2-morpholinoethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
| CSrc --- CABL | (S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]-butyric acid | Drug Info |
| CAII --- CAI | 4-[3-(4-Sulfamoyl-phenyl)-thioureido]-benzoic acid | Drug Info |
| CSrc --- Ckit | 1-(4-acetylphenyl)-3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1H)-one | Drug Info |
| CAII --- CAI | 6-aminobenzo[d]thiazole-2-sulfonamide | Drug Info |
| DHFR --- TYMS | N-{4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid | Drug Info |
| CAII --- CAI | 2-[3-(4-Sulfamoyl-phenyl)-thioureido]-pentanedioic acid | Drug Info |
| DHFR --- TYMS | 2-Amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | 5,10-dihydroindeno[1,2-b]indol-3-ol | Drug Info |
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