Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | 2-amino-N-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonyl)acetamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-(1H-pyrazol-3-yl)indolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-[5-(4-Amino-phenyl)-2H-pyrazol-3-ylamino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-((4-(hydroxymethyl)-2-oxoindolin-3-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 1-(dimethylamino)-3-(4-(4-(6-morpholinopyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-ylamino)phenoxy)propan-2-ol | Drug Info |
| CDK2 --- CDK4 | CHEMBL101119 | Drug Info |
| CDK2 --- CDK4 | N-cyclopropyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- CSrc | (2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thiazol-4-yl)methanol | Drug Info |
| CDK2 --- Cyclin E | [6-(3-Amino-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-tert-butyl-amine | Drug Info |
| CDK2 --- Cyclin E | 2-[2-[Bis-(2-hydroxy-ethyl)-amino]-6-(4-methoxy-benzylamino)-purin-9-yl]-ethanol | Drug Info |
| CDK2 --- Cyclin E | 2-[[6-(4-Bromo-phenylamino)-9-isopropyl-9H-purin-2-yl]-(2-hydroxy-ethyl)-amino]-ethanol | Drug Info |
| CDK2 --- Cyclin E | N2-(trans-4-aminocyclohexyl)-9-isopropyl-N6-((3'-methylbiphenyl-4-yl)methyl)-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | tert-Butyl-[6-(3-methoxy-phenyl)-2-trifluoromethyl-quinazolin-4-yl]-amine | Drug Info |
| CDK2 --- Cyclin E | (E)-N'-benzylidene-2-(5-((2-(2-chloroacetamido)thiazol-4-yl)methyl)-4-(4-chlorobenzamido)-4H-1,2,4-triazol-3-ylthio)acetohydrazide | Drug Info |
| CDK2 --- Cyclin E | 3-Methylsulfanyl-6-methylsulfanylmethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- GSK3 | N-(6-(3-bromo-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | 4-[N-(2,3,4,5,6-Pentafluoro-benzenesulfonyl)]-Hydrazino-benzenesulfonamide | Drug Info |
| CDK4 --- Cyclin E | N-[3-(2-furyl)-4-oxo-2,4-dihydroindeno[1,2-c]pyrazol-5-yl]-2,2-dimethylhydrazinecarboxamide | Drug Info |
| CAII --- CAI | 4-phenylacetamido-benzenesulfonamide | Drug Info |
| Ckit --- BRaf | 4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)-N-(2-methoxyethyl)picolinamide | Drug Info |
| CAII --- CAI | 6-(4-Sulfamoyl-benzylcarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
| COX2 --- 5LOX | 4-[2-(3H-1lambda*4*-Benzo[b]thiophen-3-yl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- 5LOX | 2-Fluoro-6-methyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | 4-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzoic acid 2-methoxy-ethyl ester | Drug Info |
| COX2 --- 5LOX | 3-(4-tert-Butylphenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide | Drug Info |
| CAII --- CAI | 4-(3,4,5-Trihydroxy-tetrahydro-pyran-2-ylamino)-benzenesulfonamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-chlorophenyl)ethyl)-6-(methylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | N-(2-Fluorobenzyl)(4-sulphonamide phenyl)ethanamine | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-(4-fluorophenyl)ethyl)-6-(methylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | (S)-3-Hydroxy-3-phenyl-2-(4-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| CSrc --- CABL | N-(5-(benzylthio)-1,3,4-thiadiazol-2-yl)-4-chlorobenzamide | Drug Info |
| CAII --- CAI | 4-[4-(4-Methoxy-phenyl)-[1,2,3]triazol-1-yl]-benzenesulfonamide | Drug Info |
| CSrc --- CABL | N-(3-bromophenyl)-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 1-[(2,3-Dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-2,6-diethyl-4-phenyl-pyridinium; perchlorate | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-isopropoxy-9H-purin-6-amine | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| CSrc --- Ckit | ethyl 4-(3-(2-aminoquinazolin-6-yl)-4-methyl-2-oxopyridin-1(2H)-yl)benzoate | Drug Info |
| CAII --- CAI | sodium trithiocarbonate | Drug Info |
| DHFR --- TYMS | N-[4-[(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)thio]-2'fluorobenzoyl]L-glutamic acid | Drug Info |
| CAII --- CAI | Hydrochlorothiazide | Drug Info |
| DHFR --- TYMS | 2-{4-[(4-Hydroxy-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | N-(2-Diethylamino-ethyl)-3-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzamide | Drug Info |
| EGFR --- HER2 | (E)-3-(3,4-Dihydroxy-phenyl)-2-(2,4,6-trimethyl-benzoyl)-acrylonitrile | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid 2-sulfamoyl-benzothiazol-6-yl ester | Drug Info |
| EGFR3 --- Beta PDGFR | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol | Drug Info |
| CAII --- CAI | (Carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- CSrc | (3-Chloro-phenyl)-[3-(3-nitro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine | Drug Info |
| CAII --- CAI | 4-Methyl-5-(nonafluorobutane-1-sulfonylimino)-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| EGFR3 --- HER2 | (E)-4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(3,4-dimethoxycinnamamido)phenoxy]pyrimidine | Drug Info |
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