Multi-target agents
Target Pair | Drug Name | |
---|---|---|
CDK2 --- Cyclin E | 6-(2-Methylamino-ethyl)-3-methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one; hydrochloride | Drug Info |
CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine | Drug Info |
CDK2 --- Cyclin E | N-(3-Cyclopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl)-acetamide | Drug Info |
CDK2 --- Cyclin E | 3-Methylsulfanyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
CDK2 --- Cyclin E | N*2*-[2-(1H-Indol-3-yl)-ethyl]-9-isopropyl-N*6*-(4-methoxy-benzyl)-9H-purine-2,6-diamine | Drug Info |
CDK2 --- GSK3 | N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide | Drug Info |
CAII --- CAI | 4-{2-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-ethyl}-benzenesulfonamide | Drug Info |
CDK4 --- Cyclin E | 1-{3-[5-(4-Ethyl-piperazine-1-carbonyl)-thiophen-2-yl]-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-3-morpholin-4-yl-urea | Drug Info |
CAII --- CAI | 6-(2-Sulfamoyl-benzothiazol-6-yloxycarbamoyl)-pyridine-2-carboxylic acid | Drug Info |
Ckit --- BRaf | 2-((2-cyanopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
CAII --- CAI | {Carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
COX2 --- 5LOX | 1-(4-chlorophenyl)-3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]-5-phenyl-1H-pyrazole | Drug Info |
CAII --- CAI | 4-Benzoyl-1-(3-cyanophenyl)-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide | Drug Info |
COX2 --- 5LOX | 4-[2-(2,6-Difluoro-phenyl)-vinyl]-2,6-dimethyl-phenol | Drug Info |
CAII --- CAI | 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid (2-methylamino-acetyl)-amide | Drug Info |
COX2 --- 5LOX | 2,6-Dimethyl-4-(2-naphthalen-2-yl-vinyl)-phenol | Drug Info |
CAII --- CAI | (R)-4-((5S,6R,8S,9R,10S,11S,14S,17R)-3,7,12-Trihydroxy-10-(R)-methyl-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2,3-dichloro-4,6-disulfamoyl-phenyl)-amide | Drug Info |
CSrc --- CABL | 2-iodo-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzamide | Drug Info |
CAII --- CAI | 5-Phenylmethanesulfonylamino-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
CSrc --- CABL | 4-(2,4-Dichloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-2-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
CAII --- CAI | 2,4,6-trimethyl-1-(5-sulfamoyl-3-m-tolyl-1H-indole-2-carboxamido)pyridinium perchlorate | Drug Info |
CSrc --- CABL | 1-(2-bromo-2-phenylethyl)-6-(methylthio)-4-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine | Drug Info |
CAII --- CAI | 4-tert-butyl-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide | Drug Info |
CSrc --- CABL | 1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
CAII --- CAI | 2-Oxo-2H-chromene-3-carboxylic acid (4-sulfamoyl-phenyl)-amide | Drug Info |
CSrc --- CABL | 2-methoxy-4-(methylthio)-N-(5-phenethyl-1,3,4-thiadiazol-2-yl)benzamide | Drug Info |
CAII --- CAI | (S)-3-Phenyl-2-[(S)-2-(4-sulfamoyl-benzoylamino)-propionylamino]-propionic acid | Drug Info |
CSrc --- FGFR1 | SID109174 | Drug Info |
CAII --- CAI | Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 4-nitrooxy-butyl ester | Drug Info |
DHFR --- TYMS | 2-Amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
CAII --- CAI | 3-(1H-Imidazol-4-yl)-2-[3-(4-sulfamoyl-phenyl)-thioureido]-propionic acid | Drug Info |
DHFR --- TYMS | 2-Amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
CAII --- CAI | (1R,2R)-4-((8S,9S,12R,14R,17S)-3-(R)-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
EGFR --- PDGFR | N-(3,4 Dimethoxyphenyl)6,7dimethoxy quinazolin-4-amine | Drug Info |
CAII --- CAI | {[(3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
EGFR3 --- CSrc | 3-{2-[3-(2-Carboxy-ethyl)-1H-indol-2-yldisulfanyl]-1H-indol-3-yl}-propionic acid | Drug Info |
CAII --- CAI | 4-Hydroxymethyl-N-[2-(N-methyl-guanidino)-acetyl]-benzenesulfonamide | Drug Info |
EGFR3 --- HER2 | N-(4-Bromophenylsulfonyl)-2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetamide | Drug Info |
CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
CAII --- CAI | N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide | Drug Info |
EGFR3 --- HER2 | 10-(3-bromophenylamino)-3,4-dihydro-2H-[1,4]dioxepino[2,3-g]quinoline-9-carbonitrile | Drug Info |
CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid [2-(4-sulfamoyl-phenyl)-ethyl]-amide | Drug Info |
EGFR3 --- HER2 | 1-(2-chloroethyl)-1-nitroso-3-methyl-3-{[4-(3-chloro-phenyl)amino]quinazolin-6-yl}urea | Drug Info |
CAII --- CAI | N-(2-fluoro-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide | Drug Info |
EGFR3 --- HER2 | GSK192082A | Drug Info |
CAII --- CAI | N,N-dialkylthio-carbonylsulfenylamino derivative | Drug Info |
EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(furan-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
CAII --- CAI | N-(4-methylphenyl)sulfamide | Drug Info |
EGFR3 --- HER2 | 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide | Drug Info |
Pagination
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