Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CAII --- CAI | 4-[2-(Heptadecafluorooctane-1-sulfonylamino)-pyrimidin-4-ylamino]-benzenesulfonamide | Drug Info |
| CSrc --- CABL | (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(difluoro-phosphono-methyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- Ckit | N3-(6-aminopyridin-3-yl)-N1-(2-cyclopentylethyl)-4-methylisophthalamide | Drug Info |
| CAII --- CAI | N-[2-Iodo-4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-5-oxo-pentanoic acid anion | Drug Info |
| CAII --- CAI | N-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-benzamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-cyanomethyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | 5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate | Drug Info |
| EGFR --- HER2 | 6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)-N-(4-(benzyloxy)-3-chlorophenyl)quinazolin-4-amine | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenesulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CABL | 4-(2-Amino-ethylcarbamoyl)-benzenesulfonic acid 4-(2-nitro-vinyl)-phenyl ester HCl | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CSrc | 3N-methyl-2-(3-methylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-2-((dimethylamino)methyl)acrylamide | Drug Info |
| CAII --- CAI | 6-[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid trans-2-piperidin-4-ylethyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methylcarbamate | Drug Info |
| CAII --- CAI | phenylarsonic acid | Drug Info |
| EGFR3 --- HER2 | GW784684X | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| EGFR3 --- HER2 | (7-Allyloxy-6-methoxyquinazolin-4-yl)-(3'-bromophenyl)amine hydrochloride | Drug Info |
| CAII --- CAI | 2-(3-chloro-4-hydroxyphenyl)-N-phenethylacetamide | Drug Info |
| EGFR3 --- HER2 | 4-[(4'-fluorobenzyl)amino]-6,7-diethoxyquinazoline hydrochloride | Drug Info |
| CAII --- CAI | Ethyl1-(2-methyl-1-(2-oxopropyl)-1H-indol-4-yl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorophenylamino)quinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CAII --- CAI | {[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 3-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | 4-(2-Trifluoromethanesulfonylamino-pyrimidin-4-ylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | (S)-3-(3H-Imidazol-4-yl)-2-(4-sulfamoyl-benzoylamino)-propionic acid | Drug Info |
| CAII --- CAI | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-nonanoic acid (2-fluoro-4-sulfamoyl-phenyl)-amide | Drug Info |
| CAII --- CAI | (S)-2-[(S)-3-(3H-Imidazol-4-yl)-2-(4-sulfamoyl-benzoylamino)-propionylamino]-3-phenyl-propionic acid | Drug Info |
| CAII --- CAIX | naphthalene-1-sulfonamide | Drug Info |
| CAII --- CAIX | 1-[2-(4-sulfamoylphenyl)ethyl]-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea | Drug Info |
| CAIX --- CAXII | 6-(hydroxymethyl)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)-3-benzyloxy-2-methanesulfonylamino-propionamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonylamino-4-phenyl-butyramide | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(6-amino-2-methoxy-9H-purin-9-yl)propyl)-2-oxophenylbutanamide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Thiophen-2-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclopentyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxobutan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | (S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid ((S)-cyano-methyl-methyl)-amide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | (R)-2-{3'-[2-(3-dimethylamino-pyrrolidin-1-yl)-thiazol-4-yl]-biphenyl-yl}-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | (S)-2-(6-chlorobenzo[d]oxazol-2-ylamino)-3-cyclohexyl-N-((S)-1-(5-fluoroindolin-1-yl)-4-(methylsulfonyl)butan-2-yl)propanamide | Drug Info |
| Cathepsin K --- MEP | 2-[2-(2-Biphenyl-4-yl-acetylamino)-3-mercapto-propionylamino]-5-guanidino-pentanoic acid [2-(4-hydroxy-phenyl)-1-phenethylcarbamoyl-ethyl]-amide | Drug Info |
| Cathepsin K --- MEP | (S)-N-(3-(3-chlorophenyl)-1-(cyanomethylamino)-1-oxopropan-2-yl)-2-methylbenzamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(2,2-dimethyl-propylamino)-pyrimidine-5-carboxylic acid {2-[3-(2-imidazol-1-yl-ethoxy)-4-methoxy-phenyl]-ethyl}-amide | Drug Info |
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