Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(methylamino)pyridin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | 2,4,6-Trimethyl-1-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-pyridinium; perchlorate | Drug Info |
| COX2 --- 5LOX | 6-(7-tert-Butyl-3,3-dimethyl-2,3-dihydro-benzofuran-5-yl)-imidazo[2,1-b]thiazole | Drug Info |
| CAII --- CAI | {Carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | N-hydroxy-N-(3-(3-phenoxyphenyl)allyl)acetamide | Drug Info |
| CAII --- CAI | 3-methyl-2-propyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| COX2 --- 5LOX | Enofelast | Drug Info |
| CAII --- CAI | 6-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-benzothiazole-2-sulfonic acid amide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(2-chlorobenzyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | Benzothiazole-2-Sulfonic Acid Amide | Drug Info |
| CSrc --- CABL | N-(5-(3-chlorobenzylthio)-1,3,4-thiadiazol-2-yl)-2-chlorobenzamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-chloro-4-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- CABL | 3-(9-(2,6-dimethylstyryl)-6-(4-(dimethylphosphoryl)phenylamino)-9H-purin-2-yl)propanenitrile | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 4-sulfamoyl-benzylamide | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-6-(ethylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-[2-(Heptadecafluorooctane-1-sulfonylamino)-pyrimidin-4-ylamino]-benzenesulfonamide | Drug Info |
| CSrc --- CABL | (S)-2-{(2S,3S)-2-[(S)-2-((S)-2-{(S)-2-Acetylamino-3-[4-(difluoro-phosphono-methyl)-phenyl]-propionylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-3-methyl-pentanoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | (R)-4-((5S,6R,8S,9S,12S,14R,17S)-7-Hydroxy-3-(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (3-sulfamoyl-phenyl)-amide | Drug Info |
| CSrc --- Ckit | N3-(6-aminopyridin-3-yl)-N1-(2-cyclopentylethyl)-4-methylisophthalamide | Drug Info |
| CAII --- CAI | N-[2-Iodo-4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-acetamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-ethynyl-amino]-benzoylamino}-5-oxo-pentanoic acid anion | Drug Info |
| CAII --- CAI | N-[3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-benzamide | Drug Info |
| DHFR --- TYMS | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-cyanomethyl-amino]-benzoylamino}-pentanedioic acid | Drug Info |
| CAII --- CAI | 5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate | Drug Info |
| EGFR --- HER2 | 6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)-N-(4-(benzyloxy)-3-chlorophenyl)quinazolin-4-amine | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenesulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CABL | 4-(2-Amino-ethylcarbamoyl)-benzenesulfonic acid 4-(2-nitro-vinyl)-phenyl ester HCl | Drug Info |
| CAII --- CAI | 2,3,4,5,6-Pentafluoro-N-[4-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-benzamide | Drug Info |
| EGFR3 --- CSrc | 3N-methyl-2-(3-methylcarbamoyl-1H-2-indolyldisulfanyl)-1H-3-indolecarboxamide | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-2-((dimethylamino)methyl)acrylamide | Drug Info |
| CAII --- CAI | 6-[2-(4-Sulfamoyl-phenyl)-ethylcarbamoyl]-pyridine-2-carboxylic acid | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid trans-2-piperidin-4-ylethyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-sulfamoyl-benzothiazol-6-yl)-acetamide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl methylcarbamate | Drug Info |
| CAII --- CAI | phenylarsonic acid | Drug Info |
| EGFR3 --- HER2 | GW784684X | Drug Info |
| CAII --- CAI | {(2-{Carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| EGFR3 --- HER2 | (7-Allyloxy-6-methoxyquinazolin-4-yl)-(3'-bromophenyl)amine hydrochloride | Drug Info |
| CAII --- CAI | 2-(3-chloro-4-hydroxyphenyl)-N-phenethylacetamide | Drug Info |
| EGFR3 --- HER2 | 4-[(4'-fluorobenzyl)amino]-6,7-diethoxyquinazoline hydrochloride | Drug Info |
| CAII --- CAI | Ethyl1-(2-methyl-1-(2-oxopropyl)-1H-indol-4-yl)-5-phenyl-3-(5-sulfamoyl-1,3,4-thiadiazol-2-ylcarbamoyl)-1Hpyrazole-4-carboxylate | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Chloro-4-fluorophenylamino)quinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide | Drug Info |
| CAII --- CAI | {[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | 3-(Heptadecafluorooctane-1-sulfonylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | 4-(2-Trifluoromethanesulfonylamino-pyrimidin-4-ylamino)-benzenesulfonamide | Drug Info |
| CAII --- CAI | [{2-[[(5-Chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | 4-Carbamoyl-2-(4-sulfamoyl-benzoylamino)-butyric acid | Drug Info |
| CAII --- CAI | 2,6-Diethyl-4-phenyl-1-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-pyridinium; perchlorate | Drug Info |
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