Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK1 --- CDK2 | 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-2-methoxy-benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | 4-[2-(2-Chloro-phenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-1-methyl-piperidin-3-one | Drug Info |
| CDK1 --- GSK3 | 9-Bromo-5,12-dihydro-7H-4,5,12-triaza-dibenzo[a,e]azulen-6-one | Drug Info |
| CDK1 --- GSK3 | 3-[({5-[1-(4-Methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazol-2-yl}sulfanyl)methyl]benzonitrile | Drug Info |
| CDK1 --- HER2 | 1-(5-(3-(5-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N-methylmethanamine | Drug Info |
| CDK2 --- AKT | (S)-6-(2-(2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)thiazol-5-yl)benzo[d]thiazol-2(3H)-one | Drug Info |
| CDK2 --- AuroraA | 8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | (S)-N-{1-(3-Methylphenyl)-2-hydroxyethyl}-4-{5-methyl-2-(phenylamino)pyrimidin-4-yl}-1H-pyrrole-2-carboxamide | Drug Info |
| CDK2 --- CD221 | CHEMBL73303 | Drug Info |
| CDK2 --- CDK1 | N-Methyl-C-{4-[N'-(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidene)-hydrazino]-phenyl}-methanesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(cyclohexylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
| CDK2 --- CDK1 | 3-{[2-(1-Hydroxymethyl-2-methyl-propylamino)-9-isopropyl-9H-purin-6-ylamino]-methyl}-phenol | Drug Info |
| CDK2 --- CDK1 | ethyl 4-(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)phenylsulfonamido)-4-oxobutanoate | Drug Info |
| CDK2 --- CDK1 | 2-oxo-3-[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-sulfonic acid amide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(5-amino-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | 8-Cyclopentyl-5-methyl-7-oxo-2-(4-piperazin-1-yl-phenylamino)-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester | Drug Info |
| CDK2 --- CDK4 | (8-Isopropyl-7-methoxy-quinazolin-2-yl)-(4-pyrrolidin-1-yl-phenyl)-amine | Drug Info |
| CDK2 --- CDK4 | 1-(5-Cyclopentylaminomethyl-1H-pyrazol-3-yl)-3-(5-oxo-2,3,5,9b-tetrahydro-1H-pyrrolo[2,1-a]isoindol-9-yl)-urea | Drug Info |
| CDK2 --- CDK4 | [4-(2-Methyl-imidazo[1,2-a]pyridin-3-yl)-pyrimidin-2-yl]-phenyl-amine | Drug Info |
| CDK2 --- Cyclin E | N2-(4-aminocyclohexyl)-9-isopropyl-N6-((5-m-tolylthiophen-2-yl)methyl)-9H-purine-2,6-diamine hydrochloride | Drug Info |
| CDK2 --- Cyclin E | 2-{(2-Hydroxy-ethyl)-[6-(4-methoxy-benzylamino)-9-(4-nitro-benzyl)-9H-purin-2-yl]-amino}-ethanol | Drug Info |
| CDK2 --- Cyclin E | 5-(2-chlorophenyl)-7-nitro-3-phenethyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine | Drug Info |
| CDK2 --- Cyclin E | N-[5-(5-tert-Butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-yl]-2-phenyl-acetamide | Drug Info |
| CDK2 --- Cyclin E | 4-((R)-Amino-5-hydroxy-3-(S)-4-hydroxy-hex-1-ynyl)-5-fluoro-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | 1-[5-(5-tert-Butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-yl]-3-ethyl-urea | Drug Info |
| CDK2 --- Cyclin E | N-[5-(4,5-Dimethyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-yl]-acetamide | Drug Info |
| CDK2 --- GSK3 | SB-725317 | Drug Info |
| CAII --- CAI | SID49680046 | Drug Info |
| CDK2 --- JNK1 | 4-(5-chloro-4-(1H-indol-1-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide | Drug Info |
| CAII --- CAI | 4-(3-Pyridin-2-ylmethyl-thioureido)-benzenesulfonamide | Drug Info |
| Chk --- Met | CHEMBL1197528 | Drug Info |
| CAII --- CAI | 2-methyl-N-(4-sulfamoylphenyl)pentanamide | Drug Info |
| Ckit --- BRaf | 2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)benzamide | Drug Info |
| CAII --- CAI | 4-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid 2-hydroxy-ethyl ester | Drug Info |
| COX2 --- 5LOX | 2,6-Di-tert-butyl-4-((Z)-2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethoxy)-ethoxy]-ethyl}-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid | Drug Info |
| COX2 --- 5LOX | 2-Chloro-6-methyl-4-(2-thiophen-2-yl-vinyl)-phenol | Drug Info |
| CAII --- CAI | [2-({[2-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethylamino]-acetic acid | Drug Info |
| COX2 --- HRH1 | 11-(2-Morpholin-4-yl-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid 2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethyl ester | Drug Info |
| CSrc --- CABL | 1-(2-chloro-2-phenylethyl)-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 1-(4-methoxyphenyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1b --- SERT | Methanesulfonic acid 4-{[2'-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carbonyl]-amino}-2-(4-methyl-piperazin-1-yl)-phenyl ester | Drug Info |
| A3AR --- ADRA1A | [3H]8-OH-DPAT | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-(1-methyl-4-piperidinyl)-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 2-({(2R)-1-[4-(4-{[3-(Hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-4-{[4-(methyloxy)phenyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 4-{[3-(Methyloxy)phenyl]methyl}-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | ENMD-2076 | Drug Info |
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