Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | 3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phenyl)-2-(3,4-dihydroxy-benzoyl)-acrylonitrile | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-iodo-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | (3R,5S)-5-((4-(3-chloro-4-(pyridin-2-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate | Drug Info |
| CAII --- CAI | 6-(2-Hydroxy-ethoxy)-benzothiazole-2-sulfonic acid (2-amino-acetyl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(2-methoxy-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | SID528890 | Drug Info |
| EGFR3 --- HER2 | (R)-7-(4-(1-(4-Chlorophenyl)ethylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-10,13-Dimethyl-3,7,12-trioxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-fluoro-4-sulfamoyl-phenyl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-(3-chloro-4-hydroxyphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| CAII --- CAI | 6-Nitrooxy-hexanoic acid ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-amide | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(3-cyano-benzyloxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide | Drug Info |
| CAII --- CAI | N-2-naphthylsulfamide | Drug Info |
| EGFR3 --- HER2 | 4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(2,4,5-trifluorophenylacetamido)phenoxy]pyrimidine | Drug Info |
| CAII --- CAI | N-(2-Diethylamino-ethyl)-4-[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenesulfamoyl]-benzamide | Drug Info |
| CAII --- CAI | {[2-(Bis-carboxymethyl-amino)-ethyl]-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | Furan-2-carboxylic acid [3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidene]-amide | Drug Info |
| CAII --- CAI | N-cyclohexylsulfamide | Drug Info |
| CAII --- CAI | 4-Methyl-5-trifluoromethanesulfonylimino-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAI | {{2-[2-(2-{Carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex | Drug Info |
| CAII --- CAI | {(2-{2-[2-(Bis-carboxymethyl-amino)-ethoxy]-ethoxy}-ethyl)-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid | Drug Info |
| CAII --- CAI | [{2-[[(2-Fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-(2-hydroxy-phenyl)-amino]-ethyl}-(2-hydroxy-phenyl)-amino]-acetic acid | Drug Info |
| CAII --- CAIX | 2-Isopropyl-4,6-diphenyl-1-[2-(4-sulfamoyl-phenyl)-ethyl]-pyridinium; perchlorate | Drug Info |
| CAII --- CAIX | 2-Butyl-4,6-diphenyl-1-(4-sulfamoyl-phenyl)-pyridinium; perchlorate | Drug Info |
| CAIX --- CAXII | 7-phenethoxy-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | 3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(4-amino-2-oxopyrimidin-1(2H)-yl)propyl))-2-oxopentanamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-4-Methyl-2-[2-(naphthalene-2-sulfinyl)-ethyl]-pentanoic acid ((S)-1-formyl-3-methyl-butyl)-amide | Drug Info |
| CALM2 --- Cathepsin B | 1-(Benzo[b]thiophene-2-carbonyl)-piperidine-4-carboxylic acid (1-benzyl-2-carbamoyl-2-oxo-ethyl)-amide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-1-((R)-4,7-Dioxo-4-(S)-oxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 6-[4-(4-Acetyl-piperazin-1-yl)-phenoxymethyl]-7-(2-cyclopentyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 5-Chloro-benzofuran-2-carboxylic acid {(S)-2-cyclohexyl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-amide | Drug Info |
| Cathepsin K --- MEP | 2-[3-(1H-Indol-6-yl)-phenyl]-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(2-fluoro-benzenesulfonylamino)-benzamide | Drug Info |
| Cathepsin K --- MEP | {(S)-1-[2-(4-Cyclohexyloxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | ((S)-3-Methyl-1-{2-[4-(tetrahydro-pyran-4-yloxy)-phenylamino]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | N-((S)-4-cyclohexyl-1-((2R,3R)-1-(5-fluoroindolin-1-yl)-3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-3-methoxybenzamide | Drug Info |
| Cathepsin K --- MEP | 2-Cyano-4-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-5-carboxylic acid (4-benzyl-1-methyl-piperidin-4-yl)-amide | Drug Info |
| CCKBR --- CCKAR | [1-[2-(4-Bromo-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | Drug Info |
| CCKBR --- CCKAR | [125I]-(R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea | Drug Info |
| CCKBR --- CCKAR | (S)-3-[(S)-2-[(S)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | Boc-Tyr(So3-)-Met-Gly-Trp-psi(CH2NH)-Nle-Asp-Phe-NH2 | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-p-tolyl-acryloylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | Quinoline-3-carboxylic acid [2-(5-benzyloxy-1H-indol-3-yl)-1-dipentylcarbamoyl-ethyl]-amide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-trifluoromethyl-phenyl)-acryloylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-amide | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-[(S)-2-((S)-3-1H-indol-3-yl-2-isobutoxycarbonylamino-propionylamino)-6-(3-o-tolyl-ureido)-hexanoylamino]-N-methyl-succinamic acid | Drug Info |
| CCKBR --- CCKAR | {3-[(1H-Indole-2-carbonyl)-amino]-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid: 0.3C4H10O. CH2Cl3 | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-hydroxy-phenyl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-N-methyl-succinamic acidAcOH; hydrate | Drug Info |
| CD221 --- JNK1 | 2-(2-(5-(3-(dimethylamino)propyl)-2-methoxy-4-methylphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- AuroraA | N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)-N-(2-(pyrrolidin-1-yl)ethyl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 3-[(2-amino)pyrimidin-4-yl]-6-bromo-1H-pyrrolo[2,3-b]pyridine | Drug Info |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.