Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 6-(4-Fluorobutyl)-4-methylpyridin-2-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyridin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-(((1-isopentylpiperidin-4-yl)(methyl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-3a-Fluoro-7-(2-methylamino-ethyl)-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (5-Imino-[1,4]thiazepan-3-yl)-methanol | Drug Info |
| BNOS --- Hepatocyte NOS | [1,4]Oxazepan-(3E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1194759 | Drug Info |
| BNOS --- Hepatocyte NOS | 3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-Methyl-piperidin-(2Z)-ylideneamine | Drug Info |
| CAI --- CAIX | sodium azide | Drug Info |
| 5HT1a --- SERT | [3-(5-Fluoro-1H-indol-2-yl)-propyl]-(2-phenoxy-ethyl)-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-[(4S,6R)-4-(4,5-Dimethoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 2-methyl-5-(2-(4-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidin-1-yl)ethoxy)quinoline-7-carbonitrile | Drug Info |
| 5HT1a --- SERT | [2-(5-Fluoro-benzofuran-7-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(3-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}propoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | methyl 1-(3-(5-(ethylcarbamoyl)-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxamido)propyl)-4-phenylpiperidine-4-carboxylate | Drug Info |
| ADRA1A --- HRH1 | 2-(4-Dimethylamino-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid {2-hydroxy-3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | 4-{[4-(Ethyloxy)phenyl]methyl}-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| CABL --- CD135 | (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone | Drug Info |
| CABL --- FGFR1 | PD-0173955 | Drug Info |
| CAI --- CAIX | 3-(3-Phenyl-ureido)-benzenesulfonamide | Drug Info |
| Aurora --- VEGFR | 6-methoxy-2-(4-(2-(4-methylpyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| AuroraA --- STK1 | N-(6-(2-(dimethylamino)ethylthio)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 1-(1H-indol-7-yl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | 4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazole-5-carbonitrile | Drug Info |
| AuroraA --- STK1 | MLN-8054 | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(pyrrolidin-1-ylmethyl)isothiazol-5-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | N-(2-(2-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)thiazol-5-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL214849 | Drug Info |
| AuroraA --- STK1 | 1-(3-fluorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| B-Raf --- VEGFR | 3,3-Dimethyl-6-(6-methyl-5-(2-(methylamino)quinazolin-6-yl)isoquinolin-1-ylamino)indolin-2-one | Drug Info |
| Beta PDGFR --- CABL | 1-(3-Chloro-phenyl)-3-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-urea | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(4-(dimethylamino)benzyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine | Drug Info |
| BNOS --- Hepatocyte NOS | Pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(1-phenethylpiperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-1-methyl-1H-imidazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | SID50111110 | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(4-phenoxy-phenyl)-isothiourea; hydriodide | Drug Info |
| CABL --- CD135 | 5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid [4-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| 5HT1a --- SERT | [2-(6-Chloro-1H-benzoimidazol-4-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1a --- SERT | WAY-100635 | Drug Info |
| 5HT1a --- SERT | (S)-1-(4-(4-methoxybenzo[b]thiophen-2-yl)piperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1b --- SERT | 3-(3,4-Dihydroxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{2-[[4-(4-{[3-(hexahydro-1Hazepin-1-yl)propyl]oxy}phenyl)butyl](methyl)amino]ethyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-cyano-4-(2,4-difluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
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