Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| AuroraA --- STK1 | (Z)-3-({3-[3-(Diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-(indolin-1-ylsulfonyl)indolin-2-one | Drug Info |
| AuroraA --- STK1 | 3-((2,2-dimethylmorpholino)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| Beta PDGFR --- CABL | 4-chloro-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-pyrazin-2-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(6-(4-(4-(((2R,4S)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-difluorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)pyridin-3-yl)-1-(1-hydroxypropan-2-yl)-1H-1,2,4-triazol-5(4H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-3a-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | [1,4]Thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyridin-3-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((2-chlorobenzyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-2-(S)-Amino-3-methyl-5-(2-methyl-isothioureido)-pentanoic acid tert-butyl ester | Drug Info |
| BNOS --- Hepatocyte NOS | ((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | trans rac-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)-N2-(3-fluorophenethyl)ethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Methyl-5,6,7,8-tetrahydro-quinolin-2-ylamine | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-fluorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | 2-{1-[(S)-2-Hydroxy-3-(1H-indol-4-yloxy)-propyl]-piperidin-4-yl}-benzo[b]thiophen-7-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Isoquinolin-1-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1b --- SERT | (-)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate | Drug Info |
| 5LOX --- HRH1 | [4-((2S,5S)-5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-tetrahydro-furan-2-yl)-but-3-ynyl]-N-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | Methyl-(2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-amine | Drug Info |
| ADRA1A --- HRH1 | (1S,5S,6S)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)-3-azabicyclo[3.1.0]hexane | Drug Info |
| ADRA1A --- HRH1 | 1-(Diphenylmethyl)-4-(3-phenylpropyl)piperazine | Drug Info |
| CABL --- CD135 | NVP-TAE684 | Drug Info |
| CABL --- FGFR1 | Sunitinib | Drug Info |
| CAI --- CAIX | 2-nonylamido-5-sulfonamidoindane | Drug Info |
| Aurora --- VEGFR | 7-(5-(3-(4-hydroxypiperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | K00590a | Drug Info |
| AuroraA --- STK1 | 1-(3-(2-(azetidin-1-yl)ethyl)phenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | N-(6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-phenoxybenzamide | Drug Info |
| AuroraA --- STK1 | 1-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-3-m-tolylurea | Drug Info |
| AuroraA --- STK1 | 2,4,5,10-Tetrahydro-3-methylpyrazolo[3,4-a]carbazole | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-morpholinopyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | N-(3-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-(methylsulfonyl)piperidin-4-yl)isothiazol-5-amine | Drug Info |
| B1R --- B2R | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Pro(4-O-propyl)-pro(2,3-dibenzo)-arg | Drug Info |
| Beta PDGFR --- CABL | 1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-3-pyridin-3-yl-urea | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | [1,3]Thiazinan-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((benzyl(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclopentylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide | Drug Info |
| BNOS --- Hepatocyte NOS | Octahydro-isoindol-(1Z)-ylideneamine | Drug Info |
| CABL --- PKCA | N-(3-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[(1R,3S,5S)-3-(4-methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-(4-(6-fluorobenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-8-methoxy-4-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine | Drug Info |
| 5HT1b --- SERT | (S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine | Drug Info |
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