Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| A3AR --- ADRA1A | CHEMBL1625779 | Drug Info |
| ADRA1A --- HRH1 | cis-(-)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole | Drug Info |
| ADRA1A --- HRH1 | SID144207521 | Drug Info |
| ADRA1A --- HRH1 | N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)methyl)-3,4-difluorobenzamide | Drug Info |
| CABL --- Ckit | AAL-993 | Drug Info |
| CABL --- STK1 | ENMD-2076 | Drug Info |
| Aurora --- GSK | 2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine | Drug Info |
| AuroraA --- ALK5 | 6-(3-Amino-1H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine | Drug Info |
| AuroraA --- STK1 | N-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | (+/-)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-morpholinopropyl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | N-[3-[(4,4-Difluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | N-(4-{4-[2-({[2-(Dimethylamino)ethyl]amino}methyl)-1Hpyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpyrimidin-2-ylthio)phenyl)acetamide | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(piperidin-1-ylsulfonyl)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide | Drug Info |
| CDK1 --- CDK4 | Purvalanol A | Drug Info |
| Beta PDGFR --- CD135 | (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | SID50107209 | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Pyrrolidin-1-yl-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-cyclohexyloxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Benzyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)ethyl)-N2-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-methylethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| CAI --- CAIX | SID144212483 | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(5-Chloro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5LOX --- HRH1 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-tetrahydro-furan-2-yl)-but-3-ynyl]-N-hydroxyurea | Drug Info |
| AChE --- NMDA | CHEMBL50608 | Drug Info |
| ADRA1A --- HRH1 | (8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| ADRA1A --- HRH1 | 3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide | Drug Info |
| ADRA1A --- HRH1 | SID170465934 | Drug Info |
| CABL --- FGFR1 | PHA848125 | Drug Info |
| CABL --- VEGFR1 | compound 8h | Drug Info |
| Aurora --- GSK | 4-(5-nitro-4-(phenylamino)pyrimidin-2-ylamino)benzoic acid | Drug Info |
| AuroraA --- CDK4 | 7-cyclohexyl-N-4-4-2-methoxyethyl-piperazin-1-yl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-ethyl-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-phenylacetamide | Drug Info |
| AuroraA --- STK1 | 3-(((2S,6R)-2,6-dimethylmorpholino)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 2-Methyl-2-[[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl](2,2,2-trifluoroethyl)amino]-1-propanol Hydrochloride | Drug Info |
| AuroraA --- STK1 | CHEMBL386253 | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | 6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(5-chloro-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | 4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine | Drug Info |
| Beta PDGFR --- CABL | 1-(3-(dimethylamino)phenyl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide | Drug Info |
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