Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CAII --- CAI | (2-{[(2-Sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethylamino)-acetic acid | Drug Info |
| CAII --- CAI | 5-[4-(4-Bromo-benzenesulfonyl)-phenyl]-4-(4-methoxy-phenyl)-4H-[1,2,4]triazole-3-thiol | Drug Info |
| CAII --- CAIX | 4-((3-(2-phenylcyclopropyl)ureido)methyl)benzenesulfonamide | Drug Info |
| CAIX --- CAXII | Sodium phenylaminomethanesulfonate | Drug Info |
| CALM2 --- Cathepsin B | 3-[4-Methyl-2-(2-naphthalen-1-yl-acetylamino)-pentanoylamino]-2-oxo-pentanoic acid ethylamide | Drug Info |
| CALM2 --- Cathepsin B | (R)-1-(3-nitrophenylsulfonyl)-N-((R,S)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide | Drug Info |
| CALM2 --- Cathepsin B | (S)-2-ethyl-N-(1-oxo-3-phenylpropan-2-yl)-2-(3-phenylpropanamido)butanamide | Drug Info |
| Cathepsin K --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-morpholinothiazol-4-yl)benzamide | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-4-methyl-2-(2-(4-(pyridin-4-yl)piperazin-1-yl)acetamido)pentanamide | Drug Info |
| Cathepsin K --- MEP | ((R)-1-Formyl-pentyl)-carbamic acid tert-butyl ester | Drug Info |
| Cathepsin K --- MEP | (S)-benzyl 1-(2-(4-methoxyphenylamino)ethylamino)-4-methyl-1-oxopentan-2-ylcarbamate | Drug Info |
| Cathepsin K --- MEP | 2-Biphenyl-3-yl-4-methyl-pentanoic acid cyanomethyl-amide | Drug Info |
| Cathepsin K --- MEP | N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-3-methanesulfonylamino-benzamide | Drug Info |
| Cathepsin K --- MEP | N-((S)-3-cyclopentenyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopropan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | N-((R)-3-(benzylthio)-1-oxo-1-((S)-1-(4-(trifluoromethoxy)phenylamino)propan-2-ylamino)propan-2-yl)morpholine-4-carboxamide | Drug Info |
| Cathepsin K --- MEP | 2-{(S)-3-Phenyl-1-[(4-piperidin-1-yl-phenylamino)-methyl]-propylcarbamoyl}-pyrrolidine-1-carboxylic acid benzyl ester | Drug Info |
| CCKBR --- CCKAR | 2-{(3R,5R)-3-[3-(3-Chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-N-(1-methyl-cyclohexyl)-acetamide | Drug Info |
| CCKBR --- CCKAR | 3-Acetylamino-N-[1-[1-({[1-{1-[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-carboxy-ethylcarbamoyl]-pentylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-pentylcarbamoyl]-2-(4-sulfooxy-phenyl)-ethyl]-succinamic acid | Drug Info |
| CCKBR --- CCKAR | (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[(S)-2-(2-carboxy-acetylamino)-3-(1H-indol-3-yl)-propionyl]-methyl-amino}-hexanoylamino)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4-chloro-N-(2-(4-chlorophenyl)-2-methylpropyl)benzamide | Drug Info |
| CCKBR --- CCKAR | 3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-cyclohexyl-propionylamino)-hexanoylamino]-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | 3-{6-[(6-Acetoxy-naphthalene-2-carbonyl)-amino]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-((3R,5R)-8-methyl-2-oxo-5-phenyl-3-{3-[3-(toluene-2-sulfonylaminocarbonyl)-phenyl]-ureido}-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide | Drug Info |
| CCKBR --- CCKAR | Pyrrolidine-1-carboxylic acid (R)-3-(4-benzoyl-piperidin-1-yl)-3-oxo-2-(3-m-tolyl-ureido)-propyl ester | Drug Info |
| CCKBR --- CCKAR | (S)-3-(3-bromo-4-fluorophenyl)-2-(4,5-dichloro-2-(quinoxaline-5-sulfonamido)benzamido)propanoic acid | Drug Info |
| CCKBR --- CCKAR | (S)-2-(2-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)-4,5-dichlorobenzamido)-3-(3-bromo-4-fluorophenyl)propanoic acid | Drug Info |
| CCKBR --- CCKAR | (S)-3-{(S)-2-[(R)-2-(2-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-phenethyl-succinamic acid | Drug Info |
| CD135 --- Ckit | (3S,5R,E)-5-bromo-16-hydroxy-14-methoxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | Drug Info |
| CD221 --- JNK1 | 2-(2-(1-(3-(dimethylamino)propanoyl)-6-methoxy-1,2,3,4-tetrahydroquinolin-7-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluorobenzamide | Drug Info |
| CDK1 --- CDK2 | GW305178X | Drug Info |
| CDK1 --- CDK2 | (6-Cyclohexylmethoxy-9H-purin-2-yl)-(4-methoxy-phenyl)-amine | Drug Info |
| CDK1 --- GSK3 | 8-Cyano-6,11-dihydro-thieno[3',2':2,3]azepino[4,5-b]indol-5(4H)-one | Drug Info |
| CDK1 --- GSK3 | SID529042 | Drug Info |
| CDK1 --- GSK3 | 4-(7-Methyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol | Drug Info |
| CDK1 --- VEGFR | 5-chloro-N-(4-(2-(dimethylamino)ethyl)phenyl)-4-(1H-indol-4-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- AKT | (S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 8-(Phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N-(5-acetyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-2-phenylacetamide | Drug Info |
| CDK2 --- CDK1 | 4-(4-amino-6-(cyclohexylmethoxy)-5-nitrosopyrimidin-2-ylamino)benzamide | Drug Info |
| CDK2 --- CDK1 | 2-(3-bromo-4-hydroxy-phenyl)-8-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-3-hydroxy-6-methyl-chromen-4-one | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(2-oxo-4-(2-(pyridin-4-yl)ethoxy)indolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | N-Methyl-C-{4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-phenyl}-methanesulfonamide | Drug Info |
| CDK2 --- CDK1 | 2-(2-aminopyrimidin-4-yl)-4-(1,1-dioxidothiomorpholin-4-yl)phenol | Drug Info |
| CDK2 --- CDK1 | N5-(4-aminocyclohexyl)-N7-(4-(phenylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diamine | Drug Info |
| CDK2 --- CDK4 | CHEMBL101311 | Drug Info |
| CDK2 --- CDK4 | ((2-chloro-5-methylphenyl)(6-(4-(3-(dimethylamino)-2-hydroxypropoxy)phenylamino)pyrimidin-4-yl)amino)acetonitrile | Drug Info |
| CDK2 --- CDK4 | (4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione | Drug Info |
| CDK2 --- CDK4 | CHEMBL100979 | Drug Info |
| CDK2 --- CSrc | N-(3,5-dimethylphenyl)-4-(5-methylthiazol-2-yl)pyrimidin-2-amine | Drug Info |
| CDK2 --- Cyclin E | 4-((2-nitrophenyl)diazenyl)-1H-pyrazole-3,5-diamine | Drug Info |
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