Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)thiophen-2-yl)thieno[2,3-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 4-(2-Hydroxy-ethyl)-N-(2-methylamino-acetyl)-benzenesulfonamide | Drug Info |
| EGFR3 --- HER2 | 4-(4-Methyl-piperazin-1-yl)-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| CAII --- CAI | 5-{4-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-benzenesulfonylamino}-[1,3,4]thiadiazole-2-sulfonic acid amide | Drug Info |
| CAII --- CAI | [(4-Sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid | Drug Info |
| CAII --- CAI | (Carboxymethyl-{2-[2-(2-{carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-acetic acid | Drug Info |
| CAII --- CAI | 5-(perfluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide | Drug Info |
| CAII --- CAI | 4-(5-Sulfamoyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-benzoic acid | Drug Info |
| CAII --- CAI | (S)-2-[3-(4-Sulfamoyl-phenyl)-thioureido]-succinamic acid | Drug Info |
| CAII --- CAI | 2-(4-Chloro-3-sulfamoyl-benzoylamino)-3-(3,4-dihydroxy-phenyl)-propionic acid | Drug Info |
| CAII --- CAIX | Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester | Drug Info |
| CAII --- CAIX | 4-(3-Allyl-4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-ylsulfanyl)-N-(4-sulfamoyl-phenyl)-butyramide | Drug Info |
| CAIX --- CAXII | 7-(2'-hydroxyethoxy)-2H-chromen-2-one | Drug Info |
| CALM2 --- Cathepsin B | 1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid (1-benzyl-2-oxo-ethyl)-amide | Drug Info |
| CALM2 --- Cathepsin B | 3-(2-Diphenylacetylamino-4-methyl-pentanoylamino)-2-oxo-pentanoic acid (3-morpholin-4-yl-propyl)-amide | Drug Info |
| CALM2 --- Cathepsin B | [1-(1-Benzyl-2-benzylcarbamoyl-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | 4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- MEP | 1H-Indole-2-carboxylic acid {(S)-1-[2-(4-cyclohexylmethoxy-phenylamino)-ethylcarbamoyl]-3-methyl-butyl}-amide | Drug Info |
| Cathepsin K --- MEP | N-((S)-4,4-dimethyl-1-((4S,7R)-7-methyl-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)-1-oxopentan-2-yl)furan-2-carboxamide | Drug Info |
| Cathepsin K --- MEP | ((S)-3-Methyl-1-{2-[4-(1-methyl-piperidin-4-yloxy)-phenylamino]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | SID85267412 | Drug Info |
| Cathepsin K --- MEP | (S)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-2-(2-(4-chlorophenylamino)-2-methylpropanamido)-4-methylpentanamide | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(cyclohexylamino)-N-phenethylpyrimidine-5-carboxamide | Drug Info |
| Cathepsin K --- MEP | (3-Methyl-1-{3-[4-methyl-2-(pyridin-4-ylmethoxycarbonylamino)-pentanoylamino]-4-oxo-pyrrolidin-1-ylmethyl}-butyl)-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- MEP | 2-cyano-4-(cyclohexylmethoxy)-N-phenethylpyrimidine-5-carboxamide | Drug Info |
| CCKBR --- CCKAR | (S)-2-[3-(4-Chloro-phenyl)-ureido]-3-(1H-indol-3-yl)-N,N-dipentyl-propionamide | Drug Info |
| CCKBR --- CCKAR | 2-{(3R,5R)-3-[3-(3-Chloro-phenyl)-ureido]-2-oxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-N-(1-methyl-1-phenyl-ethyl)-acetamide | Drug Info |
| CCKBR --- CCKAR | [5-(2-Fluoro-phenyl)-3-(1H-indol-3-ylmethyl)-3H-benzo[e][1,4]diazepin-2-ylamino]-acetic acid | Drug Info |
| CCKBR --- CCKAR | (R)-4-Dicyclohexylcarbamoyl-4-[(1H-indole-2-carbonyl)-amino]-butyric acid | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sulfooxy-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-formylamino-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | 4-Chloro-N-[1-(4-chloro-benzoyl)-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-benzamide | Drug Info |
| CCKBR --- CCKAR | 3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(4-chloro-phenyl)-thioureido]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | Drug Info |
| CCKBR --- CCKAR | {5-(2-Fluoro-phenyl)-3-[(1H-indole-2-carbonyl)-amino]-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-acetic acid: C3H6O. 0.8H2O | Drug Info |
| CCKBR --- CCKAR | 3-{6-[3-(4-Bromo-phenyl)-acryloylamino]-2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid; hydrate.NH4OH | Drug Info |
| CCKBR --- CCKAR | N-tert-Butyl-2-{(3R,5S,7R)-3-[3-(3-fluoro-phenyl)-ureido]-2-oxo-7-phenyl-5-o-tolyl-azepan-1-yl}-acetamide | Drug Info |
| CCKBR --- CCKAR | 1-[(R)-1-(4-Benzoyl-piperidine-1-carbonyl)-3-methyl-butyl]-3-m-tolyl-urea | Drug Info |
| CD221 --- JNK1 | 2-fluoro-6-(2-(5-methoxy-1-(2-(pyrrolidin-1-yl)acetyl)indolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide | Drug Info |
| CDK1 --- AuroraA | N-(2-aminoethyl)-N-(5-(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)pyridin-2-yl)methanesulfonamide | Drug Info |
| CDK1 --- CDK2 | 4-(2-(7-oxo-6,7-dihydropyrrolo[3,2-e]indazol-8(3H)-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK1 --- CDK4 | 2-(3-Chloro-phenyl)-5,7-dihydroxy-8-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-chromen-4-one | Drug Info |
| CDK1 --- GSK3 | SID516209 | Drug Info |
| CDK1 --- GSK3 | 2-Methoxy-9-nitro-5,12-dihydro-7H-benzo[2,3]azepino[4,5-b]indol-6-one | Drug Info |
| CDK1 --- NPKCdelta | (Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one | Drug Info |
| CDK2 --- AKT | (S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)propane-1,2-diamine | Drug Info |
| CDK2 --- AuroraA | 1-Methyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- AuroraA | N,1,4,4-Tetramethyl-8-({4-[(4-methylpiperazin-1-yl)methyl]-phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| CDK2 --- CD221 | CHEMBL1809193 | Drug Info |
| CDK2 --- CDK1 | 4-((2-oxo-2,3-dihydropyrrolo[3,2-f]quinolin-1-ylidene)methylamino)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | 4-(2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (3S,4S)-1-(3-(2-amino-6-(2-morpholinoethylamino)pyrimidin-4-yl)-4-hydroxyphenyl)pyrrolidine-3,4-diol | Drug Info |
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