Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| CDK2 --- CDK1 | N,N-Dimethyl-4-[(7-oxo-6,7-dihydro-thiazolo[5,4-e]indol-8-ylidenemethyl)-amino]-benzenesulfonamide | Drug Info |
| CDK2 --- CDK1 | (Z)-4-(2-(6-bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide | Drug Info |
| CDK2 --- CDK4 | (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-amine | Drug Info |
| CDK2 --- CDK4 | (4-butoxy-1H-indazol-5-yl)(2,6-difluoro-4-methylphenyl)methanone | Drug Info |
| CDK2 --- CDK4 | (3,5-Dimethyl-phenyl)-(4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-yl)-amine | Drug Info |
| CDK2 --- CDK4 | CHEMBL317378 | Drug Info |
| CDK2 --- Cyclin E | Indenopyrazoles derivative | Drug Info |
| CDK2 --- Cyclin E | [5-(5-tert-Butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-yl]-carbamic acid benzyl ester | Drug Info |
| CDK2 --- Cyclin E | 6-(3-Amino-2-methyl-benzyl)-3-ethyl-1-(2,4,6-trichloro-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | Drug Info |
| CDK2 --- Cyclin E | 1-[(3-Cyclopropyl-4-oxo-2,4-dihydro-indeno[1,2-c]pyrazol-5-ylcarbamoyl)-methyl]-piperidine-4-carboxylic acid amide | Drug Info |
| CDK2 --- Cyclin E | 5-Fluoro-4-((R)-4-hydroxy-3-methylamino-but-1-ynyl)-3-(3-methoxy-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one | Drug Info |
| CDK2 --- Cyclin E | N6-(2,2'-bipyridin-5-ylmethyl)-N2-(4-aminocyclohexyl)-9-isopropyl-9H-purine-2,6-diamine | Drug Info |
| CDK2 --- Cyclin E | N-(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepin-7-yl)methanesulfonamide | Drug Info |
| CDK2 --- GSK3 | (Z)-4-(5-((2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)-N-methylbenzenesulfonamide | Drug Info |
| CDK2 --- GSK3 | N-(6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)cyclopropanecarboxamide | Drug Info |
| CAII --- CAI | N-butylsulfamide | Drug Info |
| Chk --- GSK | Isogranulatimide | Drug Info |
| CAII --- CAI | 2,6-Diisopropyl-4-phenyl-1-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-pyridinium; perchlorate | Drug Info |
| Ckit --- BRaf | N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-2-((2-(dimethylamino)pyrimidin-4-yl)methylamino)benzamide | Drug Info |
| CAII --- CAI | p-nitrophenyl phosphate | Drug Info |
| COX2 --- 5LOX | N-Hydroxy-N-methyl-3-(3-phenoxy-phenyl)-acrylamide | Drug Info |
| CAII --- CAI | (R)-4-((8S,10S,12S,14R,15R,17S)-3,12-Di(R)-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid (2-fluoro-4-sulfamoyl-phenyl)-amide | Drug Info |
| COX2 --- 5LOX | 7-tert-butyl-3,3-dimethyl-5-(thiophen-2-ylmethyl)-2,3-dihydrobenzofuran | Drug Info |
| CAII --- CAI | 2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-nicotinic acid | Drug Info |
| COX2 --- HRH1 | 2-(11-(2-(3-benzylpiperidin-1-yl)ethylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid | Drug Info |
| CAII --- CAI | [{2-[Carboxymethyl-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-ethyl}-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid | Drug Info |
| CSrc --- CABL | 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-2-(pyridin-3-yloxy)-9H-purin-6-amine | Drug Info |
| CAII --- CAI | Phenyl-[3-(4-sulfamoyl-phenyl)-thioureido]-acetic acid | Drug Info |
| CSrc --- CABL | 6-(Methylsulfonyl)-1-(2-phenylvinyl)-N-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| CAII --- CAI | 1-[(2-Chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-2,4,6-trimethyl-pyridinium; perchlorate | Drug Info |
| CSrc --- CABL | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{5-[(dimethylamino)methyl]-3-furyl}-3-quinolinecarbonitrile | Drug Info |
| CAII --- CAI | 3-(4-Iodo-benzenesulfonylamino)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| CSrc --- CABL | [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine) | Drug Info |
| CAII --- CAI | 4-Methoxybenzohydrazide | Drug Info |
| CSrc --- CABL | EPQpYEEIPIYL | Drug Info |
| CAII --- CAI | 3-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide | Drug Info |
| CSrc --- FGFR1 | 3-(2,6-Dichloro-phenyl)-7-(4-diethylamino-butylamino)-1H-[1,6]naphthyridin-2-one | Drug Info |
| CAII --- CAI | sodium diethylcarbamodithioate | Drug Info |
| DHFR --- TYMS | 2-Amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | N-(3-carboxybenzylidene)(4-sulphonamidephenyl)ethanamine | Drug Info |
| DHFR --- TYMS | 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | Drug Info |
| CAII --- CAI | (2-{[1-(4-Sulfamoyl-phenylthiocarbamoyl)-pyrrolidine-2-carbonyl]-amino}-acetylamino)-acetic acid | Drug Info |
| EGFR --- HER2 | 6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)-N-(4-(benzyloxy)phenyl)quinazolin-4-amine | Drug Info |
| CAII --- CAI | CHEMBL327487 | Drug Info |
| EGFR3 --- CDK1 | N*4*-(3-Chloro-phenyl)-N*3*-(4-methoxy-benzyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine | Drug Info |
| CAII --- CAI | 2,4,6-trimethyl-1-(5-sulfamoyl-3-p-tolyl-1H-indole-2-carboxamido)pyridinium perchlorate | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-((4-((dimethylamino)methyl)phenyl)ethynyl)-6-methylpyrimidin-4-amine | Drug Info |
| CAII --- CAI | nitrite | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-fluorobenzyloxy)-3-(trifluoromethyl)phenyl)-6-(5-((2-(1-methyl-1H-imidazol-2-ylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine | Drug Info |
| CAII --- CAI | 4-(5,7-Dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-3-fluoro-benzenesulfonamide | Drug Info |
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