Target Information

Target General Infomation
Target ID
T85228
Former ID
TTDI02253
Target Name
mRNA of CCR3 chemokine
Gene Name
CCR3
Synonyms
CC CKR3 (mRNA); CC chemokine receptor type 3 (mRNA); CCCKR3 (mRNA); CCR3 (mRNA); CD193 (mRNA); CKR3 (mRNA); Eosinophil eotaxin receptor (mRNA); CCR3
Target Type
Clinical Trial
Disease Allergic asthma [ICD9: 493, 995.3; ICD10: J45, T78.4]
Function
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
BioChemical Class
Target of antisense drug
UniProt ID
P51677
Sequence
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
Drugs and Mode of Action
Drug(s) ASM8 Drug Info Phase 2 Allergic asthma [523524]
Antagonist banyu (I) Drug Info [526467]
BMS compound 87b Drug Info [526362]
RO116-4875/608 Drug Info [526363]
RO116-9132/238 Drug Info [526363]
RO320-2947/001 Drug Info [526363]
RO330-0802/001 Drug Info [526363]
[3H]banyu (I) Drug Info [526467]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
NetPath Pathway IL3 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
References
Ref 523524ClinicalTrials.gov (NCT01380236) A Single Blind Study to Evaluate the Safety, Tolerability and Explore the Efficacy of 8.0 mg ASM8 Inhaled Daily for 14 Days in Severe Asthma. U.S. National Institutesof Health.
Ref 526362CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1785-9.
Ref 526363Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9.
Ref 526467Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002 Dec 5;456(1-3):1-10.
Ref 543892(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 60).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.