Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T19244 | Target Info | |||
Target Name | S-mephenytoin 4-hydroxylase (CYP2C9) | ||||
Synonyms |
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
Click to Show/Hide
|
||||
Target Type | Successful Target | ||||
Gene Name | CYP2C9 | ||||
Biochemical Class | Paired donor oxygen oxidoreductase | ||||
UniProt ID |
Poor Binders of This Target (in total, 568 binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
Chlorpromazine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Aminasine; Aminazin; Aminazine; Ampliactil; Amplicitil; Amplictil; BC 135; Chlor-PZ; Chlor-Promanyl; Chlordelazine; Chlorderazin; Chloropromazine; Chlorpromados; Chlorpromanyl (discontinued); Chlorpromazin; Chlorpromazine (USP/INN); Chlorpromazine Tannate; Chlorpromazine [USAN:INN:BAN]; Chlorpromazinum; Chlorpromazinum [INN-Latin]; Clorpromazina; Clorpromazina [INN-Spanish]; Clorpromazina [Italian]; Contomin; Cromedazine; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746; JHICC02042; Largactil; Largactil (TN); Largactil Liquid; Largactil Oral Drops; Largactilothiazine; Largactyl; Megaphen; Novo-Chlorpromazine; Novomazina; Phenactyl; Phenathyl; Phenothiazine hydrochloride; Plegomasine; Plegomazin; Prazilpromactil; Proma; Promactil; Promazil; Propaphen; Propaphenin; Prozil; Psychozine; SKF 2601-A; SKF 2601A; SKF-2601; Sanopron; Thorazine; Thorazine (TN); Thorazine Spansule; Thorazine Suppositories; Thorazine hydrochloride; Torazina; Wintermin; Z80
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Triamcinolone
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Adcortyl; Aristocort; Celeste; Cinolone; Delphicort; Fluoxiprednisolone; Fluoxyprednisolone; Fougera; Ione; Kenacort; Ledercort; Mycolog; Omcilon; Omicilon; Orion; Rodinolone; Tiamcinolonum; Triamcet; Triamcinalone; Triamcinlon; Triamcinolon; Triamcinolona; Triamcinolonum; Tricortale; Trilone; Tristoject; Volon; Aristocort Tablets; Triamcinolonum [INN]; CL 19823; Aristocort (TN); Azmacort (TN); Cinolone-T; Fougera (TN); Kenacort (TN); Kenacort-AG; Kenalog (TN); Nasacort (TN); SK-Triamcinolone; Tiamcinolonum [INN-Latin]; Triam-Tablinen; Triamcinolona [INN-Spanish]; Tricortone (TN); Triderm (TN); Triesence (TN); Trilone (TN); Tristoject (TN); Volon A (TN); Tri-Nasal (TN); Triamcinolone (JP15/USP/INN); Triamcinolone [USAN:INN:BAN:JAN]; Droxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dio; TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7)); Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy-(8CI); Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha); (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione; 11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione; 11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione; 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9-alpha-Fluoro-16-alpha-hydroxyprednisolone; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d; 9.Alpha.-Fluoro-16.alpha.-hydroxyprednisolone; 9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone; 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; 9alpha-Fluoro-16alpha-hydroxyprednisolone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Amodiaquine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Amodiachin; Amodiachinum; Amodiaquin; Amodiaquina; Amodiaquinum; Basoquin; CQA; Camochin; Camoquin; Camoquinal; Camoquine; Flavoquin; Flavoquine; Miaquin; Sunoquine; Amodiaquine hydrochloride; Amodiaquine USP24; SN 10751; AMODIAQUINE, FLAVOQUINE; Amodiaquina [INN-Spanish]; Amodiaquinum [INN-Latin]; CAM-AQ 1; CAM-AQI; Cam-AQ1; Camoquin (TN); Flavoquine (TN); SN 10,751; WR-002977; Amodiaquine (USAN/INN); Amodiaquine [USAN:INN:BAN]; Amodiaquine, ring-closed; S. N. 10751
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Flunarizine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Flufenal; Flunarizin; Flunarizina; Flunarizinum; Fluvert; Issium; Sibelium; Vertix; Zinasen; Apo-flunarizine capsules; Flunarizina [INN-Spanish]; Flunarizine (INN); Flunarizine [INN:BAN]; Flunarizinum [INN-Latin]; Novo-Flunarizine; R-14950; Sibelium (TN); (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine; 1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-en-1-yl)piperazine; 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
BAY 1021189
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Vericiguat; 1350653-20-1; UNII-LV66ADM269; BAY-1021189; Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate; BAY1021189; LV66ADM269; MK-1242; Methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate; methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate; Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)pyrimidin-5-yl)carbam
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[2] | |||
Compound Name |
Ceftriaxone
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Biotrakson; CTRX; Cefatriaxone; Ceftriaxon; Ceftriaxona; Ceftriaxonum; Ceftriazone; Longacef; Longaceph; Rocefin; Rocephin; Rocephine; CEFTRIAXONE SODIUM; Ceftriaxone intravenous; Ro 139904; Ceftriaxona [INN-Spanish]; Ceftriaxone (INN); Ceftriaxone (TN); Ceftriaxone [USAN:JAN]; Ceftriaxone, Disodium Salt; Ceftriaxonum [INN-Latin]; DRG-0071; Ro13-9904; Rocephin (TN); Ceftriaxone, Disodium Salt, Hemiheptahydrate; Ro-13-9904; (6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate; (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Haloperidol
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Aldo; Aloperidin; Aloperidol; Aloperidolo; Aloperidon; Bioperidolo; Brotopon; Dozic; Dozix; Eukystol; Fortunan; Galoperidol; Haldol; Halidol; Halojust; Halol; Halopal; Haloperido; Haloperidolum; Halopidol; Halopoidol; Halosten; Keselan; Linton; Mixidol; Pekuces; Peluces; Peridol; Pernox; Serenace; Serenase; Serenelfi; Sernas; Sernel; Sigaperidol; Ulcolind; Uliolind; Vesalium; Aloperidolo [DCIT]; Aloperidolo [Italian]; Einalon S; Haldol La; Haldol Solutab; Lealgin compositum; Pms Haloperidol; H 1512; R 1625; Aloperidin (TN); Apo-Haloperidol; Bioperidolo (TN); Brotopon (TN); Dozic (TN); Duraperidol (TN); Einalon S (TN); Eukystol (TN); Haldol (TN); Haloperidolum [INN-Latin]; Halosten (TN); Keselan (TN); Linton (TN);Novo-Peridol; Peluces (TN); R-1625; Serenace (TN); Serenase (TN); Sigaperidol (TN); Haloperidol (JP15/USP); McN-JR-1625; Haloperidol (JP15/USP/INN); Haloperidol [USAN:INN:BAN:JAN]
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Raltegravir
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
RGV; MK 0518; Isentress(TM); K-0518; MK-0518; Raltegravir (INN); N-(2-(4-(4-fluorobenzylcarbamoyl); N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide; RAL
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[3] | |||
Compound Name |
Metoprolol
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Beatrolol; BelocDuriles; Betaloc; BetalocAstra; Betalok; Dutoprol; LOPRESSIDONE; Lopresor; Lopresoretic; Lopressor; Meijoprolol; Metohexal; Metoprololum; Metroprolol; Preblok; Presolol; Seloken; Seroken; Spesicor; Spesikor; Toprol; AstraZeneca Brand of Metaoprolol Tartrate; AstraZeneca Brand of Seloken; Beloc Duriles; Betaloc Astra; Leiras Brand of Metoprolol Succinate or Metoprolol Tartrate; Metoprolol succinate; Novartis Brand of Metprolol Tartrate; Seloken AstraZeneca Brand; CGP 2175; CGP2175; H 93 26; H 9326; Beloc-Duriles; Betaloc (TN); Betaloc-Astra; CGP-2175; Corvitol (TN); Dl-Metoprolol; H 93-26; Lopressor (TN); Metoprololum [INN-Latin]; Metrol (TN); Minax (TN); Neobloc (TN); Selo-Zok; Selokeen (TN); TOPROL-XL; Tartrate, Metoprolol; Metoprolol (USAN/INN); Metoprolol [USAN:INN:BAN]; Toprol-XL (TN); (RS)-Metoprolol; 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol; 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol; 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; 1-[(1-methylethyl)amino]-3-({4-[2-(methyloxy)ethyl]phenyl}oxy)propan-2-ol; 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol; 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Sertraline
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Lustral; SRE; Sertralina; Sertralinum; Sertralina [Spanish]; Sertraline [Zoloft]; Sertralinum [Latin]; CP 51974; Cp 51974; Apo-Sertraline; Lustral (TN); Sertraline (INN); Sertraline (Zoloft); Sertraline [INN:BAN]; Zoloft (TN); (+)-Sertraline; (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Saxagliptin
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Onglyza; BMS 477118-11; BMS-477118; Kombiglyze XR (TN); OPC-262; Onglyza (TN); BMS-477118-11; (1S,5S)-2-[2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-amino(3-hydroxytricyclo[3.3
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[4] | |||
Compound Name |
Norfloxacin
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Baccidal; Barazan; Chibroxin; Fulgram; Lexinor; NFLX; Norflo; Norfloxacine; Norfloxacino; Norfloxacinum; Noroxin; Sebercim; Merck Brand of Norfloxacin; Norfloxacin Merck Brand; AM 0715; AM 715; AM0715; MK 0366; MK 366; MK0366; MK366; AM-0715; AM-715; Chibroxin (TN); Insensye (TN); MK-0366; MK-366; Norflohexal (TN); Norfloxacine [INN-French]; Norfloxacino [INN-Spanish]; Norfloxacinum [INN-Latin]; Norfocin (TN); Noroxin (TN); Nufloxib (TN); Roxin (TN); Utin (TN); Utinor (TN); Apo-Norflox (TN); Norfloxacin (JP15/USP/INN); Norfloxacin [USAN:BAN:INN:JAN]; Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Verapamil
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Arpamyl; Calan; Calcan; Cordilox; Dexverapamil; Dilacoran; Drosteakard; Iproveratril; Isoptimo; Isoptin; Isotopin; Vasolan; Veracim; Verapamilo; Verapamilum; Veraptin; Verexamil; Bosoptin (TN); Calan (TN); D-365; Isoptin (TN); Verapamilo [INN-Spanish]; Verapamilum [INN-Latin]; Verelan (TN); CP-16533-1; Covera-HS (TN); Verapamil (USAN/INN); Verapamil [USAN:BAN:INN]; Verapamil [USAN:INN:BAN]; Alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile; (+-)-Verapamil; (+/-)-VERAPAMIL; (1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile; 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile; 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; Verapamil (Na-Ca chanel blocker)
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Ibuprofen
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
ibuprofen; 15687-27-1; 2-(4-Isobutylphenyl)propanoic acid; Motrin; Brufen; Advil; Nurofen; Dolgit; Nuprin; Liptan; Ibuprocin; Buburone; Medipren; Butylenin; Ibumetin; Anflagen; Lamidon; Ebufac; Mynosedin; Trendar; Roidenin; Apsifen; Haltran; Epobron; Nobgen; Adran; Nobfen; Rufen; PediaProfen; Andran; Bluton; Nobfelon; Pantrop; Brufort; Suspren; Rebugen; Tabalon; Inabrin; (RS)-Ibuprofen; Urem; Anco; 2-[4-(2-methylpropyl)phenyl]propanoic acid; Ibu-slo; Napacetin; Brufanic; Ibuprohm; Ibufen; Ibren; 4-Isobutylhydratropic acid; p-Isobutylhydratropic acid; Actiprofen; Alaxan; Algofen; Amelior; Amersol; Amibufen; Anafen; Antagil; Antalfene; Antarene; Antiflam; Artofen; Artril; Balkaprofen; Betaprofen; Bloom; Brofen; Bruflam; Bufeno; Bufigen; Bukrefen; Bupron; Buracaps; Burana; Carol;Cesra; Citalgan; Cobo; Codral; Combiflam; Cunil; Daiprophen; Dalsy; Dansida; Dentigoa; Dibufen; Dignoflex; Dolgirid; Dolibu; Dolmaral; Dolocyl; Dolofen; Dolofin; Dolofort; Dologel; Dolomax; Doloren; Dolormin; Doltibil; Dolven; Dorival; Drin; Duafen; Duobrus; Dysdolen; Easifon; Emflam; Eputex; Ergix; Esprenit; Exneural; Faspic; Femadon; Femafen; Femapirin; Femidol; Fenbid;Fendol; Fenspan; Fibraflex; Gelufene; Gofen; Grefen; Gynofug; Ibol; Ibu; Ibubest; Ibubeta; Ibucasen; Ibudol; Ibudolor; Ibuflamar; Ibufug; Ibugel; Ibugen; Ibugesic; Ibuhexal; Ibulagic; Ibular; Ibulav; Ibuleve; Ibulgan; Ibumed; Ibumerck; Ibupirac; Ibuprin; Ibuprofene; Ibuprofeno; Ibuprofenum; Ibuprophen; Ibusal; Ibutid; Ifen; Inflam; Inoven; Ipren; Irfen; Isodol; Jenaprofen; Junifen; Kesan; Kratalgin; Lebrufen; Librofem; Lidifen; Lopane; Malafene; Manypren; Melfen; Mensoton; Midol; Moment; Narfen; Neobrufen; Nerofen; Noalgil; Nobafon; Noritis; Norton; Novadol; Novogent; Novoprofen; Nuprilan; Optifen; Opturem; Oralfene; Ostarin; Ostofen; Ozonol; Paduden; Panafen; Paxofen; Perofen; Proartinal; Profen; Proflex; Provon; Quadrax; Rafen; Ranofen; Relcofen; Rhinadvil; Rofen; Rufin; Rupan; Sadefen; Salivia; Salprofen; Seclodin; Sednafen; Seklodin; Seskafen; Siyafen; Solpaflex; Solufen; Stelar; Sugafen; Suprafen; Syntofene; Tatanal; Tempil; Tofen; Tonal; Unipron; Upfen; Uprofen; Zafen; Zofen; DOLO PUREN; Deep Relief; Donjust B; Motrin IB; Novogent N; Togal N; Adex 200; Artril 300; Brufen 400; I 4883; IP 82; IP82; Midol 200; RD 13621; Tabalon 400; U 18573; UCB 79171; VUFB 9649; Act-3; Advil (TN); Ak+C2278tren; Aktre (TN); Alaxan (TN); Algoflex (TN); Alivium (TN); Am-Fam 400; Apsifen-F; Arthrofen (TN); Bonifen (TN); Brufen (TN); Bugesic (TN); Burana (TN); Caldolor (TN); Calprofen (TN); Cap-Profen; Dalsy (TN); Dismenol (TN); Diverin (TN); Dolgit (TN); Dolo-Dolgit; Dolofen-F; Dolofort (TN); Doloraz (TN); Dolormin (TN); Dorival (TN); Dura-Ibu; Ebufac (TN); Emflam-200; EmuProfen (TN); Espidifen (TN); Eve (TN); Fenbid (TN); Fenpaed (TN); Finalflex (TN); Galprofen (TN); Hedex (TN); Herron Blue (TN); IB-100; IBUFEN (TN); IP-82; Ibalgin (TN); Ibu-Attritin; Ibu-Tab; Ibu-Tab 200; Ibu-slow; IbuHEXAL (TN); Ibugel (TN); Ibuleve (TN); Ibum (TN); Ibumax (TN); Ibumetin (TN); Ibuprom (TN); Ibuprosyn (TN); Ibux (TN); Ibuxin (TN); Ipren (TN); Kratalgin (TN); Medicol (TN); Moment (TN); Motrin (TN); Nagifen-D; Narfen (TN); Neo-Helvagit; Neo-Mindol; Neobrufen (TN); Neofen (TN); Norvectan (TN); Novo-Profen; Nuprin (TN); Nureflex (TN); Nurofen (TN); Orbifen (TN); Panafen (TN); Pedia-Profen; Perifar (TN); Profin (TN); Ratiodolor (TN); Retard (TN); Rimafen (TN); Salvarina (TN); Solpaflex (TN); Spedifen (TN); Speedpain NANO (TN); Spidifen (TN); Tab-Profen; U-18573; Upfen (TN); ACHES-N-PAIN; Act-3 (TN); Dolo-Spedifen (TN); I-profen (TN); IBU-Ratiopharm (TN); Ibu-Vivimed (TN); U-18,573; IBUPROPHEN
Click to Show/Hide
|
||||
Activity |
Ki = 50000 nM
|
[5] | |||
Compound Name |
Benzbromarone
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Acifugan; Azubromaron; Benzbromaron; Benzbromaronratiopharm; Benzbromaronum; Benzobromarona; Besuric; Desuric; Exurate; Harolan; Hipurik; Minuric; Narcaricin; Normurat; Uricovac; Urinorm; Uroleap; Aliud Brand of Benzbromarone; Benzbromaron AL; Benzbromaron ratiopharm; Benzbromarone Aliud Brand; Benzbromarone Heumann Brand; Benzbromarone Sanfer Brand; Benzbromarone ratiopharm Brand; Heumann Brand of Benzbromarone; Ratiopharm Brand of Benzbromarone; Sanfer Brand of Benzbromarone; Sanofi Winthrop Brand of Benzbromarone; L 2214; L2214; MJ 10061; NCI85433; AL, Benzbromaron; Benzbromaron-ratiopharm; Benzbromaronum [INN-Latin]; Benzobromarona [INN-Spanish]; L 2214-Labaz; L-2214; Uroleap (TN); Benzbromarone [USAN:INN:BAN]; Methanone, (3; Benzbromarone (JP15/USAN/INN); KETONE, 3,5-DIBROMO-4-HYDROXYPHENYL 2-ETHYL-3-BENZOFURANYL; Ketone, 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl; (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone; 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; 3, 5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
Pyrimethamine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Chloridin; Chloridine; Chloridyn; Darachlor; Daraclor; Darapram; Daraprim; Daraprime; Daraprin; Diaminopyritamin; Erbaprelina; Ethylpyrimidine; Khloridin; Malacid; Malocid; Malocide; Maloprim; Pirimecidan; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethaminum; Tindurin; Tindurine; Tinduring; Aventis Brand of Pyrimethamine; Glaxo Wellcome Brand of Pyrimethamine; GlaxoSmithKline Brand of Pyrimethamine; M alocid; Pirimetamina [Spanish]; Pyrimethamine Hcl; Wellcome Brand of Pyrimethamine; BW 5063; RP 4753; WR 2978; AZT + Pyrimethamine combination; BW 50-63; Daraprim (TN); EXR-101; Lactoferrin B & Pyrimethamine; Lactoferrin H & Pyrimethamine; Pirimetamina [INN-Spanish]; Pyrimethamine (Pyr); Pyrimethaminum [INN-Latin]; TCMDC-123831; TCMDC-125860; CRL-8131 & Pyrimethamine; CRL-8142 & Pyrimethamine; Fansidar (Pyrimethamine/Sulfadoxine); Pyrimethamine (JAN/USP/INN); Pyrimethamine [USAN:INN:BAN:JAN]; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE; 5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine; 5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
Activity |
Ki = 51500 nM
|
[6] | |||
Compound Name |
Daclatasvir
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
1009119-64-5; Daclatasvir (BMS-790052); 1214735-16-6; CHEBI:82977; C40H50N8O6; methyl N-[(1S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate; Daclatasvir (USAN); cc-39; Daclatasvir BMS 790052; MLS006011140; SCHEMBL2756027; CHEMBL2023898; SCHEMBL17897804; KS-00000XPC; EX-A410
Click to Show/Hide
|
||||
Activity |
IC50 = 59500 nM
|
[7] | |||
Compound Name |
PSI-7977
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
1190307-88-0; SOVALDI; PSI 7977; GS-7977; GS 7977; UNII-WJ6CA3ZU8B; WJ6CA3ZU8B; CHEBI:85083; Sofosbuvir (PSI-7977, GS-7977); Hepcvir; Hepcinat; HSDB 8226; 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester; Sofosbuvir [USAN:INN]; Resof; SoviHep; Sovaldi (TN); Sofosbuvir (JAN/USAN); Sofosbuvir(PSI-7977); GTPL7368; SCHEMBL2010114; CHEMBL1259059; AMMD00019; EX-A389; MolPort-028-720-482; isopropyl (2S)-2-[[[(2R,
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[8] | |||
Compound Name |
Tolbutamide
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Aglicid; Arcosal; Arkozal; Artosin; Artozin; Beglucin; Butamid; Butamide; Butamidum; Diaben; Diabesan; Diabetamid; Diabetol; Diabuton; Diasulfon; Diaval; Dirastan; Dolipol; Drabet; Glyconon; Ipoglicone; Mobenol; Orabet; Oralin; Oramide; Orezan; Orinase; Orinaz; Oterben; Pramidex; Rastinon; Restinon; Tarasina; Tolbet;Tolbusal; Tolbutamid; Tolbutamida; Tolbutamidum; Tolbutone; Toluina; Tolumid; Toluran; Toluvan; Tolylsulfonylbutylurea; Willbutamide; Apotex Brand of Tolbutamide; Aventis Brand of Tolbutamide; BerlinChemie Brand of Tolbutamide; Butamide Brand of Tolbutamide; Hoechst Brand of Tolbutamide; Pfizer Brand of Tolbutamide; TOLBUTAMIDE USP; Tolbutamide Aventis Brand; Tolbutamide Butamide Brand; Tolbutamide Hoechst Brand; Tolbutamide Pfizer Brand; Valdecasas Brand of Tolbutamide; Yamanouchi Brand of Tolbutamide; D 860; HLS 831; T 0891; U 2043; Apo-Tolbutamide; Berlin-Chemie Brand of Tolbutamide; Novo-Butamide; Orinase (TN); Sk-tolbutamide; Tol-Tab; Tolbutamida [INN-Spanish]; Tolbutamidum [INN-Latin]; Tolbutamide [INN:BAN:JAN]; R.A.N. Brand of Tolbutamide; Tolbutamid R.A.N.; Tolbutamide (JP15/USP/INN); N-4-Methylbenzolsulfonyl-N-butylurea; N-4-(Methylbenzolsulfonyl)-n-butylurea; N-Butyl-N'-p-toluenesulfonylurea; N-n-Butyl-N'-tosylurea; N-(4-Methylbenzenesulfonyl)-N'-butylurea; N-(4-Methylphenylsulfonyl)-N'-butylurea; N-(p-Tolylsulfonyl)-N'-butylcarbamide; N-Butyl-N'-(4-methylphenylsulfonyl)urea; N-Butyl-N'-(p-tolylsulfonyl)urea; N-Butyl-N'-toluene-p-sulfonylurea; N-(p-tolylsulfonyl)-N'-n-butylurea; 1-Butyl-3-(4-methylphenylsulfonyl)urea; 1-Butyl-3-(p-methylphenylsulfonyl)urea; 1-Butyl-3-(p-tolylsulfonyl)urea; 1-Butyl-3-(para-tolylsulfonyl) urea; 1-Butyl-3-tosylurea; 1-butyl-3-(4-methylphenyl)sulfonylurea; 1-p-Toluenesulfonyl-3-butylurea; 3-(p-Tolyl-4-sulfonyl)-1-butylurea; 3-(p-tolylsulfonyl)-1-butylurea; 3-[p-Tolyl-4-sulfonyl]-1-butylurea
Click to Show/Hide
|
||||
Activity |
Ki = 70000 nM
|
[5] | |||
Compound Name |
Lesinurad
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
LESINURAD; 878672-00-5; RDEA594; Zurampic; RDEA 594; UNII-09ERP08I3W; RDEA-594; 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid; 09ERP08I3W; AK323774; C17H14BrN3O2S; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid; 2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 78700 nM
|
[9] | |||
Compound Name |
Miltefosine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
HDPC; HePC; Hexadecylphosphocholine; Hexadecylphosphorylcholine; Impavido; Miltefosina; Miltefosinum; Miltex; Baxter Oncology brand of miltefosine; Baxter brand of miltefosine; Miltefosin C; Prasfarma brand of miltefosine; D 18506; IN1227; D-18506; H-1850; M-7200; Miltefosina [INN-Spanish]; Miltefosine (INN); Miltefosine[INN:BAN]; Miltefosinum [INN-Latin]; N-Hexadecylphosphorylcholine; TF-002; Choline hydroxide, hexadecyl hydrogen phosphate, inner salt; Choline, hexadecyl hydrogen phosphate, inner salt; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; Choline phosphate, hexadecyl ester, hydroxide, inner salt; Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI); Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt; 1-Hexadecylphosphorylcholine; 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt; 3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[10] | |||
Compound Name |
Dolutegravir
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
1051375-16-6; GSK1349572; Tivicay; S/GSK1349572; Dolutegravir (GSK1349572); S-349572; GSK-1349572; GSK 1349572; UNII-DKO1W9H7M1; (4r,12as)-N-(2,4-Difluorobenzyl)-7-Hydroxy-4-Methyl-6,8-Dioxo-3,4,6,8,12,12a-Hexahydro-2h-Pyrido[1',2':4,5]pyrazino[2,1-B][1,3]oxazine-9-Carboxamide; CHEBI:76010; DKO1W9H7M1; Tivicay (TN); (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide; Dolutegravir Sodium (
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[11] | |||
Compound Name |
Benznidazole
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
BENZNIDAZOLE; Radanil; Benzonidazole; 22994-85-0; Benznidazol; benzonidazol; Benznidazolum;Ro 07-1051; Rochagan; UNII-YC42NRJ1ZD; Benznidazolum [INN-Latin]; Benznidazol [INN-Spanish]; Ro 71051; NSC 299972; Benznidazole [INN]; CCRIS 2200
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[10] | |||
Compound Name |
Pentamidine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[10] | |||
Compound Name |
Setipiprant
Click to Show/Hide
|
Phase 3 | Compound Info | ||
Synonyms |
ACT-129968
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[12] | |||
Compound Name |
TZP-101
Click to Show/Hide
|
Phase 2b | Compound Info | ||
Synonyms |
Ulimorelin; TZP-101; TZP 101; UNII-LGI67MCW2S; 842131-33-3; LGI67MCW2S; CHEMBL1923502; Ulimorelin [USAN:INN]; Ulimorelin (USAN/INN); SCHEMBL804500; TZP101; GTPL3535; CHEMBL1963249; DTXSID00233139; BDBM50359256; DB12128; D09981; (3R,6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-3,8,9-trimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-7,10,13-trione; D-Phenylalanine, (2S)-N-((2R)-2-(2-(3-aminopropyl)phenoxy)propyl)-2- cyclopropylglycyl-N-methyl-D-alanyl-4-fluoro-, (3-1)-lactam
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[13] | |||
Compound Name |
SCH-900271
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
SCH-900271; UNII-G2283XQ6VJ; SCH 900271; G2283XQ6VJ; 915210-50-3; CHEMBL2036958; GTPL8469; SCHEMBL12602910; DTXSID00238609; BDBM50384612; SCH900271; SB17408; DB12433; 2H-Pyrano(2,3-d)pyrimidine-2,4,7(1H,3h)-trione, 5-(3-(1-methylcyclopropyl)propyl)-; 5-(3-(1-Methylcyclopropyl)propyl)-1H-pyrano(2,3-d)pyrimidine-2,4,7(3H)-trione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
VBP15
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
vamorolone; Vamorolone; 13209-41-1; UNII-8XP29XMB43; VBP-15; 8XP29XMB43; CHEMBL2348780; 17,21-Dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione; A-Methyl-9,11-dehydro Prednisolone; (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one; Vamorolone [USAN]; VBP-15 free alcohol; VBP 15; EINECS 236-177-8; AC1MHYKY; Vamorolone (USAN/INN); SCHEMBL143459; GTPL9247; A)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; ZINC33650317
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[15] | |||
Compound Name |
APD371
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
Olorinab; UNII-581F7DFA9B; 581F7DFA9B; Olorinab [USAN]; SCHEMBL11995430; 1268881-20-4; (4aS,5aS)-N-((2S)-1-hydroxy-3,3-dimethylbutan-2-yl)-1-(4-oxidopyrazin-2-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa(4,5)cyclopenta(1,2-c)pyrazole-3-carboxamide; 1H-Cyclopropa(4,5)cyclopenta(1,2-c)pyrazole-3-carboxamide, 4,4a,5,5a-tetrahydro-N-((1S)-1-(hydroxymethyl)-2,2-dimethylpropyl)-1-(4-oxido-2-pyrazinyl)-, (4aS,5aS)-; (1aS,5aS)-2-(4-Oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa(a)pentalene-4-carboxylic aci
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[16] | |||
Compound Name |
Ralinepag
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
UNII-CQY12ZJN6E; CQY12ZJN6E; 1187856-49-0; Ralinepag [USAN:INN]; Ralinepag (USAN/INN); SCHEMBL1118504; SCHEMBL1118506; SCHEMBL12786473; CHEMBL3919269; CHEMBL3301604; AKOS027337124; DB12462; 2-((trans-4-((((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetic acid; Acetic acid, 2-((trans-4-(((((4-chlorophenyl)phenylamino)carbonyl)oxy)methyl)cyclohexyl)methoxy)-; HY-16751; CS-0012350; J3.614.088G; D10725
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[17] | |||
Compound Name |
PLECONARIL
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
Picovir; Pleconaril < Prop INN; SR-263843; SR-63843; VP-63843; Win-63843; 3-[3,5-Dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[18] | |||
Compound Name |
GLPG-0634
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
Click to Show/Hide
|
||||
Activity |
IC50 ~ 70000 nM
|
[19] | |||
Compound Name |
Q203
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
Telacebec; 1334719-95-7; UNII-55G92WGH3X; 55G92WGH3X; Q-203; CHEMBL3298910; SCHEMBL12295312; MMV687696; BDBM50022086; ZINC169325657; CS-6412; Imidazo(1,2-a)pyridine-3-carboxamide, 6-chloro-2-ethyl-N-((4-(4-(4-(trifluoromethoxy)phenyl)-1-piperidinyl)phenyl)methyl)-; AS-35270; HY-101040; Q 203; EN300-218150; Z2235679010; 6-chloro-2-ethyl-N-[(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methyl]imidazo[1,2-a]pyridine-3-carboxamide; 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidyl]phenyl]methyl]im
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[20] | |||
Compound Name |
Camicinal
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
962040
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[21] | |||
Compound Name |
GSK-557296
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
Epelsiban; Epelsiban besylate; Premature ejaculation therapeutic (oral), GlaxoSmithKline
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[22] | |||
Compound Name |
GLPG-1837
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
GHTGYZMBQPXTCQ-UHFFFAOYSA-N; GLPG1837; 1654725-02-6; SCHEMBL16444982; GLPG 1837; EX-A1819; BCP23611; GLPG-1837(ABBV-974); HY-111099; CS-0034220; N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-3-carboxamide
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[23] | |||
Compound Name |
842166X
Click to Show/Hide
|
Phase 2 | Compound Info | ||
Synonyms |
GW842166X; 666260-75-9; GW 842166X; GW-842166X; UNII-VL1I6P2DZ8; VL1I6P2DZ8; GW842166; GW 842166; CHEMBL225411; 2-((2,4-dichlorophenyl)amino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide; TWQYWUXBZHPIIV-UHFFFAOYSA-N; 842166X; MLS006010287; C18H17Cl2F3N4O2; SCHEMBL3015040; DTXSID60216786; MolPort-009-019-316; HMS3656P06; BCP05306; ZINC3947932; BDBM50211843; s2778; 2455AH; AKOS032945128; DB11903; BCP9000755; CS-7768; SB19546; API0013938; GW-842,166X; NCGC00346697-05; NCGC00346697-01; KB-77649; HY-14167
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[24] | |||
Compound Name |
BMS-863233
Click to Show/Hide
|
Phase 1/2 | Compound Info | ||
Activity |
IC50 ~ 50000 nM
|
[25] | |||
Compound Name |
ISOQUINE
Click to Show/Hide
|
Phase 1 | Compound Info | ||
Synonyms |
ISOQUINE; CHEMBL147587; NINDS_000687; Spectrum_000046; Spectrum4_000147; Spectrum2_000768; Spectrum5_000808; Spectrum3_000299; AC1L1D2I; KBioSS_000426; BSPBio_001838; KBioGR_000594; DivK1c_000687; SPBio_000816; SCHEMBL5836418; KBio2_000426; KBio1_000687; KBio3_001338; KBio2_002994; CTK6E7963; KBio2_005562; ZINC36378506; BDBM50134931; IDI1_000687; NCGC00178968-01; SBI-0051280.P003; AB00053418_02; 5-(7-chloroquinolin-4-ylamino)-2-diethylaminomethylphenol; 5-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[26] | |||
Compound Name |
PF-06840003
Click to Show/Hide
|
Phase 1 | Compound Info | ||
Synonyms |
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione; 198474-05-4; PF06840003; 2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-; 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione; SCHEMBL5463464; GTPL9565; CTK0A0183; DTXSID00630149; MXKLDYKORJEOPR-UHFFFAOYSA-N; KS-000008MY; EX-A1186; EOS200271; AKOS027252536; CS-6186; AS-51973; HY-101111; 3-(5-Fluoro-1H-indol-3-yl)-pyrrolidine-2,5-dione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[27] | |||
Compound Name |
Tetra-hydro-oxazolopyridine derivative 3
Click to Show/Hide
|
Patented | Compound Info | ||
Synonyms |
PMID28067079-Compound-63
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[28] | |||
Compound Name |
GSK163090
Click to Show/Hide
|
Discontinued in Phase 2 | Compound Info | ||
Synonyms |
844903-58-8; GSK-163090; UNII-7XI927X82B; CHEMBL1631540; 7XI927X82B; 1-(3-(2-(4-(2-Methyl-5-quinolinyl)-1-piperazinyl)ethyl)phenyl)-2-imidazolidinone; 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone; 1-[3-[2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl]phenyl]-2-imidazolidinone; ANGUXJDGJCHGOG-UHFFFAOYSA-N; GSK 163090; SCHEMBL2881345; DTXSID30233480; EX-A1027; BCP16941; ZINC34451922; BDBM50333015; AKOS030526918; CS-5315; HY-14348
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[29] | |||
Compound Name |
DOV-216303
Click to Show/Hide
|
Discontinued in Phase 2 | Compound Info | ||
Synonyms |
66504-40-3; CHEMBL528995; 3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-; SCHEMBL79279; SCHEMBL9604846; CTK1J4675; MolPort-035-942-269; BSMNRYCSBFHEMQ-UHFFFAOYSA-N; DOV-2947; BDBM50243895; AKOS025396236; FCH1601649; SB10890; KB-50426; AS-51627; AK173863; CS-0052898; KS-00000461
Click to Show/Hide
|
||||
Activity |
IC50 = 99000 nM
|
[30] | |||
Compound Name |
AZD5672
Click to Show/Hide
|
Terminated | Compound Info | ||
Synonyms |
CHEMBL1951914; SCHEMBL2767780; GTPL7686; QOSMEMHKXNNIGG-SSEXGKCCSA-N; AZD 5672; BDBM50364743; N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(1-methylsulfonylpiperidin-4-yl)propyl]piperidin-4-yl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[31] | |||
Compound Name |
SB 206553
Click to Show/Hide
|
Terminated | Compound Info | ||
Synonyms |
SB 206553; 158942-04-2; SB-206553; Tocris-1661; CHEMBL297784; CHEBI:8977; UNII-AL4387525T; AL4387525T; SB-206,553; 1-methyl-N-pyridin-3-yl-6,7-dihydropyrrolo[2,3-f]indole-5-carboxamide; SB-206553 hydrochloride hydrate; SB206553; Lopac-S-180; AC1L1JQU; AC1Q5NRE; Lopac0_001163; GTPL189; SCHEMBL1459242; ZINC5994; DTXSID9043984; CTK8H1211; BDBM50060417; pyrrolo[2,3-f]indole-1(2h)-carboxamide, 3,5-dihydro-5-methyl-n-3-pyridinyl-; AKOS027381420; 5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide; CCG-205237
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[32] | |||
Compound Name |
5-amino-2-phenyl-oxazole-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL207987; 5-amino-2-phenyloxazole-4-carboxylic acid amide; 99185-68-9; 5-amino-2-phenyl-oxazole-4-carboxylic acid amide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[33] | |||
Compound Name |
Go-Y026
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Go-Y026; CHEMBL493001; SCHEMBL2743841; SCHEMBL2743839; GO-Y-026; BDBM50258200; 1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one; 1,5-Bis(3,5-dimethoxy-4-hydroxyphenyl)-1,4-pentadien-3-one
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[34] | |||
Compound Name |
SB 228357
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SB-228357; SB228357
Click to Show/Hide
|
||||
Activity |
IC50 = 82000 nM
|
[35] | |||
Compound Name |
3-(3-methylthiophen-2-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(3-methylthiophen-2-yl)pyridine; CHEMBL179669; Pyridine, 3-(3-methyl-2-thienyl)-; 837376-35-9; SCHEMBL3606167; BDBM12351; CTK3D1375; DTXSID20635313; nicotine 3-heteroaromatic analogue 4; US8609708, 4
Click to Show/Hide
|
||||
Activity |
IC50 = 93100 nM
|
[36] | |||
Compound Name |
2-Hexyloxy-5-imidazol-1-yl-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL320105; 2-Hexyloxy-5-imidazol-1-yl-pyridine; SCHEMBL14129948; BDBM50138236
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[37] | |||
Compound Name |
SB 242084
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SB-242,084; SB242084
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[35] | |||
Compound Name |
SB-214111
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
209480-37-5
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[38] | |||
Compound Name |
BMS pyrazole inhibitor 7f
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL468927; BMS pyrazole inhibitor 7f; ASIS-P021; GTPL7030; SCHEMBL14565559; ZINC40891759; BDBM50258790; (2S)-2-amino-N-[(3-{5-[5-(1,3-benzothiazol-7-yl)-1,3,4-oxadiazol-2-yl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}phenyl)methyl]propanamide; (S)-2-amino-N-(3-(5-(5-(benzo[d]thiazol-7-yl)-1,3,4-oxadiazol-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzyl)propanamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[39] | |||
Compound Name |
SB 221284
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SB-221284; SB221284
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[35] | |||
Compound Name |
TG-100435
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
TG-100435; CHEMBL230686; SCHEMBL4266197; ZINC28702706; BDBM50198782; US8481536, 367; US8481536, 575; ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine); 7-(2,6-dichlorophenyl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[40] | |||
Compound Name |
Desethyl isoquine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
desethyl isoquine; CHEMBL146826; ZINC1912679; BDBM50134934
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[41] | |||
Compound Name |
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one; CHEMBL448743; 5-(pyridin-3-yl)-2,3-dihydroinden-1-one; 5-Pyridin-3-yl-1-indanone; 5-(3-Pyridyl)-1-indanone; SCHEMBL6205709; CTK8E5276; QNSOPUXDEXJMIY-UHFFFAOYSA-N; BDBM50273704; ZINC40829496; 255895-87-5; TX-011073
Click to Show/Hide
|
||||
Activity |
IC50 = 123000 nM
|
[42] | |||
Compound Name |
CID 71544946
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3234858; SCHEMBL14873629; BDBM50009583
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[43] | |||
Compound Name |
3-[7-Chloro-2-[(1-cyclopropyl-2-oxoimidazo[4,5-c]pyridin-3-yl)methyl]imidazo[1,2-a]pyridin-3-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427272; BDBM50088179
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476763; SCHEMBL2010557; BDBM50263396; AKOS008854805; N-[2-[[(4-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(2S)-N-(5-Tert-butyl-1,2-oxazol-3-yl)-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3353862; SCHEMBL9893080; BDBM50042591
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[46] | |||
Compound Name |
(1S,2R,5S)-5-(4,7,8,12-Tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3806003
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
(2S)-N-[5-[2-(6-Methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3929505; SCHEMBL17492299; BDBM254004; US9481673, (S)-14
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
2-((R)-8-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1641811; SCHEMBL2214672; BDBM50333497
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[49] | |||
Compound Name |
S-[2-[6-[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonylamino]pyridin-3-yl]-2-oxoethyl] ethanethioate;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL520237; SCHEMBL5131584
Click to Show/Hide
|
||||
Activity |
EC50 ~ 50000 nM
|
[50] | |||
Compound Name |
(4R)-4-(4-Cyanophenyl)-N-(2-hydroxyethyl)-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4111285; SCHEMBL15913378; BDBM211750; US9290459, 7.2A
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
1-[5-(4-Methylpyridin-3-yl)-2,3-dihydroindol-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3287188; SCHEMBL16989882; BDBM50019867
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[52] | |||
Compound Name |
CID 44125704
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3359854; SCHEMBL2915796; BDBM50034554
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
1-Propanol, 3-[(6-methoxy-1H-benzimidazol-2-yl)thio]-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2018913; BDBM50380527; AKOS008902078; J3.516.542H; 2-(3-Hydroxypropylthio)-6-methoxy-1H-benzoimidazole
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
4-Fluoro-N-[2-[(2-fluoro-6,11-dihydrobenzo[c][1]benzoxepin-11-yl)methylamino]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL515644; BDBM50263682; 4-Fluoro-N-{[(2-fluoro-6,11-dihydro-dibenzo[b,e]oxepin-11-ylmethyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(2S)-N-[5-[2-(2-Methoxypyridin-4-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3969059; SCHEMBL17492290; BDBM254003; US9481673, (S)-13
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
(1R,2S,3R,5R)-3-[[2-[(2-Cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601190; SCHEMBL16481787; BDBM50107893
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
(10S)-4-(1H-Indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-triene
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3921669; SCHEMBL16085284; BDBM251580; US9453031, 3
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[56] | |||
Compound Name |
N-[4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3623824; SCHEMBL15311560; BDBM191880; US9187429, 5; US9187429, 6; US9187429, 7; N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinoline-8-yl)propanamide; (rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[57] | |||
Compound Name |
Rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1777861; BDBM50344068
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[58] | |||
Compound Name |
CID 49848896
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043326; SCHEMBL2120049; BDBM50385820
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
3-(4-Cyclohexylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043327; BDBM50385821
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyridin-3-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3973040; SCHEMBL17492337; BDBM253995; US9481673, (S)-5
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
(1R)-1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4107014; SCHEMBL17147204; BDBM244144; US9428492, 14
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
(S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL330425; SCHEMBL5347277; BDBM50146654
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[61] | |||
Compound Name |
2-[(3S)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4079801; BDBM50264807
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
Propan-2-yl 4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3325843; BDBM50055993
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[63] | |||
Compound Name |
2-[(3R)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4066339; SCHEMBL10146409; BDBM50264806
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
2-Methyl-5-cyano-6-[3-[(benzylsulfonyl)carbamoyl]-1-azetidinyl]nicotinic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2419501; SCHEMBL3223721; BDBM50439281; ZINC34846050; ethyl 6-[3-(benzylsulfonylcarbamoyl)azetidin-1-yl]-5-cyano-2-methylpyridine-3-carboxylate; 5-Cyano-2-methyl-6 (3-phenylmethanesulfonylaminocarbonyl-azetidin-1-yl)-nicotinic acid ethyl ester; 5-Cyano-2-methyl-6-(3-phenylmethanesulfonylaminocarbonyl-azetidin-1-yl)-nicotinic acid ethyl ester
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[64] | |||
Compound Name |
2-(Ethylsulfanyl)-6-methoxy-1h-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Methoxybemitil; CHEMBL2018906; Methoxybemithyl; 2-ethylsulfanyl-6-methoxy-1H-benzimidazole; 1H-Benzimidazole, 2-(ethylthio)-6-methoxy-; SCHEMBL13651209; CTK8D7266; DTXSID20914099; ZINC9187549; BDBM50380518; STL164078; AKOS000423048; AKOS005363656; MCULE-3849567164; CS-0117859; 2-(ethylsulfanyl)-6-methoxy-1H-1,3-benzodiazole; 2-(Ethylsulfanyl)-1h-benzimidazol-5-yl methyl ether; Z16077930; 2-(ETHYLSULFANYL)-5-METHOXY-1H-1,3-BENZODIAZOLE
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinoline-8-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3623823; SCHEMBL15312033; BDBM191882; US9187429, 8; N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]acetamide; (rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)acetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[57] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261485; SCHEMBL1077301; BDBM50014554
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041191; BDBM50385804
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
5-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041010; BDBM50385826
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-3-((S)-1-(4-(1-Ethyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL118755; CHEMBL3664668; BDBM107612; US8575157, 62
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
(4,4-Difluoropiperidin-1-yl)(1-isopropyl-5-((1-isopropylpiperidin-4-yl)oxy)-1H-indol-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL497031; SCHEMBL1379627; BDBM50269055; ZINC40428795; (4,4-difluoropiperidin-1-yl)-[1-propan-2-yl-5-(1-propan-2-ylpiperidin-4-yl)oxyindol-2-yl]methanone; (4,4-Difluoropiperidin-1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]methanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
Chembl4283853
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
RG7834; 2072057-17-9 (S-isomer); RG7834 S-isomer; SCHEMBL16942404; EX-A3683; BDBM50467761; MFCD31555773; ZINC584641403; HY-117650A; RG 7834; CS-0084529; RG7834 (RO 7020322)
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[68] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(6-methylpyridin-3-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3896543; SCHEMBL17492273; BDBM253996; US9481673, (S)-6
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
N-(2-((3-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL518287; SCHEMBL2010076; BDBM50263678; N-[2-[[(3-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]-4-fluorobenzamide; rac-n-({[(3-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-4-fluoro-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4069245; SCHEMBL17723589; BDBM50249183
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[69] | |||
Compound Name |
2-(3,4-Dimethoxyphenyl)-5-(3-methoxypropyl)benzofuran
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
DWK-1339; UNII-WN8TEM4Q1F; MDR-1339; WN8TEM4Q1F; CHEMBL4066961; SNU-0039; 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl) benzofuran; Benzofuran, 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-; SCHEMBL3002082; BCP34010; EX-A1942; BDBM50250939; ZB1549; HY-14503; CS-0003407; Q27292735; 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[70] | |||
Compound Name |
4-Fluoro-N-[2-oxo-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylmethylamino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478036; BDBM50263681; N-{[(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylmethyl)-carbamoyl]-methyl}-4-fluoro-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
CID 57384750
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041181; SCHEMBL2119681; BDBM50385794
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BI-7273; CHEMBL3823478; BI7273; GTPL9146; SCHEMBL19869878; EX-A990; BCP17545; BDBM50183448; MFCD30489736; s8179; ZINC575448880; CCG-268068; CS-5887; HY-100351; J3.533.936A; A16068; Q27075221
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[71] | |||
Compound Name |
3-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043169; BDBM50385814
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
2-Bromo-N-[2-(2,6-dimethylpyridin-4-yl)propan-2-yl]-3,3-dimethylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Pyridine-based ligand, 14; CHEMBL271581; BDBM21163
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
9-Fluoro-7-(5-fluoro-pyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2331699; SCHEMBL13727574; BDBM50428331; 9-fluoro-7-(5-fluoropyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[73] | |||
Compound Name |
2-(3-(1-(5-Hydroxypyridin-2-yl)-1H-pyrazol-4-yl)propanamido)cyclohex-1-enecarboxylicacid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1085150; SCHEMBL4548329; BDBM50319242
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[74] | |||
Compound Name |
4-[(4S)-2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]-3,4,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl]-3-methylsulfonylbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4112385; SCHEMBL15912930; BDBM211757; US9290459, 10A; US9290459, 47.21
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
(2S)-2-[6-Chloro-2-(4-chlorophenyl)-5-fluorobenzimidazol-1-yl]-N,2-dicyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1642362; SCHEMBL3568324; BDBM50334234; RO-5186026; (S)-2-(6-chloro-2-(4-chlorophenyl)-5-fluoro-1H-benzo[d]imidazol-1-yl)-N,2-dicyclohexylacetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[75] | |||
Compound Name |
Nav1.7-IN-3
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4061793; SCHEMBL16760693; HY-101789; CS-0021899
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[76] | |||
Compound Name |
(1S)-1-(2,4-Difluorophenyl)-2-pyrazol-1-yl-1-(1,2,4-triazol-1-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3085388
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
trans-4-((2S)-2-Cyclohexyl-2-(2-(2,4-dimethoxypyridin-3-yl)-5,6-difluoro-1H-benzo[d]imidazol-1-yl)acetamido)cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1668261; FXR_68; BDBM225975; BDBM50336388
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[75] | |||
Compound Name |
(S)-6-(4-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL117858; CHEMBL3664711; BDBM107657; US8575157, 32
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
(2S)-N-[5-[2-(2-Methoxypyridin-4-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3928571; SCHEMBL17492321; BDBM253998; US9481673, (S)-8
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
XAV-939; XAV939; XAV 939; C14H11F3N2OS; CHEMBL1086580; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol; MFCD16879017; 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol; 2-[4-(Trifluoromethyl)phenyl]-7,8-Dihydro-5h-Thiopyrano[4,3-D]pyrimidin-4-Ol; NVP-XAV-939; NVP-XAV 939; Maybridge3_005018; cc-343; MLS006012021; SCHEMBL7783488; TB3748-GMP; SCHEMBL15315468; AOB4150; DTXSID60369423; XAV939,XAV-939; BCPP000009; HMS1445E02; HMS3414D07; HMS3648B17; HMS3654O16; HMS3678D07; HMS3743E05; BCP02128; EX-A1760; ABP000288; BDBM50188594; BDBM50318567; s1180; ZINC13467799; AKOS015954858; AKOS024457786; AKOS026750243; CCG-208105; CS-0494; MCULE-6143908878; SB19432; IDI1_016405; KS-0000181U; NCGC00250397-01; NCGC00484998-01; AC-28393; AK198691; CS-10386; HY-15147; SC-95571; SMR003874205; XAV 939/XAV939,NVP-XAV939; XAV939, >=98% (HPLC); DB-067924; FT-0675873; SW218311-2; X7558; A25698; W-5666; SR-01000946403; J-511234; SR-01000946403-1; BRD-K12762134-001-01-3; BRD-K12762134-001-05-4; Q27132250; 6,8-Dihydro-2-[4-(trifluoromethyl)phenyl]-5H-thiopyrano[3,4-d]pyrimidine; 2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol; 2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[77] | |||
Compound Name |
Chembl4126548
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50270668
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[78] | |||
Compound Name |
(S)-N-((3S,4S)-5-Acetyl-7-cyano-1-((2-methoxynaphthalen-1-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2436225; SCHEMBL15621759
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[79] | |||
Compound Name |
N-[(2S)-3-[3-Chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-methyltriazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4093444; SCHEMBL18893754; BDBM50263623
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[80] | |||
Compound Name |
3-{(S)-1-[4-(1,4-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL959530; CHEMBL3645517; BDBM107478; US8592410, 18
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[81] | |||
Compound Name |
6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2896906; CHEMBL3612810; BDBM155928; US9018211, 52
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[82] | |||
Compound Name |
N-(2-(Bis(4-methoxyphenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL514198; BDBM50263400
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-[4-(2,4-Dichlorophenoxy)phenyl]-3H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4100866
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
(S)-6-(2-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL116078; CHEMBL3664646; BDBM107588; US8575157, 26
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
(S)-6-(2-Hydroxyethyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)propyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL119315; CHEMBL3664651; BDBM107594; US8575157, 40
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
(3r,4r)-4-[4-Cyclopropyl-5-[3-(2-Methylpropyl)cyclobutyl]-1,2,4-Triazol-3-Yl]-N-(2,4-Dimethylphenyl)-1-Ethanoyl-Pyrrolidine-3-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3774855; SCHEMBL17761865; SCHEMBL17762388; BDBM50153594; J3.591.555I
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[84] | |||
Compound Name |
(S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4064672; RO6889678; SCHEMBL15508072; SCHEMBL17874012; BDBM50237769
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[85] | |||
Compound Name |
1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-3-[4-[4-(5-oxo-1,2-dihydropyrazol-3-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041171; BDBM50385784
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
Chembl4227911
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50461934
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[86] | |||
Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3805400
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
(6S)-6-(2-Hydroxy-2-methylpropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]propyl]-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL116926; CHEMBL3664661; BDBM107605; US8575157, 54
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
3-[[7-Chloro-3-(2-methylsulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1-cyclopropylimidazo[4,5-c]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427276; BDBM50088180
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]-2,6-dimethylphenoxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3909872; BDBM50203652
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[87] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)isonicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL452423; SCHEMBL2008516; BDBM50263627; N-[2-[[(4-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]pyridine-4-carboxamide; rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-isonicotinamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043172; BDBM50385817
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-N,N-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041179; BDBM50385792
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-[(S)-2-oxo-5-phenyl-1-(2,4,6-trifluoro-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL329477; SCHEMBL5349058; BDBM50146683
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[61] | |||
Compound Name |
trans-4-((S)-2-(2-(4-Chlorophenyl)-5,6-difluoro-1H-benzo[d]imidazol-1-yl)-2-cyclohexylacetamido)cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1668240; BDBM50336385
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[75] | |||
Compound Name |
4-[7-(5-{3-Cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3359847; SCHEMBL2121313; BDBM50034555
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
6-Chloranyl-4-Phenyl-2-Piperidin-1-Yl-Quinoline-3-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3941588; SCHEMBL14916322; BDBM50197094; Q27455848; 6-chloro-4-phenyl-2-piperidin-1-ylquinoline-3-carboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[88] | |||
Compound Name |
3-[(2R)-6-[3,4-Difluoro-6-(3-methoxycyclobutyl)oxypyridin-2-yl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3980898; BDBM50207061
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[89] | |||
Compound Name |
2-[2-(3-Chlorobenzoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386077; SCHEMBL3090455; BDBM50434988
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[12] | |||
Compound Name |
CID 44123747
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[90] | |||
Compound Name |
(R)-2-(7-(1-(4-Fluorophenyl)-N-methylcyclopentanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1778388; SCHEMBL2189353; BDBM50344162
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[91] | |||
Compound Name |
4-[[2-[(5-Cyano-1,3-thiazol-2-yl)amino]pyridin-4-yl]methyl]-N-methylpiperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-4-yl}methyl)-N-methylpiperazine-1-carboxamide; N-(1,3-Thiazol-2-yl)pyridin-2-amine 20; BDBM5290; CHEMBL375248; SCHEMBL5742011; 4-[2-(5-cyanothiazol-2-ylamino)pyridin-4-ylmethyl]piperazine-1-carboxylic acid methylamide; N-Methyl-4-[2-[(5-cyano-2-thiazolyl)amino]-4-pyridylmethyl]piperazine-1-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[92] | |||
Compound Name |
6,7-Dihydro-4H-thieno[3,2-c]pyridin-5-yl-(2,4-dihydroxy-5-propan-2-ylphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3935883; BDBM50210933
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[93] | |||
Compound Name |
3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-carbonyl]-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL188068; BDBM50156458
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[94] | |||
Compound Name |
4-[2-(2-Carboxyethyl)-3-[6-(3,5-diphenylphenoxy)hexyl]phenoxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1099323; SCHEMBL1689881; BDBM50317625; 4-{2-(2-Carboxyethyl)-3-[6-([1,1'',3,1'''']terphenyl-5''-yloxy)-hexyl]phenoxy}butyric Acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[95] | |||
Compound Name |
(5R)-5-[5-[(3,6-Dichloroquinolin-8-yl)amino]-2-fluorophenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3969614; SCHEMBL10321207; BDBM202618; US9242943, 27
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[96] | |||
Compound Name |
(2R,3S,5R)-5-(11-Methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3806029
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
Chembl4175429
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366405
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
(S)-3-((S)-1-(4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL617645; CHEMBL3660140; BDBM108092; US8598163, 3
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[98] | |||
Compound Name |
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601185; SCHEMBL17194054; BDBM50107848
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
2-Phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2010880; BDBM50379681
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[99] | |||
Compound Name |
N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
RIPA-56; CHEMBL4092421; GTPL9643; SCHEMBL17874088; EX-A4338; BDBM50229025; MFCD30738006; s6511; ZINC616570725; CS-6266; compound 92 [WO2016101885]; compound 56 [PMID: 27992216]; HY-101032; A1-28956
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[100] | |||
Compound Name |
9-Fluoro-1-methyl-7-(4-methyl-3-pyridyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3313969; 9-fluoro-1-methyl-7-(4-methylpyridin-3-yl)-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline; SCHEMBL15463725; BDBM50044143
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[73] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(4-morpholin-4-ylphenyl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041170; SCHEMBL2120298; BDBM50385783
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
Chembl4127317
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18011897; TQR0549; BDBM50276098
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[101] | |||
Compound Name |
3-[3-[4-(Methylsulfonylamino)styryl]-4-methoxy-5-tert-butylphenyl]-5-fluoro-2(1H)-pyridone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2431365; SCHEMBL1542606; BDBM50441245
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[102] | |||
Compound Name |
CID 49847379
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041180; SCHEMBL2119928; BDBM50385793
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
Chembl4172462
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366402
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
(3-Fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4102181; BDBM50261310
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[28] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3967713; SCHEMBL17492284; BDBM253997; US9481673, (S)-7
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041189; BDBM50385802
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
CID 49849123
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041168; SCHEMBL2120225; BDBM50385781
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
Chembl4165094
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366336
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
(S)-8-(1-Isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257964; SCHEMBL2975728; BDBM50327476; (S)-8-(1-Isopropyl-piperidin-4-yloxy)-4-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; (4S)-4-methyl-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
CID 49847377
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041193; SCHEMBL2121755; BDBM50385806
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3359523; SCHEMBL2018583; BDBM50041983
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[103] | |||
Compound Name |
2,2,2-Trifluoro-1-[5-methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3915808; SCHEMBL15717951; BDBM244119; US9428492, 3a; US9428492, 3b; US9428492, 3
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233058; SCHEMBL15091041; BDBM50007038; 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(6-methylpyridin-2-yl)amino]pyridazine-3-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[104] | |||
Compound Name |
N-({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-2-phenyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476762; SCHEMBL2009811; BDBM50263395; AKOS006514857; N-[2-[[(4-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]-2-phenylacetamide; rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-2-phenyl-acetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(S)-4-((S)-2-Phenylbutyl)-4,5-dihydrooxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
RO5256390; (S)-4-((S)-2-Phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine; SCHEMBL503518; CHEMBL3684869; BDBM109524; ZINC113978348; HY-12700; CS-0012279; RO5256390, >=98% (HPLC); US8604061, 292; (4S)-4-[(2S)-2-phenylbutyl]-4,5-dihydro-1,3-oxazol-2-amine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[105] | |||
Compound Name |
N-[(3R,5S)-1-(1-Benzofuran-3-carbonyl)-5-carbamoylpyrrolidin-3-yl]-2,5-diethylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3125270; BDBM50448866
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[106] | |||
Compound Name |
3-{(S)-1-[4-(5-Fluoro-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL589124; CHEMBL3664683; BDBM107627; US8575157, 79
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
Chembl4203179
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18288802; BDBM50458024
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[107] | |||
Compound Name |
Etaconazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Benit; Sonax; Caswell No. 321AB; CGA 64251; UNII-3MT15AE9VG; 3MT15AE9VG; 1-[[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole; 1-((2-(2,4-Dichlorophenyl)-4-ethyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole; 1-[[2-(2,4-Dichlorophenyl)-4-ethyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole; Etaconazole [BSI:ISO]; EINECS 262-107-0; EPA Pesticide Chemical Code 120501; BRN 0834090; 1-{[2-(2,4-dichlorophenyl)-4-ethyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole; Triazole-based ligand, 17; DSSTox_CID_21913; DSSTox_RID_79874; DSSTox_GSID_41913; SCHEMBL21043; CHEMBL270271; ETACONAZOLE-.beta. (ESO); DTXSID2041913; ETACONAZOLE-.alpha. (ESO); BDBM21166; Tox21_301568; CGA-64251; AKOS015903377; Etaconazole 10 microg/mL in Cyclohexane; NCGC00166188-01; NCGC00255938-01; Etaconazol, PESTANAL(R), analytical standard; C11293; Q19279347
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3911035; SCHEMBL17492274; BDBM253992; US9481673, (S)-2
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
8-(1-Isopropylpiperidin-4-yloxy)-2-(pyridin-4-ylmethyl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257487; SCHEMBL2976686; BDBM50327473; 8-(1-Isopropyl-piperidin-4-yloxy)-2-pyridin-4-ylmethyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; 8-(1-propan-2-ylpiperidin-4-yl)oxy-2-(pyridin-4-ylmethyl)-3,4-dihydropyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
Chembl4227903
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50460860
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[108] | |||
Compound Name |
1-Cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-433771; UNII-G2427554NW; BMS-433771 free base; CHEMBL243876; 543700-68-1 (free base); G2427554NW; SCHEMBL3822776; DTXSID20202746; BDBM50088178; ZINC28820871; DS-021688; Q27278636
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4087688; SCHEMBL10146406; BDBM50264821
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041164; BDBM50385778
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3981054; SCHEMBL17492316; BDBM253993; US9481673, (S)-3
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
4-[(5-Methoxybenzimidazol-2-ylthio)methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2018922; Oprea1_174290; SCHEMBL1065421; ZINC3848073; BDBM50380533; AKOS000101026; ST049297
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
CID 44512094
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4063121; SCHEMBL956633; BDBM50253397
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[98] | |||
Compound Name |
2-[(3R)-3-Aminopiperidin-1-yl]-3-[(2-chloro-5-fluorophenyl)methyl]-5-methyl-4-oxoimidazo[4,5-c]quinoline-7-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2147070
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[109] | |||
Compound Name |
5-[[5-(4-Fluorophenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2016639; ZINC2626372; BDBM50380604; AKOS007963767; MCULE-5549066893
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[77] | |||
Compound Name |
2-Amino-6-Bromo-7-(Trifluoromethyl)-1,8-Naphthyridine-3-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2163365; SCHEMBL14969065; BDBM50395799; Q27451524
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[110] | |||
Compound Name |
(R)-6-Methoxymethyl-3-{(S)-1-[4-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-ethyl}-6-phenyl-[1,3]oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL118290; CHEMBL3664681; BDBM107625; US8575157, 77
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
6-((1R,2S)-2-Aminocyclohexylamino)-4-(6,7-dihydro-5H-cyclopenta[b]pyridin-2-ylamino)pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3237564; SCHEMBL15091013; BDBM50007093
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[104] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[5-[7-methyl-2-(2-methylpyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3935923; SCHEMBL17492280; BDBM254002; US9481673, (S)-12
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
2-[[4-[[(3-Fluorophenyl)-phenylcarbamoyl]oxymethyl]cyclohexyl]methoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3922000; CHEMBL3933704; SCHEMBL1118763; SCHEMBL6519634; SCHEMBL12786478; BDBM50235370; BDBM50235371
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[17] | |||
Compound Name |
2-[2-(3-Chlorobenzoyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386076; SCHEMBL3073307; BDBM50434986
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[12] | |||
Compound Name |
CID 25118804
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593760; SCHEMBL2792395; BDBM50095968
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[111] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL116872; CHEMBL3664718; BDBM107665; US8575157, 59
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
N-Methyl-pyrimidinone derivative, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL495331; SCHEMBL1150565; BDBM25335; L-900525
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[3] | |||
Compound Name |
CID 68046989
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4075203; SCHEMBL10147223; BDBM50264803
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(pyridazin-3-yl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL516125; SCHEMBL2011567; BDBM50263403; 4-fluoro-N-[2-oxo-2-[[phenyl(pyridazin-3-yl)methyl]amino]ethyl]benzamide; rac-4-fluoro-n-{[(phenyl-pyridazin-3-yl-methyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
4-[(4R)-2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]-3,4,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3617971; SCHEMBL15913030; BDBM50120423
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
DprE1-IN-1
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZ7371; TBA-7371; UNII-R3T98GBE3C; R3T98GBE3C; CHEMBL3109802; ZA7371; AZ-7371DprE1-IN-1; AZ7371;DprE1-IN-1; SCHEMBL16395186; EX-A777; BCP16818; BDBM50019654; MFCD29477419; ZINC103248024; AZ-7371; CS-5414; ZA-7371; HY-19750; FT-0700212; J-690193
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
4-Methyl-5-[4-methyl-5-[3-[(2S,3R)-2-phenyl-5-azaspiro[2.4]heptan-5-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3983937; SCHEMBL17712767; BDBM50192034
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[113] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041167; BDBM50385829
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
2-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043170; BDBM50385815
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)thiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476360; SCHEMBL2007032; BDBM50263628; rac-thiophene-3-carboxylic acid ({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-amide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(6S)-3-[(1S)-1-[4-(1-Ethyl-6-oxopyridazin-3-yl)phenyl]ethyl]-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL958632; CHEMBL3645513; BDBM107474; US8592410, 14
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[81] | |||
Compound Name |
N-(6,8-Dimethylimidazo[1,2-a]pyrazin-2-yl)-4-(4-methylpiperazin-1-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4081789; BDBM50266625
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[114] | |||
Compound Name |
N-[7-[Acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-2-methylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1170367; BDBM50321518; N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[115] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methyl-propyl)-3-((S)-1-{4-[1-(2-hydroxy-2-methyl-propyl)-2-oxo-1,2-dihydro-pyridin-4-yl]-phenyl}ethyl)-6-phenyl-[1,3]oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL117100; CHEMBL3664684; BDBM107628; US8575157, 80
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
Cyclopropyl-[5-methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3929295; SCHEMBL15728740; BDBM244127; US9428492, 6a; US9428492, 6b; US9428492, 6
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BI-9564; BI 9564; CHEMBL3823101; GTPL8950; SCHEMBL19869872; BCP17135; EX-A1652; BDBM50183449; BI9564; s8113; AKOS027470219; ZINC526061652; CCG-268067; CS-5888; AK685542; BP-25349; BS-15735; DS-001715; HY-100352; BI-9564, >=97% (HPLC); J3.600.898I; Q27075224
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[71] | |||
Compound Name |
2-[3-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4105361; BDBM50264796
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
4-Fluoro-N-[2-[(5-methyl-6-oxo-11H-benzo[c][1]benzazepin-11-yl)methylamino]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL490609; BDBM50263726
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(R)-8-(3-(2-Methylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258308; SCHEMBL2971194; BDBM50327480; 8-[3-((R)-2-Methyl-pyrrolidin-1-yl)-propoxy]-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; 8-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-cis-cyclohexanecarboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1766811; CHEMBL1766812; SCHEMBL594863; SCHEMBL1101806; SCHEMBL1102060; BDBM50341782; BDBM50341783
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[116] | |||
Compound Name |
CCS(=O)(=O)CCc1c(CN2C(=O)N(C3CC3)c4ccncc24)nc5cc(Cl)ccn15
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427277; SCHEMBL18191219; BDBM50088181
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(2S,3S,11Bs)-3-butyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL234412; BDBM50209938; B2Q
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[117] | |||
Compound Name |
(R)-2-(7-(1-(4-Fluorophenyl)-N-methylcyclobutanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1778524; SCHEMBL2188929; BDBM50344164
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[91] | |||
Compound Name |
N-[(5-Methylpyrimidin-2-yl)methyl]-6-phenyl-2-pyridin-2-ylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Pyridine-based ligand, 9; CHEMBL406832; BDBM21158; DTXSID30409547; N-[(5-methylpyrimidin-2-yl)methyl]-6-phenyl-2-(pyridin-2-yl)pyrimidin-4-amine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
4-(Methanesulfonylmethyl)-2-phenyl-6-(pyrrolidin-1-yl)pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
methyl [2-phenyl-6-(1-pyrrolidinyl)-4-pyrimidinyl]methyl sulfone; Pyrimidine-based ligand, 7; Oprea1_100270; MLS000707192; CHEMBL271620; BDBM21156; HMS2645M09; KS-000037UC; ZINC1388954; AKOS005090374; 4L-594S; MCULE-6196943082; SMR000334574
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
N-(Diphenylmethyl)-2-[(4-fluorophenyl)formamido]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476568; N-(2-(benzhydrylamino)-2-oxoethyl)-4-fluorobenzamide; N-[2-(benzhydrylamino)-2-oxoethyl]-4-fluorobenzamide; SCHEMBL2010308; BDBM50263631; ZINC16636899; AKOS016883463; MCULE-2505051243; N-[(Benzhydryl-carbamoyl)-methyl]-4-fluoro-benzamide; Z68358697
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
3-{(S)-1-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL958210; CHEMBL3645516; BDBM107477; US8592410, 17
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[81] | |||
Compound Name |
3-[4-(1H-Indazol-6-yl)phenyl]-1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041172; BDBM50385785
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(2S)-N-[5-[2-(6-Methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3964219; SCHEMBL17492286; BDBM253999; US9481673, (S)-9
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
(Rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3623825; SCHEMBL15312196; BDBM191883; US9187429, 9; N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinoline-8-yl)-2-methylpropanamide; N-[4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]-2-methylpropanamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[57] | |||
Compound Name |
(S)-7-Bromo-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258079; BDBM50327479
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BI-135585; UNII-DA4HT8614K; DA4HT8614K; SCHEMBL117891; CHEMBL3664717; BDBM107664; US8575157, 48; Q27276296
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261482; SCHEMBL1078926; BDBM50014551
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
4-[(4R)-3-Methylsulfonyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidin-4-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4107405; SCHEMBL15912986; BDBM211754; US9290459, 9A
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
(R)-8-(1-Isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257851; SCHEMBL2982400; BDBM50327485; (R)-8-(1-Isopropyl-piperidin-4-yloxy)-4-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; (4R)-4-methyl-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
SSTR5 antagonist 2 (TFA)
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4282052; BDBM50468128; HY-114191A; CS-0081939
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[118] | |||
Compound Name |
1-[[6-(Dimethylamino)-5-methyl-pyrimidin-4-yl]methyl]-N-(2-hydroxyethyl)-6-methoxy-pyrrolo[3,2-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3291430; SCHEMBL16395051; BDBM50019659
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
N-(2-((2-Chloro-9H-thioxanthen-9-yl)methylamino)-2-oxoethyl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478035; BDBM50263680
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-(4-Fluorobenzyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257376; SCHEMBL2980351; BDBM50327483; 2-(4-Fluoro-benzyl)-8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; 2-[(4-fluorophenyl)methyl]-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydropyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
8-(1-Isopropylpiperidin-4-yloxy)-2-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258873; SCHEMBL2980067; BDBM50327482; 2-methyl-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydropyrazino[1,2-a]indol-1-one; 8-(1-Isopropyl-piperidin-4-yloxy)-2-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
CID 49848895
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043168; SCHEMBL2119741; BDBM50385813
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
2-(2-(4-((Dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-5-((5-methoxypyridin-2-yl)methoxy)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601377; SCHEMBL15238663; BDBM142122; SB19163; BI-186908; US8933079, 149; US8933079, 150; US8933079, 9.1
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[119] | |||
Compound Name |
CID 49849122
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041183; SCHEMBL2120998; BDBM50385797
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
2-Methoxy-N-[(3R)-1-methyl-3-phenylpiperidin-3-yl]-6-methylsulfanyl-4-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3259928; SCHEMBL3019971; BDBM50011135
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[120] | |||
Compound Name |
Chembl4227117
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50461935
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[86] | |||
Compound Name |
N-[(8R)-4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3623830; SCHEMBL15313271; BDBM50125049
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[57] | |||
Compound Name |
CID 49848897
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043325; SCHEMBL2119915; BDBM50385819
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL514681; BDBM50263361
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
5-[(3,5-Dichlorophenoxy)methyl]-4-pyrazoline-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1939222; SCHEMBL2439299; BDBM50394680; 5-[(3,5-dichlorophenoxy)methyl]-1,2-dihydropyrazol-3-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[121] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)cyclopentanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL514209; BDBM50263629
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-(11-Oxo-2-phenylbenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl)methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1803004; SCHEMBL1270932; BDBM50347656; N-(5-oxo-3-phenyl-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)methanesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[122] | |||
Compound Name |
N-(2-Fluoroethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3109801; SCHEMBL16394701; BDBM50019652
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(3-(trifluoromethyl)phenyl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479071; SCHEMBL2009265; BDBM50263364; 4-fluoro-N-[2-oxo-2-[[phenyl-[3-(trifluoromethyl)phenyl]methyl]amino]ethyl]benzamide; rac-4-fluoro-n-({[phenyl-(3-trifluoromethyl-phenyl)-methyl]-carbamoyl}-methyl)-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
3-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043171; BDBM50385816
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(1S)-1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3962106; SCHEMBL17147199; BDBM244143; US9428492, 13
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
9-(1-Isopropyl-piperidin-4-yloxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258755; SCHEMBL2978274; BDBM50327471; 9-(1-isopropylpiperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-1-one; 9-(1-propan-2-ylpiperidin-4-yl)oxy-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(m-tolyl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479084; SCHEMBL2007955; BDBM50263676; 4-fluoro-N-[2-[[(3-methylphenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; rac-4-fluoro-n-{[(phenyl-m-tolyl-methyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
2-(4-bromophenyl)quinazolin-4(3h)-one; CHEMBL2058057; 2-(4-bromophenyl)quinazolin-4(1h)-one; 2-(4-bromophenyl)-1H-quinazolin-4-one; Cambridge id 5234833; Oprea1_095695; SCHEMBL5795292; SCHEMBL15775265; DTXSID50966728; HMS1579J06; ZINC289772; BDBM50188337; STL506688; AKOS034469035; MCULE-8062991764; 2-(4-Bromophenyl)quinazoline-4(3H)-one; Q27452728; Z56974849
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
(R)-2-(Cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257965; SCHEMBL2973865; BDBM50327477
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
(4S)-4-(4-Cyano-2-methylsulfonylphenyl)-N-methyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3617975; SCHEMBL15932518; BDBM50120439
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
N-((3r,5s)-1-(Benzofuran-3-Carbonyl)-5-(Ethylcarbamoyl)pyrrolidin-3-Yl)-3-Ethyl-1-Methyl-1h-Pyrazole-5-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3125272; BDBM50448861; Q27462145
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[106] | |||
Compound Name |
(1S,2R,5S)-5-(12-Cyclopropyl-1,4,8,10,11-pentazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3806041
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
Chembl4176506
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366408
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
DprE1-IN-2
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3291423; MDK3875; SCHEMBL16395193; BDBM50019656; ZINC169353747; CS-5834; HY-100531
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL296580; 2-(2-pyridylmethylthio)benzimidazole; 2-[(pyridin-2-ylmethyl)thio]-1H-benzimidazole; 2-((PYRIDIN-2-YLMETHYL)THIO)-1H-BENZIMIDAZOLE; 2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazole; Oprea1_808681; SCHEMBL599673; ZINC50235; BDBM50380514; SBB046276; STK749434; 2-(2-pyridylmethylthio) benzimidazole; AKOS000275697; MCULE-6022662385; 2-(2-pyridylmethylthio)-1h-benzimidazole; 2-(2-Pyridinylmethylthio)-1H-benzimidazole; ST4010867; BB 0219625; EU-0050806; 2-(2-pyridylmethylsulfanyl)-1H-benzimidazole; 2-[(2-pyridinylmethyl)hio]-1H-Benzimidazole; VU0102703-4; 1H-Benzimidazole, 2-[(2-pyridinylmethyl)thio]-; 2-[(2-pyridinylmethyl)sulfanyl]-1H-benzimidazole; 2-[(pyridin-2-ylmethyl)sulfanyl]-1H-benzimidazole; F3366-5428; Z262134322; 2-{[(pyridin-2-yl)methyl]sulfanyl}-1H-1,3-benzodiazole
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
MLI-2; MLi-2 - Bio-X; CHEMBL4098877; SCHEMBL16022474; EX-A4118; AKOS030210950; CS-6349; HY-100411; S9694; J3.645.913A; Q27225595
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[123] | |||
Compound Name |
5-(3-Cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671877; SCHEMBL12560406; BDBM50337038; 4H-Pyrano[2,3-d]pyrimidine-4,7(3H)-dione, 5-(3-cyclopropylpropyl)-2-(difluoromethyl)-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[124] | |||
Compound Name |
(6R)-6-(3-Hydroxypropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridazin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3645534; BDBM107496; US8592410, 12
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[81] | |||
Compound Name |
N-({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476567; BDBM50263630
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-[2-(4-Ethylsulfonyl-2-methylphenyl)-4-(trifluoromethyl)phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1778639; SCHEMBL1690240; BDBM50344991; 2-(4''-(ethylsulfonyl)-2''-methyl-5-(trifluoromethyl)biphenyl-2-yloxy)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[125] | |||
Compound Name |
[2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid sodium salt
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1668898
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[126] | |||
Compound Name |
2-[8-Fluoro-2-[2-(1H-indol-3-yl)acetyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2385902; BDBM50434981
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[12] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(2-oxoazetidin-1-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043328; BDBM50385808
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
1-[5-Methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3909277; SCHEMBL15728771; BDBM244121; US9428492, 4a; US9428492, 4b; US9428492, 4
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
Chembl4128835
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50272591
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[127] | |||
Compound Name |
1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4107580; SCHEMBL17147206; BDBM244149; US9428492, 19a; US9428492, 19
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3781694; RO5263397; (4S)-4-(3-fluoro-2-methylphenyl)-4,5-dihydro-1,3-oxazol-2-amine; SCHEMBL502960; GTPL10722; BDBM50158471; MFCD28405323; ZINC113977145; AS-43404; HY-108015; CS-0027152; RO-5256390
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[105] | |||
Compound Name |
(S)-3-((S)-1-(4-(1-Ethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL119977; CHEMBL3664671; BDBM107615; US8575157, 65
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
2-[2-[(5-Acetyl-2-methoxyphenyl)methylsulfanyl]-5-fluorobenzimidazol-1-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2048187; SCHEMBL5122847; BDBM50387184
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[128] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrazol-1-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2040895; BDBM50385823
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
CID 44517795
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1916399; SCHEMBL4429194; BDBM50357764
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[129] | |||
Compound Name |
CID 49849002
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041192; SCHEMBL2121722; BDBM50385805
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
1-[({2-[(1S)-1-Cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}amino)methyl]cyclohexanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356251; SCHEMBL2794046; BDBM50037212; 1-[(1S)-1-cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-[(1-hydroxycyclohexyl)methylamino]ethanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[130] | |||
Compound Name |
Chembl4127941
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50270669
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[78] | |||
Compound Name |
7-Methoxy-4-trifluoromethylcoumarin-3-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL5273533; CHEMBL1080003; BDBM26480; 2-[7-methoxy-2-oxo-4-(trifluoromethyl)chromen-3-yl]acetic Acid; 2-[7-methoxy-2-oxo-4-(trifluoromethyl)-2H-chromen-3-yl]acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[131] | |||
Compound Name |
N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL475926; SCHEMBL2012516; BDBM50263398; N-[2-[[(4-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]-4-fluorobenzamide; rac-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-4-fluoro-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
1,3-Bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1412368; 1,3-bis(2-phenylethyl)-1,3-diazinane-2,4,6-trione; 1,3-Diphenethylpyrimidine-2,4,6(1H,3H,5H)-trione; MLS000088153; Oprea1_515089; SCHEMBL10158776; CTK7H5070; HMS2411F07; ZINC2828642; BBL026129; BDBM50341432; STK398281; AKOS000313385; MCULE-3285865765; SMR000072388; VS-08217; T9386; SR-01000260907; SR-01000260907-1; Z336067476; 1,3-bis(2-phenylethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[132] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(pyrimidin-2-yl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL514241; BDBM50263404
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-(2-Hydroxyethyl)-6-methoxy-1-[(6-methoxy-5-methyl-pyrimidin-4-yl)methyl]pyrrolo[3,2-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3291427; SCHEMBL16395561; BDBM50019658
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
2-(2-Hydroxyethyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257607; SCHEMBL2972830; BDBM50327484; 2-(2-Hydroxy-ethyl)-8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; 2-(2-hydroxyethyl)-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydropyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
1-(5-Isoquinolin-4-yl-2,3-dihydroindol-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3287179; SCHEMBL15639951; BDBM50019887
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[52] | |||
Compound Name |
1-[(2-Chloroquinolin-3-Yl)methyl]-6-Fluoro-5-Methyl-3-(2-Oxo-1,2-Dihydropyridin-3-Yl)-1h-Indole-2-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3092124; SCHEMBL12665480; BDBM50444436; Q27452958; 1-[(2-chloro-3-quinolyl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1H-pyridin-3-yl)indole-2-carboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[133] | |||
Compound Name |
6-(4-((S)-1-((S)-6-(2-Hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)nicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4076599; SCHEMBL956297; BDBM50253338
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[98] | |||
Compound Name |
5-Chloro-4-[[(8R)-6,6-dimethyl-2,3,5,7-tetrahydro-1H-pyrrolizin-8-yl]methylamino]-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4062780; SCHEMBL16757057
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[76] | |||
Compound Name |
(S)-3-((S)-1-(4-(1-Ethyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL116853; CHEMBL3664660; BDBM107604; US8575157, 53
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
[2-(5-Fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4060556; BDBM50261325
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[28] | |||
Compound Name |
(R)-6-(3-Hydroxypropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL116631; CHEMBL3664710; BDBM107656; US8575157, 30
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(o-tolyl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476775; SCHEMBL2014764; BDBM50263675; 4-fluoro-N-[2-[[(2-methylphenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; rac-4-fluoro-n-{[(phenyl-o-tolyl-methyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
3-[4-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2040894; BDBM50385822
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(thiazol-2-yl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478037; BDBM50263679
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
4-Methyl-5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL4549272; CHEMBL3692706; BDBM162872; US9056859, 72
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[134] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2040896; BDBM50385824
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-6-(2-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL117676; CHEMBL3664706; BDBM107652; US8575157, 23
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
4-(Methanesulfonylmethyl)-2-(pyridin-4-yl)-6-(pyrrolidin-1-yl)pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
methyl [2-(4-pyridinyl)-6-(1-pyrrolidinyl)-4-pyrimidinyl]methyl sulfone; Pyridine-based ligand, 8; Oprea1_456986; CHEMBL405565; BDBM21157; KS-00003BCK; ZINC5362089; AKOS005095955; 6L-547S; MCULE-5618960238
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
N-(2-(Bis(3-fluorophenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL476557; N-[2-[bis(3-fluorophenyl)methylamino]-2-oxoethyl]-4-fluorobenzamide; SCHEMBL2007259; BDBM50263363; N-({[Bis-(3-fluoro-phenyl)-methyl]-carbamoyl}-methyl)-4-fluoro-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
1-[[6-(Difluoromethoxy)-5-methylpyrimidin-4-yl]methyl]-N-(2-hydroxyethyl)-6-methylpyrrolo[3,2-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3291424; SCHEMBL16395017; BDBM50019657
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
CID 49849008
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041190; SCHEMBL2119517; BDBM50385803
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601192; SCHEMBL17184129; BDBM50107864
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
3-Methyl-4-[4-[1-(3-methylpyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041186; BDBM50385799
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
3-[4-(1,3-Benzothiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041175; BDBM50385788
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
C14H15Cl2N3O5S; Itraconazole Impurity 7; Triazole-based ligand, 18; CHEMBL410503; SCHEMBL9283241; BDBM21167; MFCD00806008; STK753364; AKOS000583102; AKOS025245596; MCULE-4497118445; DB-041289; FT-0642822; FT-0657654; SR-01000316975; SR-01000316975-1
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
4-Amino-N-butyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL331485; BDBM50105825; 4-Amino-N-butyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[135] | |||
Compound Name |
CID 49849007
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043324; SCHEMBL2121670; BDBM50385818
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2040854; BDBM50385795
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(2-methylpyrimidin-5-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4105041; SCHEMBL956584; BDBM50253396
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[98] | |||
Compound Name |
Chembl4164781
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366396
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,9,12-pentazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3806052
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(p-tolyl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479085; SCHEMBL2009614; BDBM50263677; 4-fluoro-N-[2-[[(4-methylphenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; rac-4-fluoro-n-{[(phenyl-p-tolyl-methyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4082282; SCHEMBL10146535; BDBM50264805
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
(S)-N-((3S,4S)-5-Acetyl-7-cyano-4-methyl-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1, 4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2436226; SCHEMBL15621755
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[79] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261481; SCHEMBL6920090; BDBM50014550
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
Chembl4162449
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366404
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[97] | |||
Compound Name |
6-Chloro-4-phenyl-2-propan-2-ylquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3947458; SCHEMBL14917093; BDBM50197092
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[88] | |||
Compound Name |
6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-fluoro-6-methylpyridin-2-yl)amino]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3237560; SCHEMBL15091170; BDBM50007089
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[104] | |||
Compound Name |
CID 49849120
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041182; SCHEMBL2121034; BDBM50385796
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
CID 56603301
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4060355; BDBM50264804
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
(4S)-4-(4-Cyano-2-methylsulfonylphenyl)-N-ethyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110666; SCHEMBL15932521; BDBM211887; US9290459, 47.2
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
(S)-7-Bromo-8-(1-isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258078; BDBM50327478
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]furan-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041165; BDBM50385779
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-6-(4-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL958050; CHEMBL3645512; BDBM107473; US8592410, 13
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[81] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(1-phenylpropylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478229; BDBM50263401
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
3-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2040897; BDBM50385825
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(6-methylpyridazin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4075178; SCHEMBL955949; BDBM50253399
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[98] | |||
Compound Name |
2-(3-Hydroxy-4-methoxyphenyl)quinazoline-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3289112; SCHEMBL15690958; BDBM50019170; 2-(3-hydroxy-4-methoxyphenyl)-1H-quinazolin-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
4-[[1-[(3-Fluoro-4-methylphenyl)sulfonyl-methylamino]cyclopropanecarbonyl]amino]adamantane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3741915
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[136] | |||
Compound Name |
6-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(5,6-Dimethylpyridin-2-Yl)amino]pyridazine-3-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
RO9021; RO-9021; CHEMBL3237561; RO0921; SCHEMBL15090991; EX-A1465; BDBM50007090; s7286; ZINC95921150; CCG-268101; CS-5899; SB17006; RO 9021;RO-9021; HY-16902; Q27451510
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[104] | |||
Compound Name |
4-Fluoro-N-(2-((4-methoxyphenyl)(phenyl)methylamino)-2-oxoethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479072; SCHEMBL2010931; BDBM50263365; AKOS001395453; 4-fluoro-N-[2-[[(4-methoxyphenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; rac-4-fluoro-n-({[(4-methoxy-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
3-(3-(2-(Benzyloxy)-5-chlorophenyl)pyridin-2-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL206096; SCHEMBL4883485; BDBM50183183; 3-[3-(5-chloro-2-phenylmethoxyphenyl)pyridin-2-yl]benzoic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[137] | |||
Compound Name |
(1R)-1-[5-Methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110385; SCHEMBL15728754; BDBM244117; US9428492, 1; US9428492, 2
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
6-[1-[(2R,3S)-2-Propyl-3-[4-(trifluoromethyl)phenoxy]-1-[4-(trifluoromethyl)pyridine-3-carbonyl]piperidine-3-carbonyl]piperidin-4-yl]oxypyridine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3797513; BDBM50165695
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[138] | |||
Compound Name |
6-[(6-Fluoroquinolin-4-yl)methyl]-5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-methyl-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218468; Thienopyrimidine-2,4-dione, 2; BDBM21987
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[139] | |||
Compound Name |
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601189; SCHEMBL16482025; BDBM50107915
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
2-[[(2R)-2-Hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601260; SCHEMBL2790929; BDBM50106739; 2-[[(2R)-2-hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[140] | |||
Compound Name |
4-[[(3S)-1-(4-Chlorophenyl)-2-oxo-3-methylpyrrolidine-3-yl]amino]benzhydroximic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3415629; BDBM50078748; J3.522.188C
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[141] | |||
Compound Name |
[(1S,2S,4S)-4-[(4-Chlorophenyl)methylamino]-2-(2-methylphenyl)cyclohexyl]-(3,3-diphenylazetidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3086045; BDBM50443344
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[142] | |||
Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3804950
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
6-Methyl-2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
compound 30 [PMID: 22239545]; CHEMBL2019024; GTPL8749; ZINC6276192; BDBM50380515; AKOS001373830; MCULE-1344498176; ST51029294; 5-methyl-2-(2-pyridylmethylthio)benzimidazole; J3.516.543F; 2-(2-Pyridinylmethylthio)-6-methyl-1H-benzoimidazole; 5-methyl-2-(2-pyridylmethylsulfanyl)-1H-benzimidazole; Q27076550; 1H-Benzimidazole, 5-methyl-2-[(2-pyridinylmethyl)thio]-; 5-Methyl-2-((pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazole
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
4-(3-Amino-propyl)-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL121241; BDBM50105826; 4-(3-Aminopropyl)-N-(3-hydroxypropyl)-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[135] | |||
Compound Name |
2-[4-[(2,4-Difluorophenyl)methoxy]phenyl]-3H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4084413
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
4-[2-(4-{[(2r,3s)-2-Propyl-1-{[4-(Trifluoromethyl)pyridin-3-Yl]carbonyl}-3-{[5-(Trifluoromethyl)thiophen-3-Yl]oxy}piperidin-3-Yl]carbonyl}piperazin-1-Yl)phenoxy]butanoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3805372; 62R; SCHEMBL8133461; BDBM50169695; Q27456183
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[143] | |||
Compound Name |
(R)-2-(7-(2-(4-Fluorophenyl)-N-methylacetamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1778506; SCHEMBL2188674; BDBM50344163
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[91] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-2,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261486; SCHEMBL6919520; BDBM50014556
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
(2S)-2-(Methylamino)-N-[5-[7-methyl-2-(2-methylpyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]-6-(2-phenylethynyl)pyridin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3958007; SCHEMBL17492304; BDBM254001; US9481673, (S)-11
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
4-Chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL475928; SCHEMBL2009334; BDBM50263397; 4-chloro-N-[2-[[(4-chlorophenyl)-phenylmethyl]amino]-2-oxoethyl]benzamide; (+)-4-chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide; (-)-4-chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide; rac-4-chloro-n-({[(4-chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
CID 73670174
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601186; SCHEMBL16481547; BDBM50107847
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
(1S,2R,5S)-5-(11-Methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3805966
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
Acetamide,N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)-1-pyrrolidinyl]-4-pyrimidinyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL458224; SCHEMBL3097080; BDBM50266416; ZINC40394057; N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxymethylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[144] | |||
Compound Name |
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041177; BDBM50385790
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
2-(Cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257138; SCHEMBL2977672; BDBM50327472; 2-(cyclopropylmethyl)-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydropyrazino[1,2-a]indol-1-one; 2-Cyclopropylmethyl-8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
MK-3697
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
MK3697; UNII-M8238285OA; M8238285OA; GTPL9307; SCHEMBL2250597; CHEMBL3338865; EX-A946; BDBM106971; AOB87171; BCP08557; 3859AH; MFCD22572350; ZINC96177816; AKOS026750261; CS-3376; MK 3697;MK3697; compound 24 [PMID: 25248679]; NCGC00387851-04; AS-17000; HY-12301; QC-11637; FT-0700429; US8592457, 7-5; J-690073; N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[145] | |||
Compound Name |
(1R)-2-[2-(1-Hydroxycyclohexylmethylamino)acetyl]-1,2,3,4-tetrahydro-1-isopropyl-6-methoxyisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593759; BDBM50095967
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[111] | |||
Compound Name |
Chembl4276719
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50467582
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[146] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261479; SCHEMBL6919475; BDBM50014548
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
(S)-3-((S)-1-(4-(1-Ethyl-5-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL117591; CHEMBL3664676; BDBM107620; US8575157, 70
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[66] | |||
Compound Name |
4-{4-Ethyl-5-[(4-methoxybenzyl)thio]-4H-1,2,4-triazol-3-yl}pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
4-(4-Ethyl-5-((4-methoxybenzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine; Pyridine-based ligand, 2; MLS000050856; CHEMBL271624; BDBM21151; HMS2477E08; ZINC529931; AKOS002188475; MCULE-7756856671; 4-(4-ethyl-5-{[(4-methoxyphenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)pyridine; SMR000078544; ST50081078; SR-01000284176; SR-01000284176-1; 4-{4-ethyl-5-[(4-methoxybenzyl)sulfanyl]-4H-1,2,4-triazol-3-yl}pyridine; 1-[(4-ethyl-5-(4-pyridyl)(1,2,4-triazol-3-ylthio))methyl]-4-methoxybenzene
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[72] | |||
Compound Name |
8-(1-Isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1258754; SCHEMBL2980042; BDBM50327481; 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; 8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
N-(2,2-Difluoroethyl)-1-[(6-methoxy-5-methyl-pyrimidin-4-yl)methyl]-6-methyl-pyrrolo[3,2-b]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3291422; SCHEMBL16394971; BDBM50019655
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[112] | |||
Compound Name |
2-(3-Methoxy-4-hydroxyphenyl)quinazoline-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4081914; SCHEMBL15691348; 2-(4-hydroxy-3-methoxyphenyl)quinazolin-4 (3h)-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
9-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-9-azaspiro[5.5]undecane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4069786; SCHEMBL10146411; BDBM50264808
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
Etrasimod
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
APD334; APD-334; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920; Etrasimod (USAN); Etrasimod [USAN]; 1206123-37-6 (free base); Etrasimod(APD334); APD-334(FREE ACID); GTPL9331; SCHEMBL1919311; BCP19558; EX-A1633; KS-00001D0Q; BDBM50041691; AKOS032944972; ZINC117522788; APD334-003; compound 4 [PMID: 25516790]; CS-6181; DB14766; SB17088; HY-12789; D10930; F10118; Q27265630
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[147] | |||
Compound Name |
4-Fluoro-N-(2-oxo-2-(phenyl(pyridin-4-yl)methylamino)ethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478230; SCHEMBL2010869; BDBM50263402; 4-fluoro-N-[2-oxo-2-[[phenyl(pyridin-4-yl)methyl]amino]ethyl]benzamide; rac-4-fluoro-n-{[(phenyl-pyridin-4-yl-methyl)-carbamoyl]-methyl}-benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
4-[(6-Methoxy-1H-1,3-benzodiazol-2-YL)sulfanyl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2018914; CTK7A7756; BDBM50380528; AKOS000151804
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[54] | |||
Compound Name |
3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041188; SCHEMBL15418981; BDBM50385801
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-chloro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3261483; SCHEMBL6919297; BDBM50014552
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
3-[2-[5-(3-Chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3769933; GTPL9492; SCHEMBL2125026; BDBM50149566; compound 43 [PMID: 26751273]; J3.605.586C
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[148] | |||
Compound Name |
(S)-8-(1-Isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257850; SCHEMBL2982334; BDBM50327475; (S)-8-(1-Isopropyl-piperidin-4-yloxy)-3-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; (3S)-3-methyl-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
(4S)-4-(4-Fluorophenyl)-N-[5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]-2-methylphenyl]-1-methyl-2-oxo-3,4-dihydropyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3739741; SCHEMBL2100436; BDBM50499488; J3.552.664A
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[149] | |||
Compound Name |
CID 73669500
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601196; SCHEMBL16481634; BDBM50107852
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
2-((R)-7-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1778387; BDBM50344161
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[91] | |||
Compound Name |
2-(4-(Prop-2-ynyloxy)phenyl)quinazolin-4(3h)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4074105; SCHEMBL16375369; AKOS032952094
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[83] | |||
Compound Name |
CID 57519510
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SR-3306; CHEMBL2144409; MLS006012045; SCHEMBL3750574; BDBM50059654; ZINC72317307; SB17012; NCGC00263146-01; HY-12829; SMR004703567
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[150] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-1-(4-oxo-1H-pyrimidin-6-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
compound 6ee [PMID: 22364528]; CHEMBL2041169; GTPL8796; SCHEMBL2120102; BDBM50385782; Q27076776
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
CID 49847378
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041184; SCHEMBL2121744; BDBM50385798
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601070; SCHEMBL16481776; BDBM50107866
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
6-Chloranyl-2-Methyl-4-Phenyl-Quinoline-3-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
6-chloro-2-methyl-4-phenylquinoline-3-carboxylic acid; CHEMBL1738980; 6-Chloro-2-methyl-4-phenyl-quinoline-3-carboxylic acid; CBMicro_027736; Oprea1_112956; Oprea1_202474; SCHEMBL21083000; ZINC243048; BDBM50197091; STK411107; AKOS003264212; MCULE-2171064453; BIM-0027634.P001; ST50449412; SR-01000395844; SR-01000395844-1; 2-Methyl-4-phenyl-6-chloroquinoline-3-carboxylic acid; Q27455852; 6-Chloro-2-methyl-4-phenyl-3-quinolinecarboxylic acid #
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[88] | |||
Compound Name |
2-[(8R)-8-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1641808; SCHEMBL15280003; BDBM50333494
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[49] | |||
Compound Name |
(4R)-4-(4-Cyanophenyl)-N-(2-hydroxy-2-methylpropyl)-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4112323; SCHEMBL15913231; BDBM211836; US9290459, 41A
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
2-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4113903; SCHEMBL17147208; BDBM244155; US9428492, A
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
(R)-8-(1-Isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1257729; SCHEMBL2972997; BDBM50327474; (R)-8-(1-Isopropyl-piperidin-4-yloxy)-3-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one; (3R)-3-methyl-8-(1-propan-2-ylpiperidin-4-yl)oxy-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
6-Fluoro-2-methyl-3-[(3R,9sS)-octahydro-8-[2-[5-(1H-tetrazol-1-yl)-2-pyridinyl]acetyl]pyrazino[2.1=c][1.4]oxazin-3-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3933749; XAN35021; SCHEMBL15036619; BDBM50204281
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[151] | |||
Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1796298; BDBM50418802
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[152] | |||
Compound Name |
5-Methyl-3-[4-[[1-(6-methylpyridazin-3-yl)azetidin-3-yl]methoxy]phenyl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1835918; BDBM50419279
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[18] | |||
Compound Name |
Schembl20719106
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1770317; BDBM50384443; 5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[153] | |||
Compound Name |
CID 71580827
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2347323; BDBM50432235
Click to Show/Hide
|
||||
Activity |
IC50 = 50500 nM
|
[154] | |||
Compound Name |
4-(5-Chloro-2-hydroxy-phenyl)-3-[3-((R)-diethyl-amino)-2-hydroxy-propylsulfanyl]-6-trifluoromethyl-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL196427; SCHEMBL6096319; BDBM50171276
Click to Show/Hide
|
||||
Activity |
IC50 = 50680 nM
|
[155] | |||
Compound Name |
2-Fluoro-N-[3-fluoro-4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022739; SCHEMBL4031628; BDBM50382048; 2-Fluoro-N-[3-fluoro-4-(5-{[4-(4-morpholinyl)butyl]amino}-1,3,4-oxadiazol-2-yl)phenyl]benzamide
Click to Show/Hide
|
||||
Activity |
IC50 = 51000 nM
|
[156] | |||
Compound Name |
3-(4-Methyl-1,3-thiazol-2-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(4-methylthiazol-2-yl)pyridine; 4-methyl-2-(pyridin-3-yl)thiazole; MLS000698326; SCHEMBL266591; CHEMBL410355; BDBM12367; 4-methyl-2-(3-pyridyl)thiazole; HMS2515A14; ZINC968481; 3-(4-methylthiazol-2-yl)-pyridine; AKOS022226069; nicotine 3-heteroaromatic analogue 26; MCULE-6568787499; 4-methyl-2-(3-pyridyl)-1,3-thiazole; 4-methyl-2-pyridin-3-yl-1,3-thiazole; SMR000224440; 4-methyl-2-(pyridin-3-yl)-1,3-thiazole; ST51005355; Z48847313
Click to Show/Hide
|
||||
Activity |
Ki = 51500 nM
|
[157] | |||
Compound Name |
[3-(Tert-Butylaminomethyl)-4-fluorophenyl](7-chloro-quinolin-4-yl)amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
TCMDC-135909; CHEMBL453384; 4-Quinolinamine,7-chloro-N-[3-[[(1,1-dimethylethyl)amino]methyl]-4-fluorophenyl]-; ZINC3963576; BDBM50247629; 4-Quinolinamine, 7-chloro-N-[3-[[(1,1-dimethylethyl)amino]methyl]-4-fluorophenyl]-; N-(3-((tert-butylamino)methyl)-4-fluorophenyl)-7-chloroquinolin-4-amine
Click to Show/Hide
|
||||
Activity |
IC50 = 52000 nM
|
[26] | |||
Compound Name |
(6-Hydroxy-1,3-benzothiazol-2-yl)-(3-hydroxy-4-methylphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2170754; SCHEMBL29654; BDBM50396080
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[158] | |||
Compound Name |
(4-Fluoro-3-hydroxyphenyl)-(6-hydroxy-1,3-benzothiazol-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2170750; SCHEMBL29673; BDBM50396084
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[158] | |||
Compound Name |
2,6-Difluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2170747; SCHEMBL29964; BDBM50396087
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[158] | |||
Compound Name |
2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Sch 28080; Sch-28080; SCH28080; UNII-00427X161I; 2-(8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile; Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-; CHEMBL47529; 00427X161I; 2-(2-methyl-8-phenylmethoxyimidazo[1,2-a]pyridin-3-yl)acetonitrile; Schering compound 28080; C17H15N3O; SR-01000076230; S28080; 2-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrile; 2-Methyl-8-(phenylmethoxy)imidazo-(1-2-a)pyrine-3-acetonitrile; Tocris-1690; Lopac-S-4443; SCHEMBL1815961; ZINC2675; DTXSID10226971; HMS3261G20; HMS3268O05; HMS3414M11; HMS3678M11; Tox21_500439; BDBM50008977; MFCD00834620; AKOS024456748; CCG-204531; LP00439; SDCCGSBI-0050424.P002; VP14349; NCGC00015953-01; NCGC00015953-02; NCGC00015953-03; NCGC00015953-04; NCGC00015953-05; NCGC00015953-08; NCGC00025259-01; NCGC00025259-02; NCGC00025259-03; NCGC00261124-01; DB-056022; HY-103261; B6832; CS-0026715; EU-0100439; FT-0641585; SCH-28080, >=98% (HPLC), solid; S 4443; SR-01000076230-1; SR-01000076230-3; BRD-K55748775-001-01-4; Q27164711; Z2738349261; 8-benzyloxy-3-cyanomethyl-2-methyl-imidazo[1,2-a]pyridine; 8-Benzyloxy-3-cyanomethyl-2-methylimidazo[1,2-a]pyridine; (8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)-acetonitrie; (8-Benzyloxy-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile; 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3acetonitrile; (8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)-acetonitrile; 2-methyl-8 (phenyl-methoxy) imidazo (1,2-a)-pyridine-3-acetonitrile
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[159] | |||
Compound Name |
Isoquinoline N-oxide, 47
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL524109; SCHEMBL4574431; BDBM29266
Click to Show/Hide
|
||||
Activity |
EC50 = 55000 nM
|
[160] | |||
Compound Name |
4-Amino-N-benzyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL120797; BDBM50105820; 4-Amino-N-benzyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[135] | |||
Compound Name |
2,5-Bis(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclopentanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL498372; BDBM50265002
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[34] | |||
Compound Name |
2-[5-Fluoro-2-methyl-3-(1-oxo-2-propan-2-ylisoquinolin-4-yl)indol-1-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3236948; SCHEMBL1757378; CRA-680; BDBM50006830; 2-(5-fluoro-3-(2-isopropyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[161] | |||
Compound Name |
4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-N-propyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL120183; SCHEMBL3847126; BDBM50105816; 4-Amino-N-propyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[135] | |||
Compound Name |
5-(Pyridin-3-yl)thiophene-2-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
5-pyridin-3-ylthiophene-2-carbaldehyde; 5-(3-PYRIDINYL)-2-THIOPHENECARBALDEHYDE; CHEMBL179398; 5-Pyridin-3-yl-thiophene-2-carbaldehyde; ACMC-20muz5; 2-Thiophenecarboxaldehyde, 5-(3-pyridinyl)-; SCHEMBL850645; CTK0H0025; DTXSID20447635; BDBM50158916; SBB090978; ZINC12370796; AKOS004113158; 5-(3-pyridyl)thiophene-2-carbaldehyde; FT-0692639; US8609708, 25; 5-(4-Methylpyridin-3-yl)thiophene-2-carbaldehyde; A1-29243
Click to Show/Hide
|
||||
Activity |
IC50 = 55200 nM
|
[36] | |||
Compound Name |
CID 86274362
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3422005; SCHEMBL16143986; BDBM50081280
Click to Show/Hide
|
||||
Activity |
IC50 = 56000 nM
|
[162] | |||
Compound Name |
Desethylamodiaquine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Monodesethylamodiaquine; N-DESETHYL AMODIAQUINE; CHEMBL1235; N-MONODESETHYLAMODIAQUINE (DEAQ); 4-[(7-chloroquinolin-4-yl)amino]-2-(ethylaminomethyl)phenol; 4-[(7-chloroquinolin-4-yl)amino]-2-[(ethylamino)methyl]phenol; 2-(Aminomethyl)-4-[(7-Chloro-4-Quinolinyl)amino]Phenol; 4-((7-Chloroquinolin-4-yl)amino)-2-((ethylamino)methyl)phenol; bidesethylamodiaquine; 4-((7-Chloro-4-quinolinyl)amino)-2-((ethylamino)methyl)phenol; DESETHYL AMODIAQUINE; SCHEMBL14067597; CTK8D5291; DTXSID20229630; BCP34368; ZINC5139697; BDBM50056190; AKOS025401980; AC-27753; HY-128554; CS-0095816; FT-0665940; 4-(7-Chloro-quinolin-4-ylamino)-2-ethylaminomethyl-phenol; 4-[(7-chloro-4-quinolyl)amino]-2-(ethylaminomethyl)phenol; Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((ethylamino)methyl)-
Click to Show/Hide
|
||||
Activity |
IC50 = 58000 nM
|
[26] | |||
Compound Name |
6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL62811; 6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one; 2(1H)-Quinolinone, 3,4-dihydro-6-(3-pyridinyl)-; ACMC-20m2to; SCHEMBL1119375; CTK3G7473; DTXSID30547791; BDBM50000306; ZINC13450004; 6-(3-pyridyl)-3,4-dihydrocarbostyril; DA-00031; FT-0707759; 6-Pyridin-3-yl-3,4-dihydroquinolin-2(1H)-on; 6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one; HCL
Click to Show/Hide
|
||||
Activity |
IC50 = 58900 nM
|
[42] | |||
Compound Name |
Chembl4173133
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50366334
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[97] | |||
Compound Name |
2-(1-Hydroxy-1-methylethyl)-5-[3-[3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridine-1(4H)-yl]phenyl]pyridine 1-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485620; SCHEMBL5340138; BDBM50274228
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[163] | |||
Compound Name |
(S)-3-(4-((2-(2,6-Dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methoxy)phenyl)hex-4-ynoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
LY3104607; UNII-2OH4RUC1V4; 2OH4RUC1V4; CHEMBL3927519; SCHEMBL16781940; BDBM50204020; LY-3104607
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[164] | |||
Compound Name |
2-[(S)-[4-(Cyclopropylmethoxy)pyridin-2-yl]methylsulfinyl]-6-fluoro-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2110248; BDBM50409895
Click to Show/Hide
|
||||
Activity |
Ki = 60000 nM
|
[6] | |||
Compound Name |
2-(2,4-Difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethyl)phenyl]pyridin-2-yl]propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3311224; SCHEMBL11896898; BDBM124183; US8754227, 2
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[165] | |||
Compound Name |
4-[6-[2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(tetrazol-1-yl)propyl]pyridin-3-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2574582; CHEMBL3311223; BDBM124182; US8754227, 1
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[165] | |||
Compound Name |
Hydroxyethylamine derivative, 4
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL445734; SCHEMBL5221449; BDBM29755
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[166] | |||
Compound Name |
4-[(2-Cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-8-fluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1801060; SCHEMBL4051908; BDBM50348733
Click to Show/Hide
|
||||
Activity |
EC50 ~ 60000 nM
|
[167] | |||
Compound Name |
4-Amino-N-(3-methyl-butyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL414238; BDBM50105814; 4-Amino-N-isopentyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[135] | |||
Compound Name |
(1S,8R)-4-[(4-Chlorophenyl)carbamoylamino]-11-methyl-5-thia-11-azatricyclo[6.2.1.02,6]undeca-2(6),3-diene-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4096279; BDBM50262768
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[168] | |||
Compound Name |
4-[(2-Cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
KD7332; CHEMBL1801504; SCHEMBL13905125; BDBM50348732; ZINC59097866; CID 25211910
Click to Show/Hide
|
||||
Activity |
EC50 ~ 60000 nM
|
[167] | |||
Compound Name |
CID 16041411
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2434978; SCHEMBL5575492; BDBM50441716
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[169] | |||
Compound Name |
3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
RO5126766; CH5126766; RO-5126766; Ro 5126766; RO-5126766 free base; RO5126766(CH5126766); RO5126766 (CH5126766); CKI-27; CH-5126766; CHEMBL3264002; UNII-D0D4252V97; D0D4252V97; RG-7304; SCHEMBL960093; BCP21067; EX-A2151; Ro 5126766 - Bio-X; BDBM50010462; s7170; ZINC68247388; AKOS030527032; ACN-038040; CCG-269457; CS-5254; DB15254; SB16628; DA-40233; HY-18652; B5820; FT-0737411; R-7304; RO5126766; CH5126766; Q27147976; RO 5126766; RO5126766; CH5126766; CH5126766; CH 5126766
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[170] | |||
Compound Name |
Chembl4288001
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50466485
Click to Show/Hide
|
||||
Activity |
IC50 = 60500 nM
|
[171] | |||
Compound Name |
4-(7-(2,6-Dimethylbenzylamino)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-yl)morpholin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1079436; BDBM50311758
Click to Show/Hide
|
||||
Activity |
IC50 = 61000 nM
|
[159] | |||
Compound Name |
3-(4-Methylthiophen-3-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL179704; Pyridine, 3-(4-methyl-3-thienyl)-; SCHEMBL3604047; BDBM12358; CTK3D1373; DTXSID00464022; nicotine 3-heteroaromatic analogue 11; US8609708,17; US8609708, 17
Click to Show/Hide
|
||||
Activity |
Ki = 61500 nM
|
[157] | |||
Compound Name |
Amodiaquine HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
TCMDC-123932; Amodiaquin (dihydrochloride); Amodiaquine hydrochloride; CHEMBL1630; SCHEMBL12094969; AKOS016339644; 4-((7-CHloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol hydrochloride; 4-((7-CHloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol xhydrochloride
Click to Show/Hide
|
||||
Activity |
IC50 = 62000 nM
|
[26] | |||
Compound Name |
1,5-Bis(3,5-dimethyl-4-hydroxyphenyl)-1,4-pentadien-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL407034; BDBM50237760; 4,4'-Dihydroxy-3,5,3',5'-tetramethyl-distyrylketon; 1,5-bis(4-hydroxy-3,5-dimethylphenyl)penta-1,4-dien-3-one
Click to Show/Hide
|
||||
Activity |
IC50 = 62800 nM
|
[34] | |||
Compound Name |
6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784172; SCHEMBL3407363; BDBM50418606
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[172] | |||
Compound Name |
Schembl21666383
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784170; BDBM50418604
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[172] | |||
Compound Name |
(-)-Pantoprazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
S-Pantoprazole; UNII-SX78SGO2TV; SX78SGO2TV; Zosecta; L-Pantoprazole; Pantoprazole, S-; S-(-)-Pantoprazole; (S)-(-)-Pantoprazole; SCHEMBL29466; CHEMBL3526697; DTXSID201015709; ZINC4099200; Q27289440; UNII-D8TST4O562 component IQPSEEYGBUAQFF-SANMLTNESA-N
Click to Show/Hide
|
||||
Activity |
Ki = 64000 nM
|
[6] | |||
Compound Name |
Methyl 2-[(S)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzimidazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2110339; BDBM50409890
Click to Show/Hide
|
||||
Activity |
Ki = 64000 nM
|
[6] | |||
Compound Name |
(4-Fluorophenyl)-[(8R)-8-methyl-3-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608683; BDBM50112242
Click to Show/Hide
|
||||
Activity |
IC50 = 64000 nM
|
[173] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043004; BDBM50385832
Click to Show/Hide
|
||||
Activity |
IC50 = 65000 nM
|
[59] | |||
Compound Name |
2-Amino-N-[(1S)-1-[1-[(2R)-1-cyano-3-(2-hydroxyphenoxy)propan-2-yl]tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL270666; BDBM50371684
Click to Show/Hide
|
||||
Activity |
IC50 ~ 66000 nM
|
[174] | |||
Compound Name |
N-(2,6-Dimethylbenzyl)-1,2-dimethyl-1H-pyrrolo[3,2-c]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1076192; BDBM50311751
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[159] | |||
Compound Name |
CID 53482945
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3421983; SCHEMBL2560731; BDBM50081200; (4-fluorophenyl)-(3-pyridin-2-yl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)methanone
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[162] | |||
Compound Name |
4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL390002; BDBM50209385
Click to Show/Hide
|
||||
Activity |
IC50 = 67000 nM
|
[175] | |||
Compound Name |
(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-methyl-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3128180; BDBM50448788
Click to Show/Hide
|
||||
Activity |
IC50 = 67200 nM
|
[176] | |||
Compound Name |
Dibenzylideneacetone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Dibenzalacetone; 1,5-Diphenylpenta-1,4-dien-3-one; trans,trans-Dibenzylideneacetone; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; Dibenzylidene acetone; 1,5-Diphenyl-1,4-pentadien-3-one; 1,5-Diphenyl-3-pentadienone; trans,trans-Dibenzalacetone; Distyryl ketone; 1,4-Pentadien-3-one, 1,5-diphenyl-, (1E,4E)-; trans,trans-1,5-Diphenyl-1,4-pentadien-3-one; UNII-9QXO7BCY9L; (1E,4E)-1,5-Diphenyl-penta-1,4-dien-3-one; DIBENZAL ACETONE; (E,E)-dibenzalacetone; MFCD00004790; 9QXO7BCY9L; CHEMBL17201; 1,4-Pentadien-3-one, 1,5-diphenyl-; MLS000331978; (1E,4E)-1,5-Diphenyl-1,4-pentadien-3-one; NSC623642; trans,trans-Dibenzylideneacetone, 98%; SMR000221439; trans,trans-1,5-Diphenylpenta-1,4-dien-3-one; (E,E)-1,5-DIPHENYL-1,4-PENTADIEN-3-ONE; EINECS 208-697-5; trans,trans-Dibenzylideneacetone, 99%; NSC-117234; Dibenzalacetone [MI]; PubChem15951; Opera_ID_794; (E)-Dibenzylideneacetone; Bis[(E)-styryl] ketone; trans,trans-Distyryl Ketone; 1,3-bis(benzylidene)acetone; ghl.PD_Mitscher_leg0.154; 1,4-Pentadien-3-one, 1,5-diphenyl-, (E,E)-; cid_640180; DTXSID0060224; trans,trans-dibenzylidene acetone; HMS1473B05; HMS2547J23; AKOS 213-33; CS-M0452; ZINC1504183; 4359AB; BBL010739; BDBM50240379; SBB055271; STK801751; 1, 5-diphenylpenta-1,4-dien-3-one; AKOS000277208; 1,5-Diphenyl-1E,4E-pentadien-3-one; AC-8839; AC-8840; AS03851; EBD2761157; LS11354; MP-0276; NSC-623642; IDI1_019345; NCGC00176652-01; AS-11697; SC-66275; (E)-1-Phenyl-2-(3-phenylacryloyl)ethene; D0903; ST50319357; (1Z,4E)-1,5-Diphenyl-1,4-pentadien-3-one; trans, trans-1,5-diphenylpenta-1,4-dien-3-one; (1E, 4E)-1,5-diphenyl penta-1,4-dien-3-one; (1E,4E)-1,5-Diphenyl-1,4-pentadien-3-one #; Q417585; J-400838; trans,trans-Dibenzylideneacetone, >=98.0% (HPLC); 1,5-diphenyl-1,4-pentadiene-3-one 35225-79-7; F0349-3714
Click to Show/Hide
|
||||
Activity |
IC50 = 67300 nM
|
[34] | |||
Compound Name |
N-(2,6-Dimethylbenzyl)-1,2-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1081870; BDBM50311752
Click to Show/Hide
|
||||
Activity |
IC50 = 68000 nM
|
[159] | |||
Compound Name |
(3R,4S)-N-(3,5-Bis(trifluoromethyl)benzyl)-1-(1-acetylpiperidine-4-carbonyl)-4-(4-fluoro-2-methylphenyl)-N-methylpyrrolidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL391964; BDBM50220132
Click to Show/Hide
|
||||
Activity |
IC50 = 69000 nM
|
[177] | |||
Compound Name |
N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3142316
Click to Show/Hide
|
||||
Activity |
IC50 = 72700 nM
|
[178] | |||
Compound Name |
4-[[6-Ethyl-5-[[4-[(5R)-2-oxo-5-phenyl-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-yl]piperidino]methyl]pyridine-2-yl]oxy]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2435856; SCHEMBL5576709; BDBM50441713
Click to Show/Hide
|
||||
Activity |
IC50 ~ 73000 nM
|
[169] | |||
Compound Name |
7-(2-Aminopyrimidin-5-yl)-1-[[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]amino]-5H-pyrido[4,3-b]indole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1835153; SCHEMBL3507573; BDBM50355405
Click to Show/Hide
|
||||
Activity |
IC50 ~ 75000 nM
|
[179] | |||
Compound Name |
(E)-Ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3891460; SCHEMBL14405714; BDBM198658; US9221791, 4
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[180] | |||
Compound Name |
N~1~-[(10S)-2-{[(4-Fluorophenyl)methyl]carbamoyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl]-N~1~,N~2~,N~2~-trimethylethanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL408962; BDBM22712; CTK5D6116; Bicyclic pyrimidinone, (S)-28c; DTXSID50716205; ZINC3842373
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[181] | |||
Compound Name |
2-(3-Chloro-2-fluoroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL225413; SCHEMBL13503382; BDBM50211854
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[24] | |||
Compound Name |
3-(1-Ethyl-1H-imidazol-4-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL361364; Pyridine, 3-(1-ethyl-1H-imidazol-4-yl)-; 3-(1-ethylimidazol-4-yl)pyridine; SCHEMBL3604362; CTK3D1371; DTXSID80467192; cid_11480732; BDBM50158928; 3-(1-Ethyl-1H-imidazol-4-yl)-pyridine; MLS-0091930.0001; US8609708, 20
Click to Show/Hide
|
||||
Activity |
IC50 = 75200 nM
|
[36] | |||
Compound Name |
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-((1-methylpiperidin-4-yl)ethynyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3672842; SCHEMBL15700461
Click to Show/Hide
|
||||
Activity |
IC50 = 75660 nM
|
[182] | |||
Compound Name |
2-(4-{[2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-2-oxo-1,2-dihydropyridin-3-yl)-N,4-dimethyl-1H-1,3-benzodiazole-6-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL425819; SCHEMBL5137596; SCHEMBL14510346; BDBM50209382
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[175] | |||
Compound Name |
(2-(Pyridin-2-yl)quinolin-4-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL509970; BDBM50273784
Click to Show/Hide
|
||||
Activity |
Ki = 76190 nM
|
[183] | |||
Compound Name |
Tert-butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3321835; BDBM50100544
Click to Show/Hide
|
||||
Activity |
IC50 = 76850 nM
|
[184] | |||
Compound Name |
CID 86274732
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608741; SCHEMBL16143074; BDBM50112245
Click to Show/Hide
|
||||
Activity |
IC50 = 77000 nM
|
[173] | |||
Compound Name |
N-(2-Methylphenyl)-N'-hydroxyformamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL103651; BDBM50106748; N''-hydroxy-N-(2-methylphenyl)imidoformamide
Click to Show/Hide
|
||||
Activity |
IC50 = 77000 nM
|
[185] | |||
Compound Name |
N-(4-Methylphenyl)-N'-hydroxyformamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL103320; BDBM50106740; N''-hydroxy-N-(4-methylphenyl)imidoformamide
Click to Show/Hide
|
||||
Activity |
IC50 = 79000 nM
|
[185] | |||
Compound Name |
Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL360999; 3-(1-methylimidazol-4-yl)pyridine; 3-(1-methyl-1H-imidazol-4-yl)pyridine; SCHEMBL3644924; BDBM12352; CTK2I3860; DTXSID90462916; cid_11344157; nicotine 3-heteroaromatic analogue 5; MLS-0091928.0001; US8609708, 5
Click to Show/Hide
|
||||
Activity |
IC50 = 79500 nM
|
[36] | |||
Compound Name |
3-(3-Methyl-1H-imidazol-4-yl)-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL179399; BDBM50158920
Click to Show/Hide
|
||||
Activity |
IC50 = 79500 nM
|
[36] | |||
Compound Name |
4-Allyl-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL333210; BDBM50105815; 4-Allyl-N-(3-hydroxypropyl)-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[135] | |||
Compound Name |
4-Amino-N-isopropyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
compound 9 [PMID: 11606127]; CHEMBL121323; GTPL8833; BDBM50105809; Q27076849; 4-amino-N-(2-phenylpyrazol-3-yl)-N-propan-2-ylbenzenesulfonamide; 4-Amino-N-isopropyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[135] | |||
Compound Name |
1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CB-13; CB 13; CRA-13; UNII-9XRJ6055XT; 1-Naphthalenyl(4-(pentyloxy)-1-naphthalenyl)methanone; naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone; 9XRJ6055XT; CHEMBL244403; CRA13; SCHEMBL247361; Naphthalen-1-yl-(4-pentoxynaphthalen-1-yl)methanone; CTK4I7171; DTXSID60430920; HMS3742A19; (NAPHTHALEN-1-YL)[4-(PENTYLOXY)NAPHTHALEN-1-YL]METHANONE; C26H24O2; 1292AH; ABP001012; BDBM50218116; MFCD11519954; ZINC28710494; AKOS024457339; CCG-208739; A20544; 047C728; Q5008954; naphthalen-1-yl-(4-pentyloxy-naphthalen-1-yl)-methanone; Methanone, 1-naphthalenyl(4-(pentyloxy)-1-naphthalenyl)-; naphthalen-1-yl(4-(pentyloxy)naphthalen-1-yl)methanone;CB-13
Click to Show/Hide
|
||||
Activity |
IC50 = 80800 nM
|
[186] | |||
Compound Name |
2-(2,4-Difluorophenyl)-1,1-difluoro-1-[5-(6-fluoropyridin-3-yl)pyridin-2-yl]-3-(tetrazol-1-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3945322; SCHEMBL14332103; BDBM198662; US9221791, 31
Click to Show/Hide
|
||||
Activity |
IC50 = 81000 nM
|
[180] | |||
Compound Name |
Methyl N-[(2S)-1-[(2S)-2-[5-chloro-4-[4-[4-[5-chloro-2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2047188; SCHEMBL8756684; BDBM50387085
Click to Show/Hide
|
||||
Activity |
IC50 = 81600 nM
|
[187] | |||
Compound Name |
CID 81689815
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608684; SCHEMBL16116207; BDBM50112183
Click to Show/Hide
|
||||
Activity |
IC50 = 82000 nM
|
[173] | |||
Compound Name |
Chembl4229237
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL3067419; BDBM50460861
Click to Show/Hide
|
||||
Activity |
IC50 = 82000 nM
|
[108] | |||
Compound Name |
Furanyl analog 2
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM9121; CHEMBL444533; SCHEMBL5255882
Click to Show/Hide
|
||||
Activity |
IC50 = 83900 nM
|
[188] | |||
Compound Name |
1-[3-Fluoro-4-[4-(4-hydroxyphenyl)phenyl]phenyl]cyclopropane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL196947; BDBM50172459; 1-(2-Fluoro-4''''-hydroxy-[1,1'';4'',1'''']terphenyl-4-yl)-cyclopropanecarboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 89000 nM
|
[189] | |||
Compound Name |
1-(4-((3S,4R)-3-(3-(2-(3,5-Bis(trifluoromethyl)phenyl)propan-2-yl)-1,2,4-oxadiazol-5-yl)-4-(4-fluoro-2-methylphenyl)pyrrolidine-1-carbonyl)piperidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL392464; BDBM50220122
Click to Show/Hide
|
||||
Activity |
IC50 = 89000 nM
|
[177] | |||
Compound Name |
Hydroxy ethylamine (HEA), 15
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMCL193664 Compound 5; CHEMBL399656; SCHEMBL5220378; BDBM26780
Click to Show/Hide
|
||||
Activity |
IC50 ~ 89000 nM
|
[166] | |||
Compound Name |
4-Amino-N-ethyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL330871; SCHEMBL3845016; BDBM50105821; 4-Amino-N-ethyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 90000 nM
|
[135] | |||
Compound Name |
N-Tert-butyl isoquine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
GSK369796; GSK 369796; CHEMBL147806; 2-[(TERT-BUTYLAMINO)METHYL]-5-[(7-CHLOROQUINOLIN-4-YL)AMINO]PHENOL; GTPL10411; ZINC1912685; BDBM50134936; 2-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-phenol
Click to Show/Hide
|
||||
Activity |
IC50 ~ 90000 nM
|
[41] | |||
Compound Name |
4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL387611; SCHEMBL5135775; BDBM50209392
Click to Show/Hide
|
||||
Activity |
IC50 = 91000 nM
|
[175] | |||
Compound Name |
2-[(R)-[4-(Cyclopropylmethoxy)pyridin-2-yl]methylsulfinyl]-6-fluoro-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2110340; BDBM50409891
Click to Show/Hide
|
||||
Activity |
Ki = 93000 nM
|
[6] | |||
Compound Name |
[4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3092189; SCHEMBL959521; BDBM50010464
Click to Show/Hide
|
||||
Activity |
IC50 = 96000 nM
|
[170] | |||
Compound Name |
3-(3-Thienyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(thiophen-3-yl)pyridine; 3-thiophen-3-ylpyridine; 3-(thiophene-3-yl)pyridine; Pyridine, 3-(3-thienyl)-; CHEMBL361153; 3-(3-thienyl)-pyridine; 3-(Thien-3-yl)pyridine; SCHEMBL2777912; BDBM12355; CTK0J7722; DTXSID20344236; MFCD06802559; nicotine 3-heteroaromatic analogue 8; ZINC13607083; AKOS004118749; DB-066480; FT-0738684; US8609708,11; Z2618249113
Click to Show/Hide
|
||||
Activity |
IC50 = 96300 nM
|
[36] | |||
Compound Name |
1-(8-((1S,2S)-2-Hydroxy-2,3-dihydro-1H-inden-1-ylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL498840; SCHEMBL4884526; BDBM50269077
Click to Show/Hide
|
||||
Activity |
IC50 = 97000 nM
|
[190] | |||
Compound Name |
1-(5-(Pyridin-3-yl)thiophen-2-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL362702; SCHEMBL3649364; BDBM50158912; ZINC13607079; AKOS026718588; 1-(5-pyridin-3-ylthiophen-2-yl)ethanone; 1-(5-Pyridin-3-yl-thiophen-2-yl)-ethanone; Ethanone, 1-[5-(3-pyridinyl)-2-thienyl]-; US8609708, 36; F2167-0965
Click to Show/Hide
|
||||
Activity |
IC50 = 98200 nM
|
[36] | |||
Compound Name |
Oteseconazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
VT-1161; UNII-VHH774W97N; VHH774W97N; CHEMBL3311228; Oteseconazole [USAN]; Oteseconazole (USAN/INN); SCHEMBL17113021; BDBM50046187; WHO 10138; DB13055; SB17420; HY-17643; CS-0016914; D11785; Q27291837
Click to Show/Hide
|
||||
Activity |
IC50 = 99000 nM
|
[191] | |||
Compound Name |
3-(2-Thienyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(THIOPHEN-2-YL)PYRIDINE; 3-thiophen-2-ylpyridine; 2-(3-pyridyl)thiophene; 3-(2-thienyl)-pyridine; 3-thiophen-2-yl-pyridine; Pyridine,3-(2-thienyl)-; CHEMBL179618; MFCD01860052; 3-thien-2-ylpyridine; ACMC-1CLKC; 7-Fluoro-6-methylisatin; 3-Thiophene-2-yl-pyridine; Pyridine, 3-(2-thienyl)-; SCHEMBL158705; CTK4E6374; DTXSID20344216; ZINC334312; BDBM50158919; SBB087543; AKOS004118920; MCULE-2037557762; VP14424; AC-29170; AS-58501; ST095204; DB-045533; FT-0613597; US8609708, 33; A815253; AI-942/25034651
Click to Show/Hide
|
||||
Activity |
IC50 = 99200 nM
|
[36] | |||
Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3216770
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[192] | |||
Compound Name |
3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-(2-methoxyethoxy)phenyl]-2-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3672840; SCHEMBL15647850; SCHEMBL15647852; SCHEMBL16476033
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[182] | |||
Compound Name |
N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3764088; SCHEMBL11982266; BDBM50146156
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
N'-[1-[2-[(2S)-1-Methylpyrrolidin-2-yl]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3142403
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[192] | |||
Compound Name |
4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1,4,5,6-tetrahydropyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230043; SCHEMBL5136769; BDBM50209389
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[175] | |||
Compound Name |
(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2315239
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[194] | |||
Compound Name |
(3-(4-(((3R,5S)-3,5-Dimethylpiperazin-1-yl)methyl)phenyl)pyridin-2-yl)(4-(4-fluorophenylamino)piperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL473921; SCHEMBL4700720; BDBM50247157
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[195] | |||
Compound Name |
(3R,4S)-N-(2-(3,5-Bis(trifluoromethyl)phenyl)propan-2-yl)-1-(1-acetylpiperidine-4-carbonyl)-4-(4-fluoro-2-methylphenyl)-N-methylpyrrolidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL391615; BDBM50220121
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[177] | |||
Compound Name |
2-[[3-[4-[[2-[[1-[3-[3-(Cyclohexylamino)propylamino]propyl]triazol-4-yl]methylamino]-6-methylpyrimidin-4-yl]amino]piperidin-1-yl]-3-oxopropyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4064397; SCHEMBL17614429; BDBM50247595
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[196] | |||
Compound Name |
N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3216551
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[197] | |||
Compound Name |
(1S,4S,5R,8R,13S,17S,18R)-24-Cyclohexyl-4,5,9,9,13,20,20-heptamethyl-10,16,23-trioxo-24-azahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosa-11,14-diene-11-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3582240; BDBM50091324
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[198] | |||
Compound Name |
4-[(2,4-Difluorophenyl)carbonyl]-1-[4-({3-[(2R)-2-methyl-1-pyrrolidinyl]propyl)oxy)phenyl]-2-piperazinone, formate salt
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL239299
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[199] | |||
Compound Name |
4-Amino-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL120825; BDBM50105819; 4-Amino-N-(3-hydroxypropyl)-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[135] | |||
Compound Name |
{1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-phenyl]-1H-imidazol-2-yl}-[4-(3-fluoro-phenylamino)-piperidin-1-yl]-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL480219; SCHEMBL5127680; BDBM50255029
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[195] | |||
Compound Name |
N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3216112
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[192] | |||
Compound Name |
4-Amino-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL443542; SCHEMBL3849461; BDBM50105818; 4-Amino-N-methyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[135] | |||
Compound Name |
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL436137; SCHEMBL4269573; BDBM50193874; ZINC34643022; US8481536, 322
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[40] | |||
Compound Name |
1-(2-(Benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL213221; SCHEMBL4096041; BDBM50191163; 1-({5-bromo-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid; 1-[(5-bromo-2-phenylmethoxyphenyl)methyl]-5-methylpyrazole-3-carboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[200] | |||
Compound Name |
CID 67453320
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3422000; SCHEMBL2563752; BDBM50081400
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[162] | |||
Compound Name |
(6S,9R,12R)-6-Cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1923642; SCHEMBL804933; BDBM50359252
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
2-(3,5-Difluorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL390526; SCHEMBL13069959; BDBM50211852
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[24] | |||
Compound Name |
(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3128178; BDBM50448787
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
CID 71225056
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3422004; SCHEMBL14634646; BDBM50081274
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[162] | |||
Compound Name |
Nvp-qav-680
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
NVP-QAV680; QAV690 free acid; QAV-680; UNII-0E3D72URPD; 0E3D72URPD; CHEMBL2442750; QAV-690 free acid; GTPL8996; QAV680; SCHEMBL1941180; BCP28134; BDBM50442299; ZINC34600373; CS-3461; DB11658; HY-12284; Q27088492; NVPQAV680; NVP-QAV-680;QAV-680;QAV 680;QAV680
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[201] | |||
Compound Name |
CYP3cide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-4981517; PF-04981517; UNII-ZRD2TT3Y1T; ZRD2TT3Y1T; CHEMBL3527048; PF 4981517; C26H32N8; SCHEMBL15522135; DTXSID60747404; SYN3007; CYP3cide;PF-04981517; CYP3cide, >=98% (HPLC); 2645AH; BDBM50088503; MFCD22417344; s2921; ZINC77286311; AKOS024458057; CCG-269301; SB16511; NCGC00379101-02; AS-16353; HY-18642; CS-0011640; SW219546-1; PF 04981517
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[202] | |||
Compound Name |
N-(4-Tert-Butylphenyl)-N'-hydroxyformamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL103163; SCHEMBL5720632; CTK1B1462; DTXSID20438003; BDBM50106742; N-(4-tert-butylphenyl)-N''-hydroxyimidoformamide; N'-(4-TERT-BUTYLPHENYL)-N-HYDROXYMETHANIMIDAMIDE; Methanimidamide, N-[4-(1,1-dimethylethyl)phenyl]-N'-hydroxy-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
CID 71580631
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2347159; BDBM50432236
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[154] | |||
Compound Name |
N-Cyclopropyl-3-fluoro-4-methyl-5-[4-[(2-methyl-1,3-thiazol-4-yl)methylcarbamoyl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784169; BDBM50418603
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[172] | |||
Compound Name |
3,5-Dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3087669; SCHEMBL220654; BDBM50443217
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[203] | |||
Compound Name |
N'-(1-Piperidin-4-yl-3,4-dihydro-2H-quinolin-6-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3217198
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[192] | |||
Compound Name |
4-(4-Fluorobenzoyl)-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;formic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL240185
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[199] | |||
Compound Name |
N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(4-oxoquinazolin-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3764774; SCHEMBL11982241; BDBM50146155
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
2-(2-Fluoro-4-chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)amide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL225465; SCHEMBL13503338; BDBM50211840
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[24] | |||
Compound Name |
4-[[2-[(5-Cyano-1,3-thiazol-2-yl)amino]-3-methylpyridin-4-yl]methyl]-N-methylpiperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
N-(1,3-Thiazol-2-yl)pyridin-2-amine 23; BDBM5293; CHEMBL376722; SCHEMBL5743511
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
N-(2,6-Dimethylbenzyl)-6,7-dimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1081504; BDBM50311748; N-[(2,6-dimethylphenyl)methyl]-6,7-dimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[159] | |||
Compound Name |
[4-Methyl-3-[[2-(methylsulfamoylamino)pyridin-4-yl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263996; SCHEMBL958763; BDBM50010465
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[170] | |||
Compound Name |
1-[(2R)-2,3-Dihydroxypropyl]-3-[1-[[(1S,2S,4R)-spiro[bicyclo[2.2.1]heptane-3,1'-cyclopropane]-2-yl]methyl]piperidin-4-yl]benzimidazol-2-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL564840; SCHEMBL4942286
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[204] | |||
Compound Name |
2-[(1S,18S,21E,28S,29S,30S)-30-[(2S,4S,5R,6S)-5-(Dimethylamino)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-52-hydroxy-18-[(1R)-1-hydroxyethyl]-9-methoxy-21-(1-methoxyethylidene)-16,19,26,31,42,46-hexaoxo-32,43,54-trioxa-3,13,23,49-tetrathia-7,17,20,27,45,51,52,55,56,57-decazadecacyclo[26.16.6.229,40.12,5.112,15.122,25.138,41.147,50.06,11.034,39]heptapentaconta-2(57),4,6,8,10,12(56),14,22(55),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-N-(3-morpholin-4-ylpropyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL504492; BDBM50258832
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[205] | |||
Compound Name |
N-[6-(2-Chlorophenyl)-5-(4-chlorophenyl)-2-(2-hydroxy-2-methylpropanoyl)furo[2,3-b]pyridin-3-yl]-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1092169; SCHEMBL1628047; BDBM50314108
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[206] | |||
Compound Name |
Chembl4126331
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50272089
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[207] | |||
Compound Name |
4-[[6-Methyl-5-[[4-[(5R)-2-oxo-5-(3-chlorophenyl)-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-yl]piperidino]methyl]pyridine-2-yl]oxy]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2435853; SCHEMBL5575383; BDBM50441719
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[169] | |||
Compound Name |
2-[4-[4-[6-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]-1H-benzimidazol-2-yl]phenyl]cyclohexyl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2409564; BDBM50437753; KR-69232
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[208] | |||
Compound Name |
Carbamic acid, N-(4-hydroxybutyl)-, 2-(5-((1S)-1-((2-amino-2-methyl-1-oxopropyl)amino)-2-(phenylmethoxy)ethyl)-1H-tetrazol-1-yl)ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-317180; D9Y5DGD9EI; UNII-D9Y5DGD9EI; CHEMBL398372; Tetrazole-based compound, 2; BDBM21941
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[209] | |||
Compound Name |
CID 76310313
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3109984; SCHEMBL15769130; BDBM50446471; (1R,2R,3R)-N-hydroxy-2-[4-(2-methyl-1,3-oxazol-5-yl)phenyl]-3-phenylcyclopropane-1-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[210] | |||
Compound Name |
1-(4-Benzyl-2-oxo-1,2-dihydro-quinolin-3-yl)-pyridinium
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL365787; BDBM50171281
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[155] | |||
Compound Name |
4-[4-[4-(1-Cyclobutylpiperidin-4-yl)oxyphenyl]-3-oxopiperazine-1-carbonyl]benzonitrile;formic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL239099
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[199] | |||
Compound Name |
Chembl4177457
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL15416328; BDBM50276954; 1-[[5-chloro-1-(oxetan-3-ylmethyl)benzimidazol-2-yl]methyl]-3-methylsulfonylpyrazolo[3,4-c]pyridine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[211] | |||
Compound Name |
2-(2-Aminothiazol-4-yl)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1684585; SCHEMBL11982260; BDBM50338821
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
JTZ-951 HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4166742; 1262131-60-1 (HCl); (7-Hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine hydrochloride; JTZ-951 hydrochloride; SCHEMBL1481939; BDBM50286071
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[212] | |||
Compound Name |
Abelcet
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Amphotericin B lipid complex; amphotericin b; Amphotericin b liposomal complex; Ambisome; Amphotec; Fungilin; Fungizone; Ampho-Moronal; NSC-527017; amophotericin B; Amphotreicin B; Amphotercin B; Ampotericin B; Amphotericitin B; Fungilin In Orabase; Amphotericin b, liposome; CHEMBL267345; BDBM50457967
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[10] | |||
Compound Name |
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
EPZ011989; EPZ-011989; EPZ011969; GTPL9273; CHEMBL3672841; SCHEMBL15647410; SCHEMBL15700498; SCHEMBL16460838; AOB87382; BCP15987; EX-A1583; AKOS026750484; AKOS027339815; ZINC207506284; ZINC253497322; CS-4592; EPZ 011989; NCGC00384304-01; NCGC00384304-03; AC-30943; HY-16986; J3.544.029A; Q27077208
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[182] | |||
Compound Name |
Vibegron
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
KRP-114V; UNII-M5TSE03W5U; MK-4618; M5TSE03W5U; MK4618; C26H28N4O3; Vibegron [USAN:INN]; vibegronum; Beova; Beova (TN); MK 4618; Vibegron (JAN/USAN); CHEMBL2107826; SCHEMBL11985457; GTPL10100; DTXSID40152299; EX-A3390; BDBM50146154; MFCD28502057; compound 7 [PMID: 26709102]; DB14895; SB16922; D10433; Q27283524
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
4-[3-Oxo-4-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazine-1-carbonyl]benzonitrile;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL534958
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[199] | |||
Compound Name |
N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL154751; SCHEMBL6278284; (R)-CVT-3501; BDBM50138599
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[213] | |||
Compound Name |
(4R)-2-Amino-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3128194; BDBM50448786
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[176] | |||
Compound Name |
3-[(5-Cyclopropyl-1,2-oxazol-3-yl)methylamino]adamantan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4077296; BDBM50247641; Tricyclo[3.3.1.13,7]decan-1-ol, 3-[[(5-cyclopropyl-3-isoxazolyl)methyl]amino]-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[214] | |||
Compound Name |
N-(9-Ethyl-9H-carbazol-3-yl)-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL150614; SCHEMBL4857901; BDBM50138611
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[213] | |||
Compound Name |
1(4H)-Pyrimidineacetamide, N-(2-(diethylamino)ethyl)-2-(((4-fluorophenyl)methyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)-4-oxo-N-((4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)methyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SB-435495; UNII-0ORT6ZXL2X; 0ORT6ZXL2X; CHEMBL10921; SCHEMBL3106248; BDBM50117772
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[215] | |||
Compound Name |
(6S)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3128188; SCHEMBL12877400; BDBM50448789
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
Chembl4246655
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50462156
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[216] | |||
Compound Name |
Chembl4224936
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL3557529; BDBM50461454; 2-[4-(4,9-diethoxy-1,3-dioxobenzo[f]isoindol-2-yl)phenyl]acetic acid; 2-(4-(4,9-Diethoxy-1,3-dioxo-1H-benzo[f]isoindol-2(3H)-yl)phenyl)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[217] | |||
Compound Name |
SB 271046 Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SB 271046 (Hydrochloride); SB-271046A; SB-271046 HCl; UNII-X289JNP23G; X289JNP23G; 209481-24-3 (HCl); ACMC-20ekpy; SB-271046 Hydrochloride; C20H22ClN3O3S2.ClH; C20H22ClN3O3S2.HCl; CHEMBL542139; SCHEMBL6977773; CTK0J8216; BCP12719; KS-00002WY0; 4027AH; HY-14336A; MFCD10565914; AKOS015924475; BCP9000018; CS-0634; QC-2290; SS-4788; BCP0726000158; AB0059577; DB-014413; A3793; FT-0721273; FT-0730856; W-5443; SB-271046A, >=98% (HPLC); J-013735
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[38] | |||
Compound Name |
(2R)-N-(4-Methoxyphenyl)-2-(pyridin-3-yloxymethyl)piperazine-1-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3262163; BDBM50016217
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[218] | |||
Compound Name |
(R)-2-(3-(1-(4-Hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl)-2-methylpropanamido)cyclohex-1-enecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL483934; BDBM50271463
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[219] | |||
Compound Name |
(19S,22R)-22-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,12,21-trioxo-2,6,9,13,20-pentazatetracyclo[22.2.2.26,9.214,17]dotriaconta-1(27),14(30),15,17(29),24(28),25-hexaene-19-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2315243
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[194] | |||
Compound Name |
N-Methyl-N-[(1-methylpyrrol-2-yl)methyl]adamantane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2159084; SCHEMBL3328459; BDBM50394437
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
MK-0952; UNII-N48GH1UIR0; 934995-87-6 (acid); N48GH1UIR0; CHEMBL1801160; SCHEMBL508648; BDBM50347348; ZINC36413737; HY-11070; CS-0003030; Q27284533
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
2-Amino-N-[(1S)-1-[1-[(2R)-1-cyano-3-pyridin-2-yloxypropan-2-yl]tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL271876; BDBM50371686
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[174] | |||
Compound Name |
Chembl4239823
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17395423; BDBM50462158
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[216] | |||
Compound Name |
3-(1-(4-Chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1079256; SCHEMBL13211171; BDBM50310808
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[222] | |||
Compound Name |
2-Fluoro-N-[3-methoxy-4-[5-(3-piperidin-1-ylpropylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022495; SCHEMBL4245240; BDBM50381980
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[223] | |||
Compound Name |
Methyl N-[(2S)-1-[(2S)-2-[5-fluoro-4-[4-[4-[5-fluoro-2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2047191; BDBM50387086
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[187] | |||
Compound Name |
2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-06282999; UNII-YO3O4Q2NC8; YO3O4Q2NC8; CHEMBL3633460; PF06282999; 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide; SCHEMBL14936135; GTPL10053; BCP20203; EX-A2535; BDBM50133595; s6648; ZINC205775084; compound 8 [PMID: 26509551]; CS-6095; DB11683; BS-15745; HY-19321; J3.552.697H; Q27294622
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[224] | |||
Compound Name |
(S)-1,1,1-Trifluoro-3-((S)-3-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-8-(3-(trifluoromethoxy)phenyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL602483; SCHEMBL4749474; BDBM50306605
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[225] | |||
Compound Name |
2-[({4-[2-(Trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
A 1120; A1120; 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid; CHEMBL1230001; compound 33 [PMID: 24835984]; BRD-K59060513-001-01-7; GTPL8792; SCHEMBL1230989; CTK8F7476; HMS3743G05; BDBM50019040; ZINC44559762; AKOS024457802; DB06985; NCGC00370977-01; A1120, >=98% (HPLC), powder; HY-107633; CS-0029033; Q27074049; 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido) benzoic acid; 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[226] | |||
Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3216313
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[192] | |||
Compound Name |
2-[[3-[1-(4-Hydroxyphenyl)-5-methylpyrazol-4-yl]-2-methylpropanoyl]amino]cyclohexene-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL4548325; CHEMBL1085402
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[74] | |||
Compound Name |
5-(4-Butoxy-phenyl)-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL151170; 1H-Imidazole, 5-(4-butoxyphenyl)-; SCHEMBL14129973; SCHEMBL16439282; BDBM50136059
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[227] | |||
Compound Name |
N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2036268; CHEMBL2036269
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[228] | |||
Compound Name |
N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(2-oxopyrimidin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3763594; SCHEMBL13648504; BDBM50146158
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[193] | |||
Compound Name |
Bicyclic pyrimidinone, (R)-22b
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL408479; BDBM22695
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[181] | |||
Compound Name |
Fevipiprant
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
NVP-QAW039; QAW039; UNII-2PEX5N7DQ4; 2PEX5N7DQ4; Fevipiprant [INN]; Fevipiprant [USAN:INN]; QAW 039; Fevipiprant (JAN/USAN/INN); GTPL8995; SCHEMBL1940595; CHEMBL3137332; QAW-039; HMS3743E19; BCP25015; EX-A2495; BDBM50233520; ZINC43101772; AB85348; CS-5956; DB12011; Fevipiprant; NVP-QAW039; QAW039; SB16897; AC-31956; AS-74870; HY-16768; DS-022511; FT-0774596; D10631; Q27077292
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
Dimethyl({[5-(pyridin-3-yl)thiophen-2-yl]methyl})amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL361969; SCHEMBL3618712; 2-Thiophenemethanamine, N,N-dimethyl-5-(3-pyridinyl)-; BDBM12344; N,N-dimethyl-1-(5-pyridin-3-ylthiophen-2-yl)methanamine; nicotine 3-heteroaromatic analogue 1c; US8609708, 75; N,N-dimethyl(5-(pyridin-3-yl)thiophen-2-yl)methanamine
Click to Show/Hide
|
||||
Activity |
Ki = 103000 nM
|
[157] | |||
Compound Name |
Posaconazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Noxafil; Sch 56592; Posaconazole SP; SCH56592; SCH-56592; UNII-6TK1G07BHZ; Schering 56592; 6TK1G07BHZ; CHEMBL1397; pasaconazole; Posconazole; Posaconazole [USAN:INN:BAN]; HSDB 7421; C37H42F2N8O4; Noxafil (TN); Posaconazole solution; cc-165; SCHEMBL991747; Posaconazole (JAN/USAN/INN); DTXSID6049066; CTK6B1621; BCP01102; KS-00000GY1; ZINC3938482; BDBM50181473; CP0094; MFCD00941162; MMV688774; s1257; AKOS005145917; AC-1350; ACN-040495; CCG-270387; CS-0998; DB01263; KS-1413; PB30668; NCGC00274060-02; HY-17373; Posaconazole in combination with MGCD290; SC-23857; AB0015409; P2477; SW219391-1; D02555; P-7020; Q-4359; AB01274762-01; AB01274762_02; Posaconazole, VETRANAL(TM), analytical standard; 228P492; Q906453; Posaconazole, Antibiotic for Culture Media Use Only
Click to Show/Hide
|
||||
Activity |
IC50 = 109000 nM
|
[230] | |||
Compound Name |
N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL360998; 2-Furanmethanamine, N,N-dimethyl-5-(3-pyridinyl)-; dimethyl({[5-(pyridin-3-yl)furan-2-yl]methyl})amine; SCHEMBL3604825; BDBM12347; nicotine 3-heteroaromatic analogue 2c; DB07609; US8609708, 56; Q27096829; N,N-dimethyl-1-(5-pyridin-3-ylfuran-2-yl)methanamine
Click to Show/Hide
|
||||
Activity |
Ki = 111000 nM
|
[157] | |||
Compound Name |
3-Phenylthiophene
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Thiophene, 3-phenyl-; 4-phenylthiophene; 3-phenyl-thiophene; EINECS 219-297-5; NSC229334; 3-Phenylthiophene, 95%; ACMC-1CK6C; EC-000.1528; NORNICOTINE,DL-(RG); BIDD:GT0455; SCHEMBL149952; CHEMBL386250; BDBM12366; CTK1A7430; ZDQZVKVIYAPRON-UHFFFAOYSA-; DTXSID90178787; ZINC967487; KS-000012EX; ANW-25309; MFCD00114997; SBB087462; AKOS005067499; nicotine 3-heteroaromatic analogue 25; AC-4933; NSC-229334; VT20255; AS-56884; DB-046332; FT-0616355; P1126; Z0414; Q-9014; 404P877; AI-942/25034734
Click to Show/Hide
|
||||
Activity |
Ki = 112000 nM
|
[157] | |||
Compound Name |
Nicotinoyl guanidine, 29
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL565383; BDBM35309
Click to Show/Hide
|
||||
Activity |
IC50 = 122000 nM
|
[231] | |||
Compound Name |
Nicotinoyl guanidine, 33
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL570639; BDBM35313
Click to Show/Hide
|
||||
Activity |
IC50 = 122000 nM
|
[231] | |||
Compound Name |
1-Methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL446083; SCHEMBL1119366; BDBM50273776; 1-methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2-one
Click to Show/Hide
|
||||
Activity |
IC50 = 125000 nM
|
[42] | |||
Compound Name |
Spiro[9h-fluorene-9,4'-imidazolidine]-2',5'-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
MLS002607885; CHEMBL163958; spiro(fluorene-9,4'-imidazolidine)-2',5'-dione; SPIRO[FLUORENE-9,4'-IMIDAZOLIDINE]-2',5'-DIONE; NSC34504; spiro[fluorene-9,5'-imidazolidine]-2',4'-dione; cid_234512; SCHEMBL9810959; CTK2B2151; DTXSID10283963; HMS3078G14; ZINC398741; BDBM50040780; NSC-34504; AKOS009112753; MCULE-5506355337; SMR001526647; DS-012447; VU0419496-1; Spiro[9h-fluorene-9,4-imidazolidine]-2,5-dione; Spiro[imidazolidine-4,9'-[9H]fluorene]-2,5-dione; SPIRO(FLUOREN-9,4'-IMIDAZOLIDINE)-2',5'-DIONE
Click to Show/Hide
|
||||
Activity |
Ki = 125000 nM
|
[6] | |||
Compound Name |
2-((4'-Chlorobiphenyl-2-yl)methylsulfinyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1956397; 2-[[2-(4-chlorophenyl)phenyl]methylsulfinyl]acetamide; SCHEMBL1195760; BDBM50365396; (-)-2-[2-(4-chlorophenyl)benzyl]sulphinylacetamide
Click to Show/Hide
|
||||
Activity |
IC50 = 129000 nM
|
[232] | |||
Compound Name |
CID 71621803
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4077246; SCHEMBL15018509; BDBM50268690
Click to Show/Hide
|
||||
Activity |
IC50 = 138000 nM
|
[230] | |||
Compound Name |
Methyl 2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzimidazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2110247; BDBM50409896
Click to Show/Hide
|
||||
Activity |
Ki = 140000 nM
|
[6] | |||
Compound Name |
(NE)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine;(NZ)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1795039
Click to Show/Hide
|
||||
Activity |
IC50 = 141000 nM
|
[36] | |||
Compound Name |
(E)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(3-(2,2,2-trifluoroethoxy)prop-1-enyl)pyridin-2-yl) propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3954501; SCHEMBL14332004; BDBM198660; US9221791, 6
Click to Show/Hide
|
||||
Activity |
IC50 = 145000 nM
|
[180] | |||
Compound Name |
(R)-(+)-Pantoprazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
UNII-8UUN42B3QT; 8UUN42B3QT; CHEMBL2096747; (R)-Pantoprazole; R-Pantoprazole; (+)-Pantoprazole; Pantoprazole, (R)-; SCHEMBL22198; ZINC4676424; BDBM50409893; UNII-D8TST4O562 component IQPSEEYGBUAQFF-AREMUKBSSA-N
Click to Show/Hide
|
||||
Activity |
Ki = 145000 nM
|
[6] | |||
Compound Name |
Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-711939; UNII-E2C4891M77; BMS 711939; E2C4891M77; SCHEMBL2742707; CHEMBL3828718; BDBM28802; BMS711939; Q27276778
Click to Show/Hide
|
||||
Activity |
IC50 ~ 150000 nM
|
[233] | |||
Compound Name |
3-(1H-Pyrazol-3-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(1H-pyrazol-5-yl)pyridine; MFCD03407951; 3pypz; 3-(3-pyridyl)pyrazole; 3-(pyridin-3-yl)pyrazole; SCHEMBL446537; 3-(3-Pyridyl)-1H-pyrazole; CHEMBL218397; 5-(3-Pyridinyl)-1H-pyrazole; SCHEMBL13425468; 3-(1h pyrazol-3-yl)-pyridine; 3-(1H-pyrazol-3-yl)-pyridine; BDBM12368; CTK4I8991; DTXSID80427736; Pyridine,3-(1H-pyrazol-3-yl)-; ALBB-013294; KS-00001X6F; ZINC9238272; 6312AB; ANW-44766; BBL029970; SBB086413; STL303694; AKOS000345412; AKOS005174219; nicotine 3-heteroaromatic analogue 27; AB14049; AC-5755; ACN-000481; MCULE-8439479564; VP12631; 3-(1H-Pyrazol-3-yl)pyridine, AldrichCPR; AB0157775; DB-011092; PYRIDINE, 3-(1H-PYRAZOL-3-YL)-; CS-0110791; FT-0683682; EN300-36077; A12267; MLS-0091915.0001; Y-5619; 4Y-0803; 887P089
Click to Show/Hide
|
||||
Activity |
Ki = 172000 nM
|
[157] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
Thiabendazole
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Biogard; Bioguard; Bovizole; Cropasal; Drawipas; Eprofil; Equizole; Hymush; Lombristop; Mertec; Mertect; Mintesol; Mintezol; Mintezole; Minzolum; Mycozol; Nemacin; Nemapan; Omnizole; Ormogal; Pitrizet; Polival; RPH; Sistesan; Storite; Tbdz; Tebuzate; Tecto; Testo; Thiaben; Thiabendazol; Thiabendazolum; Thiabendole; Thiabenzazole; Thiabenzole; Thibendole; Thibenzol; Thibenzole; Thiprazole; Tiabenda; Tiabendazol; Tiabendazole; Tiabendazolum; Tobaz; Tresaderm; Triasox; Tubazole; Captan T; Equivet TZ; Equizole A; Helmindrax octelmin; Hokustar HP; Mertect lsp; RTU Flowable Fungicide; Tecto B; Tecto rph; Thibenzole att; Top Form Wormer; Chemviron TK 100; G 491; MK 360; Mertect 160; Mertect 340f; Metasol TK 100; Metasol tk 10; PS1057_SUPELCO; Sanaizol 100; Syntol M100; TBZ 6; TBZ 60W; Tecto 10P; Tecto 40F; Tecto 60; Thibenzole 200; Tibimix 20; APL-luster; Arbotect (TN); MK-360; Metasol TK-100; Mintezol (TN); TBZ-6; Thiabendazole (USP); Thiabendazole [BSI:ISO]; Thiabendazole [USAN:BAN]; Tiabendazolum [INN-Latin]; Tresaderm (TN); E-Z-Ex; Mintezol, Equizole, Thiabendazole; Tiabendazol [INN-Spanish, French]; Tiabendazole (JAN/INN); 2-(1,3-Thiazol-4-yl)-1H-benzimidazole; 2-(1,3-Thiazol-4-yl)benzimidazole; 2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazole; 2-(4'-Thiazolyl)benzimidazole; 2-(4-Thiazolyl)-1H-benzimidazole; 2-(4-Thiazolyl)benzimidazole; 2-(Thiazol-4-yl)benzimidazole; 2-Thiazol-4-yl-1H-benzoimidazole; 2-Thiazole-4-ylbenzimidazole; 2-[4-Thiazoly]benzimidazole; 4-(1H-benzimidazol-2-yl)-1,3-thiazole; 4-(2-Benzimidazolyl)thiazole
Click to Show/Hide
|
||||
Activity |
Ki = 245000 nM
|
[6] | |||
Compound Name |
WAY-181187
Click to Show/Hide
|
Discontinued in Phase 1 | Compound Info | ||
Synonyms |
WAY-181187; 554403-49-5; UNII-WXE3H7W295; WXE3H7W295; WAY-181,187; WAY 181187; SCHEMBL801436; WAY181187 HCl; GTPL3240; CHEMBL392760; BDBM21358; SAX-187; DTXSID50204011; EX-A799; MolPort-005-933-335; ZINC3816551; AKOS028111927; WAY-181187(SAX-187); KB-81479; FT-0700331; WAY181187.HCl pound WAY-181 187 pound(c); J-690323; N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine; 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine
Click to Show/Hide
|
||||
Activity |
IC50 > 500000 nM
|
[234] | |||
Compound Name |
BMS-269223
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL551991; cyanoguanidine, 3; BMS-269223
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[235] | |||
Compound Name |
BMS-344577
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-344577; UNII-U259PQB19A; U259PQB19A; CHEMBL570867; 288079-93-6; BDBM35316; BDBM50328724; 2,5-Pyridinedicarboxamide, N5-((((3S)-hexahydro-2-oxo-1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-1H-azepin-3-yl)imino)((2-methyl-5-benzofuranyl)amino)methyl)-N2,N2-dimethyl-; 2,5-Pyridinedicarboxamide, N5-((((3S)-hexahydro-2-oxo-1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-1H-azepin-3-yl)amino)((2-methyl-5-benzofuranyl)amino)methylene)-N2,N2-dimethyl-
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[231] | |||
Compound Name |
2-fluoro-5-(3-methylthiophen-2-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
2-fluoro-5-(3-methylthiophen-2-yl)pyridine; CHEMBL179621; 837376-37-1; Pyridine, 2-fluoro-5-(3-methyl-2-thienyl)-; SCHEMBL957977; BDBM12354; CTK3D1374; DTXSID90456895; RYGQGRAICBWYPW-UHFFFAOYSA-N; nicotine 3-heteroaromatic analogue 7; US8609708,10
Click to Show/Hide
|
||||
Activity |
Ki > 400000 nM
|
[157] | |||
Compound Name |
1-[5-(6-Methoxynaphthalen-2-yl)pyridin-3-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL502824; BDBM50272291
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[236] | |||
Compound Name |
4-Allyl-N-benzyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL332690; BDBM50105813; 4-Allyl-N-benzyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[135] | |||
Compound Name |
4-Allyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL333704; BDBM50105828; 4-Allyl-N-methyl-N-(1-phenyl-1H-pyrazole-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[135] | |||
Compound Name |
5-Hydroxy saxagliptin
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
UNII-PB91NV4HAN; PB91NV4HAN; Saxagliptin analogue 28; Saxagliptin metabolite M2; CHEMBL3350936; SCHEMBL13096265; BDBM11543; M2 saxagliptin hydroxylated metabolite; BMS 510849; (S)-3,5-Dihydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile TFA salt
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[4] | |||
Compound Name |
(5-Pyridin-3-ylthiophen-2-yl)methanamine;(5-pyridin-3-ylthiophen-2-yl)methanimine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL178681
Click to Show/Hide
|
||||
Activity |
IC50 = 208000 nM
|
[36] | |||
Compound Name |
2-[[2-(3,4-Dichlorophenoxy)phenyl]methylsulfinyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043240; SCHEMBL1195480; BDBM50386200
Click to Show/Hide
|
||||
Activity |
IC50 = 216000 nM
|
[237] | |||
Compound Name |
Pyridine, 3-(4-methyl-1H-imidazol-1-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL178781; SCHEMBL3617491; 3-(4-methylimidazol-1-yl)pyridine; BDBM50158922; 3-(4-Methyl-imidazol-1-yl)-pyridine
Click to Show/Hide
|
||||
Activity |
IC50 > 300000 nM
|
[36] | |||
Compound Name |
3,3'-Bipyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3,3'-Bipyridyl; 3,3'-Dipyridyl; [3,3']Bipyridinyl; 3-pyridin-3-ylpyridine; UNII-7B4E4PPN49; 7B4E4PPN49; CHEMBL179763; 3,3'-Dipyridine; CCRIS 3427; EINECS 209-466-1; 3,3'-Diphridyl; 3-(3-pyridyl)pyridine; ChemDiv3_000071; 3-(pyridin-3-yl)pyridine; [3,3'''']Bipyridinyl; MLS000084686; SCHEMBL120088; CTK1H3030; DTXSID80206821; HMS1473D05; HMS2388I13; ZINC262514; BDBM50158918; MFCD00006371; AKOS006282824; MCULE-2048309802; IDI1_019389; KS-000012B8; NCGC00043241-02; AC-20964; AS-56903; SMR000019033; 3,3 inverted exclamation mark(R)-bipyridine; B3984; EU-0066981; US8609708, 30; Q222984; SR-01000390733; J-511054; SR-01000390733-1
Click to Show/Hide
|
||||
Activity |
IC50 > 300000 nM
|
[36] | |||
Compound Name |
3-(2-Methyl-1H-imidazol-1-yl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL368883; Pyridine, 3-(2-methyl-1H-imidazol-1-yl)-; 3-(2-methylimidazol-1-yl)pyridine; SCHEMBL3609259; BDBM12356; CTK3D1370; DTXSID90586500; cid_16654686; nicotine 3-heteroaromatic analogue 9; ZINC13607175; AKOS033848776; MLS-0091920.0001; US8609708,13; Z2284398422
Click to Show/Hide
|
||||
Activity |
Ki > 300000 nM
|
[157] | |||
Compound Name |
2-(4-{[(2S)-8-Methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl}piperazin-1-yl)-quinoline-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL551964; SCHEMBL5912876; BDBM50295052
Click to Show/Hide
|
||||
Activity |
IC50 = 358000 nM
|
[238] | |||
Compound Name |
(NZ)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL178330; SCHEMBL13035362
Click to Show/Hide
|
||||
Activity |
IC50 = 398000 nM
|
[36] | |||
Compound Name |
Pyridine, 2-fluoro-5-(4-methyl-3-thienyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL425519; 2-fluoro-5-(4-methylthiophen-3-yl)pyridine; SCHEMBL3613490; BDBM50158927; 2-Fluoro-5-(4-methyl-thiophen-3-yl)-pyridine; US8609708, 45
Click to Show/Hide
|
||||
Activity |
IC50 > 400000 nM
|
[36] | |||
Compound Name |
Dimethyl[3-(pyridin-3-yl)prop-2-yn-1-yl]amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL180270; 2-Propyn-1-amine, N,N-dimethyl-3-(3-pyridinyl)-; SCHEMBL3619456; BDBM12350; nicotine 3-heteroaromatic analogue 3c; N,N-dimethyl-3-pyridin-3-ylprop-2-yn-1-amine; US8609708, 76; N,N-Dimethyl-3-(3-pyridinyl)-2-propyne-1-amine; N,N-dimethyl-3-(pyridin-3-yl)prop-2-yn-1-amine
Click to Show/Hide
|
||||
Activity |
Ki > 400000 nM
|
[157] | |||
Compound Name |
3-(Pyridin-3-yl)propan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(3-PYRIDYL)PROPYLAMINE; 3-PYRIDINEPROPANAMINE; 3-PYRIDIN-3-YLPROPAN-1-AMINE; 3-PYRIDIN-3-YL-PROPYLAMINE; MFCD09886637; 3-(3-PYRIDINYL)-1-PROPANAMINE; 3-pyridylpropylamine; 3-pyridine propanamine; 3-Pyridine-1-propanamine; 3-(3-pyridinyl)propanamine; CHEMBL385023; SCHEMBL1188053; BDBM12369; KS-00000DVE; DTXSID50543790; 3-(pyridine-3-yl)propan-1-amine; (3-PYRIDIN-3-YLPROPYL)AMINE; ZINC11570838; AKOS005216860; nicotine 3-heteroaromatic analogue 30; AB54556; MCULE-1632771311; (3-pyridin-3-ylpropyl)amine AldrichCPR; (3-pyridin-3-ylpropyl)amine, AldrichCPR; AK105794; AS-32159; SC-49861; SY022422; X2118; Y-5938
Click to Show/Hide
|
||||
Activity |
Ki > 400000 nM
|
[157] | |||
Compound Name |
3-Methyl-4-phenylthiophene
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Thiophene, 3-methyl-4-phenyl-; CHEMBL215183; SCHEMBL3609702; BDBM12365; nicotine 3-heteroaromatic analogue 24
Click to Show/Hide
|
||||
Activity |
Ki > 400000 nM
|
[157] | |||
Compound Name |
Pyridine, 2-fluoro-5-(3-thienyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL179005; 2-fluoro-5-thiophen-3-yl-pyridine; SCHEMBL3601434; 2-Fluoro-5-(3-thienyl)pyridine; 2-fluoro-5-thiophen-3-ylpyridine; BDBM50158913; 2-fluoro-5-(thiophen-3-yl)pyridine; US8609708, 28
Click to Show/Hide
|
||||
Activity |
IC50 > 400000 nM
|
[36] | |||
Compound Name |
2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL168471; SCHEMBL3913553; BDBM50124010; ZINC13493521
Click to Show/Hide
|
||||
Activity |
IC50 = 492000 nM
|
[239] | |||
Compound Name |
(5R)-3-[3-Fluoro-4-(1-oxidotetrahydro-2H-thiopyran-4-yl)phenyl]-2-oxo-1,3-oxazolidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-00422602; CHEMBL437955; SCHEMBL3038620; SCHEMBL3038621; SCHEMBL3043361; CHEMBL2062151; BDBM50226483
Click to Show/Hide
|
||||
Activity |
IC50 > 900000 nM
|
[240] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71. | ||||
REF 2 | Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure. J Med Chem. 2017 Jun 22;60(12):5146-5161. | ||||
REF 3 | Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem. 2008 Sep 25;51(18):5843-55 | ||||
REF 4 | Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human. Drug Metab Dispos. 2012 Jul;40(7):1345-56. | ||||
REF 5 | A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions. J Med Chem. 2000 Jul 27;43(15):2789-96. | ||||
REF 6 | Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors. J Med Chem. 2004 Feb 12;47(4):907-14. | ||||
REF 7 | Discovery of novel highly potent hepatitis C virus NS5A inhibitor (AV4025). J Med Chem. 2014 Sep 25;57(18):7716-30. | ||||
REF 8 | 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture. J Med Chem. 2017 Jul 13;60(13):5424-5437. | ||||
REF 9 | Discovery and Assessment of Atropisomers of (?-Lesinurad. ACS Med Chem Lett. 2017 Feb 14;8(3):299-303. | ||||
REF 10 | Aryl thiosemicarbazones for the treatment of trypanosomatidic infections. Eur J Med Chem. 2018 Feb 25;146:423-434. | ||||
REF 11 | In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Drug Metab Dispos. 2013 Feb;41(2):353-61. | ||||
REF 12 | Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. J Med Chem. 2013 Jun 27;56(12):4899-911. | ||||
REF 13 | Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic. J Med Chem. 2011 Dec 22;54(24):8305-20. | ||||
REF 14 | Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. | ||||
REF 15 | VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem. 2013 Apr 15;21(8):2241-2249. | ||||
REF 16 | Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain. ACS Med Chem Lett. 2017 Nov 30;8(12):1309-1313. | ||||
REF 17 | Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2017 Feb 9;60(3):913-927. | ||||
REF 18 | Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6031-5. | ||||
REF 19 | Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634. J Med Chem. 2014 Nov 26;57(22):9323-42. | ||||
REF 20 | Lead optimization of a novel series of imidazo[1,2-a]pyridine amides leading to a clinical candidate (Q203) as a multi- and extensively-drug-resistant anti-tuberculosis agent. J Med Chem. 2014 Jun 26;57(12):5293-305. | ||||
REF 21 | Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate. J Med Chem. 2009 Feb 26;52(4):1180-9. | ||||
REF 22 | Pyridyl-2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists: synthesis, pharmacokinetics, and in vivo potency. J Med Chem. 2012 Jan 26;55(2):783-96. | ||||
REF 23 | Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61(4):1425-1435. | ||||
REF 24 | Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600. | ||||
REF 25 | Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. | ||||
REF 26 | Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine. J Med Chem. 2009 Apr 9;52(7):1828-44. | ||||
REF 27 | Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. J Med Chem. 2017 Dec 14;60(23):9617-9629. | ||||
REF 28 | Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulators. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4331-4335. | ||||
REF 29 | Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist. J Med Chem. 2010 Dec 9;53(23):8228-40. | ||||
REF 30 | Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3234-7. | ||||
REF 31 | Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1655-9. | ||||
REF 32 | 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. J Med Chem. 1997 Oct 24;40(22):3494-6. | ||||
REF 33 | Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. | ||||
REF 34 | Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. | ||||
REF 35 | Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. | ||||
REF 36 | 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39. | ||||
REF 37 | Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. | ||||
REF 38 | 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J Med Chem. 1999 Jan 28;42(2):202-5. | ||||
REF 39 | Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1). Bioorg Med Chem Lett. 2009 Jun 1;19(11):2924-7. | ||||
REF 40 | Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. | ||||
REF 41 | Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15. | ||||
REF 42 | In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. | ||||
REF 43 | Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1681-4. | ||||
REF 44 | Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors. ACS Med Chem Lett. 2015 Jan 25;6(3):359-62. | ||||
REF 45 | Design, synthesis and structure-activity relationship of simple bis-amides as potent inhibitors of GlyT1. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5533-6. | ||||
REF 46 | Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds. Bioorg Med Chem Lett. 2015 Feb 1;25(3):581-6. | ||||
REF 47 | The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2622-6. | ||||
REF 48 | US patent application no. 9481673B2, 6-alkynyl-pyridine derivatives | ||||
REF 49 | Azaindoles as potent CRTH2 receptor antagonists. Bioorg Med Chem Lett. 2011 Jan 15;21(2):841-5. | ||||
REF 50 | Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6. | ||||
REF 51 | US patent application no. 9290459B1, Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | ||||
REF 52 | Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors. J Med Chem. 2014 Jun 26;57(12):5179-89. | ||||
REF 53 | Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles. J Med Chem. 2014 Dec 26;57(24):10424-42. | ||||
REF 54 | Ligand-based design of a potent and selective inhibitor of cytochrome P450 2C19. J Med Chem. 2012 Feb 9;55(3):1205-14. | ||||
REF 55 | Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3203-7. | ||||
REF 56 | US patent application no. 9453031B2, Chemical entities | ||||
REF 57 | Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. J Med Chem. 2015 Oct 22;58(20):8054-65. | ||||
REF 58 | 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3390-4. | ||||
REF 59 | 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem. 2012 Apr 12;55(7):2945-59. | ||||
REF 60 | US patent application no. 9428492B2, Secondary alcohol substituted triazoles as PDE10 inhibitors | ||||
REF 61 | Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists. J Med Chem. 2004 May 20;47(11):2776-95. | ||||
REF 62 | Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors. J Med Chem. 2017 May 11;60(9):3594-3605. | ||||
REF 63 | Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-5. | ||||
REF 64 | Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24. | ||||
REF 65 | The discovery of diazepinone-based 5-HT3 receptor partial agonists. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2578-81. | ||||
REF 66 | US patent application no. 8575157B2, Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. | ||||
REF 67 | Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5713-7 | ||||
REF 68 | Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Dec 13;61(23):10619-10634. | ||||
REF 69 | Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566. | ||||
REF 70 | Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a -Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease. J Med Chem. 2018 Jan 11;61(1):396-402. | ||||
REF 71 | Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75. | ||||
REF 72 | Characterization of type II ligands in CYP2C9 and CYP3A4. J Med Chem. 2008 Mar 27;51(6):1755-63. | ||||
REF 73 | Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. J Med Chem. 2015 Mar 12;58(5):2530-7. | ||||
REF 74 | Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3372-5. | ||||
REF 75 | Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1134-40. | ||||
REF 76 | Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na v 1.7 inhibitors with pain efficacy in mice. Bioorg Med Chem Lett. 2017 May 15;27(10):2087-2093. | ||||
REF 77 | [1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55(3):1127-36. | ||||
REF 78 | Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents. Eur J Med Chem. 2017 Sep 8;137:96-107. | ||||
REF 79 | Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. J Med Chem. 2013 Oct 24;56(20):7788-803. | ||||
REF 80 | 2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design. J Med Chem. 2018 Apr 26;61(8):3370-3388. | ||||
REF 81 | US patent application no. 8592410B2, Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 | ||||
REF 82 | Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett. 2015 May 7;6(7):747-52. | ||||
REF 83 | Quinazoline derivatives as selective CYP1B1 inhibitors. Eur J Med Chem. 2017 Apr 21;130:320-327. | ||||
REF 84 | SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR Inhibitor. ACS Med Chem Lett. 2015 Nov 4;7(1):23-7. | ||||
REF 85 | Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors. J Med Chem. 2017 Apr 27;60(8):3352-3371. | ||||
REF 86 | Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51. Bioorg Med Chem. 2018 Jul 23;26(12):3242-3253. | ||||
REF 87 | Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. | ||||
REF 88 | Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5092-7. | ||||
REF 89 | Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents. ACS Med Chem Lett. 2016 Dec 6;8(1):96-101. | ||||
REF 90 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
REF 91 | New indole amide derivatives as potent CRTH2 receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3471-4. | ||||
REF 92 | Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel. J Med Chem. 2004 Dec 2;47(25):6363-72. | ||||
REF 93 | Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide. Eur J Med Chem. 2016 Nov 29;124:1069-1080. | ||||
REF 94 | Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6053-6. | ||||
REF 95 | Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1. J Med Chem. 2010 May 13;53(9):3502-16. | ||||
REF 96 | US patent application no. 9242943B2, 1,4 oxazines as BACE1 and/or BACE2 inhibitors | ||||
REF 97 | Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition. J Med Chem. 2018 Aug 23;61(16):7065-7086. | ||||
REF 98 | Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11 hydroxysteroid dehydrogenase type 1 inhibitor. Bioorg Med Chem. 2017 Jul 15;25(14):3649-3657. | ||||
REF 99 | A novel series of benzimidazole NR2B-selective NMDA receptor antagonists. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2620-3. | ||||
REF 100 | Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome. J Med Chem. 2017 Feb 9;60(3):972-986. | ||||
REF 101 | Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation. J Med Chem. 2018 Jul 12;61(13):5609-5622. | ||||
REF 102 | Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B. J Med Chem. 2013 Oct 24;56(20):8163-82. | ||||
REF 103 | (7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists. ACS Med Chem Lett. 2014 Nov 25;5(12):1334-9. | ||||
REF 104 | Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors. J Med Chem. 2014 Mar 27;57(6):2683-91. | ||||
REF 105 | Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists. ACS Med Chem Lett. 2015 Dec 30;7(2):192-7. | ||||
REF 106 | Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA. J Med Chem. 2014 Feb 27;57(4):1276-88. | ||||
REF 107 | Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy. Eur J Med Chem. 2018 Mar 25;148:140-153. | ||||
REF 108 | Identification of second-generation P2X3 antagonists for treatment of pain. Bioorg Med Chem Lett. 2018 May 1;28(8):1392-1396. | ||||
REF 109 | Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem. 2012 Oct 1;20(19):5864-83. | ||||
REF 110 | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6705-11. | ||||
REF 111 | Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain. Bioorg Med Chem. 2015 Aug 1;23(15):4624-4637. | ||||
REF 112 | Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37. | ||||
REF 113 | 1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists. J Med Chem. 2016 Sep 22;59(18):8549-76. | ||||
REF 114 | Discovery of a Novel Class of Survival Motor Neuron 2 Splicing Modifiers for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 May 25;60(10):4444-4457. | ||||
REF 115 | Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1933-6 | ||||
REF 116 | Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(7):2433-46. | ||||
REF 117 | 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. | ||||
REF 118 | Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. | ||||
REF 119 | Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. | ||||
REF 120 | 3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors. ACS Med Chem Lett. 2014 Feb 4;5(4):428-33. | ||||
REF 121 | ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. J Med Chem. 2012 Jan 12;55(1):515-27. | ||||
REF 122 | Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem. 2011 Jun 23;54(12):4092-108. | ||||
REF 123 | Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J Med Chem. 2017 Apr 13;60(7):2983-2992. | ||||
REF 124 | Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia. ACS Med Chem Lett. 2010 Dec 8;2(2):171-6. | ||||
REF 125 | Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. | ||||
REF 126 | Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1036-40. | ||||
REF 127 | Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2055-2060. | ||||
REF 128 | Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4660-4. | ||||
REF 129 | Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists. Bioorg Med Chem Lett. 2011 Oct 1;21(19):6013-8. | ||||
REF 130 | Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels. Bioorg Med Chem. 2014 Dec 15;22(24):6899-907. | ||||
REF 131 | Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem. 2010 Oct 14;53(19):7129-39. | ||||
REF 132 | Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem. 2011 Apr 14;54(7):2409-21. | ||||
REF 133 | Discovery of an irreversible HCV NS5B polymerase inhibitor. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6585-7. | ||||
REF 134 | Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorg Med Chem Lett. 2016 May 1;26(9):2339-43. | ||||
REF 135 | Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. J Med Chem. 2001 Oct 25;44(22):3622-31. | ||||
REF 136 | Synthesis and biological evaluation of alpha-sulfonamido-N-adamantanecarboxamide derivatives as 11beta-HSD1 inhibitors. Medchemcomm. 2015;6:1360-9. | ||||
REF 137 | Discovery of novel biaryl heterocyclic EP1 receptor antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2666-71. | ||||
REF 138 | Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2735-8. | ||||
REF 139 | Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties. J Med Chem. 2007 Jan 25;50(2):254-63. | ||||
REF 140 | Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability. Bioorg Med Chem. 2015 Aug 1;23(15):4638-4648. | ||||
REF 141 | Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. J Med Chem. 2015 Mar 26;58(6):2809-20. | ||||
REF 142 | Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6228-33. | ||||
REF 143 | Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors. ACS Med Chem Lett. 2016 Jan 20;7(3):324-9. | ||||
REF 144 | N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy. J Med Chem. 2009 Feb 12;52(3):709-17. | ||||
REF 145 | Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90. | ||||
REF 146 | Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity. Eur J Med Chem. 2018 Oct 5;158:832-52. | ||||
REF 147 | Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7. | ||||
REF 148 | Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses. J Med Chem. 2016 Feb 11;59(3):1003-20. | ||||
REF 149 | Novel Series of Dihydropyridinone P2X7 Receptor Antagonists. J Med Chem. 2015 Nov 12;58(21):8413-26. | ||||
REF 150 | Inhibitors of c-Jun N-terminal kinases: an update. J Med Chem. 2015 Jan 8;58(1):72-95. | ||||
REF 151 | Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. | ||||
REF 152 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
REF 153 | Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. | ||||
REF 154 | Synthesis and evaluation of non-dimeric HCV NS5A inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2031-4. | ||||
REF 155 | Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4286-90. | ||||
REF 156 | The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. Bioorg Med Chem Lett. 2012 May 15;22(10):3531-4. | ||||
REF 157 | Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. | ||||
REF 158 | Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17-HSD1. J Med Chem. 2012 Mar 8;55(5):2469-73. | ||||
REF 159 | Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs). Bioorg Med Chem Lett. 2009 Dec 1;19(23):6813-7. | ||||
REF 160 | Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J Med Chem. 2009 May 14;52(9):3047-62. | ||||
REF 161 | Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem. 2014 Feb 27;57(4):1299-322. | ||||
REF 162 | Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I). J Med Chem. 2015 Apr 9;58(7):3060-82. | ||||
REF 163 | Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8. | ||||
REF 164 | Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus. J Med Chem. 2018 Feb 8;61(3):934-945. | ||||
REF 165 | US patent application no. 8754227B2, Metalloenzyme inhibitor compounds | ||||
REF 166 | Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3664-8. | ||||
REF 167 | Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models. J Med Chem. 2010 Nov 11;53(21):7739-55. | ||||
REF 168 | Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss. J Med Chem. 2018 Jan 11;61(1):84-97. | ||||
REF 169 | Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication. J Med Chem. 2013 Oct 24;56(20):8049-65. | ||||
REF 170 | Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning. ACS Med Chem Lett. 2014 Jan 22;5(4):309-14. | ||||
REF 171 | Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles. Bioorg Med Chem. 2018 Dec 1;26(22):5780-5791. | ||||
REF 172 | p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. J Med Chem. 2009 Oct 22;52(20):6257-69. | ||||
REF 173 | Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). ACS Med Chem Lett. 2015 May 19;6(7):736-40. | ||||
REF 174 | Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2067-72. | ||||
REF 175 | Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3072-6. | ||||
REF 176 | Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective 3 adrenergic receptor agonists for the treatment of overactive bladder. J Med Chem. 2014 Feb 27;57(4):1437-53. | ||||
REF 177 | Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5310-5. | ||||
REF 178 | Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. J Med Chem. 2011 Oct 27;54(20):7408-16. | ||||
REF 179 | Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem. 2011 Oct 27;54(20):7334-49. | ||||
REF 180 | US patent application no. 9221791B2, Metalloenzyme inhibitor compounds | ||||
REF 181 | Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors. J Med Chem. 2008 Feb 28;51(4):861-74. | ||||
REF 182 | US patent application no. 9006242B2, Substituted benzene compounds | ||||
REF 183 | Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues. J Med Chem. 2008 Dec 25;51(24):8000-11. | ||||
REF 184 | Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4281-5. | ||||
REF 185 | Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5. | ||||
REF 186 | Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem. 2007 Aug 9;50(16):3851-6. | ||||
REF 187 | Synthesis and evaluation of novel potent HCV NS5A inhibitors. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4864-8. | ||||
REF 188 | HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3323-6. | ||||
REF 189 | Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem. 2005 Sep 8;48(18):5705-20. | ||||
REF 190 | Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs). Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6. | ||||
REF 191 | Design and optimization of highly-selective fungal CYP51 inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8. | ||||
REF 192 | Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. J Med Chem. 2011 Aug 11;54(15):5562-75. | ||||
REF 193 | Discovery of Vibegron: A Potent and Selective 3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder. J Med Chem. 2016 Jan 28;59(2):609-23. | ||||
REF 194 | Development of new cyclic plasmin inhibitors with excellent potency and selectivity. J Med Chem. 2013 Feb 14;56(3):820-31. | ||||
REF 195 | The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6429-36. | ||||
REF 196 | Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond. J Med Chem. 2018 Feb 8;61(3):818-833. | ||||
REF 197 | 3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1980-4. | ||||
REF 198 | Synthesis and Biological Evaluation of Novel Olean-28,13-lactams as Potential Antiprostate Cancer Agents. J Med Chem. 2015 Jun 11;58(11):4506-20. | ||||
REF 199 | 4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists. J Med Chem. 2007 Dec 27;50(26):6706-17. | ||||
REF 200 | Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4767-71. | ||||
REF 201 | Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91. | ||||
REF 202 | Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Drug Metab Dispos. 2012 Sep;40(9):1686-97. | ||||
REF 203 | Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6269-73. | ||||
REF 204 | Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate. J Med Chem. 2009 Jul 23;52(14):4091-4. | ||||
REF 205 | Nocathiacin analogs: Synthesis and antibacterial activity of novel water-soluble amides. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3531-5. | ||||
REF 206 | Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1448-52. | ||||
REF 207 | Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1686-1692. | ||||
REF 208 | Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4713-8. | ||||
REF 209 | Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180). J Med Chem. 2007 Nov 29;50(24):5890-3. | ||||
REF 210 | Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease. J Med Chem. 2013 Dec 27;56(24):9934-54. | ||||
REF 211 | Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. Eur J Med Chem. 2017 Sep 29;138:1147-1157. | ||||
REF 212 | Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. | ||||
REF 213 | New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties. Bioorg Med Chem Lett. 2004 Jan 19;14(2):549-52. | ||||
REF 214 | In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses. J Med Chem. 2018 Feb 8;61(3):1074-1085. | ||||
REF 215 | The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6. | ||||
REF 216 | Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects. Eur J Med Chem. 2018 Feb 10;145:790-804. | ||||
REF 217 | Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP 4 receptor partial agonist for the treatment of pain. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1892-1896. | ||||
REF 218 | Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as alpha7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. J Med Chem. 2014 May 22;57(10):3966-83. | ||||
REF 219 | Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3163-7. | ||||
REF 220 | Adamantyl carboxamides and acetamides as potent human 11-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorg Med Chem. 2012 Nov 1;20(21):6394-402. | ||||
REF 221 | Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6387-93. | ||||
REF 222 | Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5314-20. | ||||
REF 223 | Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition. Bioorg Med Chem Lett. 2012 May 15;22(10):3560-3. | ||||
REF 224 | Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. J Med Chem. 2015 Nov 12;58(21):8513-28. | ||||
REF 225 | Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1432-5. | ||||
REF 226 | Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease. J Med Chem. 2014 Sep 25;57(18):7731-57. | ||||
REF 227 | Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. J Med Chem. 2003 Dec 4;46(25):5416-27. | ||||
REF 228 | First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain. J Med Chem. 2012 Apr 12;55(7):3488-501. | ||||
REF 229 | Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP 2 Receptor Antagonist for Treatment of Asthma. ACS Med Chem Lett. 2017 Apr 25;8(5):582-586. | ||||
REF 230 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. | ||||
REF 231 | Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. | ||||
REF 232 | Wake-promoting agents: search for next generation modafinil: part II. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2315-7. | ||||
REF 233 | Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARalpha Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. | ||||
REF 234 | Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. J Med Chem. 2007 Nov 15;50(23):5535-8. | ||||
REF 235 | Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. | ||||
REF 236 | Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. | ||||
REF 237 | Wake-promoting agents: search for next generation modafinil: part IV. Eur J Med Chem. 2012 Aug;54:949-51. | ||||
REF 238 | Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. J Med Chem. 2009 Aug 13;52(15):4955-9. | ||||
REF 239 | Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem. 2003 Feb 27;46(5):868-71. | ||||
REF 240 | Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound. J Med Chem. 2007 Nov 29;50(24):5886-9. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.