Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ADRA1A --- HRH1 | (11-Chloro-2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine | Drug Info |
| CABL --- CD135 | ENMD-2076 | Drug Info |
| CABL --- FGFR1 | compound 8h | Drug Info |
| CAI --- CAIX | 1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide | Drug Info |
| Aurora --- VEGFR | 7-(5-methoxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | (R)-N-(5-(2-hydroxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide | Drug Info |
| AuroraA --- STK1 | N-3-fluorophenyl-2-3-7-3-2-hydroxyethyl-methyl-amino-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-acetamide | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)-6-methyl-phenyl]-1H-pyrrolo-[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylmethylsulfonamido)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | CHEMBL384054 | Drug Info |
| AuroraA --- STK1 | 3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo-[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole | Drug Info |
| AuroraA --- STK1 | (Z)-N-[2-Oxo-3-({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | (+/-)-N-{1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-3-piperidinyl}benzamide | Drug Info |
| B1R --- B2R | 4-(1-Benzyl-2-phenyl-ethylamino)-N,N-bis-(3-dimethylamino-propyl)-3-nitro-benzenesulfonamide | Drug Info |
| Beta PDGFR --- CABL | 1-{2-[(Cyclohexyl-methyl-amino)-methyl]-phenyl}-3-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-urea | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Aminomethyl-phenyl)-2-fluoro-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((isobutyl(piperidin-3-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-(3-methylpyridin-4-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(1-propylpiperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | AR-C102222 | Drug Info |
| BNOS --- Hepatocyte NOS | rac-N-(1-(Pyrrolidin-3-yl)indolin-6-yl)thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1801504 | Drug Info |
| BNOS --- Hepatocyte NOS | Azocan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Nitro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-azetidine-2-carboximidamide | Drug Info |
| 5HT1a --- SERT | 6-((1-(2-(6-fluoro-2-methylquinolin-5-yloxy)ethyl)piperidin-4-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | Drug Info |
| 5HT1a --- SERT | 6-((1-(2-(7-chloro-2-methylquinolin-5-yloxy)ethyl)piperidin-4-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | Drug Info |
| 5HT1a --- SERT | 6-{2-[2-Hydroxy-3-(1H-indol-4-yloxy)-propylamino]-propoxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1b --- SERT | (+/-)-(2-(1-(3,4-dichlorophenyl)ethyl)phenyl)-N,N-dimethylmethanamine | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}butoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-4-(2-phenylethyl)-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | SID170465966 | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-cyano-4-(2-cyano-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| CABL --- Ckit | PD-0166326 | Drug Info |
| CABL --- PI3K gamma | PP121 | Drug Info |
| Aurora --- Chk | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-[4-(4-morpholinyl)phenyl]acetamide | Drug Info |
| Aurora --- VEGFR | 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile | Drug Info |
| AuroraA --- STK1 | (R)-tert-butyl 1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)piperidin-3-ylcarbamate | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | ALISERTIB | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(pyrrolidin-1-ylsulfonyl)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | (Z)-Ethyl 3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate | Drug Info |
| AuroraA --- STK1 | (Z)-3-(2-{[5-(Morpholinosulfonyl)-2-oxoindolin-3-ylidene]-methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | 4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1Hpyrazol-4-yl]-N-[2-(4-methyl-1-piperazinyl)ethyl]-1H-pyrrolo-[2,3-b]pyridine-2-carboxamide | Drug Info |
| B1R --- B2R | Lys-Lys-[deltaPhe7] Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(2-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Ethyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
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