Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Aurora --- Chk | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-[4-(4-morpholinyl)phenyl]acetamide | Drug Info |
| Aurora --- VEGFR | 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile | Drug Info |
| AuroraA --- STK1 | (R)-tert-butyl 1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)piperidin-3-ylcarbamate | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | ALISERTIB | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(pyrrolidin-1-ylsulfonyl)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | (Z)-Ethyl 3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoate | Drug Info |
| AuroraA --- STK1 | (Z)-3-(2-{[5-(Morpholinosulfonyl)-2-oxoindolin-3-ylidene]-methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | 4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1Hpyrazol-4-yl]-N-[2-(4-methyl-1-piperazinyl)ethyl]-1H-pyrrolo-[2,3-b]pyridine-2-carboxamide | Drug Info |
| B1R --- B2R | Lys-Lys-[deltaPhe7] Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(2-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Ethyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL112866 | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Cyanophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)-methyl)-4-methylthiazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-difluoro-4-(((2-methylbenzyl)(pyrazin-2-yl)amino)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (4S,4aS,5S)-4-Methyl-octahydro-quinolin-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-(2,3,3a,9b-Tetrahydro-1H-cyclopenta[c]quinolin-4-yl)amine | Drug Info |
| BNOS --- Hepatocyte NOS | N-[4-(Acetimidoylamino-methyl)-phenyl]-acetamidine | Drug Info |
| CABL --- CD135 | 5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid {4-[3-(4-methyl-piperazin-1-yl)-propyl]-phenyl}-amide | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Quinolin-8-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-((2S,4S)-4-(4-methoxybenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(4,6-Dimethyl-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | (2-(3,4-dichlorobenzyl)phenyl)-N,N-dimethylmethanamine | Drug Info |
| AChE --- NMDA | 1-Methyl-9-[9-(1-methyl-beta-carboline-9-yl)nonyl]-beta-carboline | Drug Info |
| ADRA1A --- HRH1 | Amitriptyline | Drug Info |
| ADRA1A --- HRH1 | CHEMBL1620822 | Drug Info |
| ADRA1A --- HRH1 | Pipamazine | Drug Info |
| CABL --- DNPK1 | PP121 | Drug Info |
| CABL --- VEGFR1 | AAL-993 | Drug Info |
| Aurora --- GSK | 1-Methyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| AuroraA --- CDK4 | 7-3-methoxyphenyl-N-4-4-methylpiperazin-1-yl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}urea | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-5-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-2,3-difluorophenyl-2-3-7-3-4-hydroxypiperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-acetamide | Drug Info |
| AuroraA --- STK1 | 8-(3-methylisothiazol-5-ylamino)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine-6-carbonitrile | Drug Info |
| AuroraA --- STK1 | N-(4-(1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | BARASERTIB | Drug Info |
| AuroraA --- STK1 | N-[3-[(3-Fluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 2,9-Dihydro-3-methylpyrazolo[4,3:4,5]cyclopenta[1,2-b]indole | Drug Info |
| CDK1 --- Cyclin E | compound 18 | Drug Info |
| Beta PDGFR --- Ckit | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-bromo-phenyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 4,5-Dimethyl-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-Benzyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-((4-methoxypyridin-2-yl)methylthio)-3H-imidazo[4,5-b]pyridine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Methyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Methyl-piperidin-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
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