Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ADRA1A --- HRH1 | 2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| CABL --- FGFR1 | NVP-TAE684 | Drug Info |
| CAI --- CAIX | Decane-1,10-diyl disulfamate | Drug Info |
| Aurora --- VEGFR | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | Drug Info |
| AuroraA --- STK1 | N-(3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-Ethyl-2-[3-(4-{[(phenylamino)carbonyl]amino}phenyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]acetamide | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-4-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-{4-[1-(1,1-Dimethylethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-5-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | 2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)-N-phenylthiazole-4-carboxamide | Drug Info |
| AuroraA --- STK1 | CHEMBL202198 | Drug Info |
| AuroraA --- STK1 | N-(3-{4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)acetamide | Drug Info |
| B-Raf --- MEK | Dimethyl-carbamic acid 3-(4-fluoro-benzyl)-2-oxo-4-propyl-2H-chromen-7-yl ester | Drug Info |
| Beta PDGFR --- CABL | N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| Beta PDGFR --- FGFR1 | 4-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1800526 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(3-trifluoromethyl-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(3-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Aminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1221607 | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(benzofuran-5-ylmethyl)propane-1,3-diamine | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(4-Chloro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | N-((4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)-3-(1H-indol-3-yl)propan-1-amine | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one oxime | Drug Info |
| 5HT1b --- SERT | (1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide | Drug Info |
| 5LOX --- HRH1 | 1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-yl)-but-3-ynyl]-N-hydroxy-urea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-[3-(dimethylamino)propyl]-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine | Drug Info |
| ADRA1A --- HRH1 | SID49679166 | Drug Info |
| CABL --- Ckit | Imatinib | Drug Info |
| CABL --- MCSF | Sorafenib | Drug Info |
| CAI --- CAIX | 7-AMINO-4-METHYL-CHROMEN-2-ONE | Drug Info |
| Aurora --- VEGFR | 5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoic acid | Drug Info |
| AuroraA --- STK1 | N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenyl}urea | Drug Info |
| AuroraA --- STK1 | 2-(1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| AuroraA --- STK1 | 2-(4-(6-chloro-2-(4-(dimethylamino)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | 2,5,6,10,12-Pentahydro-3,8,8-trimethyl-9-oxopyrazolo[4,3:6,7]cyclohepta[1,2-b]pyrrolo[3,2-f]indole | Drug Info |
| AuroraA --- STK1 | N-(4-{1-Ethyl-4-[2-({[3-(4-methyl-1-piperazinyl)propyl]amino}-methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N-(4-(morpholinosulfonyl)phenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL373013 | Drug Info |
| AuroraA --- STK1 | N,N-dimethyl-1-(4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)methanamine | Drug Info |
| B1R --- B2R | Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | 1-(4-(6,7-dimethoxyquinazolin-4-yloxy)benzyl)-3-(3-methoxyphenyl)urea | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-(aminomethyl)benzyl)acetimidamide | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Methylaminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-{1-[2-(3H-imidazol-4-yl)-ethyl]-piperidin-4-ylamino}-benzothiazol-6-yl)-thiophene-2-carboxamidine | Drug Info |
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