Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 6-Propyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(1-(2-(2-Hydroxyethylamino)ethyl)indolin-6-yl)thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Chloro-3-(4-methyl-piperazin-1-ylmethyl)-3H-benzooxazol-2-one | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-difluoro-4-(((2-fluorobenzyl)(pyrazin-2-yl)amino)methyl)quinolin-2(1H)-one | Drug Info |
| CAI --- CAIX | 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(4,6-Dimethoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(6-Methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | 3-(3,4-Diacetyl-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| 5LOX --- HRH1 | 1-(4-{4-[2-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidin-1-yl)ethoxy]phenyl}but-3-yn-1-yl)-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | DROPERIDOL | Drug Info |
| ADRA1A --- HRH1 | CHEMBL2068762 | Drug Info |
| ADRA1A --- HRH1 | 2-({(2R)-1-[4-(4-{[3-(Hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-4-[(4-hydroxyphenyl)methyl]-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | PD-0173956 | Drug Info |
| CABL --- MCSF | Sunitinib | Drug Info |
| CAI --- CAIX | Zonisamide | Drug Info |
| Aurora --- VEGFR | N-(4-(benzo[d]thiazol-2-yl)phenyl)-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-((4-(methylsulfonyl)piperazin-1-yl)methyl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(3-(1H-pyrazol-4-yl)-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(3-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(piperidin-4-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | (Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}indolin-2-one | Drug Info |
| AuroraA --- STK1 | N-(6-(ethylthio)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-methylbutyl)acetamide | Drug Info |
| AuroraA --- STK1 | 5-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)-N-phenylthiophene-2-carboxamide | Drug Info |
| AuroraA --- STK1 | 3-(8-oxa-5-azaspiro[3.5]nonan-5-ylmethyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| B1R --- B2R | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Pro(4-0-n-Propyl)-pro(2,3-dihexyl)-arg | Drug Info |
| Beta PDGFR --- CD135 | CHEMBL1940272 | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(4-hydroxy-phenyl)-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((isopropyl(piperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 2-((azepan-4-yl(methyl)amino)methyl)-4-chlorobenzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 6-Isopropyl-4-methyl-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Butyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | SID56462977 | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-Chloro-7-[2-(3-chloro-benzylamino)-ethyl]-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | SID11113814 | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{4-[2-(4-Dimethylamino-piperidin-1-yl)-ethoxy]-naphthalen-1-yl}-pyridin-2-ylamine | Drug Info |
| 5HT1a --- SERT | 1-phenyl-3-(4-(pyrimidin-2-yl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1a --- SERT | [2-(5-Fluoro-2-methoxy-phenoxy)-ethyl]-[2-(1H-indol-3-yl)-ethyl]-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(4-isopropoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1b --- SERT | N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N-methylamine | Drug Info |
| AChE --- NMDA | SID124882535 | Drug Info |
| ADRA1A --- HRH1 | N-((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)-3-methylbenzamide | Drug Info |
| ADRA1A --- HRH1 | 7-[3-(4-Benzhydryl-piperidin-1-yl)-propyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; compound with (E)-but-2-enedioic acid | Drug Info |
| ADRA1A --- HRH1 | 2,8-dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| CABL --- Ckit | Sunitinib | Drug Info |
| CABL --- TEK | WYE-130600 | Drug Info |
| Aurora --- GSK | 4-[4-(3-Hydroxy-adamantan-1-ylamino)-5-nitro-pyrimidin-2-ylamino]-benzoic acid | Drug Info |
| AuroraA --- CDK4 | N-4-4-methylpiperazin-1-yl-phenyl-7-3-methylsulfonyl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | PHA-680632 | Drug Info |
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