Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 3-(2-Acetimidoylamino-phenyl)-2-amino-propionic acid | Drug Info |
| CAI --- CAIX | 1,2-pyrone | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Naphthalen-1-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2R,4S)-4-(4-Methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-benzofuran-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Quinolin-5-yloxy)-ethyl]-piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1b --- SERT | (3,4-dichlorophenyl)(2-((dimethylamino)methyl)phenyl)methanone | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | (-)-Thioridazine | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | 1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1-yl}-4-phenyl-butan-1-one | Drug Info |
| CABL --- CD135 | Sorafenib | Drug Info |
| CABL --- MCSF | AAL-993 | Drug Info |
| CAI --- CAIX | Ethoxzolamide | Drug Info |
| Aurora --- VEGFR | 7-(5-(3-(4-ethylpiperazin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | ZM-447439 | Drug Info |
| AuroraA --- STK1 | N,N-dimethyl-1-(3-(4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)phenyl)methanamine | Drug Info |
| AuroraA --- STK1 | CHEMBL201297 | Drug Info |
| AuroraA --- STK1 | N-{4-[1-(2,3-Dihydroxypropyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | (Z)-3-(2-{[5-(Indolin-1-ylsulfonyl)-2-oxoindolin-3-ylidene]-methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | 2-[({2-[(7-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetyl)amino]benzamide | Drug Info |
| AuroraA --- STK1 | N-(3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-(methylsulfonyl)piperidin-4-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(pyridin-3-yl)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| B1R --- B2R | CHEMBL446325 | Drug Info |
| Beta PDGFR --- CD135 | CHEMBL1940268 | Drug Info |
| BNOS --- Hepatocyte NOS | N-(1-(Tetrahydro-2H-thiopyran-4-yl)indolin-6-yl)thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Methyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-difluoro-4-((pyrazin-2-yl(pyridin-2-ylmethyl)amino)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 8-Fluoro-4-((2-isobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1194697 | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-[4-(2-Amino-ethyl)-phenyl]-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-phenyl-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(2-Oxo-3-o-tolyl-2,3-dihydro-oxazol-4-yl)-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(5-methoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | [3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2-methoxy-phenoxy)-ethyl]-amine | Drug Info |
| 5HT1a --- SERT | [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1b --- SERT | 4'-Carbamimidoyl-2'-methyl-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| AChE --- COX | SID11111897 | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Methylphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | SID26749206 | Drug Info |
| ADRA1A --- HRH1 | OLANZAPINE_2-HYDROXYMETHYL METABOLITE | Drug Info |
| CABL --- Ckit | AZD0530 | Drug Info |
| CABL --- STK1 | VX-680 | Drug Info |
| Aurora --- GSK | 4-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)benzoic acid | Drug Info |
| AuroraA --- CD135 | N1-3-[5-(2-Methyl-6-[(3-morpholinopropyl)amino]-4-pyrimidinylamino)-1H-3-pyrazolyl]phenyl-1-benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | N-{4-[1-(3-Hydroxypropyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | (Z)-N-Methyl-3-(4-oxo-2-{[2-oxo-5-(phenylsulfonamido)-indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)-propanamide | Drug Info |
| AuroraA --- STK1 | (R)-4-(4-methylpiperazin-1-yl)-N-(5-(2-phenylpropanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide | Drug Info |
| AuroraA --- STK1 | tert-butyl 4-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-ylthio)phenylcarbamate | Drug Info |
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