Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| AuroraA --- STK1 | N-(6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-phenoxybenzamide | Drug Info |
| AuroraA --- STK1 | 1-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-3-m-tolylurea | Drug Info |
| AuroraA --- STK1 | N-(4-{4-[2-({[2-(Dimethylamino)ethyl]amino}methyl)-1Hpyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl}phenyl)-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpyrimidin-2-ylthio)phenyl)acetamide | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(piperidin-1-ylsulfonyl)indolin-3-ylidene]methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide | Drug Info |
| CDK1 --- CDK4 | Purvalanol A | Drug Info |
| Beta PDGFR --- CD135 | (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | [1,3]Thiazinan-(2E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((benzyl(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclopentylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide | Drug Info |
| BNOS --- Hepatocyte NOS | Octahydro-isoindol-(1Z)-ylideneamine | Drug Info |
| CABL --- PKCA | N-(3-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[(1R,3S,5S)-3-(4-methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-(4-(6-fluorobenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 2-((4-(5-fluoro-1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-8-methoxy-4-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine | Drug Info |
| 5HT1b --- SERT | (S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine | Drug Info |
| A3AR --- ADRA1A | CHEMBL1625779 | Drug Info |
| ADRA1A --- HRH1 | cis-(-)-7,8-dimethoxy-3-[4-(2-methyl-3-(4-fluoro)phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole | Drug Info |
| ADRA1A --- HRH1 | SID144207521 | Drug Info |
| ADRA1A --- HRH1 | N-(((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)methyl)-3,4-difluorobenzamide | Drug Info |
| CABL --- Ckit | AAL-993 | Drug Info |
| CABL --- STK1 | ENMD-2076 | Drug Info |
| Aurora --- GSK | 2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine | Drug Info |
| AuroraA --- ALK5 | 6-(3-Amino-1H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine | Drug Info |
| AuroraA --- STK1 | N-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | (+/-)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-(1-morpholinopropyl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | N-[3-[(4,4-Difluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | 6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(5-chloro-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | 4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine | Drug Info |
| Beta PDGFR --- CABL | 1-(3-(dimethylamino)phenyl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 7-(2-Ethyl-butyl)-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | SID50107209 | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Pyrrolidin-1-yl-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-cyclohexyloxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Benzyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)ethyl)-N2-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-methylethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
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