Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | (4R,5S)-5-Ethyl-4-methyl-selenazolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-5,6,7,8-tetrahydro-naphthalen-1-yl}-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(2-isopropyl-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Aminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)-methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-isobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)-methyl)quinolin-2(1H)-one | Drug Info |
| CAI --- CAIX | 6,7-Dimethoxy1-(4'-methylphenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide | Drug Info |
| 5HT1a --- SERT | [2-(1H-Indol-4-yloxy)-ethyl]-[3-(1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1a --- SERT | 3-(1H-indol-3-yl)-N-((4-isopropyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)propan-1-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-((2S,4R)-4-(benzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(4-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}butoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | N-[4-(4-Dimethylamino-quinazolin-2-ylamino)-cyclohexyl]-2,3,4-trifluoro-benzamide | Drug Info |
| ADRA1A --- HRH1 | (R)-2-((1-(4-(4-(3-(azepan-1-yl)propoxy)phenyl)butyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one | Drug Info |
| ADRA1A --- HRH1 | 1-(3-chlorophenyl)-3-(piperidin-2-ylmethyl)imidazolidin-2-one | Drug Info |
| ADRA1A --- HRH1 | 2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| CABL --- FGFR1 | NVP-TAE684 | Drug Info |
| CAI --- CAIX | Decane-1,10-diyl disulfamate | Drug Info |
| Aurora --- VEGFR | N-(2-methoxyethyl)-6-(7-methoxyquinolin-4-yloxy)-1-naphthamide | Drug Info |
| AuroraA --- STK1 | N-(3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-Ethyl-2-[3-(4-{[(phenylamino)carbonyl]amino}phenyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]acetamide | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-4-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-{4-[1-(1,1-Dimethylethyl)-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-5-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | 2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)-N-phenylthiazole-4-carboxamide | Drug Info |
| AuroraA --- STK1 | CHEMBL202198 | Drug Info |
| AuroraA --- STK1 | N-(3-{4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)acetamide | Drug Info |
| B-Raf --- MEK | Dimethyl-carbamic acid 3-(4-fluoro-benzyl)-2-oxo-4-propyl-2H-chromen-7-yl ester | Drug Info |
| Beta PDGFR --- CABL | N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| Beta PDGFR --- FGFR1 | 4-hydroxy-3-(1-methyl-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1800526 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(3-trifluoromethyl-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(3-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(1-Methyl-pyrrolidin-2-ylmethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-(((1-(cyclopropylmethyl)piperidin-4-yl)(methyl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1221607 | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(benzofuran-5-ylmethyl)propane-1,3-diamine | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(4-Chloro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | N-((4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)-3-(1H-indol-3-yl)propan-1-amine | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one oxime | Drug Info |
| 5HT1b --- SERT | (1R)-1-(2-((S)-4-(6-fluoronaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide | Drug Info |
| 5LOX --- HRH1 | 1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-yl)-but-3-ynyl]-N-hydroxy-urea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-[3-(dimethylamino)propyl]-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | methyl(3-{tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9(14),10,12-hexaen-1-yl}propyl)amine | Drug Info |
| ADRA1A --- HRH1 | SID49679166 | Drug Info |
| CABL --- Ckit | Imatinib | Drug Info |
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