Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | (3aR,9bS)-7-[(3-Chloro-benzylamino)-methyl]-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(3-methoxy-phenyl)-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(3,3-Difluorocyclobutyl)-1H-imidazo[4,5-b]pyrazin-1-yl)-methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-propylpropane-1,3-diamine | Drug Info |
| CAI --- CAIX | 4-{4-[2-(1,4-oxazinan-4-yl)ethylamino(thioxo)methylamino]phenylsulfonamido}-1-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(4-Methoxy-benzo[b]thiophen-2-yl)-2,2-dimethyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 1-phenyl-3-(4-(pyrimidin-2-yl)piperazin-1-yl)propan-1-one | Drug Info |
| 5HT1a --- SERT | [3-(1H-Indol-3-yl)-propyl]-[2-(naphthalen-1-yloxy)-ethyl]-amine | Drug Info |
| 5HT1b --- SERT | 6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(3-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}propoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-1,2-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-cyano-4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | 7-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 2HCl | Drug Info |
| ADRA1A --- HRH1 | SID124880667 | Drug Info |
| CABL --- CD135 | compound 8h | Drug Info |
| CABL --- MCSF | Imatinib | Drug Info |
| CAI --- CAIX | BENZOLAMIDE | Drug Info |
| Aurora --- VEGFR | 7-(5-(2-(piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | N-(6-(4-fluorophenylthio)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 1-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| AuroraA --- STK1 | CHEMBL216053 | Drug Info |
| AuroraA --- STK1 | 6-Methyl-N-[3-[[(2,2,3,3,3-pentafluoropropyl)amino]methyl]-5-isothiazolyl]-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | CHEMBL215322 | Drug Info |
| AuroraA --- STK1 | (+/-)-3-methyl-N-(6-(methylsulfinyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | (8-(3-methylisothiazol-5-ylamino)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-6-yl)(pyrrolidin-1-yl)methanone | Drug Info |
| AuroraA --- STK1 | N-{(3R,5R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}-N,3,3-trimethylbutanamide | Drug Info |
| B1R --- B2R | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Pro(4-O-methyl)-pro(2,3-dibenzo)-arg | Drug Info |
| Beta PDGFR --- CABL | 4-methyl-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-1-methyl-1H-imidazole-5-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-isobutyl-1H-benzo[d]imidazol-1-yl)methyl)-quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-3,5-dimethylisoxazole-4-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Hydroxyaminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | (3R)-((1,2,3,4-tetrahydroisoquinolin-6-yloxy)methyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-methoxy-2-(methylthiomethyl)pyridine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorobenzyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-2-methylnicotinamide | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-6-Methyl-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(5-Chloro-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-4-(6-methoxybenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-((1-(2-(8-chloro-2-methylquinolin-5-yloxy)ethyl)piperidin-4-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | Drug Info |
| 5HT1b --- SERT | (1R)-1-(2-((S)-4-(6-cyanonaphthalen-1-yl)-2-methylpiperazin-1-yl)ethyl)-1,3,7,7a-tetrahydroisobenzofuran-5-carboxamide | Drug Info |
| ABL --- FGFR | 3-(4-(1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-1,2,3-triazol-1-yl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| ADRA1A --- HRH1 | SID104171359 | Drug Info |
| ADRA1A --- HRH1 | 2-Ethyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene | Drug Info |
| ADRA1A --- HRH1 | 2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione | Drug Info |
| CABL --- Ckit | PHA-739358 | Drug Info |
| CABL --- STK1 | Dasatinib | Drug Info |
| Aurora --- GSK | 4-(3-Adamantan-1-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)-benzoic acid | Drug Info |
| AuroraA --- CD135 | N1-[3-(5-[6-(4-Hydroxypiperidino)-2-methyl-4-pyrimidinyl]amino-1H-3-pyrazolyl)phenyl]-1-benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | 3-fluoro-N-({2-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}methyl)-benzamide | Drug Info |
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