Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-cyclohexyloxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Benzyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)ethyl)-N2-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-methylethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| CAI --- CAIX | SID144212483 | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(5-Chloro-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5LOX --- HRH1 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-tetrahydro-furan-2-yl)-but-3-ynyl]-N-hydroxyurea | Drug Info |
| AChE --- NMDA | CHEMBL50608 | Drug Info |
| ADRA1A --- HRH1 | (8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| ADRA1A --- HRH1 | 3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide | Drug Info |
| ADRA1A --- HRH1 | SID170465934 | Drug Info |
| CABL --- FGFR1 | PHA848125 | Drug Info |
| CABL --- VEGFR1 | compound 8h | Drug Info |
| Aurora --- VEGFR | 7-(1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | (Z)-N-(3-{[3-(3-Morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}-2-oxoindolin-5-yl)benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | (R)-N-(5-(2-fluoro-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide | Drug Info |
| AuroraA --- STK1 | 6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[(3,3,4,4-tetrafluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 3-methyl-N-(6-(morpholinomethyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (R)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-N-phenylpiperidine-3-carboxamide | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(3-(7-(3-((2-hydroxyethyl)(propyl)amino)propoxy)-6-methoxyquinazolin-4-ylamino)-1H-pyrazol-5-yl)acetamide | Drug Info |
| B1R --- B2R | H-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH (JMV1639) | Drug Info |
| Beta PDGFR --- CABL | (E)-4-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)benzamide | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-(4-methylthiazol-5-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Isopropyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | Azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Carbamimidoylsulfanylmethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-N-(1-(2-(3-Hydroxypyrrolidin-1-yl)ethyl)indolin-6-yl)-thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | SID11111542 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-ethylpyridin-2-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Methyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-chloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Trifluoromethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| 5HT1a --- SERT | 4-{(S)-2-Hydroxy-3-[(2R,4R)-4-(4-methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-propoxy}-1H-indole-2-carboxylic acid amide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-isopropoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4S)-4-(4-Methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-hydroxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| 5LOX --- HRH1 | 1-(4-{4-[3-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidin-1-yl)propoxy]phenyl}but-3-yn-1-yl)-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(3,4-Difluorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | Dimethyl-[(2S,3aR)-1-(2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-yl)methyl]-amine | Drug Info |
| ADRA1A --- HRH1 | Esmirtazapine | Drug Info |
| CABL --- CD135 | VX-680 | Drug Info |
| CABL --- FGFR1 | PHA-665752 | Drug Info |
| CAI --- CAIX | 2-cyclohexylamido-5-sulfonamidoindane | Drug Info |
| Aurora --- GSK | 3-(4-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)phenyl)propanoic acid | Drug Info |
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