Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ADRA1A --- HRH1 | Dimethyl-[(2S,3aR)-1-(2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-yl)methyl]-amine | Drug Info |
| ADRA1A --- HRH1 | Esmirtazapine | Drug Info |
| CABL --- CD135 | VX-680 | Drug Info |
| CABL --- FGFR1 | PHA-665752 | Drug Info |
| CAI --- CAIX | 2-cyclohexylamido-5-sulfonamidoindane | Drug Info |
| Aurora --- VEGFR | 7-(1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | (Z)-N-(3-{[3-(3-Morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}-2-oxoindolin-5-yl)benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | (R)-N-(5-(2-fluoro-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide | Drug Info |
| AuroraA --- STK1 | 6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[(3,3,4,4-tetrafluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 3-methyl-N-(6-(morpholinomethyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (R)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-N-phenylpiperidine-3-carboxamide | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(3-(7-(3-((2-hydroxyethyl)(propyl)amino)propoxy)-6-methoxyquinazolin-4-ylamino)-1H-pyrazol-5-yl)acetamide | Drug Info |
| B1R --- B2R | H-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH (JMV1639) | Drug Info |
| Beta PDGFR --- CABL | (E)-4-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)benzamide | Drug Info |
| BNOS --- Hepatocyte NOS | 7,8-Difluoro-4-((2-(4-methylthiazol-5-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Isopropyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | Azepan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Carbamimidoylsulfanylmethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-N-(1-(2-(3-Hydroxypyrrolidin-1-yl)ethyl)indolin-6-yl)-thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | SID11111542 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-ethylpyridin-2-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Methyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-chloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-Trifluoromethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| 5HT1a --- SERT | 4-{(S)-2-Hydroxy-3-[(2R,4R)-4-(4-methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-propoxy}-1H-indole-2-carboxylic acid amide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-isopropoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 1-(4-methoxyphenyl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1b --- SERT | Methanesulfonic acid 4-{[2'-methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carbonyl]-amino}-2-(4-methyl-piperazin-1-yl)-phenyl ester | Drug Info |
| A3AR --- ADRA1A | [3H]8-OH-DPAT | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-(1-methyl-4-piperidinyl)-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 2-({(2R)-1-[4-(4-{[3-(Hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-4-{[4-(methyloxy)phenyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 4-{[3-(Methyloxy)phenyl]methyl}-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | ENMD-2076 | Drug Info |
| CABL --- STK1 | PHA-739358 | Drug Info |
| Aurora --- GSK | 3-(4-(3-phenyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ylamino)phenyl)propanoic acid | Drug Info |
| AuroraA --- ALK5 | 6-(2-Amino-6-methyl-4-pyrimidinyl)-1H-indazol-3-amine | Drug Info |
| AuroraA --- STK1 | 3-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| AuroraA --- STK1 | 3-(((2S,5S)-2,5-dimethylmorpholino)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 4-Chloro-N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| AuroraA --- STK1 | CHEMBL215022 | Drug Info |
| AuroraA --- STK1 | N-[3-[(3-Fluoro-1-azetidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Trifluoroacetate | Drug Info |
| AuroraA --- STK1 | 3-methyl-N-(3-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 3-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| CDK1 --- Cyclin E | SNS-032 | Drug Info |
| Beta PDGFR --- Ckit | N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalazin-6-yl)-benzo[d]isoxazol-3-amine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)isobutyramide | Drug Info |
| BNOS --- Hepatocyte NOS | (S)-4-chloro-2-((isobutyl(1-methylpiperidin-3-yl)amino)methyl)benzonitrile | Drug Info |
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