Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 2-(2-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)pyrrolidin-1-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylethanamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((isobutyl(piperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 2,7-dinitro-2H-indazole | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(2-Bromo-phenyl)-2-ethyl-isothiourea | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(3,3-Difluorocyclobutyl)-1H-imidazo[4,5-b]pyrazin-1-yl)-methyl)-8-fluoroquinolin-2(1H)-one | Drug Info |
| CABL --- PKCA | N-(3-chlorophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[4-(5-Fluoro-3-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-phenyl-propan-1-one oxime | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- CD243 | Isoconazole | Drug Info |
| ADRA1A --- HRH1 | N-((cis)-4-(4-(dimethylamino)-5-methylpyrimidin-2-ylamino)cyclohexyl)-4-fluorobenzamide | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 3-[4-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-butyl]-1H-indole-5-carboxylic acid amide | Drug Info |
| CABL --- FGFR1 | PD-0166326 | Drug Info |
| CAI --- CAIX | 4-(Carbamolymethylthio)pyridine-3-sulfonamide | Drug Info |
| Aurora --- VEGFR | 4-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| AuroraA --- CDK4 | 7-cyclohexyl-N-4-morpholinophenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-styryl-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-ethyl-4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)piperazine-1-carboxamide | Drug Info |
| AuroraA --- STK1 | 1-cyclohexyl-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | N-[3-(dimethylamino)phenyl]-2-{2-[(7-{3-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide | Drug Info |
| AuroraA --- STK1 | (Z)-N-[3-({3-[3-(Diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-2-oxoindolin-5-yl]benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | (Z)-3-(4-Oxo-2-{[2-oxo-5-(phenylsulfonamido)indolin-3-ylidene]-methyl}-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | 4-(2-(4-(2-(4-Acetylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)-N-(2-chlorophenyl)benzamide | Drug Info |
| AuroraA --- STK1 | 1-phenyl-N-(3-styryl-1H-indazol-5-yl)methanesulfonamide | Drug Info |
| Beta PDGFR --- CABL | 4-fluoro-N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-chloro-pyridin-3-yl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-{[3-(1-Imino-ethyl)-benzylamino]-methyl}-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Ethyl-4-methyl-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Methyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyrimidin-5-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 5,6,7,8-tetrahydro-6-(D-threo-1,2-dihydroxypropyl)pterin | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL354516 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclohexyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 8-Fluoro-4-((2-(4-methylthiazol-5-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 3-(2-Acetimidoylamino-phenyl)-2-amino-propionic acid | Drug Info |
| CAI --- CAIX | 1,2-pyrone | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Naphthalen-1-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2R,4S)-4-(4-Methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-benzofuran-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Quinolin-5-yloxy)-ethyl]-piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1b --- SERT | (3,4-dichlorophenyl)(2-((dimethylamino)methyl)phenyl)methanone | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | (-)-Thioridazine | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | 1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1-yl}-4-phenyl-butan-1-one | Drug Info |
| CABL --- CD135 | Sorafenib | Drug Info |
| CABL --- MCSF | AAL-993 | Drug Info |
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