Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-bromo-5-chlorobenzyl)-N,1-dimethylpiperidin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(thiazol-2-ylmethyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-omega-nitro-L-arginine | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1221659 | Drug Info |
| BNOS --- Hepatocyte NOS | 7-NITROINDAZOLE | Drug Info |
| CAI --- CAIX | 4-{4-[4-sulfamoylphenethylamino(thioxo)methylamino]phenylsulfonamidomethyl}-1-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(4-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | [3-(1H-Indol-3-yl)-propyl]-[2-(quinolin-8-yloxy)-ethyl]-amine | Drug Info |
| 5HT1a --- SERT | [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-[3-(1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1b --- SERT | ((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-(2-quinoxalin-6-yl-ethyl)-amine | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | 4-[(3-Methylphenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-[2-(dimethylamino)ethyl]-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-[(1-methyl-3-pyrrolidinyl)methyl]-1(2H)-phthalazinone | Drug Info |
| CABL --- CD135 | Sunitinib | Drug Info |
| CABL --- MCSF | Dasatinib | Drug Info |
| CAI --- CAIX | 4-(2-Propynylthio)pyridine-3-sulfonamide | Drug Info |
| Aurora --- VEGFR | 7-(5-(3-hydroxypropoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | N-(5-butyl-1,3-thiazol-2-yl)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL382054 | Drug Info |
| AuroraA --- STK1 | N-(6-(tert-butylthio)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(Phenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo-[2,3-b]pyridin-2-yl]phenyl}acetamide | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-phenylpyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 6-Methyl-N-[3-(1-piperidinylmethyl)-5-isothiazolyl]-3-(1Hpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 4-[1-Ethyl-3-(4-{[(phenylamino)carbonyl]amino}phenyl)-1Hpyrazol-4-yl]-N-[2-(4-morpholinyl)ethyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide | Drug Info |
| AuroraA --- STK1 | 7,7-Dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-6-oxo-1H-imidazo[4,5-f]indole | Drug Info |
| B1R --- B2R | D-Arg-[Hyp3, D-NMF7, L-NMF8] Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | CHEMBL1940269 | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(piperidin-3-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | SID11111337 | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-8-Chloro-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Pentyl-4-trifluoromethyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4,4-Dimethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-7-[3-(3-Chloro-benzylamino)-propyl]-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Butyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-p-tolyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-3-methylpicolinamide | Drug Info |
| 5HT1a --- SERT | 2-{1-[(S)-2-Hydroxy-3-(1H-indol-4-yloxy)-propyl]-piperidin-4-yl}-benzo[b]thiophen-6-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(3a,7a-Dihydro-1H-indol-4-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(4-nitrophenyl)propan-1-ol | Drug Info |
| 5HT1b --- SERT | SID396188 | Drug Info |
| AChE --- NMDA | CHEMBL1198977 | Drug Info |
| ADRA1A --- HRH1 | 4-chloro-N-((cis)-4-(4-(dimethylamino)-6-methylpyrimidin-2-ylamino)cyclohexyl)benzamide | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)methyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 11-(piperazin-1-yl)-5H-benzo[e]imidazo[1,2-a]azepine | Drug Info |
| CABL --- Ckit | Dasatinib | Drug Info |
| CABL --- TEK | NVP-TAE684 | Drug Info |
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