Target Validation Information
Target ID T20401
Target Name Carbonic anhydrase II
Target Type
Successful
Drug Potency against Target MAFENIDE Drug Info Ki = 170 nM [1]
4,6-Dinitro salicylic acid Drug Info Ki = 5450 nM [2]
2-methoxyestradiol 3,17-O,O-bis-sulfamate Drug Info IC50 = 379 nM [3]
EMATE Drug Info IC50 = 42 nM [4]
4-(2-Phenylacetamidomethyl)benzenesulfonamide Drug Info Ki = 54 nM [5]
(2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate Drug Info Ki = 1020 nM [6]
CATECHIN Drug Info Ki = 1840 nM [7]
Octane-1,8-diyl disulfamate Drug Info Ki = 14.6 nM [8]
Decyl sulfamate Drug Info Ki = 0.7 nM [8]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide Drug Info Ki = 94.4 nM [9]
4-Ethoxy-3-pyridinesulfonamide Drug Info Ki = 76.7 nM [9]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide Drug Info Ki = 140 nM [9]
4-(Quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 105 nM [9]
5-Amino-[1,3,4]thiadiazole-2-thiol Drug Info Ki = 9200 nM [10]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide Drug Info Ki = 84.5 nM [9]
2-methoxyestradiol-17-O-sulfamate Drug Info IC50 = 526 nM [3]
2-methoxyestrrone-3-O-sulfamate Drug Info IC50 = 376 nM [3]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide Drug Info Ki = 16 nM [11]
4-isothiocyanatobenzenesulfonamide Drug Info Ki = 185 nM [12]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 87 nM [13]
5-amino-1,3,4-thiadiazole-2-sulfonamide Drug Info Ki = 7400 nM [14]
Azide Drug Info Ki = 1.5 nM [15]
Phenyl Boronic acid Drug Info Ki = 23.1 nM [15]
Phenoxyarsonous acid Drug Info Ki = 49.2 nM [15]
2,6-di-t-butylphenol Drug Info Ki = 510 nM [16]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info Ki = 106 nM [17]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide Drug Info Ki = 77 nM [18]
MMI270 Drug Info Ki = 8600 nM [19]
2,4-Disulfamyltrifluoromethylaniline Drug Info Ki = 63 nM [20]
SULFAMIDE Drug Info Ki = 1.13 nM [15]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide Drug Info Ki = 33 nM [20]
3-phenylprop-1-enylboronic acid Drug Info Ki = 18100 nM [21]
Di(2,6-dimethylphenol) Drug Info Ki = 4050 nM [16]
PHENYLDIFLUOROMETHANESULFONAMIDE Drug Info Ki = 156 nM [22]
Di(2,6-diisopropylphenol) Drug Info Ki = 1870 nM [16]
PHENYLSULFAMIDE Drug Info Ki = 8020 nM [6]
4-phenoxyphenylboronic acid Drug Info Ki = 11500 nM [21]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 46 nM [20]
Phenethylboronic acid Drug Info Ki = 17900 nM [21]
5-Chlorosalicylic Acid Drug Info Ki = 1270 nM [2]
3-Nitro-benzenesulfonamide Drug Info IC50 = 410 nM [23]
SULFAMATE Drug Info Ki = 0.39 nM [15]
PARAOXON Drug Info IC50 = 59 nM [24]
PHENOL Drug Info Ki = 5500 nM [7]
N-hydroxysulfamide Drug Info Ki = 566 nM [25]
4-bromophenylboronic acid Drug Info Ki = 7000 nM [21]
GUAIACOL Drug Info Ki = 2940 nM [16]
1-pentenyl-4-(aminosulfonyl)benzoate Drug Info Ki = 7.7 nM [26]
2-acetamido-5-sulfonamidoindane Drug Info Ki = 1 nM [27]
BENZOLAMIDE Drug Info Ki = 9 nM [20]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide Drug Info Ki = 701.8 nM [28]
BUTYLATEDHYDROXYTOLUENE Drug Info Ki = 630 nM [16]
4-Hydrazino-3-pyridinesulfonamide Drug Info Ki = 85.6 nM [9]
P-TOLUENESULFONAMIDE Drug Info Ki = 320 nM [20]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide Drug Info Ki = 8800 nM [10]
3-(4-sulfamoylphenyl)propanoic acid Drug Info Ki = 495 nM [20]
4-Amino-3-bromo-benzenesulfonamide Drug Info Ki = 40 nM [20]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide Drug Info Ki = 230 nM [29]
2-Amino-benzenesulfonamide Drug Info Ki = 295 nM [20]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide Drug Info Ki = 80.4 nM [9]
IODIDE Drug Info Ki = 26 nM [15]
NITRATE Drug Info Ki = 35 nM [15]
P-tolylboronic acid Drug Info Ki = 10800 nM [21]
N-(pentafluorophenyl)sulfamide Drug Info Ki = 32 nM [30]
2-Acetylamino-indan-5-sulfonic acid hydrate Drug Info Ki = 65 nM [31]
Biphenyl-4-ylboronic acid Drug Info Ki = 4500 nM [21]
1-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 490 nM [27]
1-valproylamido-5-sulfonamidoindane Drug Info Ki = 1.2 nM [27]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 950 nM [32]
2-ethylamido-5-sulfonamidoindane Drug Info Ki = 10 nM [27]
4-butylphenylboronic acid Drug Info Ki = 8700 nM [21]
1-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 32 nM [27]
4-((benzylideneamino)methyl)benzenesulfonamide Drug Info Ki = 38.5 nM [28]
4-(2-Propynylthio)pyridine-3-sulfonamide Drug Info Ki = 108 nM [9]
N-(4-cyanophenyl)sulfamide Drug Info Ki = 16 nM [30]
3-Fluoro-4-hydrazino-benzenesulfonamide Drug Info Ki = 51 nM [33]
4-Hydrazino-benzenesulfonamide Drug Info Ki = 300 nM [34]
(4-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 98 nM [22]
Sulfamic acid 3-sulfamoyloxy-phenyl ester Drug Info Ki = 9.4 nM [35]
SACCHARIN Drug Info Ki = 5959 nM [36]
PHENYLMETHANESULFONAMIDE Drug Info Ki = 645 nM [22]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester Drug Info Ki = 84.2 nM [35]
2-Sulfamoyl-benzoic acid methyl ester Drug Info Ki = 420 nM [33]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide Drug Info Ki = 58 nM [5]
2-(benzylideneamino)ethanesulfonamide Drug Info Ki = 160 nM [28]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 13400 nM [37]
2-Amino-indan-5-sulfonic acid Drug Info Ki = 84 nM [31]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide Drug Info Ki = 53 nM [5]
4-Benzythiopyridine-3-sulfonamide Drug Info Ki = 9.9 nM [9]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide Drug Info Ki = 264 nM [33]
N-(4-Sulfamoyl-phenyl)-isobutyramide Drug Info Ki = 258 nM [29]
3-Chloro-4-hydrazino-benzenesulfonamide Drug Info Ki = 76 nM [33]
3-bromophenyl-difluoromethanesulfonamide Drug Info Ki = 565 nM [22]
Sulfamic acid 6-sulfamoyloxy-hexyl ester Drug Info Ki = 8.3 nM [35]
4-methyl-2-oxo-2H-chromen-7-yl sulfamate Drug Info Ki = 25 nM [22]
4-(Allylamino)-3-pyridinesulfonamide Drug Info Ki = 133 nM [9]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester Drug Info Ki = 643 nM [35]
Allyl 4-(aminosulfonyl)benzoate Drug Info Ki = 8.6 nM [26]
4-(2-Hydroxy-ethyl)-benzenesulfonamide Drug Info Ki = 125 nM [36]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester Drug Info Ki = 563 nM [35]
2-nonylamido-5-sulfonamidoindane Drug Info Ki = 128 nM [27]
4-(2-Phenylacetamidoethyl)benzenesulfonamide Drug Info Ki = 67 nM [5]
4-(Cyanomethylthio)pyridine-3-sulfonamide Drug Info Ki = 91.1 nM [9]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide Drug Info Ki = 74 nM [5]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide Drug Info Ki = 50 nM [5]
2,3-dihydro-1H-indene-5-sulfonamide Drug Info Ki = 52 nM [31]
4-(benzylideneamino)benzenesulfonamide Drug Info Ki = 21.4 nM [28]
Methyl 4-(4-hydroxybenzylideneamino)benzoate Drug Info Ki = 141.5 nM [28]
4-(4-hydroxybenzylideneamino)benzoic acid Drug Info Ki = 200.5 nM [28]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 870 nM [32]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide Drug Info Ki = 4800 nM [19]
3-((4-aminophenyl)diazenyl)benzenesulfonamide Drug Info Ki = 88 nM [17]
2-(4-hydroxybenzylideneamino)ethanesulfonamide Drug Info Ki = 236 nM [28]
N-[4-(trifluoromethyl)phenyl]sulfamide Drug Info Ki = 7000 nM [30]
Quinoline-8-sulfonamide Drug Info Ki = 125 nM [38]
4-nitrophenylsulfamide Drug Info Ki = 1740 nM [6]
4-(benzylideneamino)benzoic acid Drug Info Ki = 123.2 nM [28]
N-1,3,4-thiadiazol-2-ylsulfamide Drug Info Ki = 970 nM [32]
INDISULAM Drug Info Ki = 15 nM [18]
4-Benzenesulfonylamino-benzenesulfonamide Drug Info Ki = 49 nM [29]
4-Amino-3-fluoro-benzenesulfonamide Drug Info Ki = 60 nM [36]
4-amino-6-chlorobenzene-1,3-disulfonamide Drug Info Ki = 75 nM [36]
2,6-di-tert-butyl-4-methoxyphenol Drug Info Ki = 420 nM [16]
Ethinamate Drug Info IC50 = 0.6~2.5 g/ml [39]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide Drug Info Ki = 100 nM [38]
4-Amino-3-iodo-benzenesulfonamide Drug Info Ki = 70 nM [20]
4-(4-tert-butylbenzylideneamino)benzoic acid Drug Info Ki = 184.5 nM [28]
1,4-phenylene disulfamate Drug Info Ki = 643 nM [38]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide Drug Info Ki = 106 nM [17]
Methyl-phosphonic acid Drug Info Ki = 98 nM [40]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 920 nM [32]
COUMATE Drug Info Ki = 21 nM [41]
6-hydroxybenzo[d][1,3]oxathiol-2-one Drug Info IC50 = 1770 nM [42]
SALICYLATE Drug Info Ki = 7100 nM [43]
N-(1-benzofuran-3-ylmethyl)sulfamide Drug Info IC50 = 7100 nM [44]
2-(4-tert-butylbenzylideneamino)ethanesulfonamide Drug Info Ki = 8.6 nM [28]
Methyl 4-(4-tert-butylbenzylideneamino)benzoate Drug Info Ki = 158.4 nM [28]
PHENYLSULFAMATE Drug Info Ki = 36 nM [6]
4-(N-Methyl-hydrazino)-benzenesulfonamide Drug Info Ki = 300 nM [45]
4-methoxyphenylboronic acid Drug Info Ki = 7900 nM [21]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide Drug Info Ki = 5 nM
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide Drug Info Ki = 31 nM [46]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide Drug Info Ki = 80 nM [18]
4-Nitro-benzenesulfonamide Drug Info IC50 = 400 nM [23]
NSC-654077 Drug Info Ki = 4975 nM [11]
4-nitrophenyl phosphate Drug Info IC50 = 63 nM [24]
6-Nitro-benzothiazole-2-sulfonic acid amide Drug Info IC50 = 250 nM [23]
SPARFOSIC ACID Drug Info Ki = 7800 nM [40]
Phenyl-phosphonic acid Drug Info Ki = 99 nM [40]
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester Drug Info IC50 = 280 nM [47]
Sulfamic acid chroman-2-ylmethyl ester Drug Info IC50 = 130 nM [47]
4-(2-Amino-ethyl)-benzenesulfonamide Drug Info Ki = 160 nM [48]
Decane-1,10-diyl disulfamate Drug Info Ki = 24.5 nM [8]
CHLORIDE Drug Info Ki = 200 nM [15]
Curcumin Drug Info Ki = 380 nM [7]
PARABEN Drug Info Ki = 870 nM [49]
Syringic Acid Drug Info Ki = 3190 nM [49]
P-Coumaric Acid Drug Info Ki = 980 nM [49]
Octyl sulfamate Drug Info Ki = 2.7 nM [8]
4-methoxyphenylsulfamide Drug Info Ki = 18800 nM [6]
3-hydroxy-2-methoxybenzaldehyde Drug Info Ki = 1250 nM [16]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide Drug Info Ki = 27 nM [50]
Di(2,6-di-t-butylphenol) Drug Info Ki = 290 nM [16]
6-Amino-benzothiazole-2-sulfonic acid amide Drug Info Ki = 9 nM [51]
SODIUM PERFLUOROHEXANESULFONAMIDE Drug Info IC50 = 122 nM [52]
4-azidobenzenesulfonamide Drug Info Ki = 47 nM [53]
Sodium trithiocarbonate Drug Info Ki = 8800 nM [54]
4-ethynyl benzene sulfonamide Drug Info Ki = 5.1 nM [55]
N-propynyl amidebenzenesulphonide Drug Info Ki = 47 nM [56]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide Drug Info Ki = 665 nM [17]
PRONTOCIL Drug Info Ki = 13000 nM [17]
FERULIC ACID Drug Info Ki = 2400 nM [49]
3-Amino-benzenesulfonamide Drug Info Ki = 240 nM [57]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Drug Info Ki = 1130 nM [32]
4-(hydroxymethyl)benzenesulfonamide Drug Info Ki = 80 nM [20]
4-Amino-3-chloro-benzenesulfonamide Drug Info Ki = 110 nM [20]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid Drug Info Ki = 9100 nM [37]
RESORCINOL Drug Info Ki = 7700 nM [43]
CATECHOL Drug Info Ki = 9900 nM [49]
4-CYANOPHENOL Drug Info Ki = 108 nM [43]
Beta-naphthylboronic acid Drug Info Ki = 6000 nM [21]
4-Thiocyanato-benzenesulfonamide Drug Info IC50 = 3600 nM [23]
6-Hydroxy-benzothiazole-2-sulfonic acid amide Drug Info Ki = 30 nM [34]
2-hydrazinylbenzenesulfonamide Drug Info Ki = 125 nM [58]
Carzenide Drug Info Ki = 151 nM [26]
4-nitrophenyl-difluoromethanesulfonamide Drug Info Ki = 113 nM [22]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Drug Info Ki = 900 nM [32]
2-oxo-2H-thiochromene-3-carboxylic acid Drug Info Ki = 7800 nM [37]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide Drug Info Ki = 61 nM [5]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide Drug Info Ki = 69 nM [5]
4-(2-Phenylacetamido)benzenesulfonamide Drug Info Ki = 107 nM [5]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide Drug Info Ki = 395 nM [5]
Aminobenzolamide derivative Drug Info Ki = 0.9 nM [59]
ELLAGIC ACID Drug Info Ki = 2180 nM [49]
4-(Carbamolymethylthio)pyridine-3-sulfonamide Drug Info Ki = 131 nM [9]
GALLICACID Drug Info Ki = 2250 nM [49]
Pentanoic acid (4-sulfamoyl-phenyl)-amide Drug Info Ki = 214 nM [29]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide Drug Info Ki = 7.5 nM [31]
ACETYLSULFANILAMIDE Drug Info Ki = 246 nM [29]
4-methylphenyl-difluoromethanesulfonamide Drug Info Ki = 348 nM [22]
4-(Methylhydrazino)-3-pyridinesulfonamide Drug Info Ki = 87.2 nM [9]
2-cyclohexylamido-5-sulfonamidoindane Drug Info Ki = 118 nM [27]
2-butylamido-5-sulfonamidoindane Drug Info Ki = 7.5 nM [27]
2-propylamido-5-sulfonamidoindane Drug Info Ki = 46 nM [27]
2-valproylamido-5-sulfonamidoindane Drug Info Ki = 0.9 nM [27]
1-(3,4-dichlorophenyl)-3-hydroxyurea Drug Info Ki = 310 nM [60]
Prop-2-ynyl 4-sulfamoylbenzoate Drug Info Ki = 45 nM [56]
1-acetamido-5-sulfonamidoindane Drug Info Ki = 186 nM [27]
4-Methanesulfonylamino-benzenesulfonamide Drug Info Ki = 64 nM [29]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide Drug Info Ki = 4700 nM [19]
2-Hydrazinocarbonyl-benzenesulfonamide Drug Info Ki = 338 nM [33]
COUMARIN Drug Info Ki = 9200 nM [61]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide Drug Info Ki = 94.5 nM [9]
Sulfamic acid 7-sulfamoyloxy-heptyl ester Drug Info Ki = 8 nM [35]
(2-bromophenyl)difluoromethanesulfonamide Drug Info Ki = 112 nM [22]
4-Methylthiopyridine-3-sulfonamide Drug Info Ki = 40.1 nM [9]
N-(4-Sulfamoyl-phenyl)-butyramide Drug Info Ki = 227 nM [29]
Sulfamic acid 4-sulfamoyloxy-butyl ester Drug Info Ki = 15 nM [35]
2-pentafluorophenylamido-5-sulfonamidoindane Drug Info Ki = 6.7 nM [27]
6-(aminomethyl)-2H-chromen-2-one Drug Info Ki = 18500 nM [37]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide Drug Info Ki = 6100 nM [19]
2-(benzyloxyamino)-N-hydroxyhexanamide Drug Info Ki = 7800 nM [19]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide Drug Info Ki = 75 nM [29]
4-Methoxy-3-pyridinesulfonamide Drug Info Ki = 93.8 nM [9]
N-(4-Sulfamoyl-phenyl)-benzamide Drug Info Ki = 37 nM [29]
Pentane-1,5-diamine Drug Info Ki = 11000 nM [62]
2,4-dichloro-5-sulfamoylbenzoic acid Drug Info IC50 = 18000 nM [63]
Sodium 2,3,5,6-tetrafluorobenzoate Drug Info Ki = 6000 nM [64]
2-Hydroxycinnamic acid Drug Info Ki = 9200 nM [7]
6-(hydroxymethyl)-2H-chromen-2-one Drug Info Ki = 19200 nM [37]
3-(3-Phenyl-ureido)-benzenesulfonamide Drug Info Ki = 150 nM [29]
N-(4-Sulfamoyl-phenyl)-propionamide Drug Info Ki = 232 nM [29]
Benzothiazole-2-sulfonic acid amide Drug Info Ki = 30 nM [65]
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide Drug Info IC50 = 3700 nM [44]
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide Drug Info IC50 = 8400 nM [44]
4-Methylamino-benzenesulfonamide Drug Info Ki = 240 nM [45]
4,4'-thiodipyridine-3-sulfonamide Drug Info Ki = 65 nM [9]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one Drug Info Ki = 14600 nM [66]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide Drug Info Ki = 133 nM [29]
References
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REF 2Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. Epub 2008 Sep 13.In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
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