Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T20251 | Target Info | |||
Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | ||||
Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Target Type | Successful Target | ||||
Gene Name | KCNH2 | ||||
Biochemical Class | Voltage-gated ion channel | ||||
UniProt ID |
Poor Binders of This Target (in total, 909 binders) | Download | Top | |||
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Compound Name |
Raltegravir
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Approved | Compound Info | ||
Synonyms |
RGV; MK 0518; Isentress(TM); K-0518; MK-0518; Raltegravir (INN); N-(2-(4-(4-fluorobenzylcarbamoyl); N-((4-Fluorophenyl)methyl)-1,6-dihydro-5-hydroxy-1-methyl-2-(1-methyl-1-(((5-methyl-1,3,4-oxadiazol-2-yl)carbonyl)amino)ethyl)-6-oxo-4-pyrimidinecarboxamide; RAL
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Activity |
IC50 ~ 50000 nM
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[1] | |||
Compound Name |
Grepafloxacin
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Approved | Compound Info | ||
Synonyms |
Raxar; Grepafloxacin [INN]; Grepafloxacin (unspecified); Raxar (TN); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
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Activity |
IC50 = 50000 nM
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[2] | |||
Compound Name |
Nifedipine
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Approved | Compound Info | ||
Synonyms |
Adalat; Adalate; Adapine; Adapress; Afeditab; Alat; Aldipin; Alfadal; Alonix; Angipec; Anifed; Anpine; Aprical; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Emaberin; Fedcor; Fenamon; Fenigidin; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; Kordafen; Korinfar; Macorel; Megalat; Myogard; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedicor; Nifedin; Nifedine; Nifedipino; Nifedipinum; Nifedipres; Nifelan; Nifelat; Nifelate; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Sepamit; Tibricol; Vascard; Zenusin; AWD Pharma Brand of Nifedipine; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate LP; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab CR; Alonix S; Aprical long; Bayer Brand of Nifedipine; Chronadalate LP; Coracten XL; Ecodipin E; Fedcor Retard; Fenamon SR; Fortipine LA; KRKA Brand of Nifedipine; Nifedical XL; Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedirex LP; Nifelat Q; Nifensar XL; Orion Brand of Nifedipine; Pfizer Brand of Nifedipine; Procardia XL; Slofedipine XL; Tensipine MR; Adalat 10; Adalat 20; Adalat 5; Adalat GITS 30; Bay1040; N 7634; N1fedilat; Adalat (TN); Afeditab CR (TN); Alpha-Nifedipine Retard;Apo-Nifed; Bay-1040; KB-1712P; Monohydrochloride, Nifedipine; Nifedical (TN); Nifedipine-GTIS; Nifedipino [INN-Spanish]; Nifedipinum [INN-Latin]; Procardia (TN); Bay-a-1040; Nifedipine (JP15/USP/INN); Nifedipine [USAN:BAN:INN:JAN]
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Activity |
IC50 = 50118.72 nM
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[3] | |||
Compound Name |
Dasatinib
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Approved | Compound Info | ||
Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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Activity |
IC50 = 50118.72 nM
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[4] | |||
Compound Name |
Darunavir
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Approved | Compound Info | ||
Synonyms |
206361-99-1; TMC114; Prezista; TMC-114; UIC-94017; Darunavirum; TMC 114; Darunavirum [INN-Latin]; UNII-YO603Y8113; AIDS073035; CHEMBL1323; (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE; CHEBI:367163; Darunavir-d9; YO603Y8113; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate; NCGC00168773-01; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl; Darunavirum; Darunavir [USAN]; UIC 94017; Prezista(TM); UIC-96017; Darunavir (USAN/INN); Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester; {(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; [(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester; N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(330)oct-2-yloxy)carboxamide; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3-((4-aminobenzenesulfonyl)isobutylamino)-1-benzyl-2-hydroxypropyl)carbamic acid hexahydrofuro(2,3-b)furan-3-yl ester; (3R,3aS,6aR)-Hexahydrofuro(2,3-b)furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N1-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate; (3R,3aS,6aR)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
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Activity |
IC50 = 63095.73 nM
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[4] | |||
Compound Name |
Fexofenadine
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Approved | Compound Info | ||
Synonyms |
Carboxyterfenadine; Fexofendine; Terfenadine acid metabolite; Terfenadine carboxylate; F 9427; MDL 16455; Allegra (TN); Fastofen (TN); Fexofenadine (INN); Fexofenadine [INN:BAN]; Telfast (TN); Terfenadine-COOH; Terfenidine carboxylate, MDL 16455; Tilfur (TN); 2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid
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Activity |
IC50 = 65000 nM
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[5] | |||
Compound Name |
Glibenclamide
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Approved | Compound Info | ||
Synonyms |
Abbenclamide; Adiab; Azuglucon; Bastiverit; Benclamin; Betanase; Calabren; Cytagon; Daonil; Debtan; Diabeta; Diabiphage; Dibelet; Duraglucon; Euclamin; Euglucan; Euglucon; Euglykon; Gewaglucon; Gilemal; Glamide; Glibadone; Gliban; Gliben; Glibenbeta; Glibenclamida; Glibenclamidum; Glibenil; Glibens; Glibesyn; Glibet; Glibetic; Glibil; Gliboral; Glicem; Glidiabet; Glimel; Glimide; Glimidstata; Glisulin; Glitisol; Glubate; Gluben; Glucobene; Glucohexal; Glucolon; Glucomid; Glucoremed; Glucoven; Glyben; Glybenclamide; Glybenzcyclamide; Glyburide; Glycolande; Glycomin; Glynase; Hexaglucon; Humedia; Lederglib; Libanil; Lisaglucon; Maninil; Melix; Micronase; Miglucan; Nadib; Neogluconin; Normoglucon; Orabetic; Pira; Praeciglucon; PresTab; Prodiabet; Renabetic; Sugril; Suraben; Tiabet; Yuglucon; Euglucon N; Glibenclamid AL; Glibenclamid Basics; Glibenclamid Fabra; Glibenclamid Genericon; Glibenclamid Heumann; Glibenclamid Riker M; Glyburide [USAN]; Micronized glyburide; Betanese 5; Euglucon 5; G 0639; GBN 5; HB 419; HB 420; HB419; HB420; Norglicem 5; U 26452; UR 606; Apo-Glibenclamide; Daonil (TN); Dia-basan; Diabeta (TN); Euglucon (TN); Gen-Glybe; Gliben-Puren N; Glibenclamid Riker M.; Glibenclamid-Cophar; Glibenclamid-Ratiopharm; Glibenclamida [INN-Spanish]; Glibenclamidum [INN-Latin]; Gluco-Tablimen; Glyburide (USP); Glyburide (micronized); Glynase (TN); HB-419; HB-420; Hemi-Daonil; Med-Glionil; Micronase (TN); Novo-Glyburide; Semi-Euglucon; Semi-daonil; U-26452; Glibenclamide (JP15/INN); Semi-Daonil (TN); Semi-Gliben-Puren N; N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea; N-p-[2-(5-Chloro-2-methoxybenzamido)-ethyl]benzene-sulfonyl-N-cyclohexylurea; N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea; 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea; 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea; 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide; 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
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Activity |
IC50 = 74000 nM
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[6] | |||
Compound Name |
Meperidine
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Approved | Compound Info | ||
Synonyms |
Demarol; Demerol; Dolcontral; Dolosal; Dolsin; Isonipecain; Isonipecaine; Lidol; Lydol; Meperidol; Nemerol; Pethanol; Pethidin; Pethidine; Pethidineter; Pethidinum; Petidina; Petydyna; Phetidine; Piperosal; Pipersal; Meperidine solution; Methyl phenylpiperidine carbonic acid ethyl ester; Operidine EPJ I; Pethidine DBL; Petydyna [Polish]; Demerol (TN); Operidine EPJ-I; Pethidine (INN); Pethidine DBL (TN); Pethidinum [INN-Latin]; Petidina [INN-Spanish]; Ethyl 1-methyl-4-phenylisonipecotate; Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate; N-Methyl-4-phenyl-4-carbethoxypiperidine; Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester; YIsonipecotic acid, 1-methyl-4-phenyl-, ethyl ester (8CI); 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester; 1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester; 1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester [German]; 1-Methyl-4-phenylisonipecotic acid, ethyl ester;1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester; 4-Carbethoxy-1-methyl-4-phenylpiperidine; 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester
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Activity |
IC50 = 74131.02 nM
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[3] | |||
Compound Name |
Moclobemide
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Approved | Compound Info | ||
Synonyms |
Arima; Aurorex; Aurorix; Deprenorm; Feraken; Manerix; Moclaime; Moclamide; Moclamine; Moclix; Moclobamide; Moclobemid; Moclobemida; Moclobemidum; Moclobeta; Moclodura; Moclonorm; NovoMoclobemide; NuMoclobemide; Rimoc; Alphapharm Brand of Moclobemide; Alpharma Brand of Moclobemide; Apo Moclobemide; Apotex Brand of Moclobemide; Azupharma Brand of Moclobemide; BC Brand of Moclobemide; Betapharm Brand of Moclobemide; Bull Brand of Moclobemide; Chem mart Brand of Moclobemide; Chem mart Moclobemide; Ct Arzneimittel Brand of Moclobemide; DBL Moclobemide; Esparma Brand of Moclobemide; Faulding Brand of Moclobemide; GenRX Moclobemide; Healthsense Brand of Moclobemide; Healthsense Moclobemide; Hexal Brand of Moclobemide; Hoffmann La Roche Brand of Moclobemide; Kendrick Brand of Moclobemide; Merck dura Brand of Moclobemide; Moclobemid AZU; Moclobemid Puren; Moclobemid Stada; Moclobemid ratiopharm; Moclobemid von ct; Moclobemide Alphapharm Brand; Moclobemide Alpharma Brand; Moclobemide Apotex Brand; Moclobemide Azupharma Brand; Moclobemide BC Brand; Moclobemide Bull Brand; Moclobemide Faulding Brand; Moclobemide Healthsense Brand; Moclobemide Hexal Brand; Moclobemide Kendrick Brand; Moclobemide Novopharm Brand; Moclobemide Pharmascience Brand; Moclobemide Roche Brand; Moclobemide Stadapharm Brand; Moclobemide Temmler Brand; Moclobemide betapharm Brand; Moclobemide esparma Brand; Moclobemide ratiopharm Brand; Novo Moclobemide; Novopharm Brand of Moclobemide; Nu Moclobemide; Nu Pharm Brand of Moclobemide; PMS Moclobemide; Pharmascience Brand of Moclobemide; Ratiopharm Brand of Moclobemide; Roche Brand of Moclobemide; Stadapharm Brand of Moclobemide; Temmler Brand of Moclobemide; Terry White Chemists Brand of Moclobemide; Terry White Chemists Moclobemide; CBMicro_048319; Moclobemid 1A Pharma; Moclobemid1A Pharma; Moclobemide 1A Brand; Ro 11 1163; AZU, Moclobemid; Apo-Moclobemide; Aurorix (TN); Ct-Arzneimittel Brand of Moclobemide; Hoffmann-La Roche Brand of Moclobemide; Manerix (TN); Moclobemid-1A Pharma; Moclobemid-Puren; Moclobemid-ratiopharm; Moclobemida [INN-Spanish]; Moclobemide Nu-Pharm Brand; Moclobemide ct-Arzneimittel Brand; Moclobemide, Chem mart; Moclobemide, DBL; Moclobemide, GenRX; Moclobemide, Healthsense; Moclobemidum [INN-Latin]; Novo-Moclobemide; Nu-Moclobemide; Nu-Pharm Brand of Moclobemide; PMS-Moclobemide; Ro 11-1163; Stada, Moclobemid; Von ct, Moclobemid; GNF-PF-695; Moclobemide (USAN/INN); Moclobemide [USAN:BAN:INN]; Moclobemide [USAN:INN:BAN]; Ro 11-1163/000; Ro-11-1163; P-Chloro-N-(2-morpholinoethyl)benzamide; 1A Brand of Moclobemide; 4-Chlor-N-(2-morpholinoethyl)benzamid; 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide; 4-Chloro-N-(2-morpholin-4-yl-ethyl)-benzamide; 4-chloro-N-(2-morpholin-4-ylethyl)benzamide; 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
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Activity |
IC50 = 79432.82 nM
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[3] | |||
Compound Name |
Tadalafil
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Approved | Compound Info | ||
Synonyms |
ADCIRCA; Acdirca; Cialis; Tadanafil; Lilly brand of tadalafil; Tadalafil [USAN]; GF 196960; IC 351; ICOS 351; Ic351; Cialis (TN); GF-196960; IC-351; KS-1117; Tadalafil (JAN/USAN/INN); Cialis, GF 196960, IC 351, ICOS 351, Tadalafil; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
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Activity |
IC50 = 79432.82 nM
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[4] | |||
Compound Name |
Ximelegatran
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Approved | Compound Info | ||
Synonyms |
Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; y-27632; 146986-50-7; Y-27632 dihydrochloride; Y27632; UNII-0X370ROP6H; Y 27632; cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; 0X370ROP6H; CHEBI:75393; 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide; (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE; 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide; (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide; Y-27632
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Activity |
Ki = 79432.82 nM
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[7] | |||
Compound Name |
Vardenafil
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Approved | Compound Info | ||
Synonyms |
VDN; Levitra (TN); VARDENAFIL, LEVITRA; Vardenafil (INN); 1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one; 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one; 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE; 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4-ol
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Activity |
IC50 = 79432.82 nM
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[4] | |||
Compound Name |
Maraviroc
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Approved | Compound Info | ||
Synonyms |
376348-65-1; Selzentry; Celsentri; UK-427857; UK-427,857; UK 427857; UNII-MD6P741W8A; MD6P741W8A; CHEMBL256907; MVC; CHEMBL1201187; CHEBI:63608; 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[321]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide; Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(321)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide; Maraviroc [USAN]; Celsentri (TN); Celsentri(TM); PRO 140 & Maraviroc; Selzentry (TN); Selzentry(TM); UK-427,857 maraviroc (MVC); Exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[321]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide; PRO 140 (Anti-CCR5 monoclonal antibody) & exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[321]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide; 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(321)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide; [3H]maraviroc
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Activity |
IC50 = 79432.82 nM
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[4] | |||
Compound Name |
Epinastine
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Approved | Compound Info | ||
Synonyms |
Epinastina; Epinastinum; Purivist; Epinastina [Spanish]; Epinastine [INN]; Epinastinum [Latin]; WAL 80; WAL 801; WAL 801CL; Elestat (TN); Epinastine (INN); Purivist (TN); Relestat (TN); WAL-80 Cl; (+-)-Epinastine; 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine; 3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine; 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
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Activity |
IC50 = 91201.08 nM
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[8] | |||
Compound Name |
Disopyramide
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Approved | Compound Info | ||
Synonyms |
Dicorantil; Disopiramida; Disopyramidum; Isorythm; Lispine; Ritmodan; Rythmodan; Disopyramide Free Base; Rythmodan P; D 7644; H 3292; SC 7031; Searle 703; Disopiramida [INN-Spanish]; Disopyramidum [INN-Latin]; Norpace (TN); Rythmodan (TN); Rythmodan P (TN); Rythmodan-La; SC-7031; Xi-Disopyramide; Disopyramide (JP15/USAN/INN); Disopyramide [USAN:BAN:INN:JAN]; Alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide; Gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide; Alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide; Alpha-[2-[Bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridine acetamide; 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide; 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
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Activity |
IC50 = 91201.08 nM
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[3] | |||
Compound Name |
Miltefosine
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Approved | Compound Info | ||
Synonyms |
HDPC; HePC; Hexadecylphosphocholine; Hexadecylphosphorylcholine; Impavido; Miltefosina; Miltefosinum; Miltex; Baxter Oncology brand of miltefosine; Baxter brand of miltefosine; Miltefosin C; Prasfarma brand of miltefosine; D 18506; IN1227; D-18506; H-1850; M-7200; Miltefosina [INN-Spanish]; Miltefosine (INN); Miltefosine[INN:BAN]; Miltefosinum [INN-Latin]; N-Hexadecylphosphorylcholine; TF-002; Choline hydroxide, hexadecyl hydrogen phosphate, inner salt; Choline, hexadecyl hydrogen phosphate, inner salt; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; Choline phosphate, hexadecyl ester, hydroxide, inner salt; Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI); Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt; 1-Hexadecylphosphorylcholine; 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt; 3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide
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Activity |
IC50 ~ 100000 nM
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[9] | |||
Compound Name |
Benznidazole
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Approved | Compound Info | ||
Synonyms |
BENZNIDAZOLE; Radanil; Benzonidazole; 22994-85-0; Benznidazol; benzonidazol; Benznidazolum;Ro 07-1051; Rochagan; UNII-YC42NRJ1ZD; Benznidazolum [INN-Latin]; Benznidazol [INN-Spanish]; Ro 71051; NSC 299972; Benznidazole [INN]; CCRIS 2200
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Activity |
IC50 ~ 100000 nM
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[9] | |||
Compound Name |
Phenytoin
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Approved | Compound Info | ||
Synonyms |
Aleviatin; Antisacer; Auranile; Causoin; Citrullamon; Citrulliamon; Comital; Comitoina; Convul; Danten; Dantinal; Dantoinal; Dantoine; Denyl; Difenilhidantoina; Difenin; Difetoin; Difhydan; Dihycon; Dihydantoin; Dilabid; Dilantin; Dilantine; Dillantin; Dintoin; Dintoina; Diphantoin; Diphedal; Diphedan; Diphenat; Diphenin; Diphenine; Diphentoin; Diphentyn; Diphenylan; Diphenylhydantoin; Diphenylhydantoine; Diphenylhydatanoin; Ditoinate; Ekko; Elepsindon; Enkelfel; Epamin; Epanutin; Epelin; Epifenyl; Epihydan; Epilantin; Epinat; Epised; Eptal; Eptoin; Fenitoin; Fenitoina; Fentoin; Fenylepsin; Fenytoine; Hidan; Hidantal; Hidantilo; Hidantina; Hidantomin; Hindatal; Hydantal; Hydantin; Hydantoinal; Hydantol; Idantoil; Idantoin; Iphenylhydantoin; Kessodanten; Labopal; Lehydan; Lepitoin; Lepsin; Minetoin; Neosidantoina; Novantoina; Novophenytoin; Oxylan; PHENYTEK; Phanantin; Phanatine; Phenatine; Phenatoine; Phenhydan; Phenhydanin; Phenitoin; Phentoin; Phentytoin; Phenytex; Phenytoine; Phenytoinum; Ritmenal; Saceril; Sanepil; Silantin; Sinergina; Sodanthon; Sodantoin; Sodanton; Solantin; Solantoin; Solantyl; Sylantoic;TOIN; Tacosal; Thilophenyl; Zentronal; Zentropil; Component of Mebroin; Dantoinal klinos; Difenilhidantoina [Spanish]; Dihydan toin; Dilantin acid; Diphenylhydantoine [French]; Ekko capsules; Elepsi ndon; Epdantoin Simple; Epdantoine simple; Epilan D; Extended Phenytoin Sodium; Fen toin; Fenantoin Mn Pharma; Fenidantoin s; Fenytoin Dak; Hidantina senosian; Hidantina vitoria; Ictalis simp le; Ictalis simple; Om hidantoina simple; Phenat ine; Phenytoin AWD; Sodium Diphenylhydantoinate; Taco sal; Toin unicelles; CL12003; D 4007; D4007_SIGMA; Didan TDC 250; Epasmir 5; IFLab1_000214; DILANTIN-30; DPH (VAN); Di-Hydan; Di-Lan; Di-Phetine; Dilantin (TN); Dilantin Infatabs (TN); Dilantin Kapseals (TN); Dilantin-125; Diphenylhydantoin (VAN); Epanutin (TN); Epasmir (5); Epilan-D; Eptoin (TN); Fenidantoin (s); Fenitoina [INN-Spanish]; Neos-Hidantoina; Om-Hydantoine; PHENYTOIN SODIUM, EXTENDED; Phenytek (TN); Phenytoin (PHN); Phenytoin-Gerot; Phenytoine [INN-French]; Phenytoinum [INN-Latin]; Di-Lan (VAN); Didan-tdc-250; Gerot-epilan-D; PHENYTOIN (5,5-DIPHENYLHYDANTOIN); Phenytoin (JP15/USP/INN); Phenytoin [USAN:INN:BAN:JAN]; Hydantoin, 5,5-diphenyl-(8CI); 2,4-Imidazolidinedione, 5,5-diphenyl-(9CI); 2-hydroxy-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one; 5,5-DIPHENYLHYDANTOIN; 5,5-Diphenyl-2,4-imidazolidinedione; 5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-Diphenylhydantoin (IUPAC); 5,5-Diphenylhydantoin (phenytoin); 5,5-Diphenylimidazolidin-2,4-dione; 5,5-Dwufenylohydantoina; 5,5-Dwufenylohydantoina [Polish]; 5,5-diphenylimidazolidine-2,4-dione
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Activity |
IC50 = 100000 nM
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[10] | |||
Compound Name |
Ciprofloxacin XR
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Approved | Compound Info | ||
Synonyms |
ciprofloxacin; 85721-33-1; Ciprofloxacine; Ciprobay; Ciproxan; Ciprofloxacina; Ciprofloxacinum; Ciprofloxacino; Cipro IV; Ciproxina; Ciprinol; Bernoflox; Ciprodar; Cifloxin; Septicide; Bacquinor; Ciproquinol; Cipromycin; Ciprocinol; Cipro XR; Superocin; Ciprowin; Ciprolon; Ciproflox; Ciprecu; BAY q 3939; Spitacin; Quintor; Quinolid; Proflaxin; Probiox; Ipiflox; Zumaflox; Ciproxine; Ciprolin; Roxytal; Italnik; Fimoflox; Corsacin; Citopcin; Ciprogis; Rancif; Ciriax; Ciplus; Baflox; Loxan; Cilab; Cycin; Cixan; Unex; GW1843; Ciprofloxacin Hydrochloride; Ciprofloxacin intratympanic - Otonomy
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Activity |
Ki ~ 100000 nM
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[11] | |||
Compound Name |
Rhucin
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Approved | Compound Info | ||
Synonyms |
sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; BNRNXUUZRGQAQC-UHFFFAOYSA-N; 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; Sildenafil
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Activity |
IC50 = 100000 nM
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[4] | |||
Compound Name |
Carbamazepine
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Approved | Compound Info | ||
Synonyms |
Carbamazepine (iv, epilepsy); Carbamazepine (iv, epilepsy), Lundbeck; Carbamazepine (iv, epilepsy), Ovation Pharmaceuticals
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Activity |
IC50 = 104712.85 nM
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[3] | |||
Compound Name |
Cetirizine
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Approved | Compound Info | ||
Synonyms |
Cetiderm; Cetirizin; Cetirizina; Cetirizinum; Cetryn; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Cetirizina [Spanish]; Cetirizinum [Latin]; Cetrizine Hcl; Hitrizin Film Tablet; Cetiderm (TN); Cetirizine (INN); Cetirizine [INN:BAN]; P-071; Reactine (TN); Zyrtec (TN); [(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]acetic acid; (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid; (2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-acetic acid; (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
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Activity |
IC50 = 108000 nM
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[12] | |||
Compound Name |
Alfuzosin
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Approved | Compound Info | ||
Synonyms |
Alfusosine; Alfuzosina; Alfuzosine; Alfuzosinum; Alphuzosine; Alfuzosina [Spanish]; Alfuzosine [French]; Alfuzosinum [Latin]; Alfuzosin (INN); Alfuzosin [INN:BAN]; Xatral (TN); N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide; N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide; N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide
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Activity |
IC50 = 125892.54 nM
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[4] | |||
Compound Name |
Sparfloxacin
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Approved | Compound Info | ||
Synonyms |
Esparfloxacino; SPFX; Spara; Sparfloxacine; Sparfloxacinum; Zagam; AT 4140; CP 103826; PD 131501; PD131501; AT-4140; CP-103826; DRG-0143; Esparfloxacino [INN-Spanish]; Liposome-encapsulated sparfloxacin; PD 1315-1; PD-131501; RP-64206; Respipac (TN); Sparfloxacin & RU 40555; Sparfloxacine [INN-French]; Sparfloxacinum [INN-Latin]; Zagam (TN); Sparfloxacin, cis-isomer; Sparfloxacin (JAN/USAN/INN); Sparfloxacin [USAN:BAN:INN:JAN]; Cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; (cis)-5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid & RU 40555; 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 5-amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
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Activity |
IC50 = 127600 nM
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[2] | |||
Compound Name |
Gatifloxacin
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Approved | Compound Info | ||
Synonyms |
Bonoq; GTFX; Gaity; Gatiflo; Gatilox; Gatiquin; Gatispan; Tequin; Zymar; Zymaxid; Zymer; AM 1155; CG 5501;PD 135432; PD135432; AM-1155; BMS 206584-01; BMS-206584; CG-5501; Gatiflo (TN); Gatifloxacin & Gamma Interferon; Gatifloxacin (INN); Gatifloxacin (TN); Gatifloxacin [USAN:INN]; PD-135432; Tequin (TN); Tequin in dextrose 5% in plastic container; Zymar (TN); Zymer (TN); BMS-206584-01; Gatiflo,Tequin and Zymar, Gatifloxacin; AM-1155 (*Sesquihydrate*); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
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Activity |
IC50 = 128824.96 nM
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[3] | |||
Compound Name |
Pentobarbital
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Approved | Compound Info | ||
Synonyms |
Aethaminalum; Dorsital; Etaminal; Ethaminal; Mebubarbital; Mebumal; Nebralin; Nembutal; Neodorm; Pentabarbital; Pentabarbitone; Pentobarbitale; Pentobarbitalum; Pentobarbitone; Pentobarbiturate; Rivadorm; Pentobarbital calcium; Pentobarbital suppository dosage form; Pentobarbitale [DCIT]; Pentobarbituric acid; Ethyl-propylmethylcarbinylbarbituric acid; Nembutal (TN); Nembutal (VAN); Neodorm (VAN); Neodorm (new); Pentobarbital (VAN); Pentobarbital [USP:INN]; Pentobarbital, Monosodium Salt; Pentobarbitalum [INN-Latin]; Pentobarbitone (VAN); Pentobarbital (USP/INN); (+-)-5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)malonylurea; 5-Ethyl-5-(sec-pentyl)barbituric acid; 5-ethyl-2-hydroxy-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
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Activity |
IC50 = 131825.67 nM
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[3] | |||
Compound Name |
Procainamide
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Approved | Compound Info | ||
Synonyms |
Biocoryl; Novocainamid; Novocainamide; Novocamid; Procainamida; Procainamidum; Procamide; Procan; Procanbid; Procapan; Pronestyl; Novocaine amide; Procaine amide; P-Aminobenzoic diethylaminoethylamide; Procainamida [INN-Spanish]; Procainamide (INN); Procainamide [INN:BAN]; Procainamidum [INN-Latin]; Procan (TN); Procanbid (TN); Procapan (free base); Pronestyl (TN); Pronestyl-Sr; P-Amino-N-(2-diethylaminoethyl)benzamide; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-(9CI); 2-Diethylaminoethylamid kyseliny p-aminobenzoove; 2-Diethylaminoethylamid kyseliny p-aminobenzoove [Czech]; 4-Amino-N-(2-(Diethylamino)Ethyl)Benzamide Sulfate; 4-Amino-N-(2-(diethylamino)ethyl)benzamide; 4-Amino-N-[2-(diethylamino)ethyl]benzamide; 4-amino-N-(2-diethylaminoethyl)-benzamide; 4-amino-N-(2-diethylaminoethyl)benzamide
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Activity |
IC50 = 138038.43 nM
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[3] | |||
Compound Name |
Mepivacaine
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Approved | Compound Info | ||
Synonyms |
Carbocaine; Mepivacaina; Mepivacainum; Mepivicaine; Scandicain; Scandicaine; Scandicane; Arestocaine HCL; Carboplyin Dental; Isocaine HCL; Carbocaine (TN); Carboplyin Dental (TN); D-mepivacaine; DL-Mepivacaine; Mepivacaina [INN-Spanish]; Mepivacaine (INN); Mepivacaine [INN:BAN]; Mepivacainum [INN-Latin]; Polocaine (TN); Polocaine-Mpf; S-Ropivacaine Mesylate; D(-)-Mepivacaine; N-Methyl-2-pipecolic acid, 2,6-dimethylanilide; N-Methyl-2-pipecolic acid, 2,6-xylidide; N-Methylhexahydro-2-picolinic acid, 2,6-dimethylanilide; N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide; N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide; (+-)-1-Methyl-2',6'-pipecoloxylidide; 1-METHYL-2',6'-PIPECOLOXYLIDIDE
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Activity |
IC50 = 154881.66 nM
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[3] | |||
Compound Name |
Etravirine
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Approved | Compound Info | ||
Synonyms |
Intelence; DAPY deriv; Diaminopyrimidine deriv; R 165335; R165335; TMC 125; TMC125; Intelence (TN); Intelence(TM); R-165335; R165335-TMC125; TMC-125; Etravirine (JAN/USAN/INN); TMC-125/R-165335; 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile; 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE; 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile; 65B; ETR
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Activity |
IC50 = 158489.32 nM
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[4] | |||
Compound Name |
Sitagliptin
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Approved | Compound Info | ||
Synonyms |
486460-32-6; Januvia; Xelevia; Sitagliptan; MK-0431; UNII-QFP0P1DV7Z; Tesavel; QFP0P1DV7Z; (3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE; CHEBI:40237; (R)-3-AMINO-1-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; Janumet; Sitagliptin phosphate; Januvia (TN); Sitagliptin (PropINN); Januvia (merck & Co); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; Sitagliptin/atovastatin
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Activity |
IC50 = 158489.32 nM
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[4] | |||
Compound Name |
Irbesartan
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Approved | Compound Info | ||
Synonyms |
irbesartan; 138402-11-6; Aprovel; Avapro; Karvea; SR-47436; BMS-186295; BMS 186295; Irbesartan [USAN:INN]; SR 47436; UNII-J0E2756Z7N; CHEMBL1513; 8-butyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-7,9-diazaspiro[44]non-8-en-6-one; CHEBI:5959; C25H28N6O; YOSHYTLCDANDAN-UHFFFAOYSA-N; J0E2756Z7N; 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[44]non-1-en-4-one; 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[44]non-1-en-4-one; NCGC00095122-01; AK-57149; DSSTox_CID_3169; Aprovel; Irbesarran; Irbetan; Lrbesartan; BMS Brand of Irbesartan; Bristol Myers Brand of Irbesartan; SanofiWinthrop Brand of Irbesartan; Aprovel (TN); Avalide (TN); Avapro (TN); Karvea (TN); Irbesartan (JAN/USAN/INN); BMS-186295, SR-47436,Aprovel, Karvea, Irbesartan; 2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(44)non-1-en-4-one; 2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[44]non-1-en-4-one; 2-butyl-3-[ p-(o-1 H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one; 2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[44]non-1-en-4-one; 2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[44]non-1-en-4-one; 2-n-butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,3-diazaspiro(4,4)non-1-en-4-one; [3H]irbesartan
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Activity |
IC50 = 194984.46 nM
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[3] | |||
Compound Name |
Berberine
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Phase 4 | Compound Info | ||
Synonyms |
berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
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Activity |
IC50 = 66069.34 nM
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[3] | |||
Compound Name |
AZD5363
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Phase 3 | Compound Info | ||
Synonyms |
AZD5363; 1143532-39-1; AZD-5363; capivasertib; AZD 5363; UNII-WFR23M21IE; WFR23M21IE; cc-638; 4-Amino-N-[(1s)-1-(4-Chlorophenyl)-3-Hydroxypropyl]-1-(7h-Pyrrolo[2,3-D]pyrimidin-4-Yl)piperidine-4-Carboxamide; C21H25ClN6O2; (S)-4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE; 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide; 4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1
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Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
JNJ-41443532
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Phase 2 | Compound Info | ||
Synonyms |
UNII-0OJB0LES1A; JNJ-41443532; 0OJB0LES1A; CHEMBL2204263; CFKBNYUHQSQBSX-UHFFFAOYSA-N; 1228650-83-6; SCHEMBL2485329; SCHEMBL2485331; SCHEMBL2545786; SCHEMBL13302364; BDBM50400695; DB12632; Benzamide, N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)
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||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
MK-7622
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|
Phase 2 | Compound Info | ||
Synonyms |
M1 receptor modulator; 1227923-29-6; MK-7622; MK7622; MK 7622; 3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one; SCHEMBL2399084; EX-A804; JUVQLZBJFOGEEO-GOTSBHOMSA-N; BCP27739; ZINC95930184; AKOS028113668; DB12897; CS-5442; HY-15618; Benzo(H)quinazolin-4(3H)-one, 3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-methyl-3-pyridinyl)methyl)-; AS-35236; KB-145903; J-690076; UNII-57R7D1Q49R component JUVQLZBJFOGEEO-GOTSBHOMSA-N
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Activity |
IC50 = 60000 nM
|
[15] | |||
Compound Name |
GDC0941
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Phase 2 | Compound Info | ||
Synonyms |
Pictilisib; GDC-0941; 957054-30-7; PICTILISIB; Pictrelisib; GDC 0941; 4-(2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine; UNII-ICY00EMP8P; ICY00EMP8P; Pictilisib (GDC-0941); CHEBI:65326; AK-40872; Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-; GD9; GDC-0941, GDC0941; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
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Activity |
IC50 = 64000 nM
|
[16] | |||
Compound Name |
MK-0873
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Phase 2 | Compound Info | ||
Synonyms |
MK-0873 (dermatological, psoriasis); MK-0873 (dermatological, psoriasis), Merck & Co
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||||
Activity |
IC50 = 65700 nM
|
[17] | |||
Compound Name |
ASTX660
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Phase 2 | Compound Info | ||
Synonyms |
YCXOHEXZVKOGEV-DNRQZRRGSA-N; 1799328-86-1; SCHEMBL16830758; CS-8216; HY-109565; 1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one
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Activity |
IC50 = 69000 nM
|
[18] | |||
Compound Name |
GLPG-0634
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Phase 2 | Compound Info | ||
Synonyms |
Small molecule, JAK1/JAK2 inhibitor (rheumatoid arthritis), Galapagos/GSK
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Activity |
IC50 = 85000 nM
|
[19] | |||
Compound Name |
Mitoglitazone
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Phase 2 | Compound Info | ||
Synonyms |
MSDC-0160; Mitoglitazone (TN)
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Activity |
IC50 ~ 100000 nM
|
[20] | |||
Compound Name |
AZD1656
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Phase 2 | Compound Info | ||
Synonyms |
AZD1656; AZD-1656; FJEJHJINOKKDCW-INIZCTEOSA-N; 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide; SCHEMBL321593; GTPL7701; UNII-660M185X4D; CHEMBL3219124; AZD 1656; 660M185X4D; 89961-EP2305674A1; 89961-EP2301929A1; 89961-EP2301935A1; 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methylpyrazin-2-yl)benzamide
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Activity |
IC50 ~ 100000 nM
|
[21] | |||
Compound Name |
AZD-4017
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Phase 2 | Compound Info | ||
Synonyms |
AZD-4017 (oral tablet, ocular hypertension)
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||||
Activity |
IC50 ~ 100000 nM
|
[22] | |||
Compound Name |
PF-00734200
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Phase 2 | Compound Info | ||
Synonyms |
GOSOGLIPTIN; 869490-23-3; UNII-GI718UO477; PF-00734200; PF-734200; CHEMBL515387; GI718UO477; 2-(4-{(3s,5s)-5-[(3,3-Difluoropyrrolidin-1-Yl)carbonyl]pyrrolidin-3-Yl}piperazin-1-Yl)pyrimidine; 869490-47-1; (3,3-difluoropyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolidin-2-yl]methanone; (3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone; (3,3-DIFLUOROPYRROLIDIN-1-YL)[(2S,4S)-4-[4-(PYRIMIDIN-2-YL)PIPERAZIN-1-YL]PYRROLIDIN-2-YL]METHANONE; Gosogliptin [USAN:
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Activity |
IC50 = 126000 nM
|
[23] | |||
Compound Name |
GSK2982772
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Phase 2 | Compound Info | ||
Synonyms |
LYPAFUINURXJSG-AWEZNQCLSA-N; 1622848-92-3; UNII-T5W3M0VO9B; T5W3M0VO9B; GSK-2982772; (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide; GTPL9554; SCHEMBL15956219; MolPort-044-830-634; s8484; AKOS030528033; compound 5 [PMID: 28151659]; ACN-041458; CS-6899; GSK 2982772; AS-35128; AC-29894; HY-101760; J3.650.802G; 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide; 3-Benzyl-N-[(3s)-5-Methyl-4-Oxo-2,3,4,5-Tetrahydr
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Activity |
IC50 = 195000 nM
|
[24] | |||
Compound Name |
DA-1229
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Phase 1 | Compound Info | ||
Synonyms |
DPP-IV inhibitor (tablet, type II diabetes), Dong-A
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Activity |
IC50 = 79600 nM
|
[25] | |||
Compound Name |
AZD8329
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Phase 1 | Compound Info | ||
Synonyms |
AZD-8329; AZD 8329; UNII-5B38CV1212; 1048668-70-7; CHEMBL2177609; 5B38CV1212; 4-[4-(2-Adamantylcarbamoyl)-5-Tert-Butyl-Pyrazol-1-Yl]benzoic Acid; AZD8329; XWBXJBSVYVJAMZ-UHFFFAOYSA-N; SCHEMBL617351; GTPL7715; BDBM50399335; 4-(4-(Adamant-2-ylcarbamoyl)-5-tert-butylpyrazol-1-yl)benzoic acid; Benzoic acid, 4-(5-(1,1-dimethylethyl)-4-((tricyclo(3.3.1.13,7)dec-2-ylamino)carbonyl)-1H-pyrazol-1-yl)-; 4-[4-(2-adamantylcarbamoyl)-5-tertbutyl-pyrazol-1-yl]benzoic acid; 4-[4-(2-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic ac
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Activity |
IC50 ~ 100000 nM
|
[26] | |||
Compound Name |
GDC-0349
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Phase 1 | Compound Info | ||
Synonyms |
MTORC1/2 inhibitors
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Activity |
IC50 ~ 100000 nM
|
[27] | |||
Compound Name |
2-(substituted ethynyl)quinoline derivative 1
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Patented | Compound Info | ||
Synonyms |
PMID28067079-Compound-34
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Activity |
IC50 = 61700 nM
|
[28] | |||
Compound Name |
Sulfonamide derivative 10
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Patented | Compound Info | ||
Synonyms |
PMID27414413-Compound-Figure3bottomleft
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Activity |
IC50 = 67000 nM
|
[29] | |||
Compound Name |
Pyrimidine derivative 33
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Patented | Compound Info | ||
Synonyms |
PMID25482888-Compound-67
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Activity |
IC50 = 100000 nM
|
[30] | |||
Compound Name |
PMID25435285-Compound-15
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Patented | Compound Info | ||
Activity |
Ki ~ 100000 nM
|
[31] | |||
Compound Name |
Terfenadine
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Withdrawn from market | Compound Info | ||
Synonyms |
Aldaban; Allerplus; Cyater; Hisfedin; Rapidal; Seldane; Teldane; Teldanex; Terdin; Terfedura; Terfemundin; Terfen; Terfenadina; Terfenadinum; Terfenidine; Terfex; Ternadin; Triludan; Aliud Brand of Terfenadine; Balkis Saft Spezial; Bial Brand of Terfenadine; Cantabria Brand of Terfenadine; Ct Arzneimittel Brand of Terfenadine; Dolorgiet Brand of Terfenadine; Heumann Brand of Terfenadine; Hoechst Brand of Terfenadine; Merck dura Brand of Terfenadine; Mundipharma Brand of Terfenadine; Ratiopharm Brand of Terfenadine; Sigma Tau Brand of Terfenadine; Stadapharm Brand of Terfenadine; Terfenadin AL; Terfenadin Heumann; Terfenadin Stada; Terfenadin von ct; Wolff Brand of Terfenadine; MDL 9918; RMI 9918; RMI9918; T 9652; Ct-Arzneimittel Brand of Terfenadine; MDL-9918; RMI-9918; Seldane (TN); Sigma-Tau Brand of Terfenadine; Teldane (TN); Terfenadin-ratiopharm; Terfenadina [INN-Spanish]; Terfenadinum [INN-Latin]; Triludan (TN); Terfenadine (JAN/USAN/INN); Terfenadine [USAN:BAN:INN:JAN]; Alpha-(4-[1,1-Dimethylethyl]phenyl)-4-[hydroxydiphenylmethyl]-1-piperidinebutanol; Alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenyl-methyl)-1-piperidine butanol; 1-(4-tert-Butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol; 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)butanol; 1-[4-(1,1-dimethylethyl)phenyl]-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol
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Activity |
IC50 = 56000 nM
|
[32] | |||
Compound Name |
Acecainide
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Discontinued in Phase 3 | Compound Info | ||
Synonyms |
N-Acetylprocainamide; Acekainid; 32795-44-1; Acecainida; Acecainidum; NAPA; N-Acetyloprokainamid; Acecainide [INN]; Acekainid [Polish]; 4'-((2-(Diethylamino)ethyl)carbamoyl)acetanilide; Acecainidum [INN-Latin]; Acecainida [INN-Spanish]; N-Acetyloprokainamid [Polish]; UNII-910Q707V6F; CHEBI:60728; Benzamide, 4-(acetylamino)-N-(2-(diethylamino)ethyl)-; BRN 2868559; CHEMBL1097; MLS000069490; KEECCEWTUVWFCV-UHFFFAOYSA-N; 4-acetamido-N-[2-(diethylamino)ethyl]benzamide; 910Q707V6F; SMR000059070; ACETANILIDE,; NAPA; Acecainide hydrochloride; ASL-601; Acetylprocainamide
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Activity |
IC50 = 100000 nM
|
[12] | |||
Compound Name |
BMS-488043
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Discontinued in Phase 2 | Compound Info | ||
Synonyms |
AIDS171276; BMS043; BMS488043; BMS-043; 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
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Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
AZD-6703
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Discontinued in Phase 1 | Compound Info | ||
Synonyms |
P38 MAP kinase inhibitors (rheumatoid arthritis), AstraZeneca
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Activity |
IC50 ~ 100000 nM
|
[34] | |||
Compound Name |
Viquidacin
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Preclinical | Compound Info | ||
Synonyms |
AVE-4221; AVE-6971; NXL-101; Topoisomerase IV inhibitor antibacterials, Novexel
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Activity |
IC50 = 124000 nM
|
[35] | |||
Compound Name |
AZ20
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Investigative | Compound Info | ||
Synonyms |
AZ-20; AZ 20; compound 6 [PMID: 46244454]
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Activity |
IC50 = 50000 nM
|
[36] | |||
Compound Name |
ABT-341
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Investigative | Compound Info | ||
Synonyms |
CHEMBL437341
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Activity |
Ki ~ 50000 nM
|
[37] | |||
Compound Name |
Clarithromycin
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Phase 2 Trial | Compound Info | ||
Synonyms |
Biaxin; 6-O-Methylerythromycin; Klaricid; 6-O-Methylerythromycin a; Clarithromycine; Clathromycin; Abbott-56268; Macladin; Kofron; Klacid; Clarith; Veclam; Clarithromycinum; Naxy; A-56268; Erythromycin, 6-O-methyl-; Biaxin XL; TE-031; Klaciped; Heliclar; Claripen; Claribid; Fromilid; Claridar; Bicrolid; Astromen; Mabicrol; Clambiotic; Claricide; Clacine; Abbotic; Clarem; Clacid; Clacee; Klarin; Klabax; Cyllid; Zeclar; Maclar; Klarid; Crixan; Helas; Mavid; Klax; Biaxin filmtab; Adel; Biaxin HP; Biaxin xl filmtab
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Activity |
IC50 = 58884.37 nM
|
[38] | |||
Compound Name |
2-morpholino-2-phenyl-1,1-di(pyridin-3-yl)ethanol
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1090794; 2-morpholino-2-phenyl-1,1-di(pyridin-3-yl)ethanol; SCHEMBL1240366
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Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
2-phenyl-1,1-di(pyridin-3-yl)ethanol
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1088805; 2-phenyl-1,1-di(pyridin-3-yl)ethanol; SCHEMBL4336663
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Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
2-amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1090816; 2-amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol
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Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
L-869298
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Investigative | Compound Info | ||
Synonyms |
L-869298; UNII-2I921E370K; CHEMBL199015; 2I921E370K; MK-298; 362718-73-8; SCHEMBL3225083; (+)-L-869298; BDBM50174020; 2-Thiazolemethanol, 5-((1S)-1-(3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl)-2-(1-oxido-3-pyridinyl)ethyl)-alpha,alpha-bis(trifluoromethyl)-; 3-[(S)-beta-[2-[1-Hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl]-5-thiazolyl]-3-(cyclopropyloxy)-4-(difluoromethoxy)phenethyl]pyridine 1-oxide
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Activity |
Ki = 61400 nM
|
[40] | |||
Compound Name |
MCL-1-specific antisense oligonucleotide + nilotinib (AMN107)
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Investigative | Compound Info | ||
Synonyms |
641571-10-0; UNII-F41401512X; Nilotinib (AMN-107); CHEMBL255863; CHEBI:52172; C28H22F3N7O; HHZIURLSWUIHRB-UHFFFAOYSA-N; NSC747599
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Activity |
IC50 = 63095.73 nM
|
[4] | |||
Compound Name |
2-morpholino-1,1,2-triphenylethanol
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1091863; 2-morpholino-1,1,2-triphenylethanol
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Activity |
IC50 ~ 65000 nM
|
[39] | |||
Compound Name |
BMS-269223
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Investigative | Compound Info | ||
Synonyms |
CHEMBL551991; cyanoguanidine, 3; BMS-269223
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Activity |
IC50 ~ 80000 nM
|
[41] | |||
Compound Name |
Diphenyl(piperidin-4-yl)methanol
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Investigative | Compound Info | ||
Synonyms |
Azacyclonol; 115-46-8; diphenyl(piperidin-4-yl)methanol; alpha,alpha-diphenyl-4-piperidinomethanol; Frenquel; alpha,alpha-Diphenyl-4-piperidinemethanol; alpha-(4-Piperidyl)benzhydrol; gamma-Pipradol; Calmeran; Ataractan; Diphenyl-piperidin-4-yl-methanol; Diphenyl(4-piperidinyl)methanol; 4-Piperidinemethanol, alpha,alpha-diphenyl-; Azaciclonolo [DCIT]; Azacyklonol; Psychosan; MER 17; Frenoton; Azacyclonol [INN:BAN]; UNII-2MMR990PEM; Azacyclonolum [INN-Latin]; EINECS 204-092-5; Diphenyl-4-piperidylmethanol; BRN 0230221; 2MMR990PEM
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Activity |
IC50 ~ 100000 nM
|
[42] | |||
Compound Name |
CM-352
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Investigative | Compound Info | ||
Synonyms |
compound 2 [PMID 25686022]
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Activity |
IC50 ~ 100000 nM
|
[43] | |||
Compound Name |
Premafloxacin
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Investigative | Compound Info | ||
Synonyms |
Premafloxacin; 143383-65-7; UNII-UOM2HMO524; UOM2HMO524; CHEMBL230599; U-95376; 1-cyclopropyl-6-fluoro-8-methoxy-7-((R)-3-((S)-1-(methylamino)ethyl)pyrrolidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Premafloxacin [USAN:INN]; Premafloxacin (USAN/INN); SCHEMBL1230382; AC1L2G72; CTK4C3611; DTXSID70162407; 3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]-1-pyrrolidinyl]-4-oxo-; BDBM50205462; AKOS030530871; D05605; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6
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Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313764; BDBM50424031
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Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-pyrimidin-2-yl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3115270; SCHEMBL15444176; BDBM50446872
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Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(3Ar,5R,6aR)-Benzyl 5-((3-methoxytetrahydro-2H-pyran-4-yl)amino)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)hexahydrocyclopenta-[c]pyrrole-2(1H)-carboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3115103; SCHEMBL15444251; BDBM50446856
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||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(2S,3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalene-2-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2313776; BDBM50423999
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Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-(3-nitro-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313785; BDBM50424015
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
Example 19 [PMID: 23886683]
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2418811; GSK255B; SCHEMBL798463; GTPL10284; GSK2833503A; BDBM50439217
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[46] | |||
Compound Name |
[(2R,3As,5R,6aS)-2-chloro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313773; BDBM50424002
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(6R,8S)-6-((4-o-Tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL471982; BDBM50244336
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,7-naphthyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2059309; BDBM50388681
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
CID 81689815
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608684; SCHEMBL16116207; BDBM50112183
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[49] | |||
Compound Name |
2-(Oxan-4-yl)ethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115108; SCHEMBL15444126; BDBM50446851
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
6-(Bis(4-chlorophenyl)methyl)-4-((1-((trifluoromethyl)sulfonyl)piperidin-4-yl)amino)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3945880; SCHEMBL17025445; 6-(bis(4-chlorophenyl)methyl)-4-(1-(trifluoromethylsulfonyl)piperidin-4-ylamino)quinolin-2(1H)-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[50] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115113; SCHEMBL15444255; BDBM50446870
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-Methoxyethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115106; SCHEMBL15444129; BDBM50446853
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
[(2R,3Ar,5R,6aR)-2-[(3-methoxyoxan-4-yl)amino]-5-(trifluoromethyl)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313775; BDBM50424000
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
GPR120 agonist 4x
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
GPR120 Agonist 1; CHEMBL4165366; SCHEMBL16048648; BDBM50278673; HY-108711; CS-0030142
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[51] | |||
Compound Name |
[(2S,3As,5R,6aS)-2-fluoro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313770; BDBM50424005
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(S)-4-((5-((1-(2-Aminonicotinoyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL484816; BDBM50279387
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[52] | |||
Compound Name |
1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,5-naphthyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2059307; BDBM50388680
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-methyl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115097; SCHEMBL15444151; BDBM50446862
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
[(2R,3As,5R,6aS)-2-hydroxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313779; BDBM50423996
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115271; SCHEMBL15444193; BDBM50446868
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
CID 71768899
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263284; SCHEMBL15320100; BDBM50012006
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|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
[(2R,3Ar,5S,6aR)-2-[(3-methoxyoxan-4-yl)amino]-5-(trifluoromethyl)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313774; BDBM50424001
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|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(3Ar,5R,6aR)-N'-cyano-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115100; SCHEMBL15444116; BDBM50446859
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-{[1-(4-Hydroxy-4-oxazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2204254; SCHEMBL3337284; SCHEMBL14980550; BDBM50400704
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
Chembl4284935
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL16261265; BDBM50467032
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[54] | |||
Compound Name |
CID 71768688
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263255; SCHEMBL15320653; BDBM50011820
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
4-(4-{2-[(2,2-Dimethylpropanoyl)amino]ethyl}piperidin-1-Yl)thieno[3,2-D]pyrimidine-6-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SIRT-IN-1; CHEMBL2332055; SCHEMBL16014053; EX-A3489; BDBM50431096; ZINC95587718; DA-21542; HY-16615; CS-0009171; FT-0755224; Q27452272; 4-(4-(2-pivalamidoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide; 4-[4-[2-(Pivaloylamino)ethyl]piperidino]thieno[3,2-d]pyrimidine-6-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
CID 86274732
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608741; SCHEMBL16143074; BDBM50112245
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[56] | |||
Compound Name |
Chembl4203179
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18288802; BDBM50458024
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[57] | |||
Compound Name |
(2,3-Dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2418806; SCHEMBL789503; BDBM50439221
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[46] | |||
Compound Name |
N-(1-(4-Hydroxy-4-(2-methylthiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2315925; SCHEMBL9999076; CHEMBL3704095; BDBM163451; BDBM50425702; US9062048, 79
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[58] | |||
Compound Name |
[(2S,3As,5R,6aS)-2-(dimethylamino)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313762; BDBM50424034
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
N-[(2R,3Ar,6aR)-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalen-2-yl]oxane-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2314063; BDBM50424022
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
[(2S,3As,5R,6aS)-2-hydroxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313778; BDBM50423997
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
4-[[[[1-[(1R)-3-[(6-Chloro-2,4-dimethyl-pyridine-3-carbonyl)amino]-1-methyl-propyl]-4-piperidyl]-(3-thienylmethyl)carbamoyl]amino]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164212; SCHEMBL3758043; BDBM50394586
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[59] | |||
Compound Name |
[(3As,5S,6aR)-5-[3-hydroxypropyl-(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263281; BDBM50012002
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
2-Pyrrolidin-1-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115110; SCHEMBL15444131; BDBM50446849
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-Methyl-pyrimidinone derivative, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL495331; SCHEMBL1150565; BDBM25335; L-900525
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[1] | |||
Compound Name |
[(2R,3As,6aS)-5,5-difluoro-2-[(3-methoxyoxan-4-yl)amino]-1,2,3,4,6,6a-hexahydropentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313769; BDBM50424006
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
Pde10A-IN-8
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2419564; N-Methyl-N-[4-(quinolin-2-ylmethoxy)-phenyl]-isonicotinamide; SCHEMBL1694846; BDBM50096249; N-methyl-N-[4-(quinolin-2-ylmethoxy)phenyl]pyridine-4-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[60] | |||
Compound Name |
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2315924; SCHEMBL9999037; SCHEMBL9999038; SCHEMBL12070897; SCHEMBL15214594; BDBM50425703
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[58] | |||
Compound Name |
N-[1-[4-(1,3-Thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1834792; BDBM50355278
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|
||||
Activity |
IC50 ~ 50000 nM
|
[61] | |||
Compound Name |
TLR7-agonist-1
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|
Investigative | Compound Info | ||
Synonyms |
TLR7-IN-1; TLR7 agonist 2; CHEMBL4103847; SCHEMBL16386579; BCP20863; EX-A1655; BDBM50249652; HY-103039; CS-0023485
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
2,2-Dimethylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115104; SCHEMBL15444184; BDBM50446855
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
[(2R,3As,5R,6aS)-2-methoxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313761; BDBM50424035
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
Chembl4203293
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL14832003; BDBM50459194; 2-((3-(2-hydroxyethoxy)-5-methoxyphenyl)amino)-1-(1H-indol-3-yl)-2-phenylethanone; 2-[3-(2-hydroxyethoxy)-5-methoxyanilino]-1-(1H-indol-3-yl)-2-phenylethanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[63] | |||
Compound Name |
N-{2-[1-(6-Carbamoylthieno[3,2-D]pyrimidin-4-Yl)piperidin-4-Yl]ethyl}-N'-Ethylthiophene-2,5-Dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2332039; SCHEMBL16023423; BDBM50431097; Q27452271
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[55] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-(oxetan-3-yl)-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115267; SCHEMBL15444253; BDBM50446874
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
Chembl4292234
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50464955
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[64] | |||
Compound Name |
[(2R,3As,5R,6aS)-2-fluoro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313771; BDBM50424004
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
N-({1-[4-Hydroxy-4-(2-isopropyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2204265; SCHEMBL3333547; SCHEMBL13302101; BDBM50400693
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
N-({1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2204264; SCHEMBL3339113; SCHEMBL13302102; BDBM50400694
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313781; BDBM50424019
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
CID 86275207
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608740; SCHEMBL16143073; BDBM50112179
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[56] | |||
Compound Name |
Phenyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115102; SCHEMBL15444218; BDBM50446857
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-Methylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115105; SCHEMBL15444112; BDBM50446854
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-((3r,5s)-1-(Benzofuran-3-Carbonyl)-5-(Ethylcarbamoyl)pyrrolidin-3-Yl)-3-Ethyl-1-Methyl-1h-Pyrazole-5-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3125272; BDBM50448861; Q27462145
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[65] | |||
Compound Name |
Oxan-4-ylmethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115107; SCHEMBL15444127; BDBM50446852
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(S)-4-((5-((1-(2-Hydroxynicotinoyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485161; BDBM50279388
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[52] | |||
Compound Name |
N-[1-(4-Aminocyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1834649; BDBM50355255
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[61] | |||
Compound Name |
N-[1-[4-Hydroxy-4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2315922; SCHEMBL9999146; SCHEMBL9999149; SCHEMBL15214618; BDBM60422; BDBM50425705; US9062048, 84
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[58] | |||
Compound Name |
(-)-(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxy-1-{[(6R,8S)-8-hydroxy-5,6,7,8-tetrahydroquinolin-6-yl]methyl}piperidinium Chloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL487458; SCHEMBL2883150; BDBM50243887
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
(2R,3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313777; BDBM50423998
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(6R,8S)-6-(((3R,4R)-3-Hydroxy-4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL488655; BDBM50243797
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[47] | |||
Compound Name |
1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylpropan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115275; SCHEMBL15444256; BDBM50446864
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115096; SCHEMBL15444179; BDBM50446863
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2316211; SCHEMBL9999090; SCHEMBL9999092; CHEMBL3659040; SCHEMBL12052640; BDBM163543; BDBM163608; BDBM50425708; US9062048, 145; US9062048, 146
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[58] | |||
Compound Name |
[(2R,3Ar,6aR)-2-(pentan-3-ylamino)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2314055; BDBM50424030
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-propan-2-yl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115098; SCHEMBL15444200; BDBM50446861
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
N-({1-[4-Hydroxy-4-(1-methyl-1H-pyrazol-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2204256; SCHEMBL3334890; SCHEMBL13302088; BDBM50400702
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-(1,3-thiazol-2-yl)-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115269; SCHEMBL15444276; BDBM50446873
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
2-Acetamidoethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115109; SCHEMBL15444254; BDBM50446850
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
Chembl4282585
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50464953
Click to Show/Hide
|
||||
Activity |
IC50 = 50000 nM
|
[64] | |||
Compound Name |
Chembl4212403
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL14831480; BDBM50459193; MCULE-4830332654; 2-(3,5-dimethoxyanilino)-1-(1H-indol-3-yl)-2-phenylethanone; 2-((3,5-dimethoxyphenyl)amino)-1-(1H-indol-3-yl)-2-phenylethanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[63] | |||
Compound Name |
[(3As,5S,6aR)-5-[(3-methoxyoxan-4-yl)-methylamino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263280; BDBM50012001
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[53] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313765; BDBM50424032
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
2-[[1-(2-Hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1834796; BDBM50355302
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[61] | |||
Compound Name |
[(2R,3As,5R,6aS)-2-(dimethylamino)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313763; BDBM50424033
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
5-[[2-(4-Phenylphenyl)-2-adamantyl]methyl]-2H-tetrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3103437; BDBM50445571
Click to Show/Hide
|
||||
Activity |
EC50 ~ 50000 nM
|
[66] | |||
Compound Name |
N-{[1-(4-Hydroxy-4-[1,3,4]thiadiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2204257; SCHEMBL3331114; SCHEMBL13302118; BDBM50400701
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[14] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[(1,1-dioxothian-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2314060; BDBM50424025
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
[(2S,3As,5R,6aS)-2-methoxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313780; BDBM50423995
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
4-[(5-Methyl-1,2,4-oxadiazol-3-yl)methoxy]-5-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4068797; SCHEMBL17828343; BDBM50249654
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-propan-2-yl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115115; SCHEMBL15444175; BDBM50446876
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,6-naphthyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2059308; BDBM50388676
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
(E)-1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-4,4-dimethylpent-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115273; SCHEMBL15444191; BDBM50446866
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
CID 72946008
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115111; SCHEMBL15422436; BDBM50446848
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
(3Ar,5R,6aR)-N-benzyl-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115099; SCHEMBL15444270; BDBM50446860
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313784; BDBM50424016
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
CID 59472858
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3609640; SCHEMBL3052118; BDBM50498591
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[67] | |||
Compound Name |
Methyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115101; SCHEMBL15444272; BDBM50446858
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
Schembl21622451
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
IIIM-290; CHEMBL4079206; BDBM50263013; HY-111356; CS-0039822
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[68] | |||
Compound Name |
4-[(5-Methyl-1,3-oxazol-2-yl)methoxy]-5-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4079597; SCHEMBL17828351; BDBM50249653
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[62] | |||
Compound Name |
[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3115112; SCHEMBL15444180; BDBM50446871
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[45] | |||
Compound Name |
[(2S,3As,5R,6aS)-2-chloro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2313772; BDBM50424003
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[44] | |||
Compound Name |
4-[3-[4-(2-Oxo-1H-imidazo[4,5-c]pyridin-3-yl)piperidin-1-yl]propyl]-1,4-benzoxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2059314; BDBM50388677
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50000 nM
|
[48] | |||
Compound Name |
Tert-butyl 4-[3-(1H-benzimidazol-2-ylamino)propylcarbamoyl]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3581790; BDBM50090912
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50100 nM
|
[69] | |||
Compound Name |
N-[3-(1H-Benzimidazol-2-ylamino)propyl]-4-(pyrrolidin-1-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3581789; BDBM50090913
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50100 nM
|
[69] | |||
Compound Name |
2-(1-Hydroxy-1-methylethyl)-5-[3-[3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridine-1(4H)-yl]phenyl]pyridine 1-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485620; SCHEMBL5340138; BDBM50274228
Click to Show/Hide
|
||||
Activity |
IC50 = 50100 nM
|
[17] | |||
Compound Name |
1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[(1-hydroxycycloheptyl)methylamino]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356249; SCHEMBL12312137; BDBM50037211
Click to Show/Hide
|
||||
Activity |
IC50 = 50100 nM
|
[70] | |||
Compound Name |
Methyl 2-[3-[(3,5-dichlorobenzoyl)amino]propylamino]-3H-benzimidazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3581791; BDBM50090911
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50100 nM
|
[69] | |||
Compound Name |
N-(3-Chloro-4-methylphenyl)-3-(2-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL576138; SCHEMBL15896190; BDBM50414955
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[71] | |||
Compound Name |
3-[4-[2-[3-(2-Methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784409; SCHEMBL3528707; BDBM50418511
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[72] | |||
Compound Name |
Chembl4241584
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19435168; BDBM50464119
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
CID 44454371
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL256653; SCHEMBL2312613; BDBM50411700
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[74] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-propan-2-yloxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL837552; CHEMBL3221502
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[75] | |||
Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1796298; BDBM50418802
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[76] | |||
Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[77] | |||
Compound Name |
5-[3-(2,4-Bis-trifluoromethyl-phenyl)-isoxazol-5-ylmethyl]-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3121666; SCHEMBL1220536; BDBM50495960
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[78] | |||
Compound Name |
(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(2-hydroxyethoxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838461; CHEMBL3221506
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[75] | |||
Compound Name |
Chembl4251444
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50464102
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
1-[4-[3-(Azepan-1-yl)propoxy]phenyl]-4-(2,4-difluorobenzoyl)piperazin-2-one;formic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL238872
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[79] | |||
Compound Name |
1-(3-Chlorophenyl)-3-[2-[methyl-[(3-methyl-1,2-oxazol-5-yl)methyl]amino]ethyl]imidazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL549438; BDBM50414577
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[80] | |||
Compound Name |
TGR5 Receptor Agonist
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide; CHEMBL575966; MDK00245; 4-Isoxazolecarboxamide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-; MFCD17169972; 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide; 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-Isoxazolecarboxamide; CCDC(TGR5-Receptor-Agonist); SCHEMBL18065752; AOB2659; EX-A276; BCP08750; BDBM50414954; ZINC43208218; AKOS026750223; CS-2030; NCGC00371150-04; HY-14229; QC-11404; SY278787; AB0098427; DB-061648; FT-0700111; A13732; J-690056; 4-Isoxazolecarboxamide,3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[71] | |||
Compound Name |
1-[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]azetidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1276948; BDBM50330751
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[81] | |||
Compound Name |
Chembl4242732
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|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19384585; BDBM50464101
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|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
CID 11496746
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL256650; SCHEMBL2310029; BDBM50411658
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[74] | |||
Compound Name |
Chembl4246111
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17642578; BDBM50464105
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|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
CID 12001832
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158784; SCHEMBL180119; BDBM50394116
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[82] | |||
Compound Name |
Chembl4237868
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL20721873; BDBM50464097
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-methylpyrazin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838553; CHEMBL3221486
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[83] | |||
Compound Name |
3-(2-Methylpyridin-3-yl)-8-[6-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1-oxa-3-azaspiro[4.5]decan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289610; SCHEMBL3032352; SCHEMBL3032355; BDBM50417393
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[84] | |||
Compound Name |
(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(3-hydroxyazetidin-1-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838998; CHEMBL3221526
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[75] | |||
Compound Name |
Chembl4240155
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17642775; BDBM50464107
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|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838119; CHEMBL3221515
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[75] | |||
Compound Name |
4-(4-Fluorobenzoyl)-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;formic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL240185
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|
||||
Activity |
IC50 = 50118.72 nM
|
[79] | |||
Compound Name |
Chembl4245829
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17642649; BDBM50464109
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
Pyrrolidine, 1,5-dimethyl-3,3-diphenyl-2-ethylidene-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; CHEMBL196431; [S-(E)]-2-Ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine; CTK8E6802; DTXSID10880951; BDBM50409961; FT-0668297; FT-0668298; FT-0668299; C16659; 1,5-dimethyl-3,3-diphenyl-2 -ethylidene pyrrolidine
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[8] | |||
Compound Name |
Chembl4245368
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19435203; BDBM50464103
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
2-[[(3R,4R)-3-Aminooxan-4-yl]amino]-4-(4-methoxyanilino)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1835072; BDBM50419259
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[85] | |||
Compound Name |
Edifenphos
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Hinosan; Ediphenphos; EDDP (pesticide); Bay-hinosan; O-ETHYL S,S-DIPHENYL PHOSPHORODITHIOATE; Bayer 78418; Ediphenophos; Edifenphos [BSI:ISO]; BAY 78418; O-Ethyl-S,S-diphenyl phosphorodithioate; O-Aethyl-S,S-diphenyl-dithiophosphat; O-Ethyl S,S-diphenyl dithiophosphate; Blastoff; Edifenfos; Phosphorodithioic acid, O-ethyl S,S-diphenyl ester; SRA 7847; UNII-770M9U0F8Q; O-Ethyl-S,S-diphenyl dithiophosphate; [ethoxy(phenylsulfanyl)phosphoryl]sulfanylbenzene; Phosphorodithioic acid, O-ethyl-S,S-diphenyl ester; CHEMBL1671900; Dithiophosphorsaeure-O-aethyl-S,S-diphenylester; 770M9U0F8Q; Caswell No. 434B; HSDB 6623; EINECS 241-178-1; EPA Pesticide Chemical Code 434300; BRN 1988797; Edifenphos, BSI; O-Aethyl-S,S-diphenyl-dithiophosphat [German]; Edifenphos (EDDP); Dithiophosphorsaeure-O-aethyl-S,S-diphenylester [German]; DSSTox_CID_21910; DSSTox_RID_79873; DSSTox_GSID_41910; SCHEMBL20330; BIDD:ER0392; Edifenphos, analytical standard; DTXSID7041910; AWZOLILCOUMRDG-UHFFFAOYSA-; ethyl bis(phenylsulfanyl)phosphinate; Tox21_301355; BDBM50417962; AKOS015901344; Edifenphos 10 microg/mL in Cyclohexane; NCGC00255720-01; AC-12684; DB-043850; FT-0630436; Edifenphos, PESTANAL(R), analytical standard; (ethoxy-phenylsulfanylphosphoryl)sulfanylbenzene; C14436; 109E498; J-010687; Q15632710
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[3] | |||
Compound Name |
2-Methyl-7-[4-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]butyl]-5,6,8,9-tetrahydro-[1,3]oxazolo[4,5-h][3]benzazepine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL271073; BDBM50411664
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[74] | |||
Compound Name |
Chembl4243686
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19435089; BDBM50464099
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
2-Chloro-4-fluoro-5-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784512; BDBM50418527
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[72] | |||
Compound Name |
N-[3-Chloro-4-[4-(3-methoxypyridine-2-carbonyl)piperazin-1-yl]phenyl]-2-methyl-2-phenylpropanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL557502
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[86] | |||
Compound Name |
Chembl4237919
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19435174; BDBM50464120
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|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
4-Chloro-3-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784510; BDBM50418542
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[72] | |||
Compound Name |
Chembl4237498
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19384626; BDBM50464106
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
Schembl20719106
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1770317; BDBM50384443; 5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[87] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-(2-hydroxyethoxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838684; CHEMBL3221507
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[75] | |||
Compound Name |
(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838249; CHEMBL3221482
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[83] | |||
Compound Name |
CID 57780007
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3926412; SCHEMBL2852768; BDBM50205354
Click to Show/Hide
|
||||
Activity |
IC50 = 50118.72 nM
|
[88] | |||
Compound Name |
1-Spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-ylazetidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1277312; SCHEMBL3014902; BDBM50330749; 1-(11''H-Spiro[cyclopentane-1,10''-dibenzo[b,f]oxepin]-3-yl)-3-azetidinecarboxylic Acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[81] | |||
Compound Name |
Chembl4249629
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17642385; BDBM50464124
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[73] | |||
Compound Name |
3-[2-[5-(3-Chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3769933; GTPL9492; SCHEMBL2125026; BDBM50149566; compound 43 [PMID: 26751273]; J3.605.586C
Click to Show/Hide
|
||||
Activity |
IC50 ~ 50118.72 nM
|
[89] | |||
Compound Name |
4-(2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164422; SCHEMBL3411851; BDBM50395520
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|
||||
Activity |
IC50 ~ 50118.72 nM
|
[90] | |||
Compound Name |
N-Hydroxy-3-[4-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417746; BDBM50078195
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|
||||
Activity |
IC50 = 50300 nM
|
[43] | |||
Compound Name |
2-Methyl-5-[[[1-[2-[2-oxo-7-methoxy-1,5-naphthyridine-1(2H)-yl]ethyl]-4-piperidinyl]amino]methyl]-3-pyridinecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290341; BDBM50018439
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|
||||
Activity |
IC50 = 50600 nM
|
[91] | |||
Compound Name |
6-{[(1-{2-[6-(Methylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824036; SCHEMBL706057; BDBM50352071
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|
||||
Activity |
IC50 = 50700 nM
|
[92] | |||
Compound Name |
N-[2-(Benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4069631
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|
||||
Activity |
IC50 = 50815.94 nM
|
[93] | |||
Compound Name |
7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230812; BDBM50205465
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|
||||
Activity |
Ki = 51000 nM
|
[11] | |||
Compound Name |
7-Fluoro-4-oxo-N-(1-((2-oxo-2H-chromen-7-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL386281; SCHEMBL6333889; BDBM50202681; 7-fluoro-4-oxo-N-[1-[(2-oxochromen-7-yl)methyl]piperidin-4-yl]chromene-2-carboxamide; 7-fluoro-4-oxo-n-{1-[(2-oxo-2h-chromen-7-yl)methyl]piperidin-4-yl}4h-chromene-2-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 = 51100 nM
|
[94] | |||
Compound Name |
3-Ethyl-5-[(1R,3R)-3-[5-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]-1,3,4-oxadiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3580681; BDBM50091426
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|
||||
Activity |
IC50 = 51500 nM
|
[95] | |||
Compound Name |
4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylmethylamino)-1-hydroxy-N-(6-methoxy-1,5-naphthyridin-4-yl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1926766; BDBM50359453
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|
||||
Activity |
IC50 = 52000 nM
|
[96] | |||
Compound Name |
4-Methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3793380; SCHEMBL4549342; BDBM50163353
Click to Show/Hide
|
||||
Activity |
IC50 = 52000 nM
|
[97] | |||
Compound Name |
6-[[2alpha-[(S)-2-(1,2-Dihydro-2-oxo-7-methoxy-1,8-naphthyridine-1-yl)-1-aminoethyl]-tetrahydro-2H-pyran-5beta-yl]aminomethyl]-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4094942; SCHEMBL1607100; BDBM50266399; J3.652.520G
Click to Show/Hide
|
||||
Activity |
IC50 = 52000 nM
|
[98] | |||
Compound Name |
5-Amino-4-(isobutylamino)-6-(piperazin-1-yl)pyrimidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL474484; BDBM50249446
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|
||||
Activity |
IC50 = 52000 nM
|
[99] | |||
Compound Name |
N-{4-[(S)-1-Amino-2-((R)-3-fluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-cyclohexyl}-2,4-difluoro-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL283309; BDBM50140522
Click to Show/Hide
|
||||
Activity |
Ki = 52000 nM
|
[100] | |||
Compound Name |
(2R)-2-(5-Fluoropyridin-2-yl)-2-{[3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl]amino}ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2151322; SCHEMBL3778126; BDBM50392792; US8486966, 7
Click to Show/Hide
|
||||
Activity |
IC50 = 52000 nM
|
[101] | |||
Compound Name |
N-Cyclohexyl-N2-[4-(dimethylamino)benzoyl]-N2-[4-(hydroxycarbamoyl)benzyl]glycinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4063658; J3.541.521A
Click to Show/Hide
|
||||
Activity |
IC50 = 52119.47 nM
|
[93] | |||
Compound Name |
(S)-3-Chloro-N-isobutyl-2-methyl-N-(pyrrolidin-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1078162; BDBM50310652
Click to Show/Hide
|
||||
Activity |
IC50 = 52400 nM
|
[102] | |||
Compound Name |
ClC1=C(C=C(C=C1)C=1C=NN(C=1)CC=1C=NN(C=1)C)OC(F)F
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3936854; SCHEMBL17494133; BDBM50201024
Click to Show/Hide
|
||||
Activity |
IC50 = 52400 nM
|
[103] | |||
Compound Name |
2,4-Dichloro-3-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784513; BDBM50418528
Click to Show/Hide
|
||||
Activity |
IC50 = 52480.75 nM
|
[72] | |||
Compound Name |
(4-Cyclopropylpiperazin-1-yl)(isoindolin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL373860; BDBM50193198
Click to Show/Hide
|
||||
Activity |
IC50 = 52500 nM
|
[104] | |||
Compound Name |
(4-Isopropylpiperazin-1-yl)(4-phenylpiperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL374493; BDBM50193195
Click to Show/Hide
|
||||
Activity |
IC50 = 52500 nM
|
[104] | |||
Compound Name |
ClC1=C(C=C(C=C1)C=1C=NN(C=1)CC=1C=NNC=1)OC(F)F
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3927856; SCHEMBL17494139; BDBM50201023
Click to Show/Hide
|
||||
Activity |
IC50 = 52600 nM
|
[103] | |||
Compound Name |
[(1S,3R)-3-[[(3S,4S)-3-Methoxyoxan-4-yl]-methylamino]-1-propan-2-ylcyclopentyl]-[4-[5-(trifluoromethyl)pyridazin-3-yl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1782378; BDBM50346296
Click to Show/Hide
|
||||
Activity |
IC50 = 52800 nM
|
[105] | |||
Compound Name |
4-Methyl-1-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)piperazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL225334; BDBM50210309
Click to Show/Hide
|
||||
Activity |
IC50 = 53000 nM
|
[106] | |||
Compound Name |
5-(4-Cyano-2-Methyl-1h-Benzimidazol-1-Yl)-N-Cyclopropylthiophene-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
genz-669178; CHEMBL2012958; 5-(4-Cyano-2-methyl-1H-benzimidazol)-1-yl-N-cyclopropyl-2-thiophenecarboxamide; SCHEMBL17166889; BDBM50379156; ZINC68247513; NCGC00263379-01; Q27461673; 5-(4-cyano-2-methylbenzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide; 5-(4-cyano-2-methyl-benzimidazol-1-yl)-N-cyclopropyl-thiophene-2-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 = 53000 nM
|
[107] | |||
Compound Name |
2-[[3-[[2-(4-Cyanophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090188; BDBM50314821; 2-((3-((2-(4-cyanophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(ptolyloxycarbonyl)amino)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 53000 nM
|
[108] | |||
Compound Name |
6-[[[1-[[(3R)-5-Chloro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402185; BDBM50068016
Click to Show/Hide
|
||||
Activity |
IC50 = 53300 nM
|
[109] | |||
Compound Name |
5-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3928846; SCHEMBL16227952; BDBM195921; US9206199, 24
Click to Show/Hide
|
||||
Activity |
IC50 = 53400 nM
|
[110] | |||
Compound Name |
1-Cyclopentyl-6-{(1r)-1-[3-(Pyrimidin-2-Yl)azetidin-1-Yl]ethyl}-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2180070; SCHEMBL2989123; BDBM50398799; Q27451487; 0WL
Click to Show/Hide
|
||||
Activity |
IC50 = 53500 nM
|
[111] | |||
Compound Name |
(R)-2-Methyl-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1086033; BDBM50319503
Click to Show/Hide
|
||||
Activity |
Ki = 54000 nM
|
[112] | |||
Compound Name |
3-[4-(Azetidine-1-carbonyl)phenoxy]-N-(1-ethylpyrazol-3-yl)-5-[(2S)-1-hydroxypropan-2-yl]oxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2654608; CHEMBL3219105
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[21] | |||
Compound Name |
cis-((3S,4R)-3,4-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL474421; SCHEMBL3842850; BDBM50249552
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[23] | |||
Compound Name |
Bradanicline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Bradanicline (TC-5619); TC 5619; TC-5619; UNII-UM3821998K; CHEMBL1258006; UM3821998K; Bradanicline [USAN:INN]; Bradanicline (USAN/INN); SCHEMBL372929; GTPL3969; ATA-101; DTXSID40213778; BDBM50393247; TC5619; ZINC64540331; compound 7a [PMID 23126648]; DB06090; TC-5619-238; D10613
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[113] | |||
Compound Name |
US10087188, Example 80
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4068919; SCHEMBL17893239; BDBM288473
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[114] | |||
Compound Name |
CID 49849007
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043324; SCHEMBL2121670; BDBM50385818
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[115] | |||
Compound Name |
(2S,3S)-1-(4-Methoxyphenyl)-3-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-4-oxoazetidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL411118; SCHEMBL12616159; BDBM50372105
Click to Show/Hide
|
||||
Activity |
IC50 = 54000 nM
|
[116] | |||
Compound Name |
US8552017, 1.1(3).HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2172186; AVN-322 free form; SCHEMBL7965912; BDBM103506; SB17474
Click to Show/Hide
|
||||
Activity |
IC50 = 54200 nM
|
[117] | |||
Compound Name |
Morpholino(4-(spiro[chromene-2,4''-piperidine]-4-yl)phenyl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL551414; SCHEMBL10258348; BDBM50297320
Click to Show/Hide
|
||||
Activity |
IC50 = 54256 nM
|
[118] | |||
Compound Name |
4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]-2,6-dimethylphenoxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3909872; BDBM50203652
Click to Show/Hide
|
||||
Activity |
IC50 = 54570 nM
|
[119] | |||
Compound Name |
1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[2-(2,6-dichlorophenyl)ethylamino]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356242; BDBM50037207
Click to Show/Hide
|
||||
Activity |
IC50 = 54700 nM
|
[70] | |||
Compound Name |
(3R,3'S)-N-Cyclopropyl-5,6-difluoro-N-(quinolin-4-ylmethyl)spiro[1H-2-benzofuran-3,4'-piperidine]-3'-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1923124; SCHEMBL11942344; BDBM50359187
Click to Show/Hide
|
||||
Activity |
Ki = 55000 nM
|
[120] | |||
Compound Name |
(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(3-methylpyrazin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485124; BDBM50278104
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[121] | |||
Compound Name |
[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[(1S,5R)-6-(1,3,4-oxadiazol-2-yl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3747356; SCHEMBL9933521; SCHEMBL9933524; BDBM50500479
Click to Show/Hide
|
||||
Activity |
IC50 = 55000 nM
|
[122] | |||
Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3330073; BDBM50098911
Click to Show/Hide
|
||||
Activity |
IC50 = 55300 nM
|
[123] | |||
Compound Name |
Chembl4279795
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50470413
Click to Show/Hide
|
||||
Activity |
IC50 = 55300 nM
|
[124] | |||
Compound Name |
Chembl4209994
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50452873
Click to Show/Hide
|
||||
Activity |
IC50 = 55400 nM
|
[125] | |||
Compound Name |
N-[4-[[(5S)-2-Methyl-5-(4-methylsulfanylphenyl)-1,5-dihydro-2,4-benzodiazepin-3-yl]oxymethyl]phenyl]methanesulfonamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3350235
Click to Show/Hide
|
||||
Activity |
IC50 = 56000 nM
|
[126] | |||
Compound Name |
N-Tert-butyl-2-[[2-(4-fluorophenyl)phenyl]methyl]-3-oxo-1H-isoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3786303; SCHEMBL3760329; BDBM50160705
Click to Show/Hide
|
||||
Activity |
IC50 = 56000 nM
|
[127] | |||
Compound Name |
3-[4-(3-Fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidin-1-yl]-2,2-dimethyl-3-oxopropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784406; BDBM50418508
Click to Show/Hide
|
||||
Activity |
IC50 = 56234.13 nM
|
[72] | |||
Compound Name |
5-[(3S,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3900159; SCHEMBL16227351; BDBM195918; US9206199, 21
Click to Show/Hide
|
||||
Activity |
IC50 = 56500 nM
|
[110] | |||
Compound Name |
ADL-5747 free base
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
ADL5747; UNII-BRJ718SA03; ADL-5747 (free base); BRJ718SA03; CHEMBL561339; Benzamide, N,N-diethyl-3-hydroxy-4-spiro(2H-1-benzopyran-2,4'-piperidin)-4-yl-; N,N-diethyl-3-hydroxy-4-spiro[chromene-2,4'-piperidine]-4-ylbenzamide; SCHEMBL471356; GTPL9003; ADL 5747; BDBM50297342; ZINC38358855; compound 36 [PMID: 19694468]; A13479; Q27074313; N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4''-piperidine]-4-yl)benzamide; N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide
Click to Show/Hide
|
||||
Activity |
IC50 = 56700 nM
|
[118] | |||
Compound Name |
1-[2-[(3S,4S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-fluoropiperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165068; BDBM50395393
Click to Show/Hide
|
||||
Activity |
IC50 = 57000 nM
|
[128] | |||
Compound Name |
4-Amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325739; SCHEMBL386620; BDBM50427351
Click to Show/Hide
|
||||
Activity |
IC50 = 57793 nM
|
[13] | |||
Compound Name |
2-(4-Methoxyphenyl)-6-methyl-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
4'-METHOXY-6-METHYLFLAVONE; 2-(4-methoxyphenyl)-6-methylchromen-4-one; Oprea1_385050; SCHEMBL535143; CHEMBL2442379; ZINC57693; DTXSID70350948; 6-METHYL-4'-METHOXYFLAVONE; AKOS001075130; MB01115; MCULE-7477337275; UPCMLD0ENAT5343805:001; 4'-methoxy-6-methylflavone, AldrichCPR; NCGC00335857-01; ST056229; AB01115709-03; SR-01000430824; SR-01000430824-1; Z57179118; 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-6-methyl-
Click to Show/Hide
|
||||
Activity |
IC50 = 57900 nM
|
[129] | |||
Compound Name |
(3R)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-5-fluoro-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2424931; SCHEMBL3547146; BDBM50493331
Click to Show/Hide
|
||||
Activity |
IC50 = 58000 nM
|
[130] | |||
Compound Name |
2-[5-[1-[3-Cyclobutyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-1,3-thiazol-2-yl]propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL310303; BDBM50128685
Click to Show/Hide
|
||||
Activity |
Ki = 58400 nM
|
[40] | |||
Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-3-[3-(2-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL375745; SCHEMBL2896776
Click to Show/Hide
|
||||
Activity |
IC50 = 58500 nM
|
[131] | |||
Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(2H-tetrazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL195378
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[132] | |||
Compound Name |
4-[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4107016; SCHEMBL17005219; BDBM242763; US9422299, 29
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[56] | |||
Compound Name |
4-[4-(Dimethylcarbamoyl)phenoxy]-2-methyl-N-(5-methylpyrazin-2-yl)-1-benzofuran-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3218482
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[133] | |||
Compound Name |
(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(imidazo[1,2-a]pyrimidin-3-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485125; BDBM50278105
Click to Show/Hide
|
||||
Activity |
IC50 = 59000 nM
|
[121] | |||
Compound Name |
5-[(3R,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3922156; SCHEMBL15036771; BDBM195920; US9206199, 23
Click to Show/Hide
|
||||
Activity |
IC50 = 59400 nM
|
[110] | |||
Compound Name |
5-[(E)-2-(2-Chloro-6-fluorophenyl)ethenyl]-N,N-dimethylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3314429; BDBM50046418
Click to Show/Hide
|
||||
Activity |
IC50 = 59500 nM
|
[134] | |||
Compound Name |
Chembl4127458
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50275434
Click to Show/Hide
|
||||
Activity |
IC50 = 59800 nM
|
[135] | |||
Compound Name |
N-[1-[2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-N-methyl-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3604806; BDBM50113650
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[136] | |||
Compound Name |
Rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1777861; BDBM50344068
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[137] | |||
Compound Name |
[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]methyl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4074920; BDBM50235077
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
6-[[[1-[(1S,2R)-2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1,2-dihydroxyethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3753988
Click to Show/Hide
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||||
Activity |
IC50 = 60000 nM
|
[139] | |||
Compound Name |
6-[7-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-methylpyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4101783; BDBM50249314
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
2-[(7R)-7-[(4-Fluorophenyl)methyl-(4-fluorophenyl)sulfonylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1643789; BDBM50333850
Click to Show/Hide
|
||||
Activity |
Ki ~ 60000 nM
|
[141] | |||
Compound Name |
(3R)-3-[[4-[(5-Chloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425824
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
trans-4-({1-[5-(5-Fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3342770; CHEMBL3342771; SCHEMBL14128553; SCHEMBL14128554; SCHEMBL14235058; BDBM50031504; BDBM50031505; 4-[1-[5-(6-fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl]oxycyclohexane-1-carboxylic acid
Click to Show/Hide
|
||||
Activity |
Ki ~ 60000 nM
|
[143] | |||
Compound Name |
[4-[[2-(2,2-Difluoroethyl)tetrazol-5-yl]methyl]piperazin-1-yl]-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4103112; BDBM50235079
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
3-[1-(4-Chlorophenyl)cyclopropyl]-8-Cyclopropyl[1,2,4]triazolo[4,3-A]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CCCTP; CHEMBL3318978; 3-(1-(4-Chlorophenyl)cyclopropyl)-8-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridine; BDBM50054691; Q27451989
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[144] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-2-oxopyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4068584; BDBM50249247
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
(1S,3R)-3-[8-Amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1,3-dimethylcyclohexane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4074833; BDBM50233382
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[114] | |||
Compound Name |
(3R)-3-[[4-[(5,8-Dichloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425827
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
N-[2-[2-[4-Bromo-3-[(3R,4R)-4-(3,4-difluorophenyl)-4-(2,3-dihydroxypropoxy)piperidin-3-yl]-1,2-oxazol-5-yl]phenyl]ethyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2017112; SCHEMBL10202743; BDBM50380996
Click to Show/Hide
|
||||
Activity |
Ki ~ 60000 nM
|
[145] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4078280; SCHEMBL19379796; BDBM50249275
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
(1R,3R)-3-[8-Amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-3-methyl-1-propan-2-ylcyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4096195; BDBM50233393
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[114] | |||
Compound Name |
(3R)-3-[[4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425822
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-5-Fluoro-3-hydroxy-3-[[4-[(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425927
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
3-Anilino-1-[(1S,2S)-2-cyanocyclohexyl]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4076821; SCHEMBL14821108; BDBM50250937
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[146] | |||
Compound Name |
9-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-4-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4075425; SCHEMBL17723480; BDBM50249308
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3400823; BDBM50068007
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
2,2-Difluoro-4-[[7-fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3605001; SCHEMBL14361656; BDBM50113940
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[147] | |||
Compound Name |
(3R)-3-[[4-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425924
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
2-[(7R)-4-Fluoro-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1643783; BDBM50333844
Click to Show/Hide
|
||||
Activity |
Ki ~ 60000 nM
|
[141] | |||
Compound Name |
6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3400818; BDBM50068002
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
(3R)-3-[[4-[(4,4-Dioxo-2,3-dihydro-[1,4]oxathiino[3,2-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425818
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-3-[[4-(6,7-Dihydro-[1,4]dioxino[2,3-c]pyridazin-3-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425820
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
6-[[[1-[[(3R)-5,10-Difluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402178; BDBM50068009
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-9-methyl-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402182; BDBM50068013
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]anilino]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4089118; SCHEMBL14820690; BDBM237874; US9394282, 9-9
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[146] | |||
Compound Name |
5-[[(2R)-2-Amino-3-methylsulfonylpropyl]amino]-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3415590; BDBM50075682
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[148] | |||
Compound Name |
(1R,2S)-2-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3605003; BDBM50113942
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[147] | |||
Compound Name |
8-[(1R,2S)-1-Hydroxy-1-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)propan-2-yl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4075415; SCHEMBL17723656; BDBM50249187
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]methyl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4095361; BDBM50235075
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
2-(Diethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1091162; SCHEMBL1242561; BDBM50315578; 2-(diethylamino)-2-phenyl-1,1-dipyridin-3-ylethanol
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
CID 68867935
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233185; SCHEMBL3992030; BDBM50009218
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[149] | |||
Compound Name |
(3R)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425819
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4066314; BDBM50235121
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
2-[[(2R)-4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-methylpiperazin-1-yl]methyl]-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3596517; BDBM50108680
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[150] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4105076; SCHEMBL16438736; BDBM50235206
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[151] | |||
Compound Name |
[4-[(2-Ethyltetrazol-5-yl)methyl]piperazin-1-yl]-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4065251; BDBM50235122
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
2-(2-Aminoimidazol-1-yl)-1-(4-chloro-2-fluorophenyl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3289792; BDBM50020421
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[152] | |||
Compound Name |
6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3400824; BDBM50068008
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
2,6-Dichloro-N-[(2R)-2-(8-fluoro-5-methyl-4-oxo-3H-quinazolin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1,2,4-triazol-1-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3627899; SCHEMBL17825634; BDBM50125979
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[153] | |||
Compound Name |
(3R)-5-Fluoro-3-[[4-[(6-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425823
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-5-Fluoro-3-hydroxy-3-[[4-[(2-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425812
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-3-[[4-(2,3-Dihydro-[1,4]oxathiino[3,2-c]pyridin-7-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425816
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041167; BDBM50385829
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[115] | |||
Compound Name |
4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]phenoxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3968947; BDBM50203654
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[119] | |||
Compound Name |
(4r)-3-Fluoro-4-Hydroxy-4-{[(1r,4r)-4-{[(3-Oxo-3,4-Dihydro-2h-Pyrido[3,2-B][1,4]oxazin-6-Yl)methyl]amino}-2-Oxabicyclo[2.2.2]oct-1-Yl]methyl}-4,5-Dihydro-7h-Pyrrolo[3,2,1-De][1,5]naphthyridin-7-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3400817; BDBM50068001; WCP
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
6-[[[1-[(10-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl)methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402180; BDBM50068011
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
N-[1-[2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3604805; BDBM50113649
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[136] | |||
Compound Name |
(3R)-3-[[4-[(6-Chloro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425514
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
2-Morpholino-1,1-di(pyridin-3-yl)propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090795; SCHEMBL1242050; BDBM50315569; 2-morpholin-4-yl-1,1-dipyridin-3-ylpropan-1-ol
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4087218; SCHEMBL16438697; BDBM50235195
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[151] | |||
Compound Name |
2-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3605116; BDBM50113934
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[147] | |||
Compound Name |
6-[[[1-[[(3S)-5,10-Difluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402179; BDBM50068010
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4093837; SCHEMBL17723585; BDBM50249307
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
7-Fluoro-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425799; BDBM50084044
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-3-[[4-(1,3-Benzodioxol-5-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425930
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-5-Fluoro-3-hydroxy-3-[[4-[(3-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425811; BDBM50084057
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoropyridin-4-yl)amino]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4067915; SCHEMBL14820644; BDBM237866; US9394282, 9-1
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[146] | |||
Compound Name |
3-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2043171; BDBM50385816
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[115] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(4-methyl-5-oxopyrazin-2-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4084167; SCHEMBL17723592; BDBM50249271
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(1-methylpyrazol-4-yl)anilino]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4078799; BDBM50250920
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[146] | |||
Compound Name |
US10087188, Example 1
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4087679; SCHEMBL17892409; US10087188, Example 6; BDBM288308
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[114] | |||
Compound Name |
6-[9-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-2-methylpyridazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4062796; SCHEMBL19379813; BDBM50249163
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[140] | |||
Compound Name |
6-[[[1-[[(3R)-6-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12),9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402184; BDBM50068015
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
N-(3,4-Dichlorophenyl)-4-{[(2R)-4-isopropylpiperazin-2-yl]carbonyl}piperazine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2036782; SCHEMBL1942682; BDBM50385450; N-(3,4-dichlorophenyl)-4-[(2R)-4-propan-2-ylpiperazine-2-carbonyl]piperazine-1-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[154] | |||
Compound Name |
7-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-8-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425813
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
7-Methoxy-2-[[(2R)-2-methyl-4-pyrimidin-2-ylpiperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3596510
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[150] | |||
Compound Name |
3-Anilino-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4100288; SCHEMBL14821179; BDBM237902; US9394282, 9-37
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[146] | |||
Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3735281; SCHEMBL18792879
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[155] | |||
Compound Name |
2-[[(2R)-4-(1-Tert-butylpyrazol-4-yl)-2-methylpiperazin-1-yl]methyl]-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3596590; BDBM50108677
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[150] | |||
Compound Name |
US10087188, Example 30
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4079697; SCHEMBL17892489; SCHEMBL17893235; BDBM288425; BDBM50233394
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[114] | |||
Compound Name |
1-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3605007; SCHEMBL14476387; BDBM50113946
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[147] | |||
Compound Name |
(R)-Phenyl[(2R,5S)-5-(4-{[4-(pyridin-2-ylmethyl)piperazin-1-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4073137; SCHEMBL9934186; BDBM50235076
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[138] | |||
Compound Name |
2-Morpholin-4-yl-2-phenylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090791; 2-morpholino-2-phenylethanol; 2-Phenyl-2-morpholinoethanol; SCHEMBL11651599; BDBM50315565
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
3-[5-[2-Fluoro-5-(trifluoromethoxy)phenyl]-1-benzofuran-2-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3896657; BDBM50203653
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[119] | |||
Compound Name |
2-(Dimethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090817; SCHEMBL1242316; BDBM50315576; 2-(dimethylamino)-2-phenyl-1,1-dipyridin-3-ylethanol
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
6-[[[1-[(9-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl)methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402183; BDBM50068014
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4082282; SCHEMBL10146535; BDBM50264805
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[156] | |||
Compound Name |
7-Methoxy-2-[[(2R)-2-methyl-4-(1-methylpyrazol-4-yl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3596514; BDBM50108683
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[150] | |||
Compound Name |
7-Ethyl-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425802; BDBM50084047
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]furan-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2041165; BDBM50385779
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[115] | |||
Compound Name |
6-[[[1-[[(3S)-5-Chloro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402186; BDBM50068017
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
2-Methyl-1-morpholino-1-phenylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090792; SCHEMBL12508295; BDBM50315566
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[39] | |||
Compound Name |
(4-Ethylsulfonylpiperidin-1-yl)-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3747710; BDBM50500476
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[122] | |||
Compound Name |
6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-7-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425801; BDBM50084046
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
(3R)-3-[[4-[(1,1-Dioxo-2,3-dihydro-[1,4]oxathiino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425817
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
6-[[[1-[[(3R)-3-Hydroxy-5-methoxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402187; BDBM50068018
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-9-methyl-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3402181; BDBM50068012
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[109] | |||
Compound Name |
N,N-Diethyl-4-(7-hydroxyspiro[chromene-2,4''-piperidine]-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL495094; SCHEMBL471246; BDBM50252952
Click to Show/Hide
|
||||
Activity |
IC50 = 60000 nM
|
[157] | |||
Compound Name |
(3R)-5-Fluoro-3-hydroxy-3-[[4-(1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425926
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
2-[4-[2-[(1S,2R)-2-[1-(5-Chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]-N-cyclopropylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4083676; SCHEMBL14970327; BDBM50232632
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[158] | |||
Compound Name |
(3R)-3-[[4-[(8-Chloro-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425814
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[142] | |||
Compound Name |
4-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3605118; SCHEMBL14361611; BDBM50113936
Click to Show/Hide
|
||||
Activity |
IC50 ~ 60000 nM
|
[147] | |||
Compound Name |
(3R,3'S)-N-Cyclopropyl-5,6-difluoro-N-(isoquinolin-1-ylmethyl)spiro[1H-2-benzofuran-3,4'-piperidine]-3'-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1923123; SCHEMBL11942355; BDBM50359186
Click to Show/Hide
|
||||
Activity |
Ki ~ 60000 nM
|
[120] | |||
Compound Name |
N-(1-(3-Acetamidobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL269352; BDBM50202674
Click to Show/Hide
|
||||
Activity |
IC50 = 60700 nM
|
[94] | |||
Compound Name |
(4-Fluorophenyl)-[(8R)-3-(3-methyl-1,2,4-thiadiazol-5-yl)-8-propyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110242; SCHEMBL16115519; BDBM242759; US9422299, 24
Click to Show/Hide
|
||||
Activity |
IC50 = 61000 nM
|
[56] | |||
Compound Name |
(2S)-2-[1-(2,6-Dichlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-(5-methylpyrazin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838574; CHEMBL3221531; AZD-9485
Click to Show/Hide
|
||||
Activity |
IC50 = 62000 nM
|
[75] | |||
Compound Name |
4-(3-Fluorophenyl)-2-(2-hydroxyethyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL214969; SCHEMBL3621068; BDBM50199067; 4-(3-fluorophenyl)-2-(2-hydroxyethyl)-6-methoxy-1-oxoisoquinoline-3-carbonitrile
Click to Show/Hide
|
||||
Activity |
IC50 = 62000 nM
|
[159] | |||
Compound Name |
7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230704; SCHEMBL13946555; BDBM50205451; PGE-9262932
Click to Show/Hide
|
||||
Activity |
Ki = 62000 nM
|
[11] | |||
Compound Name |
N-Tert-butyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3786542; SCHEMBL3749157; BDBM50160565
Click to Show/Hide
|
||||
Activity |
IC50 = 62000 nM
|
[127] | |||
Compound Name |
N-((3S,4S)-4-(4-(5-Fluoropyridin-2-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289409; SCHEMBL4095180; BDBM50331389; N-[(3S,4R)-4-[4-(5-fluoropyridin-2-yl)phenyl]oxolan-3-yl]propane-2-sulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-[(3S,4R)-4-[4-(3-Acetylphenyl)phenyl]oxolan-3-yl]propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289293; SCHEMBL4097607; BDBM50331386; N-((3S,4S)-4-(3''-acetylbiphenyl-4-yl)tetrahydrofuran-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-((3R,4R)-1-Methyl-4-(4-(thiophen-2-yl)phenyl)pyrrolidin-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289179; SCHEMBL4957451; BDBM50331383
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-[(3S,4R)-4-(4-Thiophen-3-ylphenyl)oxolan-3-yl]propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289523; SCHEMBL4102241; BDBM50331391; N-((3S,4S)-4-(4-(thiophen-3-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
(1S,4R)-1-(((S)-4-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL480016; BDBM50254678
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[161] | |||
Compound Name |
N-((3R,4R)-1-Methyl-4-(3''-(methylsulfonyl)biphenyl-4-yl)pyrrolidin-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1290392; SCHEMBL4958366; BDBM50331374
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-((3S,4S)-4-(4-(5-Fluoropyridin-3-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289408; SCHEMBL4093358; BDBM50331388; N-[(3S,4R)-4-[4-(5-fluoropyridin-3-yl)phenyl]oxolan-3-yl]propane-2-sulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-[(3S,4R)-4-(4-Thiophen-2-ylphenyl)oxolan-3-yl]propane-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1289410; SCHEMBL4099320; BDBM50331390; N-((3S,4S)-4-(4-(thiophen-2-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63000 nM
|
[160] | |||
Compound Name |
N-[4-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-1-yl]phenyl]-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1223599; BDBM50416721
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[162] | |||
Compound Name |
(E)-3-[8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinolin-2-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3952802; SCHEMBL2850269; SCHEMBL2850271; BDBM50205355
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[88] | |||
Compound Name |
3-[[(3R)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1278115; BDBM50417375
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[81] | |||
Compound Name |
8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3896541; BDBM50205362
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[88] | |||
Compound Name |
Chembl4248589
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17640885; BDBM50464112
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[73] | |||
Compound Name |
Chembl4238909
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17629329; BDBM50464110
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[73] | |||
Compound Name |
4-Benzoyl-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL559206
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[79] | |||
Compound Name |
2-[5-Chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-hydroxyethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1169660; SCHEMBL4909619; BDBM50416305
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[163] | |||
Compound Name |
8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinoline-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3953018; BDBM50205366
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[88] | |||
Compound Name |
CID 57663637
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022502; SCHEMBL4247646; BDBM50382037; N-[4-[5-[3-(4,4-difluoropiperidin-1-yl)propylamino]-1,3,4-oxadiazol-2-yl]phenyl]-2-fluorobenzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[164] | |||
Compound Name |
2-Fluoro-N-[3-methoxy-4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022738; SCHEMBL4238487; BDBM50382047
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[164] | |||
Compound Name |
(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-cyanopyridin-2-yl)-3-((R)-1-hydroxypropan-2-yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL840012; CHEMBL3221514
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[75] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-fluoropyridin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL837916; CHEMBL3221498
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[83] | |||
Compound Name |
(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839191; CHEMBL3221493
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[75] | |||
Compound Name |
2-Fluoro-N-[4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022729; SCHEMBL4249007; BDBM50382050
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[164] | |||
Compound Name |
CID 11662194
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL270209; SCHEMBL2308553; BDBM50411708
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[74] | |||
Compound Name |
2-Fluoro-N-[4-[5-[3-(4-methylpiperazin-1-yl)propylamino]-1,3,4-oxadiazol-2-yl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2022501; SCHEMBL4249990; BDBM50382036
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[164] | |||
Compound Name |
3-(1-Cyclohexylpiperidin-4-yl)-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2146597; SCHEMBL4572894; BDBM50391743
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[165] | |||
Compound Name |
3-[[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1278114; BDBM50417355
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[81] | |||
Compound Name |
(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxy-N-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839940; CHEMBL3221500
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[83] | |||
Compound Name |
N-Methyl-3-[4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784476; BDBM50418523
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[72] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-methylpyridin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838835; CHEMBL3221485
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[83] | |||
Compound Name |
3-[4-[2-[3-(2-Methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784473; BDBM50418521
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[72] | |||
Compound Name |
1-(3-Methoxyphenyl)-3-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]imidazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL550358; BDBM50414400
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[166] | |||
Compound Name |
(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838724; CHEMBL3221527
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[75] | |||
Compound Name |
1-[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1277770; BDBM50330747
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[81] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-[(2S)-1-hydroxypropan-2-yl]oxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838901; CHEMBL3221511
Click to Show/Hide
|
||||
Activity |
IC50 = 63095.73 nM
|
[75] | |||
Compound Name |
3-[1-(Oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2146598; SCHEMBL4301164; SCHEMBL4636037; BDBM50391742
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[165] | |||
Compound Name |
Chembl4243367
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50464100
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[73] | |||
Compound Name |
Chembl4242263
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17640912; BDBM50464123
Click to Show/Hide
|
||||
Activity |
IC50 ~ 63095.73 nM
|
[73] | |||
Compound Name |
(1S)-2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1927166; BDBM50359543
Click to Show/Hide
|
||||
Activity |
IC50 = 63100 nM
|
[167] | |||
Compound Name |
[4-[[3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenyl] 4-methoxybenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417767; SCHEMBL16817979; BDBM50078174
Click to Show/Hide
|
||||
Activity |
IC50 = 63400 nM
|
[43] | |||
Compound Name |
(S)-7-(3-(Aminomethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL387838; BDBM50205466
Click to Show/Hide
|
||||
Activity |
Ki = 64000 nM
|
[11] | |||
Compound Name |
[2-(5-Fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4060556; BDBM50261325
Click to Show/Hide
|
||||
Activity |
IC50 = 64000 nM
|
[168] | |||
Compound Name |
1-(((3R)-3-Methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclobutanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL465956; SCHEMBL4051323; BDBM50248567
Click to Show/Hide
|
||||
Activity |
IC50 = 65000 nM
|
[169] | |||
Compound Name |
N-[(2s,4s)-1-({4-[2-(3,5-Dimethyl-1,2-Oxazol-4-Yl)ethyl]piperidin-1-Yl}sulfonyl)-4-(5-Fluoropyrimidin-2-Yl)-2-Methylpentan-2-Yl]-N-Hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1615187; 3q2h; BDBM50337735; Q27464726; QHF
Click to Show/Hide
|
||||
Activity |
IC50 = 65000 nM
|
[170] | |||
Compound Name |
N-(1-(4-(3-(Dimethylamino)propoxy)-3-fluorobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL248296; BDBM50207677
Click to Show/Hide
|
||||
Activity |
IC50 = 65000 nM
|
[171] | |||
Compound Name |
5-Methoxy-2-(2-pyridin-3-ylethynyl)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335285; SCHEMBL15877643; BDBM50429061
Click to Show/Hide
|
||||
Activity |
IC50 = 65300 nM
|
[28] | |||
Compound Name |
N-((cis)-4-Aminocyclohexyl)-N-(3-chlorobenzyl)-1-methyl-1H-imidazole-4-carboxamide dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3217125; CHEMBL596895; BDBM50309961
Click to Show/Hide
|
||||
Activity |
IC50 = 65600 nM
|
[172] | |||
Compound Name |
cis-N-(3-Chlorobenzyl)-N-(-4-aminocyclohexyl)-1-methyl-1H-imidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL563761; BDBM50293568
Click to Show/Hide
|
||||
Activity |
IC50 = 65600 nM
|
[173] | |||
Compound Name |
N-(1-(4-((2-(Piperidin-1-yl)ethyl)carbamoyl)benzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL246050; SCHEMBL6332989; BDBM50207684
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[171] | |||
Compound Name |
CID 86274489
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608687; SCHEMBL16114677; BDBM50112181
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[56] | |||
Compound Name |
2-(2-Methoxypyrimidin-5-yl)-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL1502650; CHEMBL4061436; ZINC116369190; DA-28594
Click to Show/Hide
|
||||
Activity |
IC50 = 66000 nM
|
[174] | |||
Compound Name |
(4-Tert-butylpiperidin-1-yl)(4-isopropylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL219128; SCHEMBL17471146; BDBM50193172
Click to Show/Hide
|
||||
Activity |
IC50 = 66923.08 nM
|
[104] | |||
Compound Name |
(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-15-[1-[(3-hydroxy-1,5-naphthyridin-4-yl)methyl]azetidin-3-yl]-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL583299; BDBM50299108
Click to Show/Hide
|
||||
Activity |
IC50 = 67000 nM
|
[175] | |||
Compound Name |
5-[[[1-[2-(7-Fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290340; BDBM50018422
Click to Show/Hide
|
||||
Activity |
IC50 = 69000 nM
|
[91] | |||
Compound Name |
2-[4-[[4-(3,4-Dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)piperidin-1-yl]methyl]phenyl]-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2391994; BDBM50492064
Click to Show/Hide
|
||||
Activity |
IC50 = 69000 nM
|
[176] | |||
Compound Name |
6-[[[1-[2-(7-Methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-3-methylpyrazine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290346; BDBM50018446
Click to Show/Hide
|
||||
Activity |
IC50 = 69000 nM
|
[91] | |||
Compound Name |
Benzeneacetamide, 3-chloro-alpha-(cyclopentylmethyl)-N-(5-((1S)-1,2-dihydroxyethyl)-2-pyrazinyl)-4-(methylsulfonyl)-, (alphaR)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
UNII-I655N5I88O; CHEMBL2338347; I655N5I88O; SCHEMBL1445792; BDBM50428287; RO4597014; RO-4597014
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[177] | |||
Compound Name |
5-Amino-4-morpholino-6-(neopentylamino)pyrimidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL471757; BDBM50249411
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[99] | |||
Compound Name |
(3-Chlorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110770; SCHEMBL16114630; BDBM242752; US9422299, 16
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
Fezolinetant
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
ESN-364; UNII-83VNE45KXX; 83VNE45KXX; ESN364; CHEMBL3608680; Fezolinetant [USAN]; SCHEMBL16114810; GTPL10422; BDBM50112244; WHO 10205; compound 3 [PMID:26191358]; CS-7952; SB19658; HY-19632; AS3472693-00; Q27269455
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
(4-Chloro-3-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4106866; SCHEMBL16143079; BDBM242742; US9422299, 4
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
(2,4-Difluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110224; SCHEMBL16115652; BDBM242754; US9422299, 18
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
(3-Methoxyphenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4114258; SCHEMBL16114605; BDBM242762; US9422299, 27
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
(3-Fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4111714; SCHEMBL16115730; BDBM242751; US9422299, 15
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(3,4,5-trifluorophenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4115594; SCHEMBL16143188; BDBM242744; US9422299, 7
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(2,3,4-trifluorophenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4115295; SCHEMBL16143189; BDBM242745; US9422299, 8
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(2,3,4,5-tetrafluorophenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4113428; SCHEMBL16143071; BDBM242747; US9422299, 10
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
(3,4-Difluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4112037; SCHEMBL16115682; BDBM242746; US9422299, 9
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
[(8R)-8-Ethyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-fluorophenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4112608; SCHEMBL16143082; BDBM242757; US9422299, 22
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
[(8R)-3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-fluorophenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4110286; SCHEMBL16143091; BDBM242749; US9422299, 13
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[56] | |||
Compound Name |
3-[4-(1-Azetidinylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZD1092; SCHEMBL2173188; CHEMBL3217925
Click to Show/Hide
|
||||
Activity |
IC50 = 70000 nM
|
[21] | |||
Compound Name |
N-Isopropyl-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL456173; BDBM50274030
Click to Show/Hide
|
||||
Activity |
IC50 = 71500 nM
|
[17] | |||
Compound Name |
N,N-Diethyl-6-(spiro[chromene-2,4''-piperidine]-4-yl)nicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL561138; SCHEMBL471595; BDBM50297335
Click to Show/Hide
|
||||
Activity |
IC50 = 71666 nM
|
[118] | |||
Compound Name |
2-[(2R)-2-(Pyridin-3-yloxymethyl)piperazin-1-yl]-[1,3]oxazolo[4,5-b]pyridine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3262132; SCHEMBL780840; BDBM50016185
Click to Show/Hide
|
||||
Activity |
IC50 = 72000 nM
|
[178] | |||
Compound Name |
7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230813; BDBM50205457
Click to Show/Hide
|
||||
Activity |
Ki = 72000 nM
|
[11] | |||
Compound Name |
Ilotycin
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Pantomicina; Erythromid; Propiocine; Dotycin; Erycinum; Eryderm; Ilocaps; Erycin; Kesso-Mycin; Taimoxin-F; erythro; Erythroguent; Erytab; Inderm; Retcin; T-Stat; adecane-2,10-dione (non-preferred name); A/T/S; IndermRetcin; NSC55929; NSC-55929; Erythromycin, sodium salt; CHEMBL1671887; component of Drixin (Salt/Mix); SCHEMBL15263177; BDBM86313; component of T-stat (Salt/Mix); CTK5C1089; Erythromycin sodium lauryl sulfate; BBL028236; NSC_12560; SBB057401; STK249736; thyl-6-oxacyclotetradecane-1,7-dione; AKOS005423023; MCULE-2023073206; SY070227; DB-041196; FT-0603313; FT-0625700; component of Benzedrex nasal spray (Salt/Mix); Sulfuric acid, sodium salt, compd. with erythromycin
Click to Show/Hide
|
||||
Activity |
IC50 = 72443.6 nM
|
[3] | |||
Compound Name |
N-{4-[(S)-1-Amino-2-((R)-3-fluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-cyclohexyl}-3,4-difluoro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL23924; BDBM50140524
Click to Show/Hide
|
||||
Activity |
Ki = 73000 nM
|
[100] | |||
Compound Name |
Auglurant
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
VU0424238; N-(5-fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide; CHEMBL2386850; UNII-GRN8X62ZW2; GRN8X62ZW2; SCHEMBL12499337; VU238; EX-A2936; BDBM50257064; MFCD28386341; VU 238; 2-PyridinecarboxaMide, N-(5-fluoro-2-pyridinyl)-6-Methyl-4-(5-pyriMidinyloxy)-; HY-16617; CS-0009173; VU 0424238; YU-0424238; J3.655.475D; 2-PyridinecarboxaMide,N-(5-fluoro-2-pyridinyl)-6-Methyl-4-(5-pyriMidinyloxy)-; N-(5-Fluoro-2-pyridinyl)-6-methyl-4-(5-pyrimidinyloxy)-2-pyridinecarboxamide; N-(5-fluoropyridin-2-yl)-6-methyl-4-pyrimidin-5-yloxypyridine-2-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 = 73600 nM
|
[179] | |||
Compound Name |
5-Cyano-N-[1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]-6-methylpyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290344; BDBM50018443
Click to Show/Hide
|
||||
Activity |
IC50 = 74000 nM
|
[91] | |||
Compound Name |
(3-Fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4102181; BDBM50261310
Click to Show/Hide
|
||||
Activity |
IC50 = 74000 nM
|
[168] | |||
Compound Name |
4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-indol-1-yl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL300927; BDBM50127996
Click to Show/Hide
|
||||
Activity |
IC50 = 74131.02 nM
|
[3] | |||
Compound Name |
3-Ethyl-4-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-2-oxocyclopent-3-ene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671908; SCHEMBL13847318; SCHEMBL16656916; BDBM50417939
Click to Show/Hide
|
||||
Activity |
IC50 = 74131.02 nM
|
[3] | |||
Compound Name |
CID 57750369
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325995; SCHEMBL391494; BDBM50427333
Click to Show/Hide
|
||||
Activity |
IC50 = 74807 nM
|
[13] | |||
Compound Name |
3-Methyl-2-morpholino-1,1-di(pyridin-3-yl)butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1091879; SCHEMBL1242858; BDBM50315570; 3-methyl-2-morpholin-4-yl-1,1-dipyridin-3-ylbutan-1-ol
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[39] | |||
Compound Name |
6-[[[(3S,4R)-3-Fluoro-1-[2-(2-oxo-7-pyridin-3-yloxy-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608757; BDBM50112265
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[180] | |||
Compound Name |
CID 60199796
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165056; SCHEMBL3354894; BDBM50395406
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[128] | |||
Compound Name |
1-[2-[(3S,4S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-fluoropiperidin-1-yl]ethyl]-7-methoxyquinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165069; BDBM50395419
Click to Show/Hide
|
||||
Activity |
IC50 = 75000 nM
|
[128] | |||
Compound Name |
3-(4-Methylpiperazin-1-yl)-N-(quinolin-7-ylmethyl)-7-(trifluoromethyl)quinolin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3221126
Click to Show/Hide
|
||||
Activity |
IC50 = 75800 nM
|
[181] | |||
Compound Name |
6-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3889781; SCHEMBL15036691; BDBM195909; US9206199, 1
Click to Show/Hide
|
||||
Activity |
IC50 = 75900 nM
|
[110] | |||
Compound Name |
2-[(2R)-2,3-Dihydroxypropyl]-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL217571; SCHEMBL3617133; BDBM50199061; 2-[(2R)-2,3-dihydroxypropyl]-6-methoxy-1-oxo-4-phenylisoquinoline-3-carbonitrile
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[159] | |||
Compound Name |
2-[5-(7-Ethoxy-6-methoxyquinolin-4-yl)oxy-3-methoxypyridin-2-yl]-N-(5-ethyl-4-methyl-1H-pyrazol-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2023802; BDBM50381928
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[182] | |||
Compound Name |
(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL445949
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[183] | |||
Compound Name |
1-[(1R)-1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-[(1-hydroxycyclohexyl)methylamino]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356252; SCHEMBL12312134; BDBM50037213
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[70] | |||
Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL364102
Click to Show/Hide
|
||||
Activity |
IC50 = 76000 nM
|
[184] | |||
Compound Name |
Ethyl 1-[3-(4-sulfamoylphenoxy)propyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024379; BDBM50382855
Click to Show/Hide
|
||||
Activity |
IC50 = 76500 nM
|
[185] | |||
Compound Name |
3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-carbonyl]-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL188068; BDBM50156458
Click to Show/Hide
|
||||
Activity |
IC50 = 76800 nM
|
[186] | |||
Compound Name |
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3741589; A-971432; A971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid; 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]azetidine-3-carboxylic acid; GTPL9496; SCHEMBL3038019; BDBM50499634; AKOS027470281; ZINC143565982; J3.559.377B; A-971432, >=95% (HPLC); A 971432; 1-(4-(3,4-dichlorobenzyloxy)benzyl)azetidine-3-carboxylic acid; 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Click to Show/Hide
|
||||
Activity |
IC50 = 77000 nM
|
[187] | |||
Compound Name |
CID 68769744
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233187; SCHEMBL3744128; BDBM50009221
Click to Show/Hide
|
||||
Activity |
IC50 = 77000 nM
|
[149] | |||
Compound Name |
Benzamide, N,N-diethyl-4-(5-hydroxyspiro(2H-1-benzopyran-2,4'-piperidin)-4-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
ADL5859; ADL-5859; UNII-FA554TW3UP; FA554TW3UP; ADL 5859; CHEMBL494480; N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidin]-4-yl)benzamide; SCHEMBL467481; GTPL9004; BDBM50252954; ZINC40424141; N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide; SB19530; N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide; compound 20 [PMID: 18788723]; NCGC00346641-01; NCGC00346641-02; NCGC00346641-07; DB-076207; FT-0760130; PF-04856880; Q27074314; N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4''-piperidine]-4-yl)benzamide; N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl) benzamide
Click to Show/Hide
|
||||
Activity |
IC50 = 78000 nM
|
[157] | |||
Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL245379
Click to Show/Hide
|
||||
Activity |
IC50 = 78000 nM
|
[188] | |||
Compound Name |
1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[(1-hydroxycyclopentyl)methylamino]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356248; SCHEMBL12312136; BDBM50037210
Click to Show/Hide
|
||||
Activity |
IC50 = 78600 nM
|
[70] | |||
Compound Name |
Ethyl 1-[3-[4-(phenylcarbamoylsulfamoyl)phenoxy]propyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021969; BDBM50382876
Click to Show/Hide
|
||||
Activity |
IC50 = 78700 nM
|
[185] | |||
Compound Name |
6-[[[1-[2-[7-(5-Fluoropyridin-3-yl)oxy-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608750; BDBM50112258
Click to Show/Hide
|
||||
Activity |
IC50 = 79000 nM
|
[180] | |||
Compound Name |
4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL182223
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Activity |
IC50 = 79000 nM
|
[184] | |||
Compound Name |
Chembl4207042
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|
Investigative | Compound Info | ||
Synonyms |
PF-06733804; Trk-IN-3; SCHEMBL17499938; TQR0426; BDBM50457825; ZINC585091590; HY-112434; CS-0046052; PF-06733804, >=98% (HPLC)
Click to Show/Hide
|
||||
Activity |
IC50 = 79000 nM
|
[189] | |||
Compound Name |
(1R)-2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1927165; BDBM50359536
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|
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Activity |
IC50 = 79400 nM
|
[167] | |||
Compound Name |
N-Hydroxy-3-[4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784468; BDBM50418515
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|
||||
Activity |
IC50 = 79432.82 nM
|
[72] | |||
Compound Name |
1-[4-Chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]-3-(2,3-dichlorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3819521; BDBM50182250
Click to Show/Hide
|
||||
Activity |
IC50 ~ 79432.82 nM
|
[190] | |||
Compound Name |
(2S)-2-[1-(2-Chloro-6-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL837944; CHEMBL3221528
Click to Show/Hide
|
||||
Activity |
IC50 = 79432.82 nM
|
[75] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyrazin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838785; CHEMBL3221484
Click to Show/Hide
|
||||
Activity |
IC50 ~ 79432.82 nM
|
[83] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-4-methoxy-N-(5-methylpyridin-2-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839177; CHEMBL3221481
Click to Show/Hide
|
||||
Activity |
IC50 = 79432.82 nM
|
[83] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-propan-2-yloxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL837943; CHEMBL3221496
Click to Show/Hide
|
||||
Activity |
IC50 = 79432.82 nM
|
[75] | |||
Compound Name |
9-[3-(4-Fluorophenyl)-1-Methyl-1h-Pyrazol-4-Yl]-2,3,4,5-Tetrahydropyrido[2,3-F][1,4]oxazepine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420703; SCHEMBL9932541; BDBM50439432; Q27452344; 9-[1-Methyl-3-(4-fluorophenyl)-1H-pyrazole-4-yl]-2,3,4,5-tetrahydropyrido[2,3-f][1,4]oxazepine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 79600 nM
|
[191] | |||
Compound Name |
N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3330442; SCHEMBL16609922; BDBM50024356
Click to Show/Hide
|
||||
Activity |
IC50 = 79750 nM
|
[192] | |||
Compound Name |
N-(2-((1S,2R,4R)-4-(Isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1091604; BDBM50315994
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|
||||
Activity |
IC50 ~ 80000 nM
|
[193] | |||
Compound Name |
4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(1H-pyrazol-5-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4060984; SCHEMBL16331220; BDBM50267854
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|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
5-[4-(Dimethylamino)phenyl]-N-(pyridin-2-ylmethyl)-2-pyrimidin-5-ylquinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4078271; SCHEMBL12170127
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|
||||
Activity |
IC50 ~ 80000 nM
|
[174] | |||
Compound Name |
CID 68768923
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233190; SCHEMBL3741901; BDBM50009250
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|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL583867; (R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[2,3-c]-pyridin-3-yl)ethane-1,2-dione; 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione; SCHEMBL1763437; BDBM50302544; 1-benzoyl-3-(R)-methyl-4-[(6-azaindol-3-yl)-oxoacetyl]piperazine; Piperazine, 4-benzoyl-1-[1,2-dioxo-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethyl]-2-methyl-, (2R)-
Click to Show/Hide
|
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Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
10-(3-Benzyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3126836; BDBM50448495
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|
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Activity |
EC50 ~ 80000 nM
|
[195] | |||
Compound Name |
CID 15950540
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1910112; SCHEMBL2702806; BDBM50356579; 2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl]acetic acid
Click to Show/Hide
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Activity |
IC50 ~ 80000 nM
|
[196] | |||
Compound Name |
3-(Aminomethyl)-4-(2,4-Dichlorophenyl)-6-(2-Methoxyethyl)-2-Methyl-5,6-Dihydro-7h-Pyrrolo[3,4-B]pyridin-7-One
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1910114; SCHEMBL2704246; BDBM50356577; Q27462156; 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5H-pyrrolo[3,4-b]pyridin-7-one
Click to Show/Hide
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||||
Activity |
IC50 ~ 80000 nM
|
[196] | |||
Compound Name |
CID 42606792
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233178; SCHEMBL3738599; BDBM50009211
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|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
(R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-indol-3-yl)-ethane-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL567570; 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione; BDBM50302545; 1-(1H-Indole-3-yl)-2-(2alpha-methyl-4-benzoylpiperazino)ethanedione; 1-(1H-Indol-3-yl)-2-[(R)-2-methyl-4-(1-phenyl-methanoyl)-piperazin-1-yl]-ethane-1,2-dione
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-3-ylpyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3671804; SCHEMBL16331054; BDBM141473; US8921368, 192
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
CID 68767109
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233182; SCHEMBL3737146; BDBM50009215
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|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-711939; UNII-E2C4891M77; BMS 711939; E2C4891M77; SCHEMBL2742707; CHEMBL3828718; BDBM28802; BMS711939; Q27276778
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[197] | |||
Compound Name |
CID 68767802
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233181; SCHEMBL3738899; BDBM50009214
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|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-4-ylpyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4063870; SCHEMBL16331223; BDBM50267856
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|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
3-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4077920; SCHEMBL12170556
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|
||||
Activity |
IC50 ~ 80000 nM
|
[174] | |||
Compound Name |
2-(2-Aminopyrimidin-5-yl)-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4076905; SCHEMBL12098964; ZINC198398932; DA-28687
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[174] | |||
Compound Name |
1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethane-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL585498; (R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[3,2-c]-pyridin-3-yl)ethane-1,2-dione; 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethane-1,2-dione; SCHEMBL6445031; BDBM50302543; Piperazine, 4-benzoyl-1-[1,2-dioxo-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethyl]-2-methyl-, (2R)-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
2-[[3-[[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1090212; BDBM50314816; 2-((3-((2-(4-chlorophenyl)-4-methylthiazol-5-yl)methoxy)benzyl)(ptolyloxycarbonyl)amino)acetic acid
Click to Show/Hide
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||||
Activity |
IC50 ~ 80000 nM
|
[108] | |||
Compound Name |
(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-1,5,7,9,11,13-hexamethyl-15-[1-(1,8-naphthyridin-4-ylmethyl)azetidin-3-yl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL583091; BDBM50299105
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[175] | |||
Compound Name |
CID 69285465
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3577938; SCHEMBL5029123; BDBM50089333
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[193] | |||
Compound Name |
2-[[3-[[2-(2-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1091980; BDBM50314818; 2-((3-((2-(2-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(ptolyloxycarbonyl)amino)acetic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[108] | |||
Compound Name |
N-[(3S)-1-[(1S,2R,4R)-2-(Tert-butylsulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233189; SCHEMBL15310574; BDBM50009243
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
2-[3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl]-N-(pyridin-3-ylmethyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1910126; SCHEMBL2701971; BDBM50356582
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[196] | |||
Compound Name |
CID 68769143
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233184; SCHEMBL3742577; BDBM50009217
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
CID 89844945
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233179; SCHEMBL15310494; BDBM50009212
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
CID 68767577
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233186; SCHEMBL3738397; BDBM50009220
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|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
CID 46187356
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3589152; SCHEMBL2172211; BDBM50094878
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[198] | |||
Compound Name |
N-[5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4084304; SCHEMBL12170424
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[174] | |||
Compound Name |
CID 45279680
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3618335; SCHEMBL2390913; BDBM50120623; 6-(4-chlorophenyl)-3-[6-(4-hydroxypiperidin-1-yl)pyridin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[199] | |||
Compound Name |
4-[4-Amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-[(5S,6R)-2,2,5,6-tetramethyl-3-oxomorpholin-4-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4091875; BDBM50245571
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[200] | |||
Compound Name |
N-[2-[[(1S,2R,4R)-2-(Methoxymethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3577936; SCHEMBL5029278; BDBM50089331
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[193] | |||
Compound Name |
4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-fluoropyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4079880; SCHEMBL16331025; BDBM50267851
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-methylpyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4084341; SCHEMBL16331380; BDBM50267853
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
N-[(3S)-1-[(1S,2R,4R)-4-[Methyl(propan-2-yl)amino]-2-(methylsulfonylmethyl)cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233183; SCHEMBL15310580; BDBM50009216
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
4-Tert-Butyl-N-[2-Methyl-3-(6-{[4-(Morpholin-4-Ylcarbonyl)phenyl]amino}-7h-Purin-2-Yl)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3263640; BDBM50012060; Q27453164; 4-t-butyl-N-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide; 4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[201] | |||
Compound Name |
6-(5-Chloropyridin-2-yl)-3-[6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3618333; SCHEMBL12257889; BDBM50120627
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|
||||
Activity |
IC50 ~ 80000 nM
|
[199] | |||
Compound Name |
N-Ethyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2333619; SCHEMBL12050303; BDBM50428777
Click to Show/Hide
|
||||
Activity |
IC50 = 80000 nM
|
[202] | |||
Compound Name |
CID 68767124
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233180; SCHEMBL3737171; BDBM50009213
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)ethane-1,2-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL585487; (R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[3,2-b]-pyridin-3-yl)ethane-1,2-dione; 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)ethane-1,2-dione; SCHEMBL6438663; BDBM50302542; Piperazine, 4-benzoyl-1-[1,2-dioxo-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)ethyl]-2-methyl-, (2R)-
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
N-[(3S)-1-[(1S,2R,4R)-2-(Tert-butylsulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3233188; SCHEMBL4288166; BDBM50009224
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[149] | |||
Compound Name |
Methyl [3-(Aminomethyl)-4-(2,4-Dichlorophenyl)-2-Methyl-7-Oxo-5,7-Dihydro-6h-Pyrrolo[3,4-B]pyridin-6-Yl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1910111; SCHEMBL2705244; BDBM50356580; Q27462493
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[196] | |||
Compound Name |
Bms-378806
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BMS-806; BMS 378806; BMS806; UNII-IMN5E6PLUK; Bms 806; BMS-806 (BMS 378806); IMN5E6PLUK; BMS-377806; CHEMBL337301; SINOVA SL-02580; BMX 806; SCHEMBL1288198; EX-A2556; ZINC3649002; BDBM50133282; s2632; AKOS015966753; BCP9000438; CCG-268720; CS-0525; SB14572; BMS-378806; BMS-806; HY-14134; QC-10457; BCP0726000252; AB0033814; BMS-378806 & PRO 140; SW219865-1; X7585; W-2622; Q27280796
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
4-((1R,3S)-3-Amino-2,2,3-trimethylcyclopentylamino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4080797; SCHEMBL16331067; BDBM50267797
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[194] | |||
Compound Name |
(2s,3s)-1-(4-Methoxyphenyl)-3-(3-(2-(5-Methyl-2-Phenyloxazol-4-Yl)ethoxy)benzyl)-4-Oxoazetidine-2-Carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL271240; SCHEMBL12616162; BDBM50372107; Q27465016
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[116] | |||
Compound Name |
Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL442078; SCHEMBL2688694; CTK1C4772; DTXSID50957136; BDBM50228518; W-2621; (R)-N-(benzoyl)-3-methyl-N'-[(7-azaindol-3-yl)-oxoacetyl]-piperazine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[33] | |||
Compound Name |
CID 15950542
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1910113; SCHEMBL2703408; BDBM50356578; 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-hydroxyethyl)-2-methyl-5H-pyrrolo[3,4-b]pyridin-7-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[196] | |||
Compound Name |
N-((S)-1-((1S,2R,4R)-4-(Isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-2-oxopyrrolidin-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1092940; BDBM50315991
Click to Show/Hide
|
||||
Activity |
IC50 ~ 80000 nM
|
[203] | |||
Compound Name |
4-Amino-N-(1-(4-chlorophenyl)-3-(methylsulfonamido)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325736; SCHEMBL388011; BDBM50427353
Click to Show/Hide
|
||||
Activity |
IC50 = 80124 nM
|
[13] | |||
Compound Name |
[1-(2,3-Dihydroxypropyl)piperidin-4-yl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3329814; BDBM50023365
Click to Show/Hide
|
||||
Activity |
IC50 = 81000 nM
|
[204] | |||
Compound Name |
8-[2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]ethyl]-2-methoxypteridin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1916544; SCHEMBL14155453; BDBM50357921
Click to Show/Hide
|
||||
Activity |
IC50 = 81000 nM
|
[205] | |||
Compound Name |
1-Ethyl-3-[3-[[[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinolin-5-yl]amino]methyl]phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3221123
Click to Show/Hide
|
||||
Activity |
IC50 = 81700 nM
|
[181] | |||
Compound Name |
4-[[5-[2-[4-[(5-Chloro-6-methylpyridin-3-yl)methylamino]piperidin-1-yl]ethyl]-6-oxo-1,5-naphthyridin-3-yl]oxy]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608744; BDBM50112251
Click to Show/Hide
|
||||
Activity |
IC50 = 82000 nM
|
[180] | |||
Compound Name |
Levobupivacaine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Levobupivacaine HCl; Chirocaine; UNII-J998RDZ51I; (S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; Levobupivacaine (hydrochloride); (S)-(-)-Bupivacaine hydrochloride; (S)-1-Butyl-2',6'-pipecoloxylidide monohydrochloride; J998RDZ51I; (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; 27262-48-2 (HCl); DSSTox_CID_26071; DSSTox_RID_81319; DSSTox_GSID_46071; (S)-Bupivacaine hydrochloride; Levobupivacaine free base; (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride; Bupicaine hydrochloride (-); MFCD00936851; NCGC00159482-02; Levobupivacaine hydrochloride [USAN]; C18H28N2O.HCl; Popscaine; L-bupivacaine; Chirocaine (TN); levobupivacaine hydrochloride (anhydrous); (S)-(-)-Bupivacaine monohydrochloride; (S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide monohydrochloride; SCHEMBL34174; (-)-Bupivacaine hydrochloride; levobupivacaine monohydrochloride; CHEMBL1200749; DTXSID9046071; HY-B0653A; 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)-; MR-8-A2; (S)-(-)-BupivacaineHydrochloride; Bupivacaine (-)-form hydrochloride; (-)-(S)-Bupivacaine hydrochloride; ACT04726; Tox21_111706; MFCD01704265; s4061; AKOS016001444; Tox21_111706_1; AC-2097; CCG-267755; CS-4301; NCGC00178579-04; AS-15053; Levobupivacaine hydrochloride (JAN/USAN); SC-18730; Levobupivacaine hydrochloride, >=98% (HPLC); D01287; (S)-1-butyl-2',6'-pipecoloxylidide hydrochloride; 262B482; Q27114682; UNII-AKA908P8J1 component SIEYLFHKZGLBNX-NTISSMGPSA-N; (2S)-1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium chloride
Click to Show/Hide
|
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Activity |
IC50 = 83000 nM
|
[206] | |||
Compound Name |
4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4075428; BDBM50249599
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|
||||
Activity |
IC50 = 83000 nM
|
[207] | |||
Compound Name |
N-[3-[(6,7-Dimethoxy-4-methylquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671906; SCHEMBL14564020; BDBM50417953
Click to Show/Hide
|
||||
Activity |
IC50 = 83176.38 nM
|
[3] | |||
Compound Name |
(R)-(+)-Bupivacaine Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
(+)-Bupicaine HCl; (+)-Bupicaine hydrochloride; dextrobupivacaine hydrochloride; (2R)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride; Bupicaine hydrochloride (+); (R)-bupivacaine hydrochloride; 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (+)-; CHEMBL2447962; dextrobupivacaine monohydrochloride; DTXSID90949994; (2R)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; dextrobupivacaine hydrochloride (anhydrous); J-016714; Q27146970; UNII-AKA908P8J1 component SIEYLFHKZGLBNX-PKLMIRHRSA-N; (2R)-1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium chloride
Click to Show/Hide
|
||||
Activity |
IC50 = 84000 nM
|
[206] | |||
Compound Name |
CID 57400418
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1951778
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|
||||
Activity |
IC50 = 84000 nM
|
[208] | |||
Compound Name |
N-[4-[2-[(5R)-5-(2,4-Difluorophenyl)-2-methyl-1,5-dihydro-2,4-benzodiazepin-3-yl]ethyl]phenyl]methanesulfonamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1788304
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|
||||
Activity |
IC50 = 85000 nM
|
[126] | |||
Compound Name |
(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(2,5-dimethylpyrimidin-4-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL485123; BDBM50278103
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|
||||
Activity |
IC50 = 85000 nM
|
[121] | |||
Compound Name |
7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230598; BDBM50205453
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|
||||
Activity |
Ki = 85000 nM
|
[11] | |||
Compound Name |
7-Fluoro-4-oxo-N-(1-((2-oxobenzo[d][1,3]dioxol-5-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL216323; BDBM50202685
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|
||||
Activity |
IC50 = 85200 nM
|
[94] | |||
Compound Name |
7-Fluoro-4-oxo-N-(1-((2-oxo-1,2-dihydroquinolin-7-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL216482; SCHEMBL6333486; BDBM50202675; 7-fluoro-4-oxo-N-[1-[(2-oxo-1H-quinolin-7-yl)methyl]piperidin-4-yl]chromene-2-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 = 85500 nM
|
[94] | |||
Compound Name |
Chembl4209354
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|
Investigative | Compound Info | ||
Synonyms |
BDBM50452881
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|
||||
Activity |
IC50 = 85600 nM
|
[125] | |||
Compound Name |
Chembl4207711
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|
Investigative | Compound Info | ||
Synonyms |
BDBM50452882
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|
||||
Activity |
IC50 = 85700 nM
|
[125] | |||
Compound Name |
(3R,4R)-1-[3-(2,5-Difluorophenyl)cyclobutyl]-4-[(3S)-3-(3-fluoro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]piperidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL461698; CHEMBL4092041
Click to Show/Hide
|
||||
Activity |
IC50 = 85900 nM
|
[209] | |||
Compound Name |
(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL459357; BDBM50276598
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|
||||
Activity |
IC50 = 86000 nM
|
[183] | |||
Compound Name |
6-(4-{(1S,2S)-2-Amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-YL]-3-oxopropyl}phenyl)-1H-[1,2,4]triazolo[1,5-A]pyridin-4-ium
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL237337; SCHEMBL14591260; BDBM50221972; DB08504; Q27097704
Click to Show/Hide
|
||||
Activity |
IC50 = 86000 nM
|
[210] | |||
Compound Name |
(E)-1-[4-[5-[(3-Nitrophenyl)methylamino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]-3-[(2S)-pyrrolidin-2-yl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3220881
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|
||||
Activity |
IC50 = 86200 nM
|
[181] | |||
Compound Name |
CID 60201425
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165057; SCHEMBL3350672; BDBM50395405
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|
||||
Activity |
IC50 = 88000 nM
|
[128] | |||
Compound Name |
1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3-ylethynyl]-phenyl}-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL520463; BDBM50274268
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|
||||
Activity |
IC50 = 89400 nM
|
[17] | |||
Compound Name |
8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4069245; SCHEMBL17723589; BDBM50249183
Click to Show/Hide
|
||||
Activity |
IC50 ~ 90000 nM
|
[140] | |||
Compound Name |
[(1S,3R)-3-[[(3S,4S)-3-Methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[4-[2-(trifluoromethyl)pyridin-4-yl]piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1782567; BDBM50346299
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|
||||
Activity |
IC50 ~ 90000 nM
|
[105] | |||
Compound Name |
6-[(3R,9As)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3894177; SCHEMBL15036763; BDBM196040; US9206199, 145
Click to Show/Hide
|
||||
Activity |
IC50 ~ 90000 nM
|
[110] | |||
Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-N-methylacetamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL245545
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|
||||
Activity |
IC50 ~ 90000 nM
|
[188] | |||
Compound Name |
(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL183418
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|
||||
Activity |
IC50 ~ 90000 nM
|
[184] | |||
Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL246374
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|
||||
Activity |
IC50 ~ 90000 nM
|
[188] | |||
Compound Name |
5-[[[(3S,4R)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290351; BDBM50018483
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|
||||
Activity |
IC50 = 90000 nM
|
[91] | |||
Compound Name |
(S)-5-(4-(Butoxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenyl-4-(4-(pyrrolidine-1-carbonyl)piperidin-1-yl)picolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL601906; BDBM50306931
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|
||||
Activity |
IC50 ~ 90000 nM
|
[211] | |||
Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]cyclohexyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL428747
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|
||||
Activity |
IC50 ~ 90000 nM
|
[188] | |||
Compound Name |
(S)-5-Oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)-4-(6-phenyl-4-(4-(pyrrolidine-1-carbonyl)piperidin-1-yl)picolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL601907; BDBM50306932
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|
||||
Activity |
IC50 ~ 90000 nM
|
[211] | |||
Compound Name |
(2s,3s)-3-Amino-4-(3,3-Difluoropyrrolidin-1-Yl)-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-6-Ylcyclohexyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL238191; CHEMBL437557; SCHEMBL2898742; BDBM50221970; BDBM50221981; DB07092; Q27096007
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|
||||
Activity |
IC50 ~ 90000 nM
|
[210] | |||
Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL245969
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|
||||
Activity |
IC50 ~ 90000 nM
|
[188] | |||
Compound Name |
(S)-2-Amino-2-cyclohexyl-1-((R)-3-fluoro-pyrrolidin-1-yl)-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL23981; SCHEMBL6262519; BDBM50140539; (2S)-2-amino-2-cyclohexyl-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone
Click to Show/Hide
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||||
Activity |
Ki ~ 90000 nM
|
[100] | |||
Compound Name |
(S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-pyrrolidin-1-yl)-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL280658; SCHEMBL6251747; BDBM50140541; (2S)-2-amino-2-cyclohexyl-1-(3,3-difluoropyrrolidin-1-yl)ethanone; (S)-2-amino-2-cyclohexyl-1-(3,3-difluoropyrrolidin-1-yl)ethanone
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||||
Activity |
Ki ~ 90000 nM
|
[100] | |||
Compound Name |
(S)-2-Amino-2-cyclohexyl-1-((S)-3-fluoro-pyrrolidin-1-yl)-ethanone
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL22511; SCHEMBL6249448; BDBM50140527; (2S)-2-amino-2-cyclohexyl-1-[(3S)-3-fluoropyrrolidin-1-yl]ethanone
Click to Show/Hide
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||||
Activity |
Ki ~ 90000 nM
|
[100] | |||
Compound Name |
(E)-4-(Dimethylamino)-1-[4-[5-[(3-nitrophenyl)methylamino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]but-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3220882
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|
||||
Activity |
IC50 = 92100 nM
|
[181] | |||
Compound Name |
CID 25008249
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165060; SCHEMBL3351600; BDBM50395402
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|
||||
Activity |
IC50 = 93000 nM
|
[128] | |||
Compound Name |
Chembl4224807
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|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL20183430; BDBM50460104
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|
||||
Activity |
IC50 = 93000 nM
|
[212] | |||
Compound Name |
4-(3-Piperidin-1-ylpropoxy)benzenesulfonamide
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024378; BDBM50382854
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|
||||
Activity |
IC50 = 93200 nM
|
[185] | |||
Compound Name |
2-Fluoro-4-[8-fluoro-3-(quinolin-6-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3582294; BDBM50091364
Click to Show/Hide
|
||||
Activity |
IC50 = 93560 nM
|
[213] | |||
Compound Name |
1-[3-[[[3-(4-Methylpiperazin-1-yl)-7-(trifluoromethyl)quinolin-5-yl]amino]methyl]phenyl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3221113
Click to Show/Hide
|
||||
Activity |
IC50 = 93600 nM
|
[181] | |||
Compound Name |
8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3799831; BDBM50500914
Click to Show/Hide
|
||||
Activity |
IC50 = 94000 nM
|
[214] | |||
Compound Name |
1-(3-Bromophenyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL464803; SCHEMBL1565705; BDBM50274788; 1-(3-bromophenyl)-4-oxo-1,8-naphthyridine-3-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 94500 nM
|
[17] | |||
Compound Name |
Bupivacaine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Bupivacaine HCL; Vivacaine; Sensorcaine; Bupivacaine (hydrochloride); Marcain; AH-2250; Win 11,318; Bloqueina; LAC-43; (S)-Bupivacaine hydrochloride; Bicain; Marcaine Spinal; SMR000058218; (+-)-Bupivacaine hydrochloride; Bupivacaine hydrochloride [JAN]; WIN-11318; MNarcaine hydrochloride; EINECS 241-917-8; 14252-80-3 (HCl); 73360-54-0 (HCl.H2O); Bupivacaine hydrochloride kit; LAC 43; SR-05000001874; Bupivacaine hydrochloride anhydrous; levobupivacaine hydrochloride (anhydrous); 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride; SKY 0302; Prestwick_894; AH 2250; Marcaine hydrochloride preservation free; bupivacain hydrochloride; Bupivacaine hydrochloride preservation free; Bupivacaine hydrochloride rs; bupivacaine monohydrochloride; Win 11318 HCl; SCHEMBL34374; MLS001361336; MLS002154259; SPECTRUM1503818; CHEMBL1200396; DTXSID0030877; CTK8F8361; HY-B0405A; KS-00000XIC; AOB6341; HMS1568N12; HMS1922I12; Pharmakon1600-01503818; Bupivacaine hydrochloride (Marcain); ACT04725; BCP22697; BCP22708; KS-00000M4Q; bupivacaine hydrochloride (anhydrous); CCG-39367; MFCD00078956; NSC119660; NSC758631; s2454; AKOS015889322; BCP9000461; FD-0235; MCULE-5414144502; NSC-119660; NSC-758631; NCGC00095072-01; NCGC00095072-02; SC-24334; SC-94629; ST013772; B3925; FT-0607564; FT-0623287; FT-0658830; FT-0663897; FT-0663899; SW197015-3; 52B803; K-4565; J-011502; Q-100158; SR-05000001874-3; Q27888209
Click to Show/Hide
|
||||
Activity |
IC50 = 95000 nM
|
[206] | |||
Compound Name |
3-{4-[(Dimethylamino)carbonyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-1H-pyrazol-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL1146895; CHEMBL3217758; 3-[4-(dimethylcarbamoyl)phenoxy]-5-[(2S)-1-methoxypropan-2-yl]oxy-N-(1H-pyrazol-5-yl)benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 95000 nM
|
[215] | |||
Compound Name |
6-Fluoro-N-(6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-3-yl)-4-oxo-8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL605785; BDBM50306587
Click to Show/Hide
|
||||
Activity |
IC50 = 95000 nM
|
[216] | |||
Compound Name |
4-Pyridin-3-yl-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2264313; CHEMBL2346971; 4-(pyridin-3-yl)-1-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-ol; 4-pyridin-3-yl-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
Click to Show/Hide
|
||||
Activity |
IC50 = 95499.26 nM
|
[217] | |||
Compound Name |
6-[(1R,3R)-3-[5-(4-Fluorophenyl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]pyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3323086; BDBM50054480
Click to Show/Hide
|
||||
Activity |
IC50 = 95600 nM
|
[95] | |||
Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3804950
Click to Show/Hide
|
||||
Activity |
IC50 = 97000 nM
|
[218] | |||
Compound Name |
(2S,4S)-1-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3330060; BDBM50098903
Click to Show/Hide
|
||||
Activity |
IC50 = 97700 nM
|
[123] | |||
Compound Name |
1-[({2-[(1S)-1-Cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}amino)methyl]cyclohexanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356251; SCHEMBL2794046; BDBM50037212; 1-[(1S)-1-cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-[(1-hydroxycyclohexyl)methylamino]ethanone
Click to Show/Hide
|
||||
Activity |
IC50 = 98000 nM
|
[70] | |||
Compound Name |
2-(2-(2,6-Dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)-N-(5-isopropyl-2-methylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3948914; SCHEMBL15643347; BDBM50210940; 2-[2-[(2,6-dichlorophenyl)methyl]benzimidazol-1-yl]-N-(2-methyl-5-propan-2-ylphenyl)acetamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[219] | |||
Compound Name |
(1S,2R,5S)-5-(4,7,8,12-Tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3806003
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[218] | |||
Compound Name |
1-Propan-2-yl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021970; BDBM50382877
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
4-[[5-[2-[4-[(5-Cyano-6-methylpyridin-3-yl)methylamino]piperidin-1-yl]ethyl]-6-oxo-1,5-naphthyridin-3-yl]oxy]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608745; BDBM50112252
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-[(2R)-1-hydroxypropan-2-yl]oxy-N-(5-methylpyrazin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839192; CHEMBL3221532; AZD-3651
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070938; SCHEMBL8123486; BDBM50390390
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
(2S)-2-[4-[[4-(4-Fluoro-2-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158781; SCHEMBL18841143; BDBM50394119
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[82] | |||
Compound Name |
1-Phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024385; BDBM50382858
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
Chembl4206035
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17379888; BDBM50457718
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-(2-cyanopropan-2-yl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070948; BDBM50390397
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
N-[4-(1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-4-(2,2,2-trifluoro-ethanesulfonylamino)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL497992; CHEMBL140577; SCHEMBL14392759; BDBM50137266; BDBM50265158
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[222] | |||
Compound Name |
1-(4-Methoxyphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021989; BDBM50382847
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N-(1,3-Dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide;sulfuric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2023803; SCHEMBL2174407
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[182] | |||
Compound Name |
1-(((3R)-3-Methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL465955; SCHEMBL4048428; BDBM50248566
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[169] | |||
Compound Name |
1-Propan-2-yl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024395; BDBM50382868
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-methylpyrazin-2-yl)-3-propan-2-yloxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3217794
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[83] | |||
Compound Name |
Ethyl 1-[4-[4-(phenylcarbamoylsulfamoyl)phenoxy]butyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021980; BDBM50382838
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-4-(3,3-dimethyl-ureido)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3084938; BDBM50137270
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[222] | |||
Compound Name |
4-[6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1957497; SCHEMBL10092217; BDBM50365506
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[16] | |||
Compound Name |
1-[2-[(3R,4R)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-hydroxypiperidin-1-yl]ethyl]-7-methoxyquinoxalin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164748; BDBM50395409
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[128] | |||
Compound Name |
6-[[[1-[2-(2-Oxo-7-pyridin-3-yloxy-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608749; BDBM50112257
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
4-[[2-[(3,4-Dichlorophenyl)carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3798983; BDBM50500971
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[223] | |||
Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL203169
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[224] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(3-hydroxyazetidin-1-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838761; CHEMBL3221516
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-fluoropyridin-2-yl)-3-((S)-1-hydroxypropan-2-yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839934; CHEMBL3221510
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
6-[[[1-[2-[7-(1,2-Oxazol-3-yloxy)-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608748; BDBM50112255
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
6-[[[1-[2-[2-Oxo-7-(pyridazin-3-ylmethoxy)-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608754; BDBM50112262
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021973; BDBM50382879
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
4-[[7-Oxo-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,8-naphthyridin-2-yl]oxy]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608743; BDBM50112249
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838202; CHEMBL3221501
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[83] | |||
Compound Name |
4-(Spiro[chromene-2,4''-piperidine]-4-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL494266; SCHEMBL10258134; BDBM50252875
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[157] | |||
Compound Name |
6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671905; IC-351; AC1NFQ3W; cis-ent-Tadalafil; SCHEMBL1852933; HMS3373E02; HMS3393N17; BCP16440; BCP16441; BCP16442; BBL036323; BDBM50532257; STL455130; AKOS026677575; Tadalafil USP Impurity C; cis-Tadalafil; VS-13421; FT-0674788; FT-0674789; FT-0674790; FT-0674791; F0001-2412; 6R,12S-Tadalafil;Tadalafil EP Impurity A; Tadalafil Impurity (6R,12aS)
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[3] | |||
Compound Name |
7-(2-Fluorophenyl)-3-(4-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3330817; SCHEMBL15940045; BDBM50058044; 7-(2-fluorophenyl)-3-(4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[225] | |||
Compound Name |
4-[1-Methyl-3-(4-fluorophenyl)-1H-pyrazole-4-yl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420700; SCHEMBL5257540; BDBM50439435; 4-[3-(4-fluorophenyl)-1-methylpyrazol-4-yl]pyridine; 4-[3-(4-fluorophenyl)-1-methyl-1h-pyrazol-4-yl]pyridine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[191] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070949; SCHEMBL8108208; BDBM50390398
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
3-Oxo-4-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,4-benzoxazine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824033; BDBM50352076
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-3246799; CHEMBL1770373; SCHEMBL1620274; BDBM50342538; ZINC68150324; NCGC00485021-01; PF-03246799; 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[226] | |||
Compound Name |
3-(1-Methylpyrazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3763646; BDBM50139158
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[227] | |||
Compound Name |
6-Fluoro-4-[[1-[(5-chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290767; BDBM50019512; 4-[[1-(5-chloro-1-methyl-pyrazole-4-carbonyl)-4-piperidyl]amino]-6-fluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[228] | |||
Compound Name |
1-[4-(2-Piperidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024393; BDBM50382866
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(trans-4-{2-[(1r)-1-Hydroxyethyl]imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl}cyclohexyl)acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386635; SCHEMBL2223993; SCHEMBL12385676; BDBM50434787; Q27452102
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
(R)-1-(1-((S)-Tetrahydro-2H-pyran-3-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386653; oJak-989; SCHEMBL2226737; BDBM50434797
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
Chembl4204215
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50452880
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[125] | |||
Compound Name |
6-[[[1-[2-[7-(1,2-Oxazol-3-yloxy)-2-oxo-1,8-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608747; BDBM50112254
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
6-[[[1-[2-[7-[(1-Methylpyrazol-3-yl)methoxy]-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608755; BDBM50112263
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
N-Hydroxy-3-[4-[[4-(methylcarbamoyl)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417761; SCHEMBL16842616; BDBM50078180
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[43] | |||
Compound Name |
4-Amino-N-(1-(4-chlorophenyl)-4-(dimethylamino)butyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325993; SCHEMBL392420; BDBM50427335
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
6-[[[(3S,4R)-1-[2-[2-Oxo-7-fluoro-1,5-naphthyridine-1(2H)-yl]ethyl]-3-fluoro-4-piperidinyl]amino]methyl]-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290353; BDBM50018485
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
1-[(2S)-3-(4-Fluorophenoxy)-2-hydroxy-2-methylpropanoyl]-2,3-dihydroindole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3238274; BDBM50007600
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[230] | |||
Compound Name |
Chembl4214785
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50452878
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[125] | |||
Compound Name |
(R)-6-(2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)-2-(o-tolyl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AS1940477; CHEMBL2170294; AS-1940477; SCHEMBL20873909; BDBM50396845; ZINC95552986; NCGC00402250-01; NCGC00402250-03
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[231] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4,5-dimethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070939; BDBM50390388
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070951; BDBM50390405
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
6-{[(1-[2-[6-(1-Hydroxyethyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824029; SCHEMBL704582; BDBM50352073
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
7-Cyclopropyl-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2376804; SCHEMBL14895371; BDBM50433359
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[232] | |||
Compound Name |
(2S)-2-[4-[[4-(4-Chloro-3-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158782; SCHEMBL18841157; BDBM50394118
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[82] | |||
Compound Name |
4-[4-[2-(4-Acetylpiperazin-1-yl)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL752809; CHEMBL2346975
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[217] | |||
Compound Name |
1-[4-(4-Methylcyclohexyl)butyl]alpha,alpha-diphenyl-4-piperdinemethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL571174; BDBM50301393
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[42] | |||
Compound Name |
6-((2R,5R)-2-Methyl-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2181928; SCHEMBL1332895; BDBM50398061; AKOS034833311; BB 0310247; 6-[(2R,5R)-2-methyl-5-phenylmorpholin-4-yl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one; 6-[(2R,5R)-2-methyl-5-phenylmorpholin-4-yl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[233] | |||
Compound Name |
N-Methyl-4-[4-[[3'-(hydroxycarbamoyl)spiro[piperidine-4,1'-cyclopentane]-3'-yl]sulfonyl]phenoxy]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417751; SCHEMBL16842565; BDBM50078190
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[43] | |||
Compound Name |
Chembl4214603
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50452885
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[125] | |||
Compound Name |
Chembl4130214
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50273084
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[234] | |||
Compound Name |
3-[(2R)-2-Methylpiperidin-1-yl]-N-[[4-[[3-[(2S)-2-methylpiperidin-1-yl]propylamino]methyl]phenyl]methyl]propan-1-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2170299
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[235] | |||
Compound Name |
N-(1,1-Dioxothian-3-yl)-4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1940315; BDBM50362091
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[236] | |||
Compound Name |
1-[6,6-Bis(4-fluorophenyl)hexyl]-4-[[4-methoxy-3,5-bis[(2-methylpropan-2-yl)oxy]phenyl]methyl]piperazine-2,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3356240; BDBM50037206
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[70] | |||
Compound Name |
Chembl4215377
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18802679; BDBM50457719
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
Ethyl 1-[2-[4-(phenylcarbamoylsulfamoyl)phenoxy]ethyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024394; BDBM50382867
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838409; CHEMBL3221483
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[83] | |||
Compound Name |
(2S)-2-[4-[[4-(4-Chloro-3-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158792; SCHEMBL18841193; BDBM50394113
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[82] | |||
Compound Name |
1-Phenyl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021971; BDBM50382878
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-[4-(Dimethylamino)phenyl]-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021985; BDBM50382843
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
5-[1-Methoxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3792808; SCHEMBL10286720; BDBM50163362
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[97] | |||
Compound Name |
6-[(3R)-3-[(1S)-1-Aminoethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL390855; BDBM50205447
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[11] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024387; BDBM50382860
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-Propan-2-yl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024384; BDBM50382832
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL375442
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[131] | |||
Compound Name |
Cxcr2-IN-1
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3819512; 1-(2-chloro-3-fluorophenyl)-3-[4-chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]urea; BDBM50182251; ZINC653863935; CS-6467; HY-101022
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[190] | |||
Compound Name |
(NE,4S)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4093905; BDBM50230398
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[237] | |||
Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL208957
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[238] | |||
Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-6-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL205872
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[224] | |||
Compound Name |
(E)-1-(2-Hydroxy-4,5-dimethoxyphenyl)-3-(3-methoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4071093; BDBM50232898
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[239] | |||
Compound Name |
1-[4-(4-Piperidin-1-ylbutoxy)phenyl]sulfonyl-3-propan-2-ylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021975; BDBM50382881
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL195755
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[132] | |||
Compound Name |
5-(2-Fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4095883; BDBM50257272; 9FG
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[240] | |||
Compound Name |
N-(2-[(2-Aminoethyl)(methyl)amino]-5-{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino}phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3103192; AZKi-012a; SCHEMBL15286132; BDBM50172243; CS-0012041; Q27456119
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[241] | |||
Compound Name |
1-(4-Methylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021983; BDBM50382841
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2S)-N-(5-Chloropyridin-2-yl)-2-(1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-((R)-1-hydroxypropan-2-yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839144; CHEMBL3221512
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
5-Methyl-3-[[(2R)-4 (2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070735; PF-04671536; SCHEMBL6910585; BDBM50390334
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[242] | |||
Compound Name |
5-[1-Fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3792978; SCHEMBL4549680; BDBM50163360
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[97] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-cyclopropyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070941; SCHEMBL8099073; BDBM50390387
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
(S)-6-(Piperidin-3-yloxy)-2H-isoquinolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1667967; SCHEMBL4005826; BDBM50417843; ZINC35322567; 6-[(3S)-piperidin-3-yl]oxy-2H-isoquinolin-1-one
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[243] | |||
Compound Name |
alpha-Amino acid pyrrolidide 28
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL216835; BDBM11666
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[131] | |||
Compound Name |
1(2H)-Isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((R)-methoxy-3-oxetanylmethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-06821497; UNII-S4L4MM20B6; S4L4MM20B6; CHEMBL4080228; SCHEMBL17330426; GTPL10516; BDBM50246967; DB14799; HY-101571A; compound 23a [PMID: 29211475]; CS-0092626; PF06821497; Q29209799
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[244] | |||
Compound Name |
6-[[[1-[2-[3-Oxo-6-(tetrazol-1-yl)-1,4-benzoxazin-4-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824028; BDBM50352072
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
3-(1-Methylimidazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3763694; BDBM50139156
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[227] | |||
Compound Name |
(E)-3-[4-[7-Hydroxy-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427402; BDBM50084974
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[245] | |||
Compound Name |
2,6-Di(4-biphenylylethynyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3590469; BDBM50095791
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[246] | |||
Compound Name |
CID 57750321
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325994; SCHEMBL392653; BDBM50427334
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
Chembl4205373
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50457738
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
CID 25118804
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593760; SCHEMBL2792395; BDBM50095968
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[247] | |||
Compound Name |
CID 57750315
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325730; SCHEMBL390402; BDBM50427359
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
1-[4-(4-Piperidin-1-ylbutoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021979; BDBM50382837
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N-[4-[[4-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784340; BDBM50345515
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[170] | |||
Compound Name |
Chembl4212905
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18802676; BDBM50457723
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
Chembl4127600
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
DS88790512; BDBM50273012; HY-112298; CS-0044756
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[234] | |||
Compound Name |
N-[7-[Acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-2-methylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1170367; BDBM50321518; N-(7-(N-ethylacetamido)-4-methoxybenzo[d]thiazol-2-yl)-1-methyl-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[248] | |||
Compound Name |
Chembl4126938
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BDBM50273049
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[234] | |||
Compound Name |
1-Cyclohexyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021977; BDBM50382883
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N,N-Diethyl-5-(spiro[chromene-2,4''-piperidine]-4-yl)pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL562280; SCHEMBL471590; BDBM50297336
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[118] | |||
Compound Name |
4-[[2-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3799746; BDBM50500969
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[223] | |||
Compound Name |
N-Hydroxy-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417745; SCHEMBL16842618; BDBM50078196
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[43] | |||
Compound Name |
N-((1S,4r)-4-((2S,3S)-3-Amino-4-((S)-3-fluoropyrrolidin-1-yl)-4-oxobutan-2-yl)cyclohexyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL237547; BDBM50221982
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[210] | |||
Compound Name |
2-[[[4-[(1R)-1-Amino-2-(7-methoxy-2-oxoquinolin-1-yl)ethyl]cyclohexyl]amino]methyl]-8H-pyrimido[5,4-b][1,4]oxazin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355568; BDBM50023593
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[249] | |||
Compound Name |
Chembl4215326
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL18788182; TQR0465; BDBM50457722
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
(E)-3-[4-[3-(4-Fluoro-2-methylphenyl)-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427414; BDBM50084987
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[245] | |||
Compound Name |
1-Cyclohexyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024391; BDBM50382864
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]sulfonyl-3-[3-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021981; BDBM50382839
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6-methylsulfonyl-1,3-benzothiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070947; SCHEMBL8108722; BDBM50390396
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
5-(2-Fluorophenyl)-4-oxo-N-[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]-1H-pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3322590; SCHEMBL15328176; SCHEMBL15328179; BDBM50051939
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[250] | |||
Compound Name |
3-[4-(Azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-1H-pyrazol-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2655031; CHEMBL3219107; 3-[4-(azetidine-1-carbonyl)phenoxy]-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1H-pyrazol-5-yl)benzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[21] | |||
Compound Name |
(E)-3-[4-[3-(4-Fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427401; BDBM50084973
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[245] | |||
Compound Name |
Irak4-IN-28
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZ1495; CHEMBL4064608; CHEMBL4094760; Irak4-in-3; SCHEMBL21105720; SCHEMBL21106082; EX-A3726; BDBM50246763; BDBM50246769; HY-111101; CS-0034227
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[251] | |||
Compound Name |
4-Amino-N-(1-(4-chlorophenyl)-2-hydroxyethyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325737; SCHEMBL393210; BDBM50427352
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
(S)-7-(3-((2-Cyanoethylamino)methyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230703; BDBM50205461
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[11] | |||
Compound Name |
1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021968; BDBM50382875
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-fluoropyridin-2-yl)-3-((R)-1-hydroxypropan-2-yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839457; CHEMBL3221513
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
BI-135585; UNII-DA4HT8614K; DA4HT8614K; SCHEMBL117891; CHEMBL3664717; BDBM107664; US8575157, 48; Q27276296
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[252] | |||
Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL209064
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[238] | |||
Compound Name |
6-[[[1-[2-[2-Oxo-7-[(3S)-oxolan-3-yl]oxy-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608752; BDBM50112260
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
(2s)-2-{[1-(3-Chloropyridin-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-4-Yl]oxy}-N-(5-Methylpyridin-2-Yl)-3-(Propan-2-Yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839212; CHEMBL3221489; Q27452131; 1JD
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[83] | |||
Compound Name |
5-[[[1-[2-(7-Methoxy-2-oxopyrido[2,3-b]pyrazin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290348; BDBM50018448
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
2-[4-[4-[6-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]-1H-benzimidazol-2-yl]phenyl]cyclohexyl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2409564; BDBM50437753; KR-69232
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[253] | |||
Compound Name |
1-{[(3R)-3-Methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL460962; SCHEMBL3953157; BDBM50248569; DB07624; Q27096844
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[169] | |||
Compound Name |
(2S)-N-(5-Chloropyridin-2-yl)-2-(1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-((S)-1-hydroxypropan-2-yloxy)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838585; CHEMBL3221509
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
N-[2,4-Difluoro-5-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]phenyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784523; BDBM50418537
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[72] | |||
Compound Name |
4-(4-Pyrrolidin-1-ylbutoxy)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024381; BDBM50382835
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
4-[2-[4-[[(1-Propan-2-ylindazole-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2179707; SCHEMBL3042859; BDBM50398964
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[254] | |||
Compound Name |
2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-benzo[e][1,2]thiazin-2-yl)-1-phenyl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL600686; SMR000122990; MLS000068557; ChemDiv3_002118; Oprea1_010077; Oprea1_573980; MLS002535947; SCHEMBL19248191; HMS1479A06; HMS2359M05; BDBM50309934; CCG-18348; STK725073; AKOS000603374; MCULE-6736164047; EU-0041358
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[255] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021978; BDBM50382834
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZD3514; AZD-3514; CS-1443; UNII-127DSS8X7J; 127DSS8X7J; CHEMBL2346976; SCHEMBL3056463; DTXSID80677133; AZD 3514 [WHO-DD]; C25H32F3N7O2; HMS3652H18; AOB87377; BCP07896; EX-A1806; 2239AH; BDBM50432188; s7040; AKOS027422738; ZINC101673084; CCG-264708; SB19559; NCGC00386284-02; NCGC00386284-05; DA-35308; HY-16079; FT-0735650; SW219684-1; A12396; W-6111
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[217] | |||
Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(1-methylpiperidin-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1940308; BDBM50362092
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[236] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024398; BDBM50382870
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
3-(3,5-Diethyl-1H-pyrazol-4-yloxy)-5-methylbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL576256; SCHEMBL2716852; BDBM50302398; 3-[(3,5-diethyl-1H-pyrazol-4-yl)oxy]-5-methyl-benzonitrile; 3-[(3,5-diethyl-1H-pyrazol-4-yl)oxy]-5-methylbenzonitrile
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[256] | |||
Compound Name |
1-[2-[(3S,4R)-4-[(5-Cyano-6-methylpyridin-3-yl)methylamino]-3-fluoropiperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290349; BDBM50018481
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070950; BDBM50390399
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
1-Benzhydryl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021992; BDBM50382850
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
4-[3-Chloro-4-(hydroxymethyl)phenoxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3688197; SCHEMBL16177838; BDBM165905; J3.563.902K; US9067922, 247; N-(5-Fluoropyridine-2-yl)-3-cyano-4-(3-chloro-4-hydroxymethylphenoxy)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[29] | |||
Compound Name |
1-Naphthalen-1-yl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021984; BDBM50382842
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-propan-2-ylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024400; BDBM50382872
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
7-Cyclopentyl-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2376803; SCHEMBL14895435; BDBM50433358
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[232] | |||
Compound Name |
(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxy-N-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL838292; CHEMBL3221499
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[83] | |||
Compound Name |
Chembl4208519
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19188998; BDBM50453823
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[257] | |||
Compound Name |
1-(4-Acetylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021982; BDBM50382840
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-[2-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021987; BDBM50382845
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
6-{[(1-{2-[6-(Ethylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824038; SCHEMBL706019; BDBM50352078
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
1-Cyclohexyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024386; BDBM50382859
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
Chembl4208812
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17379893; BDBM50457727
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
3-[4-(Dimethylcarbamoyl)phenoxy]-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL2654503; CHEMBL3217924
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[215] | |||
Compound Name |
[(2R)-1-[3-[1-[[1-[2-(2,3-Difluoroanilino)-2-oxoethyl]pyrazol-4-yl]amino]phthalazin-6-yl]oxypropyl]pyrrolidin-2-yl]methyl dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL250766
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[258] | |||
Compound Name |
JTZ-951 HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4166742; 1262131-60-1 (HCl); (7-Hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine hydrochloride; JTZ-951 hydrochloride; SCHEMBL1481939; BDBM50286071
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[259] | |||
Compound Name |
6-[4-[(2,3-Difluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2346969
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[217] | |||
Compound Name |
Abelcet
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Amphotericin B lipid complex; amphotericin b; Amphotericin b liposomal complex; Ambisome; Amphotec; Fungilin; Fungizone; Ampho-Moronal; NSC-527017; amophotericin B; Amphotreicin B; Amphotercin B; Ampotericin B; Amphotericitin B; Fungilin In Orabase; Amphotericin b, liposome; CHEMBL267345; BDBM50457967
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[9] | |||
Compound Name |
1-(4-Methylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021991; BDBM50382849
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(7,7-dimethyl-4,6-dihydropyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2071098; BDBM50390403
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
4-[[2-[[3,5-Bis(trifluoromethyl)phenyl]carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3797601; BDBM50500970
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[223] | |||
Compound Name |
(2S)-2-[4-[[4-(4-Fluoro-2-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158793; SCHEMBL18841162; BDBM50394112
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[82] | |||
Compound Name |
4-[[(3S,4R)-1-(5-Cyano-2-pyridyl)-3-fluoropiperidine-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593777; SCHEMBL3312708; BDBM50095952
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[260] | |||
Compound Name |
CID 44517795
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1916399; SCHEMBL4429194; BDBM50357764
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[261] | |||
Compound Name |
1-Phenyl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024401; BDBM50382836
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
trans-4-{2-[(1r)-1-Hydroxyethyl]imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl}cyclohexanecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386633; CHEMBL2386634; SCHEMBL2224822; SCHEMBL12385674; SCHEMBL21419615; BDBM50434788; BDBM50434789; Q27452100
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
6-[[[1-[2-[2-Oxo-7-[(3R)-oxolan-3-yl]oxy-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608751; BDBM50112259
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
5-Amino-4-(isobutylamino)-6-morpholinopyrimidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL450061; BDBM50249410
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[99] | |||
Compound Name |
6-[[[1-[2-[2-Oxo-7-(pyridin-2-ylmethoxy)-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608753; BDBM50112261
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
2,2,2-Trifluoro-N-[3-oxo-4-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,4-benzoxazin-6-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824032; BDBM50352075
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
Chembl4217332
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17379861; BDBM50457747
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
N-(1-(3-Fluoro-4-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)benzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL245846; SCHEMBL6337337; BDBM50207683
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[171] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024392; BDBM50382865
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N-Hydroxy-3-[4-[4-(pyrrolidine-1-carbonyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417752; SCHEMBL16842606; BDBM50078189
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[43] | |||
Compound Name |
4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZD5363 RACEMATE; SCHEMBL390244; CHEMBL2325738; BDBM256834; HMS3653N19; HMS3673C21; BCP04083; EX-A1624; AKOS026750264; NCGC00389738-01; AK316078; US9492453, 13
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
3-[[3-(Hydroxymethyl)morpholin-4-yl]methyl]-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3764275; SCHEMBL3105612; BDBM50139152
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[227] | |||
Compound Name |
Chembl4170114
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CM-272; 1846570-31-7 (free base); SCHEMBL17379969; TQR0469; CM272; BCP32745; EX-A4015; BDBM50281297; s8812; CM 272; CM272; HY-101925; CS-0022181
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[221] | |||
Compound Name |
(3R,4R)-1-([1,2,4]Triazolo[4,3-a]pyrimidin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL231294
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[262] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2071095; SCHEMBL8109493; BDBM50390400
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
N-[5-(Trifluoromethyl)pyridine-3-yl]-2-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3929544; SCHEMBL17559545; ZINC584597026; J3.563.830J
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[263] | |||
Compound Name |
4-[[1-[(5-Chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290766; BDBM50019511; 4-[[1-(5-chloro-1-methyl-pyrazole-4-carbonyl)-4-piperidyl]amino]-1H-quinolin-2-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[228] | |||
Compound Name |
N-Methyl-4-(spiro[chromene-2,4''-piperidine]-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL551413; SCHEMBL10259030; BDBM50297314
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[118] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-ethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2070940; BDBM50390389
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
1-(2,5-Dichlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021967; BDBM50382874
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
2-Methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2413849; [4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methyl-1H-indol-2-yl)methanone; SCHEMBL3104370; BDBM50438582
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[264] | |||
Compound Name |
N-(3,4-Difluorophenyl)-6-(trifluoromethoxy)-1H-pyrazolo[4,3-b]pyridin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4062193; BDBM50254387
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[265] | |||
Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2071097; SCHEMBL8122264; BDBM50390402
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[220] | |||
Compound Name |
1-[4-[5-[[Deuterio-(3-nitrophenyl)methyl]amino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3221132
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[181] | |||
Compound Name |
4-Amino-N-(1-(4-chlorophenyl)-3-(dimethylamino)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325992; SCHEMBL390582; BDBM50427336
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
4-Amino-5-cyano-6-ethoxy-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL424872; Kinome_3022; SCHEMBL1145537; 2-pyridinecarboxamide deriv. 8c; BDBM15913; ZINC14959980; 4-amino-5-cyano-6-ethoxy-n-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[266] | |||
Compound Name |
1-(4-Fluorophenyl)-3-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-ylpyrimidin-2-yl]phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2030451; SCHEMBL3593328; BDBM50384248
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[267] | |||
Compound Name |
1-(((R)-3-Methyl-4-(4-((R)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL489500; SCHEMBL3946072; BDBM50247925
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[169] | |||
Compound Name |
6-[[[4-[(1R)-1-Amino-2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355576; BDBM50023583
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[249] | |||
Compound Name |
6-[[[(3S,4R)-3-Methoxy-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290357; BDBM50018489
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
9-Chloro-N-(2,4-difluorophenyl)-2,3,4,5-tetrahydro-3-methyl-3-ethyl-2,5-dioxo-1H-1,4-benzodiazepine-7-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3134098
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[268] | |||
Compound Name |
6-[[[(3R,4S)-3-Fluoro-1-[2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290354; BDBM50018486
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
(1R)-1-[3-[4-(2,2,2-Trifluoroethylamino)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2386629; CHEMBL2386631; SCHEMBL2279329; SCHEMBL12425936; BDBM50434793; BDBM50434801
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
4-Amino-5-cyano-6-ethoxy-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Kinome_2049; CHEMBL209534; SCHEMBL1144214; 2-pyridinecarboxamide deriv. 8e; BDBM15915; 4-amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid (pyridin-3-ylmethyl)-amide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[266] | |||
Compound Name |
1-Cyclohexyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024397; BDBM50382869
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL206383
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[224] | |||
Compound Name |
4-[1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]cinnamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
GW7604; CHEMBL195515; SCHEMBL5070366; AOB4791; SYN5135; BDBM50084948; ZINC13641250; GW-7604; AS-16499; HY-117153; CS-0064011; (2e)-3-[4-[(1e)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl]-2-propenoic acid; (E)-3-(4-((E)-1-(4-Hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid; (E)-3-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[245] | |||
Compound Name |
6,7-Difluoro-4-[[1-[(5-chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290768; BDBM50019513; 4-[[1-(5-chloro-1-methyl-pyrazole-4-carbonyl)-4-piperidyl]amino]-6,7-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[228] | |||
Compound Name |
4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
A939572; SCD inhibitor; 4-(2-CHLOROPHENOXY)-N-[3-[(METHYLAMINO)CARBONYL]PHENYL]-1-PIPERIDINECARBOXAMIDE; CHEMBL469169; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide; C20H22ClN3O3; SCHEMBL14554165; CTK4A1885; KS-00001DUF; DTXSID40648006; BCP27670; EX-A3456; ABP000839; BDBM50261716; ZINC35323148; AKOS022179820; CS-0305; AK-54596; AS-73726; HY-50709; QC-11448; SC-94483; DB-002537; DB-014948; FT-0741571; X5567; W-5453; A 939572; 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]ph; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)-phenyl)piperidine-1-carboxamide; stearoyl-CoA desaturase (SCD) inhibitor;SCD-inhibitor; A-939572; A 939572
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[269] | |||
Compound Name |
3-[(2R)-2-Methylpiperidin-1-yl]-N-[[4-[[3-[(2R)-2-methylpiperidin-1-yl]propylamino]methyl]phenyl]methyl]propan-1-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2170444
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[235] | |||
Compound Name |
Chembl4293085
Click to Show/Hide
|
Investigative | Compound Info | ||
Activity |
IC50 ~ 100000 nM
|
[270] | |||
Compound Name |
2-[[(2R)-2-Hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3601260; SCHEMBL2790929; BDBM50106739; 2-[[(2R)-2-hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[271] | |||
Compound Name |
2-Cyclohexyl-6-[[(3S)-1-(2-methoxyethyl)piperidin-3-yl]methyl]-5-(2-methylpyridin-3-yl)pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3218892
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[272] | |||
Compound Name |
(1R)-1-[3-[(1S,3R)-3-(2,2,2-Trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2385096; SCHEMBL14644527; BDBM50434791
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[229] | |||
Compound Name |
6-[({1-[2-(6-Hydroxy-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl)amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1824030; SCHEMBL704021; BDBM50352074
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[92] | |||
Compound Name |
(E)-3-(4-((7-Hydroxy-2-oxo-3-phenyl-2H-chromen-4-yl)methyl)phenyl)acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3427385; SS5020; SS-5020; SCHEMBL13183969; BDBM50084947; J3.629.235K
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[245] | |||
Compound Name |
Teixobactin
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
UNII-LC730GUE72; LC730GUE72; CHEMBL3977597; SCHEMBL15790568; GTPL10972; BDBM237161; US9402878, II; J3.653.642J; compound of formula II [WO2014089053A1]; Q18720369
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[273] | |||
Compound Name |
4-[[1-(6-Cyanopyridazin-3-yl)piperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593776; SCHEMBL13398301; BDBM50095953
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[260] | |||
Compound Name |
4-[(2-(Pyrrolidin-1-yl)ethoxy)]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024308; SCHEMBL7466649; BDBM50382851; 4-(2-pyrrolidin-1-ylethoxy)benzenesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL183289
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[184] | |||
Compound Name |
2-Amino-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidine-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2376802; SCHEMBL14895133
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[232] | |||
Compound Name |
6-[[[4-[(1S)-1-Amino-2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355578; BDBM50023585
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[249] | |||
Compound Name |
7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL390854; BDBM50205446
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[11] | |||
Compound Name |
N-[[4,4-Difluoro-1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-2,6-difluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2324491; SCHEMBL14836189; BDBM50427173
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[274] | |||
Compound Name |
(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL839287; CHEMBL3221518
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[75] | |||
Compound Name |
N-(2,3-Difluorophenyl)-2-[4-[[6-[3-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy]phthalazin-1-yl]amino]pyrazol-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL253968
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[258] | |||
Compound Name |
4-[[1-(5-Cyanopyrazin-2-yl)piperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593775; SCHEMBL13398365; BDBM50095954
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[260] | |||
Compound Name |
7-Cyclopropyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2376806; SCHEMBL14895231
Click to Show/Hide
|
||||
Activity |
Ki ~ 100000 nM
|
[232] | |||
Compound Name |
6-[[[(3S,4R)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290355; BDBM50018487
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
Plerixafor Octahydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Plerixafor hcl; Amd 3100; Sid 791; AMD 3100 octahydrochloride; AMD-3100; Plerixafor 8HCl (AMD3100 8HCl); Plerixafor hydrochloride; Plerixafor (octahydrochloride); UNII-OD49913540; Bicyclam; SDZ-SID-791; AMD3100 octahydrochloride; AMD3100 octahydrochloride hydrate; 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride; Plerixafor 8HCl; OD49913540; 155148-31-5 (HCl); SID791; C28H54N8.8HCl; CHEMBL2311028; Plerixafor 8HCl (DB06809); DTXSID20935148; BCP11743; MFCD04974488; s3013; AKOS017343984; CCG-270485; CS-0321; KS-000000X8; AC-32780; AK187770; AS-19545; HY-50912; DB-010929; Y0232; 148A315; Q27285584; CXCR4 Antagonist I, AMD3100 - CAS 155148-31-5; 1,1-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[235] | |||
Compound Name |
(2S)-2-[4-[[4-(4-Chlorophenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158778; SCHEMBL18841150; BDBM50394122
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[82] | |||
Compound Name |
4-{4-[1-(Methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325704; SCHEMBL2517353; BDBM50427321; 4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[275] | |||
Compound Name |
(1R)-2-[2-(1-Hydroxycyclohexylmethylamino)acetyl]-1,2,3,4-tetrahydro-1-isopropyl-6-methoxyisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593759; BDBM50095967
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[247] | |||
Compound Name |
1-(4-Acetylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021990; BDBM50382848
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
4-[[(3R,4S)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3593778; SCHEMBL3312282; BDBM50095951
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[260] | |||
Compound Name |
6-[[[(3R,4S)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290356; BDBM50018488
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[91] | |||
Compound Name |
Mavelertinib
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
PF-06747775; UNII-YXX2180047; YXX2180047; Mavelertinib [USAN]; Mavelertinib (USAN/INN); GTPL9765; CHEMBL3989970; SCHEMBL16714537; BDBM50450870; MFCD29079007; ZINC231225813; SB19002; compound 21 [PMID: 28287730]; Egfr T790M inhibitor PF-06747775; PF06747775; J3.645.972G; D11368; PF-06747775, >=98% (HPLC)
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[276] | |||
Compound Name |
Chembl4215407
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL19188995; BDBM50453825
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[257] | |||
Compound Name |
1-Cyclohexyl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021972; BDBM50382833
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
(3S)-N-Hydroxy-3-[4-[4-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3417769; BDBM50078172
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[43] | |||
Compound Name |
4-Cyclopropyl-N-(5-hydroxy-2-adamantyl)-2-morpholin-4-ylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2158485; SCHEMBL1014905; SCHEMBL1014907; SCHEMBL19248170; BDBM50394004
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[277] | |||
Compound Name |
1-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024388; BDBM50382861
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL231396
Click to Show/Hide
|
||||
Activity |
IC50 = 100000 nM
|
[262] | |||
Compound Name |
4-[5-[5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydroindol-1-yl]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1916559; SCHEMBL4421450; BDBM50357781
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[261] | |||
Compound Name |
6-[[[(3S,4R)-3-Fluoro-1-[2-[7-(1,2-oxazol-3-yloxy)-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3608756; BDBM50112264
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[180] | |||
Compound Name |
N-[6-(Trifluoromethyl)pyridine-3-yl]-2-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3924161; SCHEMBL17559542; ZINC121179910; J3.563.829F
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[263] | |||
Compound Name |
1-[4-Chloro-3-(1-ethylpiperidin-4-yl)sulfonyl-2-hydroxyphenyl]-3-(2-chloro-3-fluorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3818331; BDBM50182252
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[190] | |||
Compound Name |
4-Amino-N-[1-(3,4-dimethoxyphenyl)ethyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2325991; BDBM50427337
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[13] | |||
Compound Name |
1-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2024399; BDBM50382871
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
1-Phenyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2021976; BDBM50382882
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[185] | |||
Compound Name |
N-(6-Chloropyridin-3-yl)-6-(trifluoromethyl)-1H-indazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4093377; BDBM50254401
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[265] | |||
Compound Name |
(3S)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-5-fluoro-3-hydroxy-1,9-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12),9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2424933; BDBM50493330
Click to Show/Hide
|
||||
Activity |
IC50 = 101000 nM
|
[130] | |||
Compound Name |
Tert-butyl 1-(1-isopropylpiperazine-4-carbonyl)piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218410; BDBM50193179
Click to Show/Hide
|
||||
Activity |
IC50 = 101111.11 nM
|
[104] | |||
Compound Name |
[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11Z,13E,16R)-4-Acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671903; BDBM50417950
Click to Show/Hide
|
||||
Activity |
IC50 = 102329.3 nM
|
[3] | |||
Compound Name |
CID 57606048
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2029729; SCHEMBL2022611; BDBM50384159
Click to Show/Hide
|
||||
Activity |
IC50 = 105000 nM
|
[278] | |||
Compound Name |
7-[(3S)-3-[(2-Cyanoethylamino)methyl]pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL395556; BDBM50205459
Click to Show/Hide
|
||||
Activity |
Ki = 106000 nM
|
[11] | |||
Compound Name |
4-Methoxy-2-fluorobenzylcyanide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1673435; 8-Hydroxysantonin; BDBM50417938; 4-Hydroxy-3,5a,9-trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione #; Eudesma-1,4-dien-12-oic acid, 6.alpha.,8.alpha.-dihydroxy-3-oxo-, 12,6-lactone, (11S)-
Click to Show/Hide
|
||||
Activity |
IC50 = 109647.82 nM
|
[3] | |||
Compound Name |
N-{6-[(1S)-1-(4-Fluorophenyl)-2,2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4065169; MK-0448; SCHEMBL1381561; BDBM50235240; N-[6-[(1S)-1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamide
Click to Show/Hide
|
||||
Activity |
IC50 = 110000 nM
|
[279] | |||
Compound Name |
7-(3-(Aminomethyl)-3-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230916; BDBM50205455
Click to Show/Hide
|
||||
Activity |
Ki = 112000 nM
|
[11] | |||
Compound Name |
4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-N-(8-fluoro-6-methoxyquinolin-4-yl)-1-hydroxycyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1926865; BDBM50359455
Click to Show/Hide
|
||||
Activity |
IC50 = 113000 nM
|
[96] | |||
Compound Name |
(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4-isopropylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218992; BDBM50193208
Click to Show/Hide
|
||||
Activity |
IC50 = 115000 nM
|
[104] | |||
Compound Name |
[4-(3-Aza-bicyclo[3.2.2]nonane-3-carbonyl)-piperidin-1-yl]-(4-isopropyl-piperazin-1-yl)-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL218834; BDBM50193189
Click to Show/Hide
|
||||
Activity |
IC50 = 115000 nM
|
[104] | |||
Compound Name |
(3,4-Dihydroisoquinolin-2(1H)-yl)(4-isopropylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL219803; BDBM50193207
Click to Show/Hide
|
||||
Activity |
IC50 = 115000 nM
|
[104] | |||
Compound Name |
CID 60202107
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164741; SCHEMBL3359359; BDBM50395416
Click to Show/Hide
|
||||
Activity |
IC50 = 117000 nM
|
[128] | |||
Compound Name |
Chembl4279819
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
SCHEMBL17551601; US10081635, Example 5; BDBM286095
Click to Show/Hide
|
||||
Activity |
IC50 = 120000 nM
|
[19] | |||
Compound Name |
1-[2-((3R,4R)-3-Methoxy-4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}piperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165059; SCHEMBL3351346; BDBM50395403
Click to Show/Hide
|
||||
Activity |
IC50 = 124000 nM
|
[128] | |||
Compound Name |
2-[(4-{2-[3-(2-Methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}-4-phenylpiperidin-1-yl)carbonyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1784408; SCHEMBL3524150; BDBM50418510
Click to Show/Hide
|
||||
Activity |
IC50 = 125892.54 nM
|
[72] | |||
Compound Name |
7-Chloro-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425800; BDBM50084045
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||||
Activity |
IC50 = 126000 nM
|
[142] | |||
Compound Name |
(1R)-1-[2-(3,5-Dichlorophenyl)pyridin-3-yl]-2,2-dipyridin-3-ylethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL4104525; SCHEMBL1858793; BDBM50235250
Click to Show/Hide
|
||||
Activity |
IC50 = 128000 nM
|
[279] | |||
Compound Name |
Chembl420197
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL559246; SCHEMBL4275786; BDBM50025417; BDBM50296932
Click to Show/Hide
|
||||
Activity |
Ki = 130000 nM
|
[280] | |||
Compound Name |
5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyrazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL575453; SCHEMBL12041472; BDBM50299049
Click to Show/Hide
|
||||
Activity |
IC50 = 132857.14 nM
|
[104] | |||
Compound Name |
5-[[[(3S,4R)-3-Fluoro-1-[2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290350; BDBM50018482
Click to Show/Hide
|
||||
Activity |
IC50 = 133000 nM
|
[91] | |||
Compound Name |
Clozapine N-oxide
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
Clozapine-N-oxide; Clozapine (N-oxide); UNII-MZA8BK588J; C18H19ClN4O; CHEMBL1688; MZA8BK588J; 4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide; N-Oxyclozapine; Clozapine N-oxide solution; SCHEMBL9014028; CTK6H2075; BCP28618; EX-A2353; ZINC3872124; BDBM50279241; MFCD00210190; NSC750266; ZINC22055066; Clozapine N-oxide (CNO) (freebase); AKOS005066164; CS-1618; NSC-750266; HY-17366; FT-0665138; Y1277; J-019512; Q27284305; 5H-Dibenzo[b,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,4]diazepine N-oxide; (E)-4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide; 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-; 8-Chloro-11-(4-methyl-4-oxido-1-pip erazinyl)-5H-dibenzo[b,e][1,4]diazepine; 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; 8-chloro-11-(4-methyl-4-oxidopiperazin-1-yl)-10h-dibenzo[b,e][1,4]diazepine
Click to Show/Hide
|
||||
Activity |
IC50 = 133299.95 nM
|
[52] | |||
Compound Name |
FC(OC=1C=C(C=CC=1F)C=1C=NN(C=1)CC1=Nnc=C1)F
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3954438; SCHEMBL17493968; BDBM50201028
Click to Show/Hide
|
||||
Activity |
IC50 = 135000 nM
|
[103] | |||
Compound Name |
N2-(Benzo[d][1,3]dioxol-5-ylmethyl)-N4-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL607259; BDBM50304833
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|
||||
Activity |
IC50 = 135000 nM
|
[281] | |||
Compound Name |
2-[(2S)-2,3-Dihydroxypropyl]-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL216894; SCHEMBL3621295; BDBM50199070; 2-[(2S)-2,3-dihydroxypropyl]-6-methoxy-1-oxo-4-phenylisoquinoline-3-carbonitrile
Click to Show/Hide
|
||||
Activity |
IC50 = 135000 nM
|
[159] | |||
Compound Name |
2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
AZD2932; AZD-2932; UNII-SJ9PP5S9IM; SJ9PP5S9IM; CHEMBL1940274; AZD 2932; SCHEMBL1099958; EX-A998; AOB87706; BCP07984; BDBM50362058; MFCD25977021; s7003; ZINC73224167; AKOS026750228; CCG-269204; CS-3356; NCGC00390637-02; NCGC00481555-01; AC-33005; HY-18179; B5835; A14156
Click to Show/Hide
|
||||
Activity |
IC50 = 137000 nM
|
[282] | |||
Compound Name |
(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-15-[1-[(3-hydroxy-1,8-naphthyridin-4-yl)methyl]azetidin-3-yl]-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL583298; BDBM50299107
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|
||||
Activity |
IC50 = 140000 nM
|
[175] | |||
Compound Name |
PF-05175157
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
PF 05175157; PF05175157; UNII-P826WR56FI; P826WR56FI; CHEMBL3359265; PF5175157; SCHEMBL1892015; HMS3874K13; BCP25103; EX-A1660; BDBM50034371; MFCD28502250; s6672; AKOS027470289; AKOS032960468; ZINC117445039; CS-7859; DB12096; SB17382; NCGC00421916-02; AC-31464; BS-15158; HY-12942; Q27286356
Click to Show/Hide
|
||||
Activity |
IC50 = 141000 nM
|
[283] | |||
Compound Name |
6-[(3R)-3-[(1S)-2-Cyano-1-(methylamino)ethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230915; BDBM50205454
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|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
7-((R)-3-((S)-1-Amino-2-cyanoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL387837; BDBM50205464
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|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL390003; BDBM50205463
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|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
6-[(3R)-3-[(1S)-1-Amino-2-cyanoethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL388043; BDBM50205449
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|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
6-[(3R)-3-[(1S)-1-(2-Cyanoethylamino)ethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230914; BDBM50205456
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|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
6-((1H-1,2,4-Triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)-prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL445404; SCHEMBL4815260; BDBM50210303
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|
||||
Activity |
IC50 ~ 150000 nM
|
[106] | |||
Compound Name |
7-(3-((2-Cyanoethylamino)methyl)-3-ethylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL388489; SCHEMBL6528115; BDBM50205448; PF-02298732
Click to Show/Hide
|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
7-((R)-3-((S)-1-Amino-2-cyanoethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230811; BDBM50205458
Click to Show/Hide
|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
7-(3-((2-Cyanoethylamino)methyl)-3-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL231016; SCHEMBL6529048; BDBM50205467
Click to Show/Hide
|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
7-((R)-3-((S)-2-Cyano-1-(methylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL230600; SCHEMBL6530890; BDBM50205460; PF-00951966
Click to Show/Hide
|
||||
Activity |
Ki ~ 150000 nM
|
[11] | |||
Compound Name |
5-[[[(3S,4R)-3-Methoxy-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3290352; BDBM50018484
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|
||||
Activity |
IC50 = 151000 nM
|
[91] | |||
Compound Name |
CID 60200280
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164747; SCHEMBL3354071; BDBM50395410
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|
||||
Activity |
IC50 = 152000 nM
|
[128] | |||
Compound Name |
CID 60202105
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164740; SCHEMBL3355626; BDBM50395417
Click to Show/Hide
|
||||
Activity |
IC50 = 156000 nM
|
[128] | |||
Compound Name |
N-(1-(1-Isopropylpiperazine-4-carbonyl)piperidin-4-yl)cyclopentanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL220407; BDBM50193180
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|
||||
Activity |
IC50 = 156666.67 nM
|
[104] | |||
Compound Name |
N'-(1-Piperidin-4-yl-2,3-dihydroindol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2203713; SCHEMBL2777995
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|
||||
Activity |
IC50 = 160000 nM
|
[284] | |||
Compound Name |
5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1290746; SCHEMBL14097139; BDBM50331629
Click to Show/Hide
|
||||
Activity |
IC50 ~ 160000 nM
|
[285] | |||
Compound Name |
(S)-1-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL399726; BDBM50226071
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|
||||
Activity |
IC50 = 165000 nM
|
[286] | |||
Compound Name |
Ceralasertib
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
AZD6738; CHEMBL4285417; AZD-6738; BDBM50468001; BDBM60432; AZD 6738; Ceralasertib (USAN/INN); GTPL9390; SCHEMBL9979340; EX-A1101; MFCD29472273; s7693; 1352226-88-0 (free base); AKOS032960475; ZINC143911816; CCG-268794; CS-5187; AC-32647; HY-19323; A15794; D11787; J-690141
Click to Show/Hide
|
||||
Activity |
IC50 = 166000 nM
|
[36] | |||
Compound Name |
CID 60199965
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165066; SCHEMBL3359342; BDBM50395396
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|
||||
Activity |
IC50 = 168000 nM
|
[128] | |||
Compound Name |
Methylecgonidine
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
Anhydroecgonine methyl ester; UNII-58C337KP3E; Ecgonidine methyl ester mesylate; 58C337KP3E; methyl (1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylate; Anhydromethylecgonine; (1R,5S)-methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate; (-)-Anhydroecgonine Methyl Ester; Anhydroecgonine methyl; CHEMBL451136; SCHEMBL1009981; CTK4J2528; DTXSID20276220; BDBM50413637; methyl (1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate; ZINC53223985; AKOS006272123; ACN-028734; Q10858037; (1R)-TROP-2-ENE-2-CARBOXYLIC ACID METHYL ESTER; Anhydroecgonine Methyl Ester 1.0 mg/ml in Acetonitrile; (1R,5S)-Methyl8-Methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate; 8-Azabicyclo(3.2.1)oct-2-ene-2-carboxylic acid, 8-methyl-, methyl ester, (1R)-
Click to Show/Hide
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||||
Activity |
IC50 = 169824.37 nM
|
[287] | |||
Compound Name |
Methyl 8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL412663; 8-Azabicyclo[3.2.1]oct-2-ene-2-carboxylic acid, 8-methyl-, methyl ester; Methyl Ecgonidine; Ecgonidine, methyl ester; ACMC-1B0C2; SCHEMBL14193545; CTK0C1951; DTXSID70343794; BDBM50064614; AKOS034118811; 2-Tropidinecarboxylic acid, methyl ester; DB-051012; FT-0639826; FT-0695377; A826108; 2-Methoxycarbonyl-8-methyl-8-azonia-bicyclo[3.2.1]oct-2-ene; Methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate; Methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate #; 8-Methyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester; 8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid methyl ester; methyl (1RS)-8-methyl-8-azabicyclo-[3.2.1]oct-2-ene-2-carboxylate
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||||
Activity |
IC50 = 169824.37 nM
|
[3] | |||
Compound Name |
CID 25008767
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164746; SCHEMBL3353562; BDBM50395411
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|
||||
Activity |
IC50 = 172000 nM
|
[128] | |||
Compound Name |
6-[[[4-[(1R)-1-Amino-2-(7-fluoro-2-oxoquinoxalin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355572; SCHEMBL1374647; SCHEMBL1374651; BDBM50023588
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|
||||
Activity |
IC50 = 174000 nM
|
[249] | |||
Compound Name |
CID 25008771
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165054; SCHEMBL3357253; BDBM50395408
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|
||||
Activity |
IC50 = 174000 nM
|
[128] | |||
Compound Name |
CID 25008593
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165058; SCHEMBL3355581; BDBM50395404
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|
||||
Activity |
IC50 = 176000 nM
|
[128] | |||
Compound Name |
(2S,4S)-1-[(2S)-2-Amino-3-(1,3-thiazol-4-yl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3127986; BDBM50449235
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|
||||
Activity |
IC50 = 176600 nM
|
[288] | |||
Compound Name |
CID 60201265
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2165055; BDBM50395407
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|
||||
Activity |
IC50 = 189000 nM
|
[128] | |||
Compound Name |
5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL575685; SCHEMBL12041427; BDBM50299046
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|
||||
Activity |
IC50 = 190000 nM
|
[104] | |||
Compound Name |
5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL578834; SCHEMBL12041469; BDBM50299045
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|
||||
Activity |
IC50 = 190000 nM
|
[104] | |||
Compound Name |
(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-1,5,7,9,11,13-hexamethyl-15-[1-(1,5-naphthyridin-4-ylmethyl)azetidin-3-yl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL583090; BDBM50299104
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||||
Activity |
IC50 = 196000 nM
|
[175] | |||
Compound Name |
CID 60201945
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2165065; SCHEMBL703873; BDBM50395397
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||||
Activity |
IC50 = 199000 nM
|
[128] | |||
Compound Name |
4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-1-hydroxy-N-(6-methoxyquinolin-4-yl)cyclohexane-1-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1926866; BDBM50359456
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||||
Activity |
IC50 = 200000 nM
|
[96] | |||
Compound Name |
Click to Show/Hide
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Compound Info | |||
Activity |
IC50 ~ 100000 nM
|
[289] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 57 non binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
Lamotrigine
Click to Show/Hide
|
Approved | Compound Info | ||
Synonyms |
Crisomet; Labileno; Lamictal; Lamictin; Lamiktal; Lamitor; Lamotrigina; Lamotriginum; Desitin Brand of Lamotrigine; Faes Brand of Lamotrigine; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Juste Brand of Lamotrigine; Lamictal Cd; Lamictal ODT; Lamictal XR; Lamotrigina [Spanish]; Lamotriginum [Latin]; BW 430C; GI 267119X; GW 273293; L 3791; BW-430C; EUR-1048; Lamictal (TN); Lamictin (TN); Lamotrigine [USAN:INN:BAN]; Lamotrigine (JAN/USAN/INN); 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine; 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
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||||
Activity |
IC50 = 229086.77 nM
|
[287] | |||
Compound Name |
Trimethoprim
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Approved | Compound Info | ||
Synonyms |
Abaprim; Alprim; Anitrim; Antrima; Antrimox; Bacdan; Bacidal; Bacide; Bacin; Bacta; Bacterial; Bacticel; Bactin; Bactoprim; Bactramin; Bencole; Bethaprim; Biosulten; Briscotrim; Chemotrin; Cidal; Colizole; Conprim; Cotrimel; Deprim; Duocide; Esbesul; Espectrin; Euctrim; Exbesul; Fermagex; Fortrim; Futin; Idotrim; Ikaprim; Instalac; Kombinax; Lagatrim; Lastrim; Methoprim; Metoprim; Monoprim; Monotrim; Monotrimin; Novotrimel; Omstat; Oraprim; Pancidim; Polytrim; Priloprim; Primosept; Primsol; Proloprim; Protrin; Purbal; Resprim; Roubac; Roubal; Salvatrim; Setprin; Sinotrim; Stopan; Streptoplus; Sugaprim; Sulfamar; Sulfamethoprim; Sulfoxaprim; Sulmeprim; Sulthrim; Sultrex; Syraprim; Tiempe; Toprim; Trimanyl; Trimethioprim; Trimethoprime; Trimethoprimum; Trimethopriom; Trimetoprim; Trimetoprima; Trimexazole; Trimexol; Trimezol; Trimogal; Trimono; Trimopan; Trimpex; Triprim; Trisul; Trisulcom; Trisulfam; Trisural; Uretrim; Urobactrim; Utetrin; Velaten; Wellcoprim; Wellcoprin; Xeroprim; Zamboprim; Bacterial [Antibiotic]; Colizole DS; Component of Bactrim; Component of Septra; Lagatrim Forte; ResprimForte; Septrin DS; Septrin Forte; Septrin S; Trimetoprim [DCIT]; Trimetoprim [Polish]; BW 5672; KUC103659N; NIH 204; T 7883; Trimpex 200; WR 5949; Alcorim-F; Apo-Sulfatrim; BW 56-72; Co-Trimoxizole; Monotrim (TN); NIH 204 (VAN); Proloprim (TN); Smz-Tmp; Sulfamethoxazole & Trimethoprim; TCMDC-125538; Tmp-Ratiopharm; Trimeth/Sulfa; Trimethopim(TMP); Trimethoprim & VRC3375; Trimethoprime [INN-French]; Trimethoprimum [INN-Latin]; Trimetoprima [INN-Spanish]; Trimez-IFSA; Trimpex (TN); Triprim (TN); U-Prin; Uro-D S; BW-56-72; KSC-4-158; AZT + TMP/SMX (mixture) combination; Trimethoprim (JAN/USP/INN); Trimethoprim [USAN:BAN:INN:JAN]
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Activity |
IC50 = 239883.29 nM
|
[3] | |||
Compound Name |
Nicotine
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Approved | Compound Info | ||
Synonyms |
Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
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Activity |
IC50 = 244299.74 nM
|
[52] | |||
Compound Name |
Desvenlafaxine
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Approved | Compound Info | ||
Synonyms |
Norvenlafaxine; Desvenlafaxine (INN); Desvenlafaxine [INN:BAN]; O-Desmethylvenlafaxine; WY 45,233; O-DESMETHYLVENLAFAXINE (ODV); WY-45,233
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Activity |
IC50 = 251188.64 nM
|
[4] | |||
Compound Name |
Lidocaine
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Approved | Compound Info | ||
Synonyms |
Alphacaine; Anestacon; Cappicaine; Cuivasil; Dalcaine; Dentipatch; DermaFlex; Dilocaine; Duncaine; EMBOLEX; Esracaine; Gravocain; Isicaina; Isicaine; Jetocaine; LIDOPEN; LQZ; Lanabiotic; Leostesin; Lidocaina; Lidocainum; Lidocaton; Lidoderm; Lignocaine; Lignocainum; Lingocaine; Maricaine; Octocaine; Remicaine; Rucaina; Solcain; Xilina; Xilocaina; Xllina; Xycaine; Xylestesin; Xylesthesin; Xylocain; Xylocaine; Xylocard; Xylocitin; Xylotox; Zingo; After Burn Double Strength Gel; After Burn Double Strength Spray; After Burn Gel; After Burn Spray; Anestacon Jelly; Cito optadren; Emla Cream; Lidocaine Carbonate; Lidocaine Hydrocarbonate; Lidocaine Monohydrochloride; Norwood Sunburn Spray; Rocephin Kit; Solarcaine aloe extraburn relief cream; Xilocaina [Italian]; Xylocaine Dental Ointment; Xylocaine Endotracheal; Xylocaine Test Dose; Xylocaine Viscous; CDS1_000283; L1026_SIGMA; Xylocaine CO2; Dentipatch (TN); ELA-Max; L-Caine; Lida-Mantle; Lidocaina [INN-Spanish]; Lidocaine (VAN); Lidocainum [INN-Latin]; Lidoject-1; Lidoject-2; Octocaine-100; Octocaine-50; Xylocaine (TN); Xylocaine 5% Spinal; Xylocaine-Mpf; Xylocaine-Mpf with Glucose; Xyloneural (free base); Zilactin-L; Lidocaine [USAN:INN:JAN]; Diethylaminoaceto-2,6-xylidide; Lidocaine (JP15/USP/INN); Alfa-Dietilamino-2,6-dimetilacetanilide; Alfa-Dietilamino-2,6-dimetilacetanilide [Italian]; Alpha-Diethylamino-2,6-dimethylacetanilide; Alpha-Diethylaminoaceto-2,6-xylidide; LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE); Omega-Diethylamino-2,6-dimethylacetanilide; Alpha-(Diethylamino)-2,6-acetoxylidide; N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide; N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide; 2-(Diethylamino)-2',6'-acetoxylidide; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide; 2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide; 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
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Activity |
IC50 = 263026.8 nM
|
[3] | |||
Compound Name |
Codeine
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Approved | Compound Info | ||
Synonyms |
codeine; Methylmorphine; Codeine anhydrous; Codicept; l-Codeine; Coducept; Morphine monomethyl ether; Morphine 3-methyl ether; 76-57-3; (-)-Codeine; O3-Methylmorphine; codeinum; Morphine-3-methyl ether; Codein; Norcodine, N-methyl; Norcodeine, N-methyl; CODEINE BASE; Codeine polistirex; codeina; O(3)-methylmorphine; CCRIS 7555; Morphine-3-methyl ester; HSDB 3043; UNII-UX6OWY2V7J; CHEBI:16714; EINECS 200-969-1; UX6OWY2V7J; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-; Codeine Anhydrate
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Activity |
IC50 = 301995.17 nM
|
[8] | |||
Compound Name |
Indomethacin
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Approved | Compound Info | ||
Synonyms |
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
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Activity |
IC50 = 301995.17 nM
|
[3] | |||
Compound Name |
Anagliptin
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Approved | Compound Info | ||
Synonyms |
Anagliptin; 739366-20-2; UNII-K726J96838; suiny; CHEMBL1929396; (S)-N-(2-((2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; K726J96838; CHEMBL1929387; N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide; Anagliptin [INN]; N-[2-({2-[(2s)-2-Cyanopyrrolidin-1-Yl]-2-Oxoethyl}amino)-2-Methylpropyl]-2-Methylpyrazolo[1,5-A]pyrimidine-6-Carboxamide; Anagliptin (JAN/INN); SCHEMBL905393; sk-0403
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Activity |
IC50 > 500000 nM
|
[290] | |||
Compound Name |
Everolimus
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Approved | Compound Info | ||
Synonyms |
Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress
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Activity |
IC50 = 501187.23 nM
|
[4] | |||
Compound Name |
VRX496
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Approved | Compound Info | ||
Synonyms |
Nelfinavir; nelfinavir; 159989-64-7; Viracept; Nelfinavir [INN:BAN]; AG1343; UNII-HO3OGH5D7I; AG-1343; C32H45N3O4S; NELFINAVIR MESYLATE AG1343; Viracept (TN); HO3OGH5D7I; CHEBI:7496; AG 1343; NLF; 1UN; 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE; (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide; NFV; NFV; Nelfinavir Monomethane Sulfonate; AG1346; Nelfinavir (INN); Nelfinavir [BAN:INN]; AG1343 (*Mesylate salt*); Viracept (TM)(*Mesylate salt*); Met-SDF-1beta & Nelfinavir; Met-Stromal Cell-derived Factor-1beta (Human) & Nelfinavir; (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
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Activity |
IC50 = 501187.23 nM
|
[4] | |||
Compound Name |
Ambrisentan
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Approved | Compound Info | ||
Synonyms |
Letairis; Ambrisentan [INN]; Gilead brand of ambrisentan; BSF 208075; BSF208075; LU 208075; LU208075; BSF-208075; LU-208075; Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid; 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
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Activity |
IC50 = 501187.23 nM
|
[4] | |||
Compound Name |
Lapatinib
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Approved | Compound Info | ||
Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
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Activity |
IC50 = 630957.34 nM
|
[4] | |||
Compound Name |
Alvimopan
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Approved | Compound Info | ||
Synonyms |
Alvimopan anhydrous; LY 246736; LY246736; Adl 8-2698; Entereg (TN); Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine; Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
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Activity |
IC50 = 794328.23 nM
|
[4] | |||
Compound Name |
[3H]nicotine
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Investigative | Compound Info | ||
Synonyms |
3-(1-methylpyrrolidin-2-yl)pyridine; 22083-74-5; Nikotin; (R,S)-Nicotine; Black Leaf 40; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-; Black leaf; Nicotine alkaloid; Nicotin; Nicocide; Tendust; (RS)-Nicotine; Nico-dust; Emo-nik; Nico-Fume; Mach-Nic; Nic-Sal; Nicotina; Nikotyna; CHEMBL440464; (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine; NSC5065; SNICXCGAKADSCV-UHFFFAOYSA-N; BRN 0082111; 3-(1-Methyl-2-pyrrolidinyl)pyridine
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Activity |
IC50 = 245470.89 nM
|
[3] | |||
Compound Name |
6-Cyano-N-[(1R)-1-[1-ethyl-6-(trifluoromethyl)imidazo[4,5-c]pyridin-2-yl]ethyl]pyridine-3-sulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3605557; SCHEMBL3449482; BDBM50113980
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Activity |
IC50 > 200000 nM
|
[291] | |||
Compound Name |
6-Cyano-N-[(1R)-1-(6-cyclopropyl-1-ethylimidazo[4,5-c]pyridin-2-yl)ethyl]pyridine-3-sulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3605558; SCHEMBL3450843; BDBM50113979
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Activity |
IC50 > 200000 nM
|
[291] | |||
Compound Name |
1-[2-[(3R,4S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-fluoropiperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
UNII-1T5080OCPW; 1T5080OCPW; CHEMBL2165064; AZD9742; SCHEMBL3357804; AZD 9742 [WHO-DD]; AZD-9742; BDBM50395398
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Activity |
IC50 > 200000 nM
|
[128] | |||
Compound Name |
Methyl (4aS,6aR,6bS,8aR,12R,12aS,14aR,14bS)-10-[[4-[[(4S)-4-amino-5-methoxy-5-oxopentanoyl]amino]phenyl]methoxy]-11-cyano-12-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-14-oxo-3,4,5,6,7,8,8a,12,14a,14b-decahydro-1H-picene-4a-carboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL4083511; BDBM50242191
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Activity |
IC50 > 200000 nM
|
[292] | |||
Compound Name |
8-[2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]ethyl]-2-methoxypyrido[2,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1916543; SCHEMBL4149485; BDBM50357922
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Activity |
IC50 = 206000 nM
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[205] | |||
Compound Name |
3-[[4-(3,4-Dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)piperidin-1-yl]methyl]cyclopentane-1-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3329811; BDBM50023367
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Activity |
IC50 = 209000 nM
|
[204] | |||
Compound Name |
N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide
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Investigative | Compound Info | ||
Synonyms |
CBS-3595; CHEMBL1773422; SCHEMBL2841705; BDBM50249598; N-[4-[5-(4-fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-yl]acetamide; N-(4-(4-(4-Fluorophenyl)-1-methyl-2-(methylsulfinyl)-1H-imidazol-5-yl)-2-pyridinyl)acetamide
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Activity |
IC50 = 213000 nM
|
[207] | |||
Compound Name |
2-[1-[2-Fluoro-4-[(5R)-2-oxo-5-(triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl]piperidin-4-ylidene]propanenitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2324519; BDBM50427201
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Activity |
IC50 = 213320 nM
|
[293] | |||
Compound Name |
1-Cyclopropyl-6-fluoro-7-[(8Z)-8-methoxyimino-2,6-diazaspiro[3.4]octan-6-yl]-4-oxo-2,3-dihydro-1,8-naphthyridine-3-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1671899; BDBM50417946
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Activity |
IC50 = 218776.16 nM
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[3] | |||
Compound Name |
6-[[[1-[2-(2-Oxo-7-pyrimidin-5-yloxy-1,8-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3608746; BDBM50112253
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Activity |
IC50 > 224000 nM
|
[180] | |||
Compound Name |
(1r)-1-[(4-{[(6,7-Dihydro[1,4]dioxino[2,3-C]pyridazin-3-Yl)methyl]amino}piperidin-1-Yl)methyl]-9-Fluoro-1,2-Dihydro-4h-Pyrrolo[3,2,1-Ij]quinolin-4-One
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Investigative | Compound Info | ||
Synonyms |
GSK945237; 944406-54-6 (free base); UNII-U9T63BZ3AS; U9T63BZ3AS; CHEMBL3793226; Gsk-945237; GSK-945237 free base; IGSK 945237; BDBM50156545; DB15345; Q27456356
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Activity |
IC50 = 238000 nM
|
[294] | |||
Compound Name |
(S)-4-((4-(((2,3-Dihydro-[1,4]dioxino[2,3-C]pyridin-7-Yl)methyl)amino)piperidin-1-Yl)methyl)-3-Fluoro-4-Hydroxy-4h-Pyrrolo[3,2,1-De][1,5]naphthyridin-7(5h)-One
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Investigative | Compound Info | ||
Synonyms |
SCHEMBL2767486; CHEMBL2424928; GSK-966587; Q27457229
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Activity |
IC50 = 239000 nM
|
[130] | |||
Compound Name |
(3S)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-5,10-difluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2424934; SCHEMBL2767059; BDBM50493333
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Activity |
IC50 = 289000 nM
|
[130] | |||
Compound Name |
(3R,4R)-4-Amino-3-(pyrrolidine-1-carbonyl)-1-(quinoxaline-3-carbonyl)pyrrolidin-2-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL428936; BDBM50226094
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Activity |
IC50 > 300000 nM
|
[286] | |||
Compound Name |
(3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]-1-[3-(1,2-oxazol-5-yl)cyclobutyl]piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL4101570
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Activity |
IC50 > 300000 nM
|
[209] | |||
Compound Name |
4-[6-(Azetidine-1-carbonyl)-5-fluoropyridin-3-yl]oxy-2-ethyl-N-(5-methylpyrazin-2-yl)indazole-6-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2204663; SCHEMBL1725323; BDBM50401849
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Activity |
IC50 > 300000 nM
|
[295] | |||
Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-7-bromo-4-oxo-5H-pyrrolo[3,2-d]pyrimidin-3-yl]methyl]benzonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2023067; BDBM50381853
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Activity |
IC50 > 300000 nM
|
[296] | |||
Compound Name |
Chembl4283796
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Investigative | Compound Info | ||
Synonyms |
BDBM50468577
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Activity |
IC50 > 300000 nM
|
[297] | |||
Compound Name |
2-(trans-4-(4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl)cyclohexyl)acetic acid
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
ABT-046; CHEMBL2165819; 2-[4-[4-(7-aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl]acetic acid; SCHEMBL4943142; ABT 046; DTXSID40718899; 3073AH; BDBM50394726; ZINC100100108; ZINC242437292; CS-1213; HY-15197; AB0081788; A14984; W-5892; {4-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexyl}acetic acid; trans-4-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexaneacetic acid
Click to Show/Hide
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||||
Activity |
IC50 > 300000 nM
|
[298] | |||
Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-methyl-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl]methyl]benzonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2022464; BDBM50381856
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||||
Activity |
IC50 > 300000 nM
|
[296] | |||
Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-bromo-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl]methyl]benzonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2022467; BDBM50381854
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||||
Activity |
IC50 > 300000 nM
|
[296] | |||
Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-4-oxo-6-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-3-yl]methyl]benzonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2023066; BDBM50381855
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||||
Activity |
IC50 > 300000 nM
|
[296] | |||
Compound Name |
4-[[3-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclobutyl]methyl]morpholine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2206288; SCHEMBL2742717; SCHEMBL2742866; SCHEMBL5786308; SCHEMBL5789522; SCHEMBL15627115; BDBM50401001; cis-4-[3-(4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutylmethyl]-morpholine
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||||
Activity |
IC50 = 300000 nM
|
[299] | |||
Compound Name |
CID 25008765
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2164742; SCHEMBL3358901; BDBM50395415
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||||
Activity |
IC50 = 305000 nM
|
[128] | |||
Compound Name |
(9S)-9-Amino-9-deoxoerythromycin
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Investigative | Compound Info | ||
Synonyms |
Erythromycylamine; 9(S)-Erythromycylamine; 9-Epierythromycylamine; (9S)-erythromycyclamine; BRN 4241492; UNII-YX9KV1OMA4; YX9KV1OMA4; Erythromycin, 9-amino-9-deoxo-, (9S)- (9CI); 9-Amino-9-deoxoerythromycin; CHEMBL290242; LY-24410; Epierythromycyl-A-amine; (9S)-9-amino-9-deoxyerythromycin; 9-Amino-9-deoxo-erythromycin, stereoisomer; (9S)-Erythromycylamine; Erythromycin, 9-amino-9-deoxo-, stereoisomer; EC 406-790-7; SCHEMBL13681694; DTXSID00180750; BDBM50417963; ZINC94303289; AC-28327; CS-15835; CS-0047729; J-016261; Q27144058
Click to Show/Hide
|
||||
Activity |
IC50 = 316227.77 nM
|
[3] | |||
Compound Name |
5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-b]pyridin-6-yl)pyridin-2-ol
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL574393; SCHEMBL12041282; BDBM50299033
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||||
Activity |
IC50 = 323333.33 nM
|
[104] | |||
Compound Name |
6-[[[4-[(1R)-1-Amino-2-(7-fluoro-4-methyl-2-oxoquinolin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355570; SCHEMBL1375507; SCHEMBL1375509; BDBM50023591
Click to Show/Hide
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||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
2-[[[4-[(1R)-1-Amino-2-(6-fluoro-7-methoxy-2-oxoquinoxalin-1-yl)ethyl]cyclohexyl]amino]methyl]-8H-pyrimido[5,4-b][1,4]oxazin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355574; BDBM50023590
Click to Show/Hide
|
||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
CID 60200128
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2164743; SCHEMBL3357772; BDBM50395414
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|
||||
Activity |
IC50 > 333000 nM
|
[128] | |||
Compound Name |
2-[[[4-[(1R)-1-Amino-2-(7-methoxy-2-oxoquinoxalin-1-yl)ethyl]cyclohexyl]amino]methyl]-8H-pyrimido[5,4-b][1,4]oxazin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3352849; SCHEMBL1376002; SCHEMBL1376008; BDBM50023586
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|
||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
6H-Pyrimido[5,4-b][1,4]oxazin-7(8H)-one, 2-[[[trans-4-[(1R)-1-amino-2-(7-fluoro-2-oxo-1(2H)-quinoxalinyl)ethyl]cyclohexyl]amino]methyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355573; SCHEMBL1375934; SCHEMBL1375938; BDBM50023589; SB19220
Click to Show/Hide
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||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
1-[(2S)-2-Amino-2-[(1r,4S)-4-[({3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-6-yl}methyl)amino]cyclohexyl]ethyl]-7-methoxy-1,2-dihydro-1,5-naphthyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355575; SCHEMBL1375971; SCHEMBL1375976; BDBM50023582; SB19210
Click to Show/Hide
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||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
6-[[[4-[(1R)-1-Amino-2-(7-methoxy-2-oxoquinoxalin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355571; SCHEMBL1374732; SCHEMBL1374736; BDBM50023587
Click to Show/Hide
|
||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
2-[[[4-[(1R)-1-Amino-2-(7-fluoro-4-methyl-2-oxoquinolin-1-yl)ethyl]cyclohexyl]amino]methyl]-8H-pyrimido[5,4-b][1,4]oxazin-7-one
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3355569; BDBM50023592
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|
||||
Activity |
IC50 > 333000 nM
|
[249] | |||
Compound Name |
2-(7-(5-(3-Cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2048293; SCHEMBL949280; BDBM50386859
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|
||||
Activity |
IC50 > 400000 nM
|
[300] | |||
Compound Name |
(2R)-2-[4-[[[(2S)-3-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidine-2-carbonyl]amino]methyl]anilino]-3-methylbutanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1683506; SCHEMBL4565902
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|
||||
Activity |
EC50 = 408000 nM
|
[301] | |||
Compound Name |
2-((2R,3S,4R,5R,6S,7R,9R,10R,11S,12S,13R)-2-Ethyl-3,4,9-trihydroxy-10-((2S,3R,4S,6R)-3-hydroxy-4-(isopropyl(methyl)amino)-6-methyltetrahydro-2H-pyran-2-yloxy)-12-((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-14-oxooxacyclotetradecan-6-yloxy)-N-methylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL572996; SCHEMBL12101996; BDBM50299517
Click to Show/Hide
|
||||
Activity |
IC50 = 411000 nM
|
[302] | |||
Compound Name |
Ecgonine methyl ester
Click to Show/Hide
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Investigative | Compound Info | ||
Synonyms |
Methyl ecgonine; ecgonine methylester; UNII-Y35FJB3QBJ; Y35FJB3QBJ; Methylecgonine; methyl (1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; CHEMBL1232472; 3-HYDROXY-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER; (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-ol; ECGONINEMETHYLESTER; methyl (1S,3S,4R,5R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate; Epitope ID:161060; SCHEMBL328854; CTK8D8862; DTXSID00891435; ZINC4654765; BDBM50417947; AKOS006274769; 2beta-Carbomethoxy-3beta-hydroxytropane; DB04688; methyl(1r,2r,3s,5s)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; Ecgonine Methyl Ester 1.0 mg/ml in Acetonitrile; Q27095434
Click to Show/Hide
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||||
Activity |
IC50 = 416869.38 nM
|
[3] | |||
Compound Name |
N-(4-Chlorophenyl)-2-[5-methoxy-3-[(E)-[(4-methylphenyl)sulfonylhydrazinylidene]methyl]indol-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2440387; BDBM50493875
Click to Show/Hide
|
||||
Activity |
IC50 = 418350 nM
|
[303] | |||
Compound Name |
N-Ethyl-2-[3-(trifluoromethyl)phenyl]ethanamine
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|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1671896; BDBM50417942; AKOS011839026
Click to Show/Hide
|
||||
Activity |
IC50 = 537031.8 nM
|
[3] | |||
Compound Name |
(3R)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3425810; BDBM50084056
Click to Show/Hide
|
||||
Activity |
IC50 = 764000 nM
|
[142] | |||
Compound Name |
Rhynchophylline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Rhyncophylline; UNII-46BQ79VJ8D; Mitrinermine; Mitrinermin; Rhynchophyllin; Rhynocophylline; 46BQ79VJ8D; CHEMBL519266; Isorhychophylline; NSC 21731; Rhyncophylline (8CI); SCHEMBL2047380; DTXSID70878612; HMS3887A03; HY-N0387; ZINC4097968; BDBM50251393; MFCD00221748; s9400; AKOS037514819; CCG-268460; CS-3807; R0105; X1218; C09236; 076R664; Q7321711
Click to Show/Hide
|
||||
Activity |
IC50 = 773000 nM
|
[304] | |||
Compound Name |
Click to Show/Hide
|
Compound Info | |||
Activity |
IC50 > 200000 nM
|
[292] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
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REF 1 | Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem. 2008 Sep 25;51(18):5843-55 | ||||
REF 2 | The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3848-51. | ||||
REF 3 | Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Eur J Med Chem. 2011 Feb;46(2):618-30. | ||||
REF 4 | Prediction of Thorough QT study results using action potential simulations based on ion channel screens. J Pharmacol Toxicol Methods. Nov-Dec 2014;70(3):246-54. | ||||
REF 5 | Docking model of drug binding to the human ether-?go-go potassium channel guided by tandem dimer mutant patch-clamp data: a synergic approach. J Med Chem. 2009 Mar 26;52(6):1630-8. | ||||
REF 6 | A binary QSAR model for classification of hERG potassium channel blockers. Bioorg Med Chem. 2008 Apr 1;16(7):4107-19. | ||||
REF 7 | Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):97-101. | ||||
REF 8 | A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2886-90. | ||||
REF 9 | Aryl thiosemicarbazones for the treatment of trypanosomatidic infections. Eur J Med Chem. 2018 Feb 25;146:423-434. | ||||
REF 10 | Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res. 2011 Jul 1;91(1):53-61. | ||||
REF 11 | The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2150-5. | ||||
REF 12 | The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. | ||||
REF 13 | Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem. 2013 Mar 14;56(5):2059-73. | ||||
REF 14 | Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate. ACS Med Chem Lett. 2012 Oct 8;3(12):1039-44. | ||||
REF 15 | MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate. ACS Med Chem Lett. 2018 Apr 30;9(7):652-656. | ||||
REF 16 | Imidazo[1,2-a]pyrazines as novel PI3K inhibitors. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1874-8. | ||||
REF 17 | Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8. | ||||
REF 18 | A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660). J Med Chem. 2018 Aug 23;61(16):7314-7329. | ||||
REF 19 | Design, synthesis and evaluation of ( R)-3-(7-(methyl(7 H-pyrrolo[2,3- d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor. Medchemcomm. 2018 Jan 15;9(3):477-489. | ||||
REF 20 | PPAR-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development. Bioorg Med Chem. 2018 Dec 1;26(22):5870-5884. | ||||
REF 21 | Property based optimisation of glucokinase activators - discovery of the phase IIb clinical candidate AZD1656. Medchemcomm. 2012;3:1077-81. | ||||
REF 22 | Discovery of a potent, selective, and orally bioavailable acidic 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem. 2012 Jun 28;55(12):5951-64. | ||||
REF 23 | (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipepti... Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5. | ||||
REF 24 | Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem. 2017 Feb 23;60(4):1247-1261. | ||||
REF 25 | Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3809-12. | ||||
REF 26 | Novel acidic 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47. | ||||
REF 27 | Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. | ||||
REF 28 | Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1472-6. | ||||
REF 29 | The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. Medchemcomm. 2016;7:1587-95. | ||||
REF 30 | Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization. Eur J Med Chem. 2013 Oct;68:312-20. | ||||
REF 31 | Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5663-5668. | ||||
REF 32 | Inhibitory effect of carboxylic acid group on hERG binding. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5507-12. | ||||
REF 33 | Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects. J Med Chem. 2009 Dec 10;52(23):7778-87. | ||||
REF 34 | The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. | ||||
REF 35 | Selenophene-containing inhibitors of type IIA bacterial topoisomerases. J Med Chem. 2011 May 12;54(9):3418-25. | ||||
REF 36 | Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907. | ||||
REF 37 | Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)... J Med Chem. 2006 Nov 2;49(22):6439-42. | ||||
REF 38 | Support vector machines classification of hERG liabilities based on atom types. Bioorg Med Chem. 2008 Jun 1;16(11):6252-60. | ||||
REF 39 | Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. | ||||
REF 40 | Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity. J Med Chem. 2003 Jun 5;46(12):2413-26. | ||||
REF 41 | Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. | ||||
REF 42 | Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. | ||||
REF 43 | Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead. J Med Chem. 2015 Mar 12;58(5):2465-88. | ||||
REF 44 | Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists. Bioorg Med Chem Lett. 2013 Jan 1;23(1):351-4. | ||||
REF 45 | Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1239-42. | ||||
REF 46 | The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. | ||||
REF 47 | A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel. J Med Chem. 2008 Jul 10;51(13):4021-9. | ||||
REF 48 | Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. | ||||
REF 49 | Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II). ACS Med Chem Lett. 2015 May 19;6(7):736-40. | ||||
REF 50 | 6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB 1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity. J Med Chem. 2018 Nov 21;61(22):10276-10298. | ||||
REF 51 | Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett. 2017 Jul 27;8(9):947-952. | ||||
REF 52 | Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new ... J Med Chem. 2009 Jul 23;52(14):4266-76. | ||||
REF 53 | The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2. Bioorg Med Chem Lett. 2014 May 1;24(9):2137-40. | ||||
REF 54 | Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3216-3221. | ||||
REF 55 | Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. | ||||
REF 56 | US patent application no. 9422299B2, Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists | ||||
REF 57 | Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy. Eur J Med Chem. 2018 Mar 25;148:140-153. | ||||
REF 58 | A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1063-9. | ||||
REF 59 | Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication. ACS Med Chem Lett. 2012 Jan 25;3(3):216-21. | ||||
REF 60 | N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62. | ||||
REF 61 | Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6042-8. | ||||
REF 62 | Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B. J Med Chem. 2017 Jul 27;60(14):6137-6151. | ||||
REF 63 | Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors. J Med Chem. 2018 Sep 27;61(18):8390-8401. | ||||
REF 64 | In vivo potent BM635 analogue with improved drug-like properties. Eur J Med Chem. 2018 Feb 10;145:539-550. | ||||
REF 65 | Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA. J Med Chem. 2014 Feb 27;57(4):1276-88. | ||||
REF 66 | Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11-hydroxysteroid dehydrogenase type 1 (11-HSD1). Bioorg Med Chem Lett. 2014 Jan 15;24(2):654-60. | ||||
REF 67 | Discovery of novel triazolobenzazepinones as -secretase modulators with central A42 lowering in rodents and rhesus monkeys. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3488-94. | ||||
REF 68 | Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem. 2018 Feb 22;61(4):1664-1687. | ||||
REF 69 | A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides. J Med Chem. 2015 Jun 11;58(11):4573-80. | ||||
REF 70 | Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels. Bioorg Med Chem. 2014 Dec 15;22(24):6899-907. | ||||
REF 71 | Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5. | ||||
REF 72 | Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile. J Med Chem. 2011 Jun 9;54(11):3756-67. | ||||
REF 73 | Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic alpha v 6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2018 Sep 27;61(18):8417-8443. | ||||
REF 74 | New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems. Bioorg Med Chem Lett. 2008 Feb 1;18(3):901-7. | ||||
REF 75 | Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets - the discovery of AZD3651 and AZD9485. Medchemcomm. 2013;4:663-8. | ||||
REF 76 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
REF 77 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
REF 78 | Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism. J Med Chem. 2014 Mar 13;57(5):1964-75. | ||||
REF 79 | 4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists. J Med Chem. 2007 Dec 27;50(26):6706-17. | ||||
REF 80 | Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5056-9. | ||||
REF 81 | Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. J Med Chem. 2010 Nov 11;53(21):7778-95. | ||||
REF 82 | Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6694-9. | ||||
REF 83 | Matched triplicate design sets in the optimisation of glucokinase activators - maximising medicinal chemistry information content. Medchemcomm. 2013;4:657-62. | ||||
REF 84 | Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7120-3 | ||||
REF 85 | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. | ||||
REF 86 | The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4022-5. | ||||
REF 87 | Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. | ||||
REF 88 | The discovery of quinoline based single-ligand human H 1 and H 3 receptor antagonists. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5855-5859. | ||||
REF 89 | Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses. J Med Chem. 2016 Feb 11;59(3):1003-20. | ||||
REF 90 | 4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5222-6. | ||||
REF 91 | Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis. J Med Chem. 2014 Jun 12;57(11):4889-905. | ||||
REF 92 | Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5432-5. | ||||
REF 93 | Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups. J Med Chem. 2017 Jul 13;60(13):5493-5506. | ||||
REF 94 | An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists. Bioorg Med Chem Lett. 2007 Feb 15;17(4):874-8. | ||||
REF 95 | Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett. 2015 Mar 18;6(5):513-7. | ||||
REF 96 | Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7483-8. | ||||
REF 97 | Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorg Med Chem Lett. 2016 May 1;26(9):2339-43. | ||||
REF 98 | Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria. J Med Chem. 2017 May 11;60(9):3776-3794. | ||||
REF 99 | 5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1658-61. | ||||
REF 100 | Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1265-8. | ||||
REF 101 | Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. | ||||
REF 102 | N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5078-81. | ||||
REF 103 | Pyrazole Inhibitors of GluN2B NMDA Receptor Subunit. ACS Med Chem Lett. 2016 Nov 10;7(12):1018-1019. | ||||
REF 104 | Novel and highly potent histamine H3 receptor ligands. Part 1: withdrawing of hERG activity. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5378-83. | ||||
REF 105 | Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. Bioorg Med Chem Lett. 2011 May 1;21(9):2626-30. | ||||
REF 106 | 1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel. J Med Chem. 2007 May 3;50(9):2011-29. | ||||
REF 107 | Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria. ACS Med Chem Lett. 2011 Jul 11;2(9):708-13. | ||||
REF 108 | Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol... J Med Chem. 2010 Apr 8;53(7):2854-64. | ||||
REF 109 | Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2). Bioorg Med Chem Lett. 2015 May 1;25(9):1831-5. | ||||
REF 110 | Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. | ||||
REF 111 | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J Med Chem. 2012 Nov 8;55(21):9055-68. | ||||
REF 112 | In vitro studies on a class of quinoline containing histamine H3 antagonists. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3295-300. | ||||
REF 113 | Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective alpha7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. J Med Chem. 2012 Nov 26;55(22):9793-809. | ||||
REF 114 | Discovery of novel BTK inhibitors with carboxylic acids. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1471-1477. | ||||
REF 115 | 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem. 2012 Apr 12;55(7):2945-59. | ||||
REF 116 | Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1939-44. | ||||
REF 117 | Antagonists of 5-HT1 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4273-80. | ||||
REF 118 | Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. | ||||
REF 119 | Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. | ||||
REF 120 | Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7399-404. | ||||
REF 121 | Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2220-3. | ||||
REF 122 | Discovery of benzamides as potent human 3 adrenergic receptor agonists. Bioorg Med Chem Lett. 2016 Jan 1;26(1):55-9. | ||||
REF 123 | Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Oct 30;86:242-56. | ||||
REF 124 | Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK- modulators. Eur J Med Chem. 2018 Sep 5;157:691-704. | ||||
REF 125 | Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, -Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61(10):4476-4504. | ||||
REF 126 | 4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: a novel class III antiarrhythmic agents. J Med Chem. 1995 Jul 7;38(14):2551-6. | ||||
REF 127 | Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2023-9. | ||||
REF 128 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. J Med Chem. 2012 Aug 9;55(15):6916-33. | ||||
REF 129 | US patent application no. 8461198B2, Use of acacetin and related compounds as potassium channel inhibitors | ||||
REF 130 | Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5437-41. | ||||
REF 131 | Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. | ||||
REF 132 | Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2533-6. | ||||
REF 133 | Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus. Medchemcomm. 2011;2:828-39. | ||||
REF 134 | 2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2. J Med Chem. 2014 Jul 24;57(14):6083-91. | ||||
REF 135 | Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents. J Med Chem. 2018 Jul 12;61(13):5704-5718. | ||||
REF 136 | Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6). Bioorg Med Chem Lett. 2015 Sep 1;25(17):3636-43. | ||||
REF 137 | 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3390-4. | ||||
REF 138 | Investigation of piperazine benzamides as human 3 adrenergic receptor agonists for the treatment of overactive bladder. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1094-1098. | ||||
REF 139 | C1-C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7). Medchemcomm. 2015;6:1773-80. | ||||
REF 140 | Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566. | ||||
REF 141 | Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. | ||||
REF 142 | Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3). Bioorg Med Chem Lett. 2015 Jun 15;25(12):2473-8. | ||||
REF 143 | Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety. ACS Med Chem Lett. 2014 Sep 8;5(10):1082-7. | ||||
REF 144 | Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11-Hydroxysteroid Dehydrogenase Type 1 (11-HSD-1). ACS Med Chem Lett. 2014 May 22;5(7):803-8. | ||||
REF 145 | Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2670-4. | ||||
REF 146 | The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties. J Med Chem. 2017 Dec 14;60(23):9676-9690. | ||||
REF 147 | Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5). Bioorg Med Chem Lett. 2015 Sep 1;25(17):3630-5. | ||||
REF 148 | Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors. J Med Chem. 2015 Feb 26;58(4):1929-39. | ||||
REF 149 | Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1843-5. | ||||
REF 150 | Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2958-62. | ||||
REF 151 | The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1109-1114. | ||||
REF 152 | Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. J Med Chem. 2014 Jul 10;57(13):5702-13. | ||||
REF 153 | Development of a novel class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4945-4949. | ||||
REF 154 | The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3895-9. | ||||
REF 155 | Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5767-71. | ||||
REF 156 | Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors. J Med Chem. 2017 May 11;60(9):3594-3605. | ||||
REF 157 | Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. | ||||
REF 158 | Discovery of phenyl acetamides as potent and selective GPR119 agonists. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1124-1128. | ||||
REF 159 | Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. J Med Chem. 2006 Nov 30;49(24):6954-7. | ||||
REF 160 | N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7116-9. | ||||
REF 161 | Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists. Bioorg Med Chem Lett. 2009 Jan 1;19(1):114-8. | ||||
REF 162 | [3-azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5491-4. | ||||
REF 163 | Identification of a sulfonamide series of CCR2 antagonists. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3961-4. | ||||
REF 164 | The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. Bioorg Med Chem Lett. 2012 May 15;22(10):3531-4. | ||||
REF 165 | Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists. ACS Med Chem Lett. 2010 Jun 8;1(6):244-8. | ||||
REF 166 | Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4011-3. | ||||
REF 167 | Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7489-95. | ||||
REF 168 | Synthesis and optimization of 4,5,6,7-tetrahydrooxazolo[4,5-c]pyridines as potent and orally-active metabotropic glutamate receptor 5 negative allosteric modulators. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4331-4335. | ||||
REF 169 | Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Bioorg Med Chem Lett. 2009 Mar 1;19(5):1522-7. | ||||
REF 170 | Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. | ||||
REF 171 | Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2365-71. | ||||
REF 172 | An octahydro-cyclopenta[c]pyrrole series of inhibitors of the type 1 glycine transporter. Bioorg Med Chem Lett. 2010 Feb 1;20(3):907-11. | ||||
REF 173 | The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6. | ||||
REF 174 | Selective I Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60(9):3795-3803. | ||||
REF 175 | Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009 Dec 10;52(23):7446-57. | ||||
REF 176 | Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. Eur J Med Chem. 2013 Jun;64:629-37. | ||||
REF 177 | Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 Mar 7;4(4):414-8. | ||||
REF 178 | Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as alpha7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. J Med Chem. 2014 May 22;57(10):3966-83. | ||||
REF 179 | Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation. J Med Chem. 2017 Jun 22;60(12):5072-5085. | ||||
REF 180 | Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding. ACS Med Chem Lett. 2015 May 22;6(7):741-6. | ||||
REF 181 | Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition. Medchemcomm. 2012;3:1423-7. | ||||
REF 182 | Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 May 1;22(9):3050-5. | ||||
REF 183 | Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. | ||||
REF 184 | Potent and selective proline derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5151-5. | ||||
REF 185 | Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies. Eur J Med Chem. 2012 Jun;52:1-13. | ||||
REF 186 | Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6053-6. | ||||
REF 187 | Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. J Med Chem. 2015 Dec 10;58(23):9154-70. | ||||
REF 188 | 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. | ||||
REF 189 | Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. | ||||
REF 190 | Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402. | ||||
REF 191 | Ligand-protein interactions of selective casein kinase 1 inhibitors. J Med Chem. 2013 Sep 12;56(17):6819-28. | ||||
REF 192 | Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor. J Med Chem. 2014 Sep 25;57(18):7770-91. | ||||
REF 193 | Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5. ACS Med Chem Lett. 2015 Mar 4;6(4):439-44. | ||||
REF 194 | Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106. | ||||
REF 195 | Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2014 Mar 13;57(5):1855-79. | ||||
REF 196 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6646-51. | ||||
REF 197 | Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARalpha Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. | ||||
REF 198 | Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2793-9. | ||||
REF 199 | Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4412-8. | ||||
REF 200 | Identification of highly potent and selective PI3K inhibitors. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2849-2853. | ||||
REF 201 | Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases. Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. | ||||
REF 202 | Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression. Bioorg Med Chem Lett. 2013 Jan 15;23(2):407-11. | ||||
REF 203 | gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2425-30. | ||||
REF 204 | Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4598-4602. | ||||
REF 205 | Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. J Med Chem. 2011 Nov 24;54(22):7834-47. | ||||
REF 206 | Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization. Eur J Med Chem. 2011 Aug;46(8):3486-98. | ||||
REF 207 | Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38alpha MAPK/PDE-4 Inhibitor with Activity against TNFalpha-Related Diseases. J Med Chem. 2017 Jul 13;60(13):5290-5305. | ||||
REF 208 | Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2(6):450-4. | ||||
REF 209 | Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. | ||||
REF 210 | 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5806-11. | ||||
REF 211 | Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1388-94. | ||||
REF 212 | Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor. Bioorg Med Chem. 2018 May 1;26(8):1495-1510. | ||||
REF 213 | Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors. ACS Med Chem Lett. 2015 Mar 2;6(5):507-12. | ||||
REF 214 | Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3K/ inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. | ||||
REF 215 | Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092. Medchemcomm. 2011;2:775-9. | ||||
REF 216 | De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist. J Med Chem. 2010 Feb 25;53(4):1876-80. | ||||
REF 217 | Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. | ||||
REF 218 | The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2622-6. | ||||
REF 219 | Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:1172-1192. | ||||
REF 220 | Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5563-8. | ||||
REF 221 | Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces. J Med Chem. 2018 Aug 9;61(15):6546-6573. | ||||
REF 222 | 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Jan 5;14(1):43-6. | ||||
REF 223 | Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf(V600E) and C-Raf kinase inhibitory activities. Eur J Med Chem. 2016 Jun 10;115:201-16. | ||||
REF 224 | Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1346-9. | ||||
REF 225 | Novel thienopyrimidinones as mGluR1 antagonists. Eur J Med Chem. 2014 Oct 6;85:629-37. | ||||
REF 226 | Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. | ||||
REF 227 | Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1156-60. | ||||
REF 228 | 4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity. J Med Chem. 2014 Jun 26;57(12):5419-34. | ||||
REF 229 | Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. J Med Chem. 2013 Jun 13;56(11):4764-85. | ||||
REF 230 | 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators. J Med Chem. 2014 Mar 27;57(6):2462-71. | ||||
REF 231 | Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor. J Med Chem. 2012 Sep 13;55(17):7772-85. | ||||
REF 232 | A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett. 2013 May 1;23(9):2663-70. | ||||
REF 233 | Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists. J Med Chem. 2018 Feb 8;61(3):1086-1097. | ||||
REF 234 | Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6). Bioorg Med Chem Lett. 2018 Jul 1;28(12):2222-2227. | ||||
REF 235 | Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells. J Med Chem. 2012 Sep 13;55(17):7560-70. | ||||
REF 236 | Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):271-7. | ||||
REF 237 | Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB 1 R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis. J Med Chem. 2017 Feb 9;60(3):1126-1141. | ||||
REF 238 | (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Jun 15;49(12):3614-27. | ||||
REF 239 | Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds. Eur J Med Chem. 2017 Jan 27;126:1129-1135. | ||||
REF 240 | Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators. J Med Chem. 2017 Jul 27;60(14):6451-6457. | ||||
REF 241 | Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett. 2016 Jan 20;7(3):300-5. | ||||
REF 242 | Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5721-6. | ||||
REF 243 | Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1084-8. | ||||
REF 244 | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665. | ||||
REF 245 | Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. J Med Chem. 2015 Apr 23;58(8):3522-33. | ||||
REF 246 | Structure-Affinity Relationships (SARs) and Structure-Kinetics Relationships (SKRs) of Kv11.1 Blockers. J Med Chem. 2015 Aug 13;58(15):5916-29. | ||||
REF 247 | Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain. Bioorg Med Chem. 2015 Aug 1;23(15):4624-4637. | ||||
REF 248 | Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1933-6 | ||||
REF 249 | Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Bioorg Med Chem. 2014 Oct 1;22(19):5392-409. | ||||
REF 250 | Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor. Eur J Med Chem. 2014 Sep 12;84:312-34. | ||||
REF 251 | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091. | ||||
REF 252 | Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11 hydroxysteroid dehydrogenase type 1 inhibitor. Bioorg Med Chem. 2017 Jul 15;25(14):3649-3657. | ||||
REF 253 | Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4713-8. | ||||
REF 254 | Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands. J Med Chem. 2012 Nov 26;55(22):9446-66. | ||||
REF 255 | Medicinal chemistry of inhibitors of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1). J Med Chem. 2014 Jun 12;57(11):4466-86. | ||||
REF 256 | Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. | ||||
REF 257 | Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. Bioorg Med Chem. 2018 Feb 15;26(4):945-956. | ||||
REF 258 | Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: selective inhibitors of Aurora B kinase with potent anti-tumor activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1904-9. | ||||
REF 259 | Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. | ||||
REF 260 | Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3. Bioorg Med Chem. 2015 Aug 1;23(15):4871-4883. | ||||
REF 261 | Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists. Bioorg Med Chem Lett. 2011 Oct 1;21(19):6013-8. | ||||
REF 262 | Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4579-83. | ||||
REF 263 | The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout. Medchemcomm. 2016;7:1572-9. | ||||
REF 264 | Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17-hydroxysteroid dehydrogenase inhibitor. Bioorg Med Chem. 2013 Sep 1;21(17):5261-70. | ||||
REF 265 | Discovery of a Series of Indazole TRPA1 Antagonists. ACS Med Chem Lett. 2017 May 18;8(6):666-671. | ||||
REF 266 | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J Med Chem. 2006 Jul 27;49(15):4455-8. | ||||
REF 267 | Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4163-8. | ||||
REF 268 | Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors. Medchemcomm. 2013;4:1305-11. | ||||
REF 269 | Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302. | ||||
REF 270 | The discovery of a potent Na v 1.3 inhibitor with good oral pharmacokinetics. Medchemcomm. 2017 Apr 28;8(6):1255-1267. | ||||
REF 271 | Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability. Bioorg Med Chem. 2015 Aug 1;23(15):4638-4648. | ||||
REF 272 | Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity. Medchemcomm. 2013;4:456-62. | ||||
REF 273 | US patent application no. 9402878B2, Depsipeptide and uses thereof | ||||
REF 274 | Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1257-61. | ||||
REF 275 | Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14;56(5):2125-38. | ||||
REF 276 | Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR. J Med Chem. 2017 Apr 13;60(7):3002-3019. | ||||
REF 277 | Optimisation of pharmacokinetic properties in a neutral series of 11-HSD1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6756-61. | ||||
REF 278 | N-Methyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamides as a novel class of cannabinoid receptors agonists with low CNS penetration. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3884-9. | ||||
REF 279 | Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069. | ||||
REF 280 | Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs). J Med Chem. 2009 Aug 13;52(15):4578-81. | ||||
REF 281 | Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. Bioorg Med Chem Lett. 2010 Jan 1;20(1):228-31. | ||||
REF 282 | Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. | ||||
REF 283 | Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J Med Chem. 2014 Dec 26;57(24):10512-26. | ||||
REF 284 | Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine. Eur J Med Chem. 2012 Sep;55:94-107. | ||||
REF 285 | 5-amino-pyrazoles as potent and selective p38alpha inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6886-9. | ||||
REF 286 | Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6707-13. | ||||
REF 287 | Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation. Eur J Med Chem. 2008 Nov;43(11):2479-88. | ||||
REF 288 | Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Mar 21;75:111-22. | ||||
REF 289 | Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem. 2016 Jan 14;59(1):335-57. | ||||
REF 290 | Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorg Med Chem. 2011 Dec 1;19(23):7221-7. | ||||
REF 291 | Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity. J Med Chem. 2015 Sep 10;58(17):7057-75. | ||||
REF 292 | Novel Derivative of Bardoxolone Methyl Improves Safety for the Treatment of Diabetic Nephropathy. J Med Chem. 2017 Nov 9;60(21):8847-8857. | ||||
REF 293 | Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1193-6. | ||||
REF 294 | Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Bioorg Med Chem Lett. 2016 May 15;26(10):2464-2469. | ||||
REF 295 | The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7100-5. | ||||
REF 296 | Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization. Eur J Med Chem. 2012 Jun;52:205-12. | ||||
REF 297 | Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus. Eur J Med Chem. 2018 Aug 5;156:269-294. | ||||
REF 298 | Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55(4):1751-7. | ||||
REF 299 | Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764). J Med Chem. 2011 Nov 10;54(21):7602-20. | ||||
REF 300 | Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4404-9. | ||||
REF 301 | Discovery of -aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1366-70. | ||||
REF 302 | The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3712-4. | ||||
REF 303 | Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. | ||||
REF 304 | Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels. J Nat Prod. 2009 May 22;72(5):830-4. |
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