The microRNAs (miRNAs) Regulating This Target |
Top |
miRNA Mature ID |
hsa-miR-331-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
gccccugggccuauccuagaa
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-331-3p by mature miRNA precursor transfection resulted in the decreased protein level of target ERBB2. |
[2] |
Evidence Score (E-score) |
5 |
+ |
1 |
Immunohistochemistry; Luciferase Reporter Assay; qRT-PCR; Western Blot |
[1] |
2 |
Immunohistochemistry; Luciferase Reporter Assay; qRT-PCR; Western Blot |
[2] |
3 |
Luciferase Reporter Assay |
[3] |
4 |
Luciferase Reporter Assay; Microarray; Western Blot |
[4] |
5 |
Luciferase Reporter Assay; Western Blot |
[5] |
Representative Target(s) Regulated by This miRNA |
E2F transcription factor 1 (E2F1)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-125a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ucccugagacccuuuaaccuguga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-125a-5p by mature miRNA transfection resulted in the decreased protein level of target ERBB2. |
[2] |
Evidence Score (E-score) |
4 |
+ |
1 |
Luciferase Reporter Assay |
[6] |
2 |
Luciferase Reporter Assay |
[2] |
3 |
Luciferase Reporter Assay; qRT-PCR; Western Blot |
[7] |
4 |
Western Blot; qRT-PCR |
[8] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator BAK (BAK)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-125b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ucccugagacccuaacuuguga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
The overexpression of miR-125b-5p by mature miRNA transfection resulted in the decreased protein level of target ERBB2. |
[2] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[9] |
2 |
Western Blot; Northern Blot; Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Apoptosis regulator BAK (BAK)
|
Target Info
|
|
Cyclin-dependent kinase 6 (CDK6)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-193a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugggucuuugcgggcgagauga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-193a-5p directly regulated HER2 by interacting with the 3-UTR. |
[3] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay |
[10] |
2 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
AP-2 transcription factor (TFAP2A)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-205-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uccuucauuccaccggagucug
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
Overexpression of erbB2 induces anchorage-independent growth in breast epithelial cells due to the deduction of miR-205. |
[12] |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay; qRT-PCR; Western Blot |
[11] |
2 |
qRT-PCR; Western Blot |
[12] |
Representative Target(s) Regulated by This miRNA |
Androgen receptor (AR)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-559 |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uaaaguaaauaugcaccaaaa
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
2 |
+ |
1 |
Luciferase Reporter Assay |
[13] |
2 |
Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
Metastasis associated gene-1 (MTA1)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-1296-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uuagggcccuggcuccaucucc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-1296-5p might be involved in the regulation on the migration and invasion of human gastric cancer cells at least in part via targeting ERBB2 signaling pathway. |
[15] |
Evidence Score (E-score) |
2 |
+ |
1 |
Dual Luciferase Reporter Assay; Western Blot |
[14] |
2 |
Luciferase Reporter Assay; Western Blot |
[15] |
Representative Target(s) Regulated by This miRNA |
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-130b-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cagugcaaugaugaaagggcau
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-130b-3p promotes TGF-b1-induced EMT in renal tubular epithelial cells by targeting ERBB2IP. |
[16] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[16] |
Representative Target(s) Regulated by This miRNA |
Acyl-CoA desaturase (SCD)
|
Target Info
|
|
Cyclin A2 (CCNA2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-134-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
ugugacugguugaccagagggg
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-134 directly regulated HER2 by interacting with the 3-UTR. |
[3] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
Angiopoietin-related protein 4 (ANGPTL4)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-155-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cuccuacauauuagcauuaaca
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-155 directly targets ErbB2 via a regulatory element in its coding region. |
[17] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[17] |
Representative Target(s) Regulated by This miRNA |
Cellular tumor antigen p53 (TP53)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-193a-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aacuggccuacaaagucccagu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-193a-5p directly regulated HER2 by interacting with the 3-UTR. |
[3] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
E2F transcription factor 1 (E2F1)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-199b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cccaguguuuagacuaucuguuc
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-199b-5p direct targets HER2 in breast cancer cell. |
[18] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[18] |
Representative Target(s) Regulated by This miRNA |
Epithelial discoidin domain receptor 1 (DDR1)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-21-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uagcuuaucagacugauguuga
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
qRT-PCR; Western Blot |
[19] |
Representative Target(s) Regulated by This miRNA |
Apoptosis antigen ligand (CD178)
|
Target Info
|
|
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-22-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aagcugccaguugaagaacugu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-22 can regulate ErbB2 by binding to the 3'UTR of ErbB2. |
[20] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[20] |
Representative Target(s) Regulated by This miRNA |
5-HT 2C receptor (HTR2C)
|
Target Info
|
|
ATP-citrate synthase (ACLY)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-25-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
cauugcacuugucucggucuga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-25 promotes gastric cancer progression by directly downregulating TOB1 expression. |
[21] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[21] |
Representative Target(s) Regulated by This miRNA |
CDK inhibitor 1C p57Kip2 (CDKN1C)
|
Target Info
|
|
Cellular tumor antigen p53 (TP53)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-34a-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggcagugucuuagcugguugu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
A luciferase reporter assay was done to understand the potential correlation between ErbB2 and miR-34a. |
[22] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[22] |
Representative Target(s) Regulated by This miRNA |
Amphiregulin (AREG)
|
Target Info
|
|
Androgen receptor (AR)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-3622b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aggcaugggaggucagguga
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-3622b-5p is involved in the proliferation and apoptosis of human ERBB2-positive cancer cells via targeting ERBB2/mTORC1 signaling pathway. |
[23] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[23] |
Representative Target(s) Regulated by This miRNA |
Epidermal growth factor receptor (EGFR)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-541-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
uggugggcacagaaucuggacu
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-541 directly regulated HER2 by interacting with the 3-UTR. |
[3] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
Voltage-gated calcium channel alpha Cav2.3 (CACNA1E)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-552-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
aacaggugacugguuagacaa
|
miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-552 directly regulated HER2 by interacting with the 3-UTR. |
[3] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
Apoptosis inhibitor survivin (BIRC5)
|
Target Info
|
|
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-323b-5p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
agguuguccguggugaguucgca
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[3] |
Representative Target(s) Regulated by This miRNA |
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|
miRNA Mature ID |
hsa-miR-548d-3p |
miRNA Info
|
miRNA Mature AC |
|
Sequence |
caaaaaccacaguuucuuuugc
|
miRNA Species |
Homo sapiens |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[2] |
Representative Target(s) Regulated by This miRNA |
Erbb2 tyrosine kinase receptor (HER2)
|
Target Info
|
|