Target Regulator(s) Information (MicroRNA)

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Target General Information
The microRNAs (miRNAs) Regulating This Target
References
Target General Information  Top
Target ID T51076 Target Info
Target Name NT-3 growth factor receptor (TrkC)
Synonyms TrkC tyrosine kinase; Trk-C; TRKC; Neurotrophic tyrosine kinase receptor type 3; NT3 growth factor receptor; GP145TrkC; GP145-TrkC
Target Type Successful Target
Gene Name NTRK3
Biochemical Class Kinase
UniProt ID
Q16288
The microRNAs (miRNAs) Regulating This Target  Top
miRNA Mature ID hsa-miR-125a-5p miRNA Info
miRNA Mature AC
MIMAT0000443
Sequence ucccugagacccuuuaaccuguga
miRNA Species Homo sapiens
Regulation Mechanism The decreased luciferase activity indicates that t-TrkC is targeted by hsa-miR-125a-5p in MB as well. [2]
Evidence Score (E-score) 3 +
1 Luciferase Reporter Assay [1]
2 Luciferase Reporter Assay [2]
3 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator BAK (BAK) Target Info
BAK_HUMAN
Apoptosis regulator Bcl-2 (BCL-2) Target Info
BCL2_HUMAN
miRNA Mature ID hsa-miR-625-5p miRNA Info
miRNA Mature AC
MIMAT0003294
Sequence agggggaaaguucuauagucc
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [4]
2 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Fragile histidine triad protein (FHIT) Target Info
FHIT_HUMAN
High mobility group protein HMG-I/Y (HMGA1) Target Info
HMGA1_HUMAN
miRNA Mature ID hsa-miR-128-3p miRNA Info
miRNA Mature AC
MIMAT0000424
Sequence ucacagugaaccggucucuuu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [3]
2 Luciferase Reporter Assay [5]
Representative Target(s) Regulated by This miRNA Adenosine A2b receptor (ADORA2B) Target Info
AA2BR_HUMAN
NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
miRNA Mature ID hsa-miR-485-3p miRNA Info
miRNA Mature AC
MIMAT0002176
Sequence gucauacacggcucuccucucu
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [4]
2 Luciferase Reporter Assay; Western Blot [3]
Representative Target(s) Regulated by This miRNA NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
Polybromo-1 (PBRM1) Target Info
PB1_HUMAN
miRNA Mature ID hsa-miR-765 miRNA Info
miRNA Mature AC
MIMAT0003945
Sequence uggaggagaaggaaggugaug
miRNA Species Homo sapiens
Evidence Score (E-score) 2 +
1 Luciferase Reporter Assay [4]
2 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Hepatocyte nuclear factor 4-alpha (HNF4A) Target Info
HNF4A_HUMAN
NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
miRNA Mature ID hsa-miR-125b-5p miRNA Info
miRNA Mature AC
MIMAT0000423
Sequence ucccugagacccuaacuuguga
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-125b-5p by mature miRNA precursor transfection resulted in the decreased protein level of target NTRK3; The Underexpression by LNA Antisense miRNA Oligonucleotides resulted in the increased protein level of target NTRK3. [3]
Evidence Score (E-score) 1 +
1 Western Blot; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Apoptosis regulator BAK (BAK) Target Info
BAK_HUMAN
Cyclin-dependent kinase 6 (CDK6) Target Info
CDK6_HUMAN
miRNA Mature ID hsa-miR-185-5p miRNA Info
miRNA Mature AC
MIMAT0000455
Sequence uggagagaaaggcaguuccuga
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [5]
Representative Target(s) Regulated by This miRNA Androgen receptor (AR) Target Info
ANDR_HUMAN
Arachidonate 12-lipoxygenase (12-LOX) Target Info
LOX12_HUMAN
miRNA Mature ID hsa-miR-198 miRNA Info
miRNA Mature AC
MIMAT0000228
Sequence gguccagaggggagauagguuc
miRNA Species Homo sapiens
Regulation Mechanism A significant reduction of luciferase activity was observed for miR-198 when compared with two different control mimics. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA Fibroblast growth factor receptor 1 (FGFR1) Target Info
FGFR1_HUMAN
Janus kinase 3 (JAK-3) Target Info
JAK3_HUMAN
miRNA Mature ID hsa-miR-330-3p miRNA Info
miRNA Mature AC
MIMAT0000751
Sequence gcaaagcacacggccugcagaga
miRNA Species Homo sapiens
Regulation Mechanism A significant reduction of luciferase activity was observed for miR-330 when compared with two different control mimics. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA E2F transcription factor 1 (E2F1) Target Info
E2F1_HUMAN
Extracellular matrix receptor III (CD44) Target Info
CD44_HUMAN
miRNA Mature ID hsa-miR-9-5p miRNA Info
miRNA Mature AC
MIMAT0000441
Sequence ucuuugguuaucuagcuguauga
miRNA Species Homo sapiens
Regulation Mechanism The overexpression of miR-9-5p by mature miRNA precursor transfection resulted in the decreased protein level of target NTRK3; The Underexpression by LNA Antisense miRNA Oligonucleotides resulted in the increased protein level of target NTRK3. [3]
Evidence Score (E-score) 1 +
1 Western Blot; Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA Beta-secretase 1 (BACE1) Target Info
BACE1_HUMAN
DNA-binding factor KBF1 (p105) Target Info
NFKB1_HUMAN
miRNA Mature ID hsa-miR-151a-3p miRNA Info
miRNA Mature AC
MIMAT0000757
Sequence cuagacugaagcuccuugagg
miRNA Species Homo sapiens
Regulation Mechanism miR-151-3p represses the full-length isoform of NTRK3. [5]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [5]
Representative Target(s) Regulated by This miRNA G1/S-specific cyclin-E1 (CCNE1) Target Info
CCNE1_HUMAN
Interleukin 12 receptor beta-2 (IL12RB2) Target Info
I12R2_HUMAN
miRNA Mature ID hsa-miR-345-5p miRNA Info
miRNA Mature AC
MIMAT0000772
Sequence gcugacuccuaguccagggcuc
miRNA Species Homo sapiens
Regulation Mechanism A significant reduction of luciferase activity was observed for miR-345 when compared with two different control mimics. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA Melanoma differentiation-associated protein 6 (CDKN1A) Target Info
CDN1A_HUMAN
Multidrug resistance-associated protein 1 (ABCC1) Target Info
MRP1_HUMAN
miRNA Mature ID hsa-miR-384 miRNA Info
miRNA Mature AC
MIMAT0001075
Sequence auuccuagaaauuguucaua
miRNA Species Homo sapiens
Regulation Mechanism A significant reduction of luciferase activity was observed for miR-384 when compared with two different control mimics. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA Endoplasmic reticulum chaperone BiP (HSPA5) Target Info
BIP_HUMAN
F-box and WD-40 domain protein 7 (Fbxw7) Target Info
FBXW7_HUMAN
miRNA Mature ID hsa-miR-509-3p miRNA Info
miRNA Mature AC
MIMAT0002881
Sequence ugauugguacgucuguggguag
miRNA Species Homo sapiens
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [3]
Representative Target(s) Regulated by This miRNA NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
miRNA Mature ID hsa-miR-617 miRNA Info
miRNA Mature AC
MIMAT0003286
Sequence agacuucccauuugaagguggc
miRNA Species Homo sapiens
Regulation Mechanism A significant reduction of luciferase activity was observed for miR-617 when compared with two different control mimics. [4]
Evidence Score (E-score) 1 +
1 Luciferase Reporter Assay [4]
Representative Target(s) Regulated by This miRNA NT-3 growth factor receptor (TrkC) Target Info
NTRK3_HUMAN
References  Top
REF 1 Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Am J Pathol. 2009 Mar;174(3):736-45.
REF 2 MicroRNA profiling in human medulloblastoma. Int J Cancer. 2009 Feb 1;124(3):568-77.
REF 3 The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62.
REF 4 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum Mutat. 2009 Jul;30(7):1062-71.
REF 5 Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol Biol. 2010 Dec 10;11:95.

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