Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T37693
|
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Former ID |
TTDC00314
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Target Name |
Cannabinoid receptor 2
|
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Gene Name |
CNR2
|
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Synonyms |
CB-2; CB2; CX5; Cannabinoid CB2 receptor; CNR2
|
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Target Type |
Successful
|
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Disease | Atopic dermatitis [ICD9: 691.8, 692.9; ICD10: L00-L99] | ||||
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63] | |||||
Chemotherapy-induced nausea [ICD9: 787, 787.0; ICD10: R11] | |||||
Immune disorder [ICD10: D80-D89] | |||||
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25] | |||||
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0] | |||||
Ischemia [ICD9: 459.89; ICD10: I99.8] | |||||
Inflammatory bowel disease [ICD9: 555, 556; ICD10: K50, K51] | |||||
Lipid metabolism disorder [ICD10: E75-E78] | |||||
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
Ovarian cancer [ICD9: 183; ICD10: C56] | |||||
Osteoporosis [ICD9: 733.0, V07.4; ICD10: M80-M81, Z79.890] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | |||||
Function |
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
|
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BioChemical Class |
GPCR rhodopsin
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Target Validation |
T37693
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UniProt ID | |||||
Sequence |
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC |
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Drugs and Mode of Action | |||||
Drug(s) | NABILONE | Drug Info | Approved | Insomnia | [551871] |
Dronabinol oral solution | Drug Info | Phase 2/3 | Chemotherapy-induced nausea | [551036] | |
842166X | Drug Info | Phase 2 | Pain | [521980] | |
GW-42004 | Drug Info | Phase 2 | Lipid metabolism disorder | [549419] | |
KHK-6188 | Drug Info | Phase 2 | Neuropathic pain | [523813] | |
LY-2828360 | Drug Info | Phase 2 | Pain | [523404] | |
S-777469 | Drug Info | Phase 2 | Atopic dermatitis | [537075] | |
Tedalinab | Drug Info | Phase 1 | Pain | [548356] | |
Research programme: small molecule therapeutics, Boehringer Ingelheim | Drug Info | Preclinical | Pain | [548042] | |
KN-38-7271 | Drug Info | Discontinued in Phase 2 | Ischemia | [547265] | |
PRS-211375 iv | Drug Info | Discontinued in Phase 2 | Pain | [542484], [547996] | |
TAK-937 | Drug Info | Discontinued in Phase 1 | Cerebrovascular ischaemia | [548963] | |
AM-577 | Drug Info | Terminated | Pain | [547668] | |
PRS-639058 | Drug Info | Terminated | Neuropathic pain | [547996] | |
PXS-2076 | Drug Info | Terminated | Rheumatoid arthritis | [548079] | |
WIN-55212-2 | Drug Info | Terminated | Discovery agent | [542353], [545702] | |
Inhibitor | (1R,2R)-N-Arachidonoylcyclopropanolamide | Drug Info | [530070] | ||
(1R,2R)-N-Oleoylcyclopropanolamide | Drug Info | [530070] | |||
(1R,2S)-N-Arachidonoylcyclopropanolamide | Drug Info | [530070] | |||
(1R,2S)-N-Oleoylcyclopropanolamide | Drug Info | [530070] | |||
(1S,2R)-N-Oleoylcyclopropanolamide | Drug Info | [530070] | |||
(1S,2S)-N-Arachidonoylcyclopropanolamide | Drug Info | [530070] | |||
(1S,2S)-N-Oleoylcyclopropanolamide | Drug Info | [530070] | |||
(2R)-N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
(2R)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
(2S)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
(4-benzhydrylpiperazin-1-yl)(cyclohexyl)methanone | Drug Info | [530617] | |||
(E)-N-(3,5-dimethoxyphenethyl)undec-2-enamide | Drug Info | [527788] | |||
(E)-N-(4-methoxyphenethyl)undec-2-enamide | Drug Info | [527788] | |||
(E)-N-(4-methoxyphenyl)undec-2-enamide | Drug Info | [527788] | |||
1,4-dihydroindeno[1,2-c]-pyrazole | Drug Info | [527858] | |||
2'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol | Drug Info | [528844] | |||
2-(2-Methoxybenzyl)-3H-benzo[f]chromen-3-one | Drug Info | [530009] | |||
3'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol | Drug Info | [528844] | |||
3,4-diarylpyrazoline derivative | Drug Info | [527721] | |||
3-benzoyl-1-pentyl-1,4-dihydroquinolin-4-one | Drug Info | [529079] | |||
3-Benzyl-5-isopropyl-8-methylchromen-2-one | Drug Info | [530009] | |||
4'-(1,1-dimethyl-heptyl)-3,5-dimethyl-biphenyl | Drug Info | [528844] | |||
4'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol | Drug Info | [528844] | |||
4-(1,1-dimethyl-heptyl)-2'-methoxy-biphenyl-2-ol | Drug Info | [528844] | |||
4-(1,1-dimethyl-heptyl)-3'-methoxy-biphenyl-2-ol | Drug Info | [528844] | |||
4-benzhydryl-N-butylpiperazine-1-carboxamide | Drug Info | [530617] | |||
4-benzhydryl-N-cyclohexylpiperazine-1-carboxamide | Drug Info | [530617] | |||
5-(1,1-dimethyl-heptyl)-2-pyridin-3-yl-phenol | Drug Info | [528844] | |||
5-Biphenyl-4-ylmethyl-1-isobutyl-1H-tetrazole | Drug Info | [529434] | |||
5-Biphenyl-4-ylmethyl-2-isobutyl-2H-tetrazole | Drug Info | [529434] | |||
5-Methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one | Drug Info | [530009] | |||
6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-((R)-1-HYDROXYETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
A-796260 | Drug Info | [530525] | |||
AM-1241 | Drug Info | [530525] | |||
AM-1710 | Drug Info | [529170] | |||
AM-1714 | Drug Info | [529170] | |||
AM-1715 | Drug Info | [529170] | |||
AM-281 | Drug Info | [530009] | |||
AM-404 | Drug Info | [529838] | |||
AM-411 | Drug Info | [531004] | |||
AM-4768 | Drug Info | [529170] | |||
AM-630 | Drug Info | [529106] | |||
Cis-N-oleoylcyclopropanolamide | Drug Info | [530070] | |||
CP-55940 | Drug Info | [528562] | |||
DELTA 8-TETRAHYDROCANNOBINOL | Drug Info | [529727] | |||
Dodeca-2E,4E-dienoic acid isobutylamide | Drug Info | [528831] | |||
GNF-PF-5188 | Drug Info | [529920] | |||
JWH-120 | Drug Info | [529920] | |||
JWH-133 | Drug Info | [528452] | |||
JWH-145 | Drug Info | [528355] | |||
JWH-146 | Drug Info | [528355] | |||
JWH-147 | Drug Info | [528355] | |||
JWH-150 | Drug Info | [528355] | |||
JWH-151 | Drug Info | [529920] | |||
JWH-156 | Drug Info | [528355] | |||
JWH-167 | Drug Info | [527630] | |||
JWH-201 | Drug Info | [527630] | |||
JWH-202 | Drug Info | [527630] | |||
JWH-203 | Drug Info | [527630] | |||
JWH-204 | Drug Info | [527630] | |||
JWH-205 | Drug Info | [527630] | |||
JWH-206 | Drug Info | [527630] | |||
JWH-207 | Drug Info | [527630] | |||
JWH-208 | Drug Info | [527630] | |||
JWH-209 | Drug Info | [527630] | |||
JWH-229 | Drug Info | [529920] | |||
JWH-237 | Drug Info | [527630] | |||
JWH-243 | Drug Info | [528355] | |||
JWH-244 | Drug Info | [528355] | |||
JWH-245 | Drug Info | [528355] | |||
JWH-246 | Drug Info | [528355] | |||
JWH-248 | Drug Info | [527630] | |||
JWH-249 | Drug Info | [527630] | |||
JWH-250 | Drug Info | [527630] | |||
JWH-251 | Drug Info | [527630] | |||
JWH-252 | Drug Info | [527630] | |||
JWH-253 | Drug Info | [527630] | |||
JWH-268 | Drug Info | [529920] | |||
JWH-292 | Drug Info | [528355] | |||
JWH-293 | Drug Info | [528355] | |||
JWH-294 | Drug Info | [529084] | |||
JWH-295 | Drug Info | [529084] | |||
JWH-296 | Drug Info | [529084] | |||
JWH-297 | Drug Info | [529084] | |||
JWH-302 | Drug Info | [527630] | |||
JWH-303 | Drug Info | [527630] | |||
JWH-305 | Drug Info | [527630] | |||
JWH-306 | Drug Info | [527630] | |||
JWH-307 | Drug Info | [528355] | |||
JWH-308 | Drug Info | [528355] | |||
JWH-309 | Drug Info | [528355] | |||
JWH-311 | Drug Info | [527630] | |||
JWH-312 | Drug Info | [527630] | |||
JWH-313 | Drug Info | [527630] | |||
JWH-314 | Drug Info | [527630] | |||
JWH-315 | Drug Info | [527630] | |||
JWH-323 | Drug Info | [529084] | |||
JWH-324 | Drug Info | [531027] | |||
JWH-325 | Drug Info | [529084] | |||
JWH-337 | Drug Info | [529084] | |||
JWH-342 | Drug Info | [529084] | |||
JWH-343 | Drug Info | [529084] | |||
JWH-344 | Drug Info | [529084] | |||
JWH-345 | Drug Info | [529084] | |||
JWH-346 | Drug Info | [528355] | |||
JWH-347 | Drug Info | [528355] | |||
JWH-348 | Drug Info | [528355] | |||
JWH-363 | Drug Info | [528355] | |||
JWH-364 | Drug Info | [528355] | |||
JWH-365 | Drug Info | [528355] | |||
JWH-366 | Drug Info | [528355] | |||
JWH-367 | Drug Info | [528355] | |||
JWH-368 | Drug Info | [528355] | |||
JWH-369 | Drug Info | [528355] | |||
JWH-370 | Drug Info | [528355] | |||
JWH-371 | Drug Info | [528355] | |||
JWH-372 | Drug Info | [528355] | |||
JWH-373 | Drug Info | [528355] | |||
JWH-385 | Drug Info | [529084] | |||
JWH-392 | Drug Info | [529084] | |||
JWH-401 | Drug Info | [529084] | |||
JWH-402 | Drug Info | [529084] | |||
JWH-403 | Drug Info | [529084] | |||
JWH-404 | Drug Info | [529084] | |||
JWH-405 | Drug Info | [529084] | |||
JWH-406 | Drug Info | [529084] | |||
JWH-407 | Drug Info | [529084] | |||
JWH-440 | Drug Info | [531027] | |||
JWH-441 | Drug Info | [531027] | |||
JWH-442 | Drug Info | [531027] | |||
KM-233 | Drug Info | [529515] | |||
KM-233-M | Drug Info | [529515] | |||
N-(1H-indazol-5-yl)icosa-5,8,11,14-tetraenamide | Drug Info | [529838] | |||
N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide | Drug Info | [529106] | |||
N-(3,3-Diphenyl)propyl-2,2-diphenylacetamide | Drug Info | [529563] | |||
N-(3-Phenyl)propyl-2-(4-bromophenylacetamide) | Drug Info | [529563] | |||
N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide | Drug Info | [529838] | |||
N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXY-2,2-DIMETHYLPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXY-2-METHYLPROPANAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
N-(7-(2-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) | Drug Info | [530929] | |||
N-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
N-arachidonoyl-O-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
N-benzyl-4-bromo-3-(morpholinosulfonyl)benzamide | Drug Info | [529872] | |||
N-oleoyl-N-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
N-oleoyl-O-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) | Drug Info | [530871] | |||
N1-(4-bromophenyl)-N2,N2-dipentylphthalamide | Drug Info | [529920] | |||
NABILONE | Drug Info | [531196] | |||
NAPHTHYRIDINONE | Drug Info | [527839] | |||
O-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
O-oleoyl-N-(2-hydroxyethyl)hydroxylamine | Drug Info | [528112] | |||
PRAVADOLINE | Drug Info | [551296] | |||
Rac-cis-N-arachidonoylcyclopropanolamide | Drug Info | [530070] | |||
Rac-trans-N-oleoylcyclopropanolamide | Drug Info | [530070] | |||
SCH-225336 | Drug Info | [530693] | |||
SCH-356036 | Drug Info | [530597] | |||
VER-156084 | Drug Info | [530200] | |||
VER-156085 | Drug Info | [530200] | |||
WIN-55212-2 | Drug Info | [528907] | |||
Agonist | 842166X | Drug Info | [532597] | ||
AM-577 | Drug Info | [547669] | |||
AR-XYZ | Drug Info | [543878] | |||
JWH-015 | Drug Info | [536731] | |||
JWH-051 | Drug Info | [543878] | |||
KHK-6188 | Drug Info | [551579] | |||
L-759,633 | Drug Info | [543878] | |||
L-759,656 | Drug Info | [543878] | |||
LY-2828360 | Drug Info | [551579] | |||
MDA-19 | Drug Info | [543878] | |||
Palmitoylethanolamide | Drug Info | [536731] | |||
PRS-211375 iv | Drug Info | [544411] | |||
PRS-639058 | Drug Info | [544486] | |||
PXS-2076 | Drug Info | [543878] | |||
Research programme: small molecule therapeutics, Boehringer Ingelheim | Drug Info | [543878] | |||
RQ-00202730 | Drug Info | [543878] | |||
S-777469 | Drug Info | [537075] | |||
Sch-036 | Drug Info | [543878] | |||
Tedalinab | Drug Info | [551201] | |||
[3H]CP55940 | Drug Info | [534133] | |||
[3H]HU-243 | Drug Info | [533602] | |||
[3H]WIN55212-2 | Drug Info | [533680] | |||
Modulator | Delta-9-tetrahydrocannabinol prodrugs | Drug Info | [543878] | ||
Dronabinol oral solution | Drug Info | [1572591] | |||
GW-42004 | Drug Info | ||||
KN-38-7271 | Drug Info | ||||
TAK-937 | Drug Info | [531715] | |||
Activator | HU-433 | Drug Info | [543878] | ||
Antagonist | SR144528 | Drug Info | [535198] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
References | |||||
Ref 521980 | ClinicalTrials.gov (NCT00444769) Dental Pain 3rd Molar Tooth Extraction GW842166. U.S. National Institutes of Health. | ||||
Ref 523404 | ClinicalTrials.gov (NCT01319929) A Study of LY2828360 in Patients With Osteoarthritic Knee Pain. U.S. National Institutes of Health. | ||||
Ref 523813 | ClinicalTrials.gov (NCT01544296) A Comparative Study of KHK6188. U.S. National Institutes of Health. | ||||
Ref 542353 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 733). | ||||
Ref 542484 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 746). | ||||
Ref 545702 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004262) | ||||
Ref 547265 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014615) | ||||
Ref 547668 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018288) | ||||
Ref 547996 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021026) | ||||
Ref 548042 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021465) | ||||
Ref 548079 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021746) | ||||
Ref 548356 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024918) | ||||
Ref 548963 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030875) | ||||
Ref 527630 | Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. | ||||
Ref 527721 | Bioorg Med Chem Lett. 2005 Nov 1;15(21):4794-8.Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. | ||||
Ref 527788 | Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. Epub 2005 Oct 6.New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. | ||||
Ref 527839 | Bioorg Med Chem Lett. 2006 Feb;16(3):681-5. Epub 2005 Nov 2.Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists. | ||||
Ref 527858 | J Med Chem. 2005 Nov 17;48(23):7351-62.Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide. | ||||
Ref 528112 | J Med Chem. 2006 Apr 6;49(7):2333-8.Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. | ||||
Ref 528355 | Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. | ||||
Ref 528452 | J Med Chem. 2006 Oct 5;49(20):5947-57.Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. | ||||
Ref 528562 | J Med Chem. 2006 Dec 14;49(25):7502-12.Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. | ||||
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